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Expressions of matrix metalloproteinases 1 and 3 and their tissue inhibitors in the conjunctival tissue and fibroblasts cultured from conjunctivochalasis

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 555-559页

作者： Min-Hong Xiang Xing-Ru Zhang Zhen-Yong Zhang Qing-Song Li Han-Min Wang Zhu-Mei Han Huan-Ming Zhou yuan-ling jia Xing-Xing Chen Department of Ophthalmology Putuo HospitalShanghai University of Traditional Chinese Medicine Liqun Hospital Putuo District

AIM：To investigate the expression of matrix metalloproteinases 1 and 3（MMP-1 and MMP-3） and their tissue inhibitors of metalloproteinases 1 and 3（ TIMP-1 and TIMP-3） in the conjunctiva of eyes with conjunctivochalasis（CCh）.METHODS：The conjunctival tissue was obtained from the CCh patients and controls,the MMPs/TIMPs expression concentration was determined by enzyme-linked immunosorbent assay（ELISA） and immunofluorescence *** expression levels of MMPs/TIMPs in the CCh fibroblasts were determined by analyzing its concentration in the cellular supernatant that was abstracted from the in vitro cultured CCh ***：MMP-1 and MMP-3 levels determined by ELISA were both significantly higher in the CCh group than that in the control group（P= 0.042,0.022,respectively）,so was the levels of TIMP-1（P= 0.010）.No significant difference in the expression of TIMP-3 in conjunctiva was found between the two groups（P= 0.298）.The expression of MMP-1 and MMP-3 were both up-regulated significantly in the CCh group（P= 0.040,0.001,respectively） on immunofluorescence ***-1 and MMP-3 expression in the fibroblasts were both significantly higher in the CCh group than that in the control group（P= 0.027,0.001,respectively）,while neither the TIMP-1 nor TIMP-3 expression was significantly different between the two groups（P= 0.421,0.237,respectively）.CONCLUSION：The overexpression of MMP-1 and MMP-3 in conjunctival tissue and fibroblasts may play an important role in the pathogenesis and development of CCh.

关键词： conjunctivochalasis relaxed conjunctiva fibroblast matrix metaUoproteinase tissue inhibitor of matrix metalloproteinase

Toward Analytical Homogenized Relaxation Modulus for Fibrous Composite Material with Reduced Order Homogenization Method

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Computers, Materials & Continua 2025年第1期82卷 193-222页

作者： Huilin jia Shanqiao Huang Zifeng yuan HEDPS Center for Applied Physics and Technology(CAPT)Department of Mechanics and Engineering SciencePeking UniversityBeijing100871China State Key Laboratory for Turbulence and Complex Systems Peking UniversityBeijing100871China

In this manuscript,we propose an analytical equivalent linear viscoelastic constitutive model for fiber-reinforced composites,bypassing general computational *** method is based on the reduced-order homogenization(ROH)*** ROH method typically involves solving multiple finite element problems under periodic conditions to evaluate elastic strain and eigenstrain influence functions in an‘off-line’stage,which offers substantial cost savings compared to direct computational homogenization *** to the unique structure of the fibrous unit cell,“off-line”stage calculation can be eliminated by influence functions obtained *** the standard solid model to the ROH method enables the creation of a comprehensive analytical homogeneous viscoelastic constitutive *** method treats fibrous composite materials as homogeneous,anisotropic viscoelastic materials,significantly reducing computational time due to its analytical *** approach also enables precise determination of a homogenized anisotropic relaxation modulus and accurate capture of various viscoelastic responses under different loading *** sets of numerical examples,including unit cell tests,three-point beam bending tests,and torsion tests,are given to demonstrate the predictive performance of the homogenized viscoelastic ***,the model is validated against experimental measurements,confirming its accuracy and reliability.

关键词： Homogenized relaxation modulus viscoelastic standard solid model reduced order homogenization fibrous composite material

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奥瑟罗的多重人格及其人文主义内涵

外国语文 2010年第6期26卷 15-18页

作者：袁佳玲邵阳学院外语系湖南邵阳422000

从分析奥瑟罗的多重人格入手,探讨莎士比亚的人文主义内涵,包括对这一人物作为悲剧英雄与异族他者的人文主义分析以及对奥赛罗爱情的癫狂、戏剧冲突与人文主义之间关系和悲剧净化作用的分析,旨在揭示莎士比亚如何借人物刻画来表达人文... 详细信息

从分析奥瑟罗的多重人格入手,探讨莎士比亚的人文主义内涵,包括对这一人物作为悲剧英雄与异族他者的人文主义分析以及对奥赛罗爱情的癫狂、戏剧冲突与人文主义之间关系和悲剧净化作用的分析,旨在揭示莎士比亚如何借人物刻画来表达人文主义精神。

关键词：奥瑟罗多重人格人文主义内涵莎士比亚

Recent Strategies and Advances in Hydrogel‑Based Delivery Platforms for Bone Regeneration

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Nano-Micro Letters 2025年第3期17卷 389-439页

作者： Xiao Wang jia Zeng Donglin Gan Kun ling Mingfang He jianshu Li Yongping Lu Scientific and Technological Innovation Center for Biomedical Materials and Clinical Research Guangyuan Key Laboratory of Multifunctional Medical HydrogelGuangyuan Central HospitalGuangyuan 628000People’s Republic of China jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio‑Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023People’s Republic of China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065People’s Republic of China

Bioactive molecules have shown great promise for effectively regulating various bone formation processes,rendering them attractive therapeutics for bone ***,the widespread application of bioactive molecules is limited by their low accumulation and short half-lives in *** have emerged as ideal carriers to address these challenges,offering the potential to prolong retention times at lesion sites,extend half-lives in vivo and mitigate side effects,avoid burst release,and promote adsorption under physiological *** review systematically summarizes the recent advances in the development of bioactive molecule-loaded hydrogels for bone regeneration,encompassing applications in cranial defect repair,femoral defect repair,periodontal bone regeneration,and bone regeneration with underlying ***,this review discusses the current strategies aimed at improving the release profiles of bioactive molecules through stimuli-responsive delivery,carrier-assisted delivery,and sequential ***,this review elucidates the existing challenges and future directions of hydrogel encapsulated bioactive molecules in the field of bone regeneration.

关键词： Hydrogel Bone regeneration Bioactive molecules Drug delivery Nano-/microscale carriers

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： Mengyu Xu Shaocong Yan Ting Liang jia jia Shengjie yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena Meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： Cell engineering

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快速成型技术在口腔修复中的应用效果评价

上海口腔医学 2017年第3期26卷 343-345页

作者：潘巧玲袁家侃山东省菏泽市立医院口腔科山东菏泽274031

目的 :评价快速成型技术在口腔修复中的应用效果。方法 :选取2013年5月—2014年11月在我院进行口腔修复治疗的120例患者,将其分为试验组和常规组,每组各60例。试验组采用快速成型技术进行修复,常规组采用临床常规治疗方法修复,比较2组... 详细信息

目的 :评价快速成型技术在口腔修复中的应用效果。方法 :选取2013年5月—2014年11月在我院进行口腔修复治疗的120例患者,将其分为试验组和常规组,每组各60例。试验组采用快速成型技术进行修复,常规组采用临床常规治疗方法修复,比较2组患者的修复效果、治疗满意程度及不良反应情况。采用SPSS 19.0软件包对数据进行统计学分析。结果:试验组患者治疗有效率显著高于常规组(P<0.05),且试验组患者对修复过程及修复结果满意度显著高于常规组(P<0.05);常规组患者出现不良反应显著多于试验组。结论:采用快速成型技术对患者进行口腔修复治疗效果理想,患者满意度较高,术后不良反应少,安全性及可行性较高,值得推广。

关键词：快速成型技术口腔修复牙列缺损