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内河航道岸线守护软体排变形监测系统框架设计

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水电能源科学 2024年第9期42卷 185-189页

作者：魏祥龙刘菁左利钦陆永军黄茗袁赛瑜河海大学水灾害防御全国重点实验室江苏南京210024 南京水利科学研究院水灾害防御全国重点实验室江苏南京210029 河海大学水利部水循环与水动力系统重点实验室江苏南京210098

构建软体排变形监测系统是实现内河航道智能化的重要举措。针对软体排变形监测系统的复杂性,从硬件与软件系统构成入手,提出了软体排变形监测系统框架包括变形监测、数据可视化及变形分析三部分,利用分布式光纤、渗压计及柔性位移计进... 详细信息

构建软体排变形监测系统是实现内河航道智能化的重要举措。针对软体排变形监测系统的复杂性,从硬件与软件系统构成入手,提出了软体排变形监测系统框架包括变形监测、数据可视化及变形分析三部分,利用分布式光纤、渗压计及柔性位移计进行多源监测,并构建了基于多源监测数据的变形交叉验证与识别方法,将处理后的监测数据载入基于LabVIEW和Matlab混合编程的变形分析系统,实现了多源监测的展示、分析与变形识别。研究结果可为内河航道整治建筑物服役状态的监测、预警及系统开发提供参考。

关键词：航道整治软体排变形监测智能航道 LabVIEW

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Two-dimensional pipe leakage through a line crack in water distribution systems

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第5期14卷 371-376页

作者： Shuai GUO Tu-qiao ZHANG wei-yun SHAO David Z.ZHU yuan-yu DUAN College of Civil Engineering and Architecture Zhejiang University Deptment of Civil and Environmental Engineering University of AlbertaEdmontonABT6G 2W2Canada

In water distribution systems,water leakage from cracked water pipes is a major concern for water ***,the relationship between the leakage rate and the water pressure can be modeled by a power function developed from the orifice *** paper presents an approximate solution for the computation of the steady-state leakage rate through a longitudinal line crack of a water distribution pipe considering the surrounding soil *** derived solution agrees well with results of numerical *** with the traditional models,the new solution allows assessment of all the parameters that related with leakage including the pressure head inside the pipe,hydraulic conductivity,crack size and its position,and pipe size and its depth.

关键词： Leakage Pipe crack Soil Water distribution systems Water pipes

基于PKCβⅡ/NOX2/ROS信号通路探讨柴胡三参胶囊对心肌缺血再灌注损伤大鼠的保护作用

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中国中药杂志 2024年第5期49卷 1361-1368页

作者：胡雅琪孙丽李雪珂卢圣花袁恒佑王伟松刘建和湖南中医药大学第一附属医院湖南长沙410007 国家中医心血管病临床医学研究中心分中心湖南长沙410007

基于氧化应激介导的程序性细胞死亡探讨心肌缺血再灌注损伤的发病机制,及基于PKCβⅡ/NOX2/ROS信号通路探讨柴胡三参胶囊调节心肌缺血再灌注损伤的机制及作用靶点。结扎左前降支建立心肌缺血再灌注损伤大鼠模型,随机分为6组:假手术组,... 详细信息

基于氧化应激介导的程序性细胞死亡探讨心肌缺血再灌注损伤的发病机制,及基于PKCβⅡ/NOX2/ROS信号通路探讨柴胡三参胶囊调节心肌缺血再灌注损伤的机制及作用靶点。结扎左前降支建立心肌缺血再灌注损伤大鼠模型,随机分为6组:假手术组,模型组,柴胡三参胶囊临床等效、高剂量组,N-乙酰半胱氨酸(N-acetylcysteine)组,蛋白激酶C抑制剂(CGP53353)组。柴胡三参胶囊各剂量组连续给药7 d后,检测各组大鼠心肌梗死面积;苏木精-伊红(HE)染色观察大鼠心肌组织病理形态;TUNEL染色观察大鼠心脏组织凋亡情况;酶联免疫吸附(enzyme-linked immunosorbent assay,ELISA)法检测大鼠心肌损伤指标和氧化应激相关指标;流式细胞仪检测心脏组织中活性氧(ROS)水平;蛋白免疫印迹法(Western blot)及实时荧光定量聚合酶链式反应(real-time quantitative PCR,RT-qPCR)检测大鼠心脏组织相关蛋白及mRNA相对表达水平。结果显示,与假手术组比较,模型组大鼠心肌梗死面积明显,心肌结构紊乱、间质水肿及出血,可见大量空泡,心肌损伤标志物及心肌凋亡水平明显升高,ROS及丙二醛(MDA)水平明显升高,超氧化物歧化酶(SOD)水平明显下降,心肌组织中蛋白激酶C(PKCβⅡ)、烟酰胺腺嘌呤二核苷酸磷酸氧化酶2(NOX2)、半胱氨酸蛋白酶3(caspase-3)、长链脂酰辅酶A合成酶4(ACSL4)蛋白及mRNA表达水平明显升高。与模型组比较,柴胡三参胶囊可改善大鼠心肌梗死面积和心脏组织病理形态,改善心肌损伤标志物和氧化应激相关指标,减少心肌组织凋亡水平,降低心肌组织中PKCβⅡ、NOX2、caspase-3、ACSL4蛋白及mRNA的表达。结果表明,柴胡三参胶囊可通过调控PKCβⅡ/NOX2/ROS信号通路,抑制氧化应激和程序性细胞死亡(凋亡、铁死亡),从而减轻心肌缺血再灌注损伤。

关键词：心肌缺血再灌注损伤柴胡三参胶囊氧化应激程序性细胞死亡

Influence of aquatic plants on the hydrogen isotope composition of sedimentary long-chain n-alkanes in the Lake Qinghai region, Qinghai-Tibet Plateau

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Science China Earth Sciences 2016年第7期59卷 1368-1377页

作者： LIU wei Guo YANG Hong WANG Huan Ye YAO yuan WANG Zheng CAO Yun Ning State Key Laboratory of Loess and Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences School of Human Settlements and Civil Engineering Xi'an Jiaotong University Laboratory for Terrestrial Environment Department of Science and Technology College of Arts and Sciences Bryant University

The hydrogen isotopic composition(δD) of leaf wax long-chain n-alkanes(C27, C29, and C31) from lacustrine sediments has been widely applied to reconstruct terrestrial paleoclimatic and paleohydrological changes. However, few studies have addressed whether the aquatic-derived n-alkanes can affect the δD values of lake sedimentary long-chain n-alkanes, which are usually regarded as a recorder of the terrestrial hydrological signals. Here we systematically investigated δD values of long-chain n-alkanes from modern aquatic plants, both near-shore and off-shore surface sediments, surrounding terrestrial plant litters, as well as river water and lake water in Lake Qinghai and its satellite lakes on the northeastern Qinghai-Tibet Plateau. Our data showed that(i) δD values of long-chain n-alkanes from aquatic plants varied from-184‰ to-132‰ for n-C27, from-183‰ to-138‰ for n-C29, and from-189‰ to-130‰ for n-C31, respectively, with no significant differences among the three n-alkanes homologues;(ii) δD values of long-chain n-alkanes from aquatic plants were generally more positive than those from surrounding terrestrial plants, possibly because that they recorded the D-enrichment of lake water in this semi-arid region;(iii) δD values of long-chain n-alkanes from surface sediments showed significant differences among the three n-alkanes homologues, due to the larger aquatic input of n-C27 to the sedimentary lipid pool than that of n-C31, and(iv) n-C27 δD values of near-shore aquatic plants and near-shore sediments are more negative than those from off-shore as a result of lower δD values of near-shore lake water. Our findings indicate that in this region(i) the offset between sedimentary n-C27 and n-C31 δD values(ΔδDC27-C31) could potentially be used to evaluate if sedimentary long-chain n-alkanes are derived from a single source;(ii) while δD values of n-C27 may be influenced by lake water hydrological changes, sedimentary n-C31 is derived predominantly from terrestrial plan

关键词： Hydrogen isotope Long-chain n-alkanes Aquatic plants Paleohydrology proxy Lake Qinghai

PDGFRA基因突变型胃肠间质瘤生物学行为再研究

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中华病理学杂志 2024年第1期53卷 46-51页

作者：袁伟黄雯任磊梁怀予董思瑶都向阳徐晨方勇沈坤堂侯英勇复旦大学附属中山医院病理科上海200032 复旦大学附属中山医院普外科上海200032

目的:探讨血小板源生长因子α受体(PDGFRA)基因突变型胃肠间质瘤(gastrointestinal stromal tumor,GIST)的生物学行为谱系,比较复旦大学附属中山医院良恶性评估方法与改良版美国国立卫生研究院(NIH)危险度分级的临床应用效能。方法:收... 详细信息

目的:探讨血小板源生长因子α受体(PDGFRA)基因突变型胃肠间质瘤(gastrointestinal stromal tumor,GIST)的生物学行为谱系,比较复旦大学附属中山医院良恶性评估方法与改良版美国国立卫生研究院(NIH)危险度分级的临床应用效能。方法:收集复旦大学附属中山医院2009—2020年手术切除PDGFRA基因突变型GIST 119例,复习其临床病理资料、随访记录后续治疗并进行统计学分析。结果:在119例PDGFRA基因突变型GIST中,男性79例,女性40例;年龄25~80岁,中位年龄60岁,此组病例均来源于胃。其中115例患者术后获得随访,随访时间1~154个月,13例疾病进展。总体5年无瘤生存率为90.1%,总生存率94.1%。参考改良版NIH危险度分级,极低危、低危、中危、高危组分别8、32、38和35例,其中5年无瘤生存率分别为100.0%、95.6%、94.3%、80.5%,非高危3组预后差异无统计学意义,仅高危与非高危组差异有统计学意义(P=0.029),而5年总生存率分别为100.0%、100.0%、95.0%、89.0%,差异均无统计学意义(P=0.221)。按照复旦大学附属中山医院良恶性评估方法,非恶性43例(37.4%),低度恶性56例(48.7%),中度恶性9例(7.8%),高度恶性7例(6.1%),5年无瘤生存率分别为100.0%、91.7%、77.8%、38.1%,差异有统计学意义(P<0.001),5年总生存率分别为100.0%、97.5%、77.8%、66.7%,差异有统计学意义(P<0.001)。结论:PDGFRA基因突变型GIST包含良性到高度恶性广谱生物学行为谱系,按照复旦大学附属中山医院良恶性评估方法,非恶性和低度恶性多见,术后预后好,少部分为中~高度恶性,单纯手术切除预后差。此型GIST总体上表现为相对惰性的生物学行为是源于中~高度恶性构成比低。改良版NIH方案不能有效地对PDGFRA突变型GIST进行危险度分层。

关键词：胃肠道间质肿瘤受体血小板源生长因子α 预后

Power supply Noise Aware Task Scheduling on Homogeneous 3D MPSoCs Considering the Thermal Constraint

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Journal of Computer Science & Technology 2018年第5期33卷 966-983页

作者： Ying-Lin Zhao Jian-Lei Yang wei-Sheng Zhao Aida Todri-Sanial yuan-Qing Cheng Fert Beijing Research Institute Beijing Advanced Innovation Center for Big Data and Brain Computing Beijing 100191 China School of Electronic and Information Engineering Beihang University Beijing 100191 China Qingdao Research Institute Beihang University Qingdao 266041 China School of Computer Science and Engineering Beihang University Beijing 100191 China Laboratory of Informaties Robotics and Mieroeleetronics University of Montpellier Montpellier 34095 France National Center for Scientific Research MontpeUier 34095 France

Thanks to the emerging 3D integration technology, The multiprocessor system on chips （MPSoCs） can now integrate more IP cores on chip with improved energy efficiency. However, several severe challenges also rise up for 3D ICs due to the die-stacking architecture. Among them, power supply noise becomes a big concern. In the paper, we investigate power supply noise （PSN） interactions among different cores and tiers and show that PSN variations largely depend on task assignments. On the other hand, high integration density incurs a severe thermal issue on 3D ICs. In the paper, we propose a novel task scheduling framework considering both the PSN and the thermal issue. It mainly consists of three parts. First, we extract current stimuli of running tasks by analyzing their power traces derived from architecture level simulations. Second, we develop an efficient power delivery network （PDN） solver to evaluate PSN magnitudes efficiently. Third, we propose a heuristic algorithm to solve the formulated task scheduling problem. Compared with the state-of-the-art task assignment algorithm, the proposed method can reduce PSN by 12% on a 2 × 2 × 2 3D MPSoCs and by 14% on a 3 × 3 × 3 3D MPSoCs. The end-to-end task execution time also improves as much as 5.5% and 7.8% respectively due to the suppressed PSN.

关键词： MPSoCs power supply noise (PSN) power delivery network (PDN) task scheduling algorithm temperature 3D

Graphene nanopores toward DNA sequencing： a review of experimental aspects

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Science China Chemistry 2017年第6期60卷 721-729页

作者： wei Chen Guo-Chang Liu Jun Ouyang Meng-Juan Gao Bo Liu yuan-Di Zhao Britton Chance Center for Biomedical Photonics at Wuhan National Laboratory for Optoelectronics-Hubei Bioinformatics and Molecular Imaging Key Laboratory Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China

Nanopores for DNA sequencing have drawn much attention due to their potentials to achieve amplification-free, low-cost, and high-throughput analysis of nuclei acids. The material configuration and fabrication of the nanopore has become one important consideration in the nanopore based DNA sequencing research. Among various materials, the newly emerged graphene has brought more opportunities to the development of sequencing technology because of its unique structures and properties. This review mainly focuses on the experimental aspects of graphene nanopore research including the nanopore fabrication methods and processes. Meanwhile, the challenges in the present graphene nanopore research including hydrophobicity, translocation velocity and noise are also addressed and discussed.

关键词： graphene nanopore DNA sequencing nanopore fabrication

Time-resolved ESI-MS Investigation on Reduction and Alkylation in Unfolding Process of Lysozyme

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Chemical Research in Chinese Universities 2001年第4期17卷 387-393页

作者： SONG Hao-wei XU Chong-feng FU Yun-lin YANG Peng-yuan WANG Hong-hai Department of Chemistry State Key Laboratory of Genetic Engineering Fudan UniversityShanghai 200433P.R.China

The kinetic procedure of the unfolding of lysozyme induced by the reduction of disulfide was monitored by the time-resolved ESI-MS with a sheath liquid assistant electrospray interface. It was found that the reduction process for the eight disulfides had a less difference in the reaction time after denatured treatment. In addition, the alkylation of the reduced free thiols was much slower than the reduction procedure. An artifact peak produced by the CID fragmentation in the mass spectra was identified and the possible mechanism of the Hofmann elimination reaction was proposed.

关键词： Unfolding Lysozyme Reduction and alkylation Time-resolved ESI-MS

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高危孕产妇焦虑水平与亲密关系的相关性研究

中华现代护理杂志 2024年第29期30卷 4025-4029页

作者：魏涛关海涛李博文吴鸿雁袁媛王德慧北京医院产科、国家老年医学中心、中国医学科学院老年医学研究院产科北京100730 北京中医药大学护理学院北京102488 解放军总医院第七医学中心妇产医学部北京100700 首都医科大学附属北京安贞医院妇产科北京100029

目的探究高危孕产妇焦虑水平与亲密关系的相关性。方法采用便利抽样法,于2023年11月—2024年3月选取北京市4所三级甲等医院产科收治的257名高危孕产妇为研究对象,采用一般资料调查表、Locke-Wollance婚姻调适量表(LWMAT)、焦虑自评量表(... 详细信息

目的探究高危孕产妇焦虑水平与亲密关系的相关性。方法采用便利抽样法,于2023年11月—2024年3月选取北京市4所三级甲等医院产科收治的257名高危孕产妇为研究对象,采用一般资料调查表、Locke-Wollance婚姻调适量表(LWMAT)、焦虑自评量表(SAS)进行调查。采用分层线性回归分析探讨高危孕产妇焦虑水平与亲密关系的相关性。结果257名高危孕产妇SAS得分为30.00(26.00,35.00)分,其中焦虑发生率为3.9%(10/257);LWMAT得分为129.00(113.50,141.00)分,其中227名(88.3%)孕产妇感知亲密关系良好。分层线性回归分析结果显示,亲密关系是高危孕产妇焦虑水平的影响因素(P<0.05)。结论亲密关系可负向预测高危孕产妇焦虑水平。医护人员应关注高危孕产妇及配偶的亲密关系,充分发挥亲密关系在改善高危孕产妇不良情绪方面的重要作用。

关键词：高危妊娠焦虑亲密关系相关性