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marine information technology:the best is yet to come

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Frontiers of Information Technology & Electronic Engineering 2018年第8期19卷 947-950页

作者： Wen XU yuan-liang ma Fumin ZHANG Daniel ROUSEFF Fei JI Jun-hong CUI Hussein YAHIA College of lnformation Science and Electrontc Engmeermg Zhejiang UniversityHangzhou 310027China School of marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072China School of Electncal and Computer Engineering Georgia Institute of TechnologyAtlantaGA 30332USA Applied Physics Laboratory University of WashingtonSeattleWA 98105USA School of Electronic and lnformation Engineering South China University of TechnologyGuangzhou 510641China Smart Ocean Research Center Jilin UniversityChangchun 130012China Research Center INRIA Bordeaux-South West Talence 33405France

marine information technology(marineIT)involves marine information gathering,transmission,processing,and ***,this topic has been referred to in the context of acoustic,optical,and electromagnetic sensing of the ocean environment,most notably sonar/radar processing and satellite remote *** its embodiment becomes enriched and its scope extends,particularly accompanied

关键词：海洋环境信息技术卫星遥感上下文

Abietane Diterpernoids from the Roots of Euphorbia ebracteolata

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Natural Products and Bioprospecting 2018年第2期8卷 131-135页

作者： yuan-liang ma Xiao-Han Tang Wen-Juan yuan Xiao Ding Ying-Tong Di Xiao-Jiang Hao State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Yunnan Institution for Food And Drug Control Kunming 650011People’s Republic of China

A new ent-abietane diterpernoid,named ebracteolata D(1),along with 11 known analogues,was isolated from the roots of Euphorbia ebracteolata *** structure of 1 was elucidated on the basis of spectroscopic analysis and molecular *** of compounds 1-12 was evaluated as well as the effect on the NF-κB *** them,compound 12,jolkinolide B,displayed broad inhibitory effects against proliferation of tumor cell *** studies indicated that the compound 12 can inhibit TNF-αinduced NF-κB activation,thereby inducing tumor cell apoptosis.

关键词： Euphorbiaceae Euphorbia ebracteolata Abietane diterpernoid Cytotoxic activity

Cascade N-Alkylation/Hemiacetalization for Facile Construction of the Spiroketal Skeleton of Acortatarin Alkaloids with Therapeutic Potentiality in Diabetic Nephropathy

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Natural Products and Bioprospecting 2015年第1期5卷 37-45页

作者： Pei Cao Zhen-Jie Li Wen-Wu Sun Shashwat malhotra yuan-liang ma Bin Wu Virinder S.Parmar State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Bioorganic Laboratory Department of ChemistryUniversity of DelhiDelhi 110007India Institute of Chemistry and Biochemistry Freie Universita¨t BerlinTakustrasse 314195 BerlinGermany

The concise building of the spiroketal core of acortatarin-type alkaloids as potential therapeutic agents in diabetic nephropathy was established in four steps,through a tandem N-alkylation/hemiacetalization between pyrrole units and the corresponding halo alcohols generated by convenient halomethylation of chiral lactones from natural aldoses.

关键词： Acortatarin alkaloids Diabetic nephropathy N-alkylation/hemiacetalization Halomethylation Chiral lactones

Comparison of Efficacy and Safety between First and Second Generation Drug-eluting Stents in Patients with Stable Coronary Artery Disease： A Single-center Retrospective Study

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Chinese Medical Journal 2017年第14期130卷 1654-1661页

作者： Ru Liu Fei Xiong yuan Wen yuan-liang ma Yi Yao Zhan Gao Bo Xu Yue-Jin Yang Shu-Bin Qiao Run-Lin Gao Jin-Qing yuan Department of Cardiology Fuwai Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing 100037 China Department of Physiology Colleges of Pharmacy and Medicine University of Kentucky Lexington KY 40536 USA

Background：Lots of trials demonstrate that second-generation drug-eluting stents （G2-DES）,with their improved properties,offer significantly superior efficacy and safety profiles compared to first generation DES （Gl-DES） for patients with coronary artery disease （CAD） receiving percutaneous coronary intervention （PCI）.This study aimed to verify the advantage of G2-DES over G1-DES in Chinese patients with stable CAD （SCAD）.Methods：For this retrospective observational analysis,2709 SCAD patients with either G1-DES （n =863） or G2-DES （n =1846） were enrolled consecutively throughout *** score matching （PSM） was applied to control differing baseline ***-year outcomes,including major adverse coronary events as well as individual events,including target vessel-related myocardial infarction,target lesion revascularization （TLR）,target vessel revascularization,and cardiogenic death were ***：The incidence of revascularization between G1-and G2-DES showed a trend of significant difference with a threshold P-value （8.6% vs.6.7%,x2 =2.995,P =0.084）.G2-DES significantly improved TLR-free survival compared to G1-DES （96.6% vs.97.9%,P =0.049） and revascularization-free survival curve showed a trend of improvement of G2-DES （92.0% vs.93.8%,P =0.082）.These difterences diminished after *** Cox proportional hazard regression analysis showed a trend for G 1-associated increase in revascularization （hazard ratio：1.28,95% confidence interval：0.95-1.72,P =0.099） while no significance was found after *** endpoints showed no significant differences after multivariate adjustment regardless of ***：G1-DES showed the same safety as G2-DES in this large Chinese cohort of real-world ***,G2-DES improved TLR-ffee survival of SCAD patients 2 years after *** advantage was influenced by baseline clinical ***-DES was associated with a trend of increase in revascularization risk and was not an independent predictor o

关键词： Drug-etuting Stents Percutaneous Coronary Intervention Stable Coronary Artery Disease

Long-term Outcomes of Primary Percutaneous Coronary Intervention with Second-generation Drug-eluting Stents in ST-elevation Myocardial Infarction Patients Caused by Very Late Stent Thrombosis

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Chinese Medical Journal 2017年第8期130卷 929-935页

作者： Chen He yuan-liang ma Chuang-Shi Wang Lin Jiang Jia-Hui Zhang Yi Yao Xiao-FangTang Bo Xu Run-Lin Gao Jin-Qing yuan State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular Diseases Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background： The ST-segment elevation myocardial inthrction （STEMI） patients due to stent thrombosis （ST） remain a therapeutic challenge for a clinician. Till date, very few researches have been conducted regarding the safety and effectiveness of primary percutaneous coronary intervention （PCI） with second-generation drug-eluting stents （DES） for STEMI caused by very late ST （VLST）. This retrospective study evaluated the safety, efficacy, and outcomes of primary PCI with second-generation DES for STEM1 due to VLST compared with primary PCI for STEM1 due to de novo lesion. Methods： Between January 2007 and December 2013, STEMI patients with primary PCI in Fuwai Hospital had only second-generation DES implanted for de novo lesion （558 patients） and VLST （50 patients） were included in this retrospective study. The primary end points included cardiac death and reinfarction. The secondary end points included cardiac death, reinfarction, and target lesion revascularization. Continuous variables were expressed as mean （standard deviation） or median （interquartile range） and compared by Student＇s t-test or mann-Whitney U-test as appropriate. Categorical variables were expressed as counts and percentages, and comparison of these variables was performed with Chi-square or Fisher＇s exact test. A two-tailed value of P 〈 0.05 was considered statistically significant for all comparisons. Statistical analyses were performed by SAS software （version 9.4, SAS Institute Inc., Cary, USA） for Windows. Results： In-hospital primary end point and the secondary end point were no significant differences between two groups （P = 1.000 and P = 1.000, respectively）. No significant differences between two groups were observed according to the long-term primary end point and the secondary end point. Kaplan-Meier survival curves showed no significant difference between the two groups in the primary end point and the secondary end point at 2 years （P- 0.340 and P = 0,243, respectively）. According to

关键词： Primary Percutaneous Coronary Intervention Second-generation Drug-eluting Stents ST-elevation Myocardial Infarction Stent Thrombosis

The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang yuan liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Head to Head Comparison of Two Point-of-care Platelet Function Tests Used for Assessment of On-clopidogrel Platelet Reactivity in Chinese Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention

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Chinese Medical Journal 2016年第19期129卷 2269-2274页

作者： Yi Yao Jia-Hui Zhang Xiao-Fang Tang Chen He yuan-liang ma Jing-Jing Xu Ying Song Ru Liu Xian-Min Meng Lei Song Miao Wang Run-Lin Gao Jin-Qing yuan Department of Cardiology State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China Department of Central Laboratory State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Background：Platelet function tests are widely used in clinical practice to guide personalized antiplatelet *** China,the thromboelastography （TEG） test has been well accepted in clinics,whereas VerifyNow,mainly used for scientific research,has not been used in routine clinical *** aim of the current study was to compare these two point-of-care platelet function tests and to analyze the consistency between the two tests for evaluating on-clopidogrel platelet reactivity in Chinese acute myocardial infarction patients undergoing percutaneous coronary intervention （PCI）.Methods：A total of 184 patients admitted to Fuwai Hospital between August 2014 and may 2015 were enrolled in the ***-clopidogrel platelet reactivity was assessed 3 days after PCI by TEG and VerifyNow using adenosine diphosphate as an *** on the previous reports,an inhibition of platelet aggregation （IPA）〈30% for TEG or a P2Y12 reaction unit （PRU）〉230 for VerifyNow was defined as high on-clopidogrel platelet reactivity （HPR）.An IPA 〉70% or a PRU 〈178 was defined as low on-clopidogrel platelet reactivity （LPR）.Correlation and agreement between the two methods were analyzed using the Spearman correlation coefficient （r） and kappa value （κ）,***：Our results showed that VerifyNow and TEG had a moderate but significant correlation in evaluating platelet reactivity （r =-0.511）.A significant although poor agreement （κ =0.225） in identifying HPR and a significantly moderate agreement in identifying LPR （κ =0.412） were observed between TEG and *** using TEG as the reference for comparison,the cutoffvalues of VerifyNow for the Chinese patients in this study were identified as PRU 〉205 for HPR and PRU 〈169 for ***：By comparing VerifyNow to TEG which has been widely used in clinics,VerifyNow could be an attractive alternative to TEG for monitoring on-clopidogrel platelet reactivity in Chinese patients.

关键词： Blood Platelets Clopidogrel Thromboelastography VerifyNow

Array gain for a conformal acoustic vector sensor array:An experimental study

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Chinese Physics B 2016年第12期25卷 126-131页

作者：汪勇杨益新何正耀雷波孙超马远良 School of Mechanical Engineering Xi'an Jiaotong University School of marine Science and Technology Northwestern Polytechnical University

An acoustic vector sensor can measure the components of particle velocity and the acoustic pressure at the same point simultaneously, which provides a larger array gain against the ambient noise and a higher angular resolution than the omnidirectional pressure sensor. This paper presents an experimental study of array gain for a conformal acoustic vector sensor array in a practical environment. First, the manifold vector is calculated using the real measured data so that the effects of array mismatches can be minimized. Second, an optimal beamformer with a specific spatial response on the basis of the stable directivity of the ambient noise is designed, which can effectively suppress the ambient noise. Experimental results show that this beamformer for the conformal acoustic vector sensor array provides good signal-to- noise ratio enhancement and is more advantageous than the delay-and-sum and minimum variance distortionless response beamformers.

关键词： conformal array acoustic vector sensor array gain optimal beamforming

环境对水解的疏水改性聚丙烯酰胺的分子行为和性能的影响

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高分子学报 2016年第6期26卷 797-804页

作者：袁静毛多鹭李海琴赵素琴马元良青海民族大学物理与电子信息工程学院西宁810007

以介观模拟耗散颗粒动力学(DPD)方法为主,结合部分实验,研究了环境条件包括p H、盐度以及外加表面活性剂十二烷基磺酸钠(SLS)对疏水改性水解聚丙烯酰胺(HMHPAM)的分子行为和体相及界面性质的影响.将均方根末端距量化表征的聚合物伸展程... 详细信息

以介观模拟耗散颗粒动力学(DPD)方法为主,结合部分实验,研究了环境条件包括p H、盐度以及外加表面活性剂十二烷基磺酸钠(SLS)对疏水改性水解聚丙烯酰胺(HMHPAM)的分子行为和体相及界面性质的影响.将均方根末端距量化表征的聚合物伸展程度与其体相黏度结合起来,通过调整相互作用参数分别讨论了无机盐的水化作用和静电作用对聚电解质HMHPAM分子行为的影响,确定HMHPAM的最佳应用环境.进一步研究了表面活性剂SLS对HMHPAM界面性质和体相性质的影响,提出了作用机制.

关键词：部分水解的疏水改性聚丙烯酰胺 pH 盐度十二烷基磺酸钠耗散颗粒动力学