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Rapid progression of heart failure secondary to radioactive iodine treatment of hyperthyroidism:A case report

World Journal of Clinical Cases 2023年第22期11卷 5316-5321页

作者： Zi-Han Li Lu-Jia Ni yuan-qiao liu Dao-yuan Si Department of Cardiology China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Jilin Provincial Engineering Laboratory for Endothelial Function China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina Department of Ultrasound China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

BACKGROUND The deterioration of thyroid health is involved in the progression of heart failure(HF).This is usually a lengthy process,so there are almost no reports on its rapid *** we report a case of a young male who rapidly developed hypothyroid cardiomyopathy secondary to radioactive iodine treatment,suggesting that severe HF might occur even after a short period of *** SUMMARY A 26-year-old man was referred to our hospital for HF presenting with dyspnea on exertion and chest discomfort lasting for 1 *** received radioactive iodine treatment for hyperthyroidism 1 year ago and had an almost normal echocardiogram 6 mo *** echocardiogram and cardiac magnetic resonance(CMR)revealed left ventricle(LV)global hypokinesia and severely depressed systolic *** addition,late gadolinium enhancement indicated no obvious changes in the *** function tests showed decreased serum levels of thyroid hormone(TH)and elevated thyroid-stimulating *** on an exclusionary examination,the patient was diagnosed with hypothyroid cardiomyopathy and was started on replacement *** HF symptoms were completely relieved during the six-month follow-up,and echocardiogram and CMR revealed recovered LV size and ejection *** This report demonstrates that severe fluctuations in TH levels may lead to acute HF,which can completely recover with timely thyroid hormone *** addition,our findings highlight the importance of routinely detecting cardiac function in patients treated with radioactive iodine.

关键词： Heart failure Hypothyroid cardiomyopathy Hormone replacement therapy Radioactive iodine therapy Case report

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Wavelet Filter and Noise Rejection for the Pulse Laser Radar

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Chinese Journal of Lasers 2000年第4期9卷 26-31页

作者： CAI Xiping ZHAO yuan qiao Lijie liu Jianbo (Department of Applied Physics, Harbin Institute of Technology, Harbin 150001, China) 哈尔滨工业大学黑龙江哈尔滨

The stochastic noise can be expanded on the basis of Fourier progression. It can be divided into two components, one is called ac noise which obeys the normal distribution statistically, on the other hand, the other is called dc noise which can decrease the detection SNR. Generally, a matched filter is used to reject noise, but it is only suitable for the rejection of white noise. In this paper, a wavelet filter is introduced to reject the dc noise for the signal detection of the pulse laser radar. The bubble function is selected as the mother function. The simulation results indicated that the SNR can be improved by wavelet filter when the dc noise is existing. It is indicated that the SNR is higher with matched filter than that with wavelet filter in the absence of the dc noise, while the SNR is greatly higher with wavelet filter than that with matched filter when dc noise is in existence.

关键词： wavelet transform noise rejection laser radar

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Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue Zhuang Yanxin qiao Yu Zhang Aihua yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

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微纳米RDX颗粒级配对压装PBX性能影响

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含能材料 2016年第12期24卷 1193-1197页

作者：肖磊刘杰郝嘎子柯香高寒戎园波刘巧娥姜炜南京理工大学国家特种超细粉体工程技术研究中心江苏南京210094 甘肃银光化学工业集团有限公司科研所甘肃白银730900

为了提高高聚物粘结炸药(PBX)的力学性能,降低其机械感度,采用溶液-水悬浮法,制备了含微纳米RDX不同颗粒级配(100/0,95/5,90/10,80/20)的PBXs。用光学显微镜观测其表观形貌,并测试了机械感度、力学性能以及爆速等性能。结果表明,微纳米... 详细信息

为了提高高聚物粘结炸药(PBX)的力学性能,降低其机械感度,采用溶液-水悬浮法,制备了含微纳米RDX不同颗粒级配(100/0,95/5,90/10,80/20)的PBXs。用光学显微镜观测其表观形貌,并测试了机械感度、力学性能以及爆速等性能。结果表明,微纳米RDX颗粒级配的PBX造型粉颗粒偏小、形貌规则、呈类球形。纳微米RDX颗粒级配为5/95的PBX性能最佳,撞击感度由44%降低到12%,摩擦感度由24%降低到4%;抗压强度从5.55 MPa提高到6.57 MPa,抗拉强度由0.66 MPa提高到0.77 MPa,抗剪强度由1.76 MPa提高到1.96 MPa;爆速从8033 m·s^(-1)增加到8186 m·s^(-1)。

关键词：高聚物粘结炸药(PBX) 级配机械感度力学性能爆速

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超广角造影在后葡萄膜炎及全葡萄膜炎诊疗中的应用

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中华眼科杂志 2016年第12期52卷 924-928页

作者：池滢郭春英彭媛乔丽君杨柳北京大学第一医院眼科视觉损伤与修复教育部重点实验室 100034

目的研究超广角FFA在后葡萄膜炎及全葡萄膜炎患者诊疗中的应用。方法前瞻性观察性研究。对北京大学第一医院眼科诊断为后葡萄膜炎及全葡萄膜炎的患者42例（82只眼）进行常规临床检查、传统FFA及超广角造影检查，观察患者的周边视网膜改... 详细信息

目的研究超广角FFA在后葡萄膜炎及全葡萄膜炎患者诊疗中的应用。方法前瞻性观察性研究。对北京大学第一医院眼科诊断为后葡萄膜炎及全葡萄膜炎的患者42例（82只眼）进行常规临床检查、传统FFA及超广角造影检查，观察患者的周边视网膜改变，并且评价这些改变对疾病活动性评估及治疗方案调整的指导作用。结果入选的42例（82只眼）患者中男性22例，女性20例，平均年龄（43±21）岁。其中6例（12只眼）为后葡萄膜炎，36例（70只眼）为全葡萄膜炎。临床检查及传统FFA诊断为活动性葡萄膜炎的有30只眼（37%），超广角造影诊断为活动性葡萄膜炎的有48只眼（59%）。超广角造影新发现活动病变的18只眼（22%）均观察到周边血管渗漏，其中4只眼（5%）观察到周边无灌注区，1只眼观察到新生血管形成（1%）。在临床检查及传统FFA诊断为活动性葡萄膜炎的患者（30只眼）中，有10只眼（33%）发现与后极部视网膜血管轻度渗漏相比更严重的周边血管渗漏。有明确病因的患者中，46%（21/45）的眼超广角造影观察到新的病变，而未找到明确病因的眼中，19%（7/37）的眼超广角造影观察到新的病变。根据超广角造影的发现，有12例患者及时调整了治疗方案。结论超广角造影可以发现传统荧光造影无法观察到的周边视网膜血管的渗漏，对治疗有一定的指导作用。

关键词：葡萄膜炎后全葡萄膜炎荧光素血管造影术视网膜血管

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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： yuan Zhao Yidan Zhang Xin liu Jian Zhang Ya Gao Shuyue Li Cui Chang Xiang liu Guofeng Yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-Yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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Physical Layer Security Scheme With AoI-Awareness for Industrial IoT Based on Covert Communications

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 276-278页

作者： Yaping Li Zhi-Xin liu Jia-Wei Su Ya-Zhou yuan the Key Laboratory of Industrial Computer Control Engineering of Hebei Province Yanshan University

Dear Editor,Industrial Internet of things(IIoT) is a typical application of cyberphysical system(CPS). In the IIoT, wireless communication is an inevitable trend to replace the deployment-limited wired transmission for cases with large-scale and mobile devices. However, wireless communication gives rise to critical issues related to physical security, such as malicious detections and attacks [1].

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan Li Xi liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao Liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi Zhen yuan Ping Wang Bin liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

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高效液相色谱法测定益之康胶囊中总蒽醌(大黄素和大黄素甲醚)的含量

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食品工业科技 2017年第21期38卷 252-256,267页

作者：寿林均程巧鸳黄柳倩周明昊浙江工业大学化学工程学院浙江杭州310014 浙江省食品药品检验研究院浙江杭州310052

建立益之康胶囊中总蒽醌含量测定的高效液相色谱法。采用HPLC测定益之康胶囊中2种蒽醌类成分大黄素和大黄素甲醚的含量;流动相为甲醇-0.1%磷酸溶液(75∶25,v/v),柱温30℃,流速1.0 m L/min,检测波长254 nm。大黄素和大黄素甲醚分别在0.05... 详细信息

建立益之康胶囊中总蒽醌含量测定的高效液相色谱法。采用HPLC测定益之康胶囊中2种蒽醌类成分大黄素和大黄素甲醚的含量;流动相为甲醇-0.1%磷酸溶液(75∶25,v/v),柱温30℃,流速1.0 m L/min,检测波长254 nm。大黄素和大黄素甲醚分别在0.054~0.65μg和0.022~0.27μg范围内呈良好的线性关系,相关系数分别为0.9999和0.9999,检出限分别为0.86μg/g和0.87μg/g,平均回收率分别为97.20%(RSD=2.26%)和99.96%(RSD=2.18%)。结论:该方法简便、准确、可靠。

关键词：益之康胶囊大黄素大黄素甲醚总蒽醌高效液相色谱法(HPLC)

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