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A Pipelining Loop Optimization Method for Dataflow Architecture

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Journal of Computer Science & Technology 2018年第1期33卷 116-130页

作者： xu Tan Xiao-Chun Ye Xiao-Wei Shen yuan-chao xu Da Wang Lunkai Zhang Wen-Ming Li Dong-Rui Fan Zhi-Min Tang State Key Laboratory of Computer Architecture Institute of Computing Technology Chinese Academy of Sciences Beijing 100190 China School of Computer and Control Engineering University of Chinese Academy of Sciences Beijing 1000J9 China State Key Laboratory of Mathematical Engineering and Advanced Computing Wuxi 214125 China College of Information Engineering Capital Normal University Beijing 100048 China Department of Computer Science The University of Chicago Chicago IL 60637 U.S.A.

With the coming of exascale supercomputing era, power efficiency has become the most important obstacle to build an exascale system. Dataflow architecture has native advantage in achieving high power efficiency for scientific applications. However, the state-of-the-art dataflow architectures fail to exploit high parallelism for loop processing. To address this issue, we propose a pipelining loop optimization method （PLO）, which makes iterations in loops flow in the processing element （PE） array of dataflow accelerator. This method consists of two techniques, architecture-assisted hardware iteration and instruction-assisted software iteration. In hardware iteration execution model, an on-chip loop controller is designed to generate loop indexes, reducing the complexity of computing kernel and laying a good f（mndation for pipelining execution. In software iteration execution model, additional loop instructions are presented to solve the iteration dependency problem. Via these two techniques, the average number of instructions ready to execute per cycle is increased to keep floating-point unit busy. Simulation results show that our proposed method outperforms static and dynamic loop execution model in floating-point efficiency by 2.45x and 1.1x on average, respectively, while the hardware cost of these two techniques is acceptable.

关键词： dataflow model control-flow model loop optimization exascale computing scientific application

春季北太平洋风暴轴的年际与年代际变化特征及其与太平洋海温异常的关系

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气象学报 2016年第6期74卷 860-875页

作者：袁超徐海明南京信息工程大学气象灾害预报预警与评估协同创新中心和气象灾害教育部重点实验室南京210044

利用20世纪大气再分析资料和欧洲中心海温资料研究了春季西北太平洋风暴轴的年(代)际变化特征以及在不同年代际背景下风暴轴与太平洋海温关系的转变。结果表明,春季西北太平洋风暴轴主要存在两种空间变化模态,即反映其强度变化的第1模... 详细信息

利用20世纪大气再分析资料和欧洲中心海温资料研究了春季西北太平洋风暴轴的年(代)际变化特征以及在不同年代际背景下风暴轴与太平洋海温关系的转变。结果表明,春季西北太平洋风暴轴主要存在两种空间变化模态,即反映其强度变化的第1模态和反映其南北位置变化的第2模态。年代际及以上时间尺度上,风暴轴强度、位置与太平洋海温的关系主要表现为大气对海洋的强迫作用。在不同年代际背景下,风暴轴与太平洋海温的关系则存在明显的年代际转变:1977年以后,风暴轴强度与太平洋海温的关系主要表现为大气对海洋的强迫作用,而在1977年之前则主要表现为海洋对大气的强迫作用,特别是同期冬季日本以东黑潮和黑潮延伸区海温异常的强迫作用;风暴轴南北位置与太平洋海温异常的关系,在1977年以后表现为大气对海洋的强迫作用,主要表现为对北太平洋中部海温的影响,但在1977年以前表现为海洋和大气的共同作用,风暴轴南北位置的变化还与同期的赤道中东太平洋海温异常有关,表明ENSO可能对风暴轴的位置变化存在影响。

关键词：风暴轴海温海-气关系太平洋年代际振荡

Complete response of gallbladder cancer treated with gemcitabine and cisplatin chemotherapy combined with durvalumab:A case report and review of literature

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 226-232页

作者： Kai Chen xu Feng yuan Shi Xin-Lin Li Zheng-Rong Shi Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Gallbladder cancer(GBC)is the most common and aggressive subtype of biliary tract cancer(BTC)and has a poor prognosis.A newly developed regimen of gemcitabine,cisplatin,and durvalumab shows promise for the treatment of advanced ***,the efficacy of this treatment for GBC remains *** SUMMARY In this report,we present a case in which the triple-drug regimen exhibited marked effectiveness in treating locally advanced GBC,thus leading to a long-term survival benefit.A 68-year-old man was diagnosed with locally advanced GBC,which rendered him ineligible for curative *** three cycles of therapy,a partial response was *** one year of combined therapy,a clinical complete response was successfully *** maintenance therapy with durvalumab monotherapy resulted in a disease-free survival of 9 months for the *** patient experienced tolerable toxicities of reversible grade 2 nausea and *** adverse events were observed in the patient throughout the entirety of the *** The combination of gemcitabine and cisplatin chemotherapy with durvalumab was proven to be an effective treatment approach for advanced GBC,with manageable adverse *** research is warranted to substantiate the effectiveness of the combined regimen in the context of GBC.

关键词： Gallbladder cancer Chemotherapy Immunotherapy Durvalumab Complete response Case report

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song chao xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Smart Cellulose‑Based Janus Fabrics with Switchable Liquid Transportation for Personal Moisture and Thermal Management

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Nano-Micro Letters 2025年第1期17卷 333-347页

作者： Jianfeng Xi Yanling Lou Liucheng Meng chao Deng Youlu Chu Zhaoyang xu Huining Xiao Weibing Wu Jiangsu Co‑Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Sustainable Pulp and Paper Technology and Biomass MaterialsNanjing Forestry UniversityNanjing 210037People’s Republic of China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037People’s Republic of China Department of Chemical Engineering University of New BrunswickFrederictonNB E3B 5A3Canada Macromolecular Chemistry and Bavarian Polymer Institute University of BayreuthBayreuth 95440Germany

The Janus fabrics designed for personal moisture/thermal regulation have garnered significant attention for their potential to enhance human ***,the development of smart and dynamic fabrics capable of managing personal moisture/thermal comfort in response to changing external environments remains a ***,a smart cellulose-based Janus fabric was designed to dynamically manage personal moisture/*** cotton fabric was grafted with N-isopropylacrylamide to construct a temperature-stimulated transport ***,hydrophobic ethyl cellulose and hydrophilic cellulose nanofiber were sprayed on the bottom and top sides of the fabric to obtain wettability *** fabric exhibits anti-gravity directional liquid transportation from hydrophobic side to hydrophilic side,and can dynamically and continuously control the transportation time in a wide range of 3–66 s as the temperature increases from 10 to 40℃.This smart fabric can quickly dissipate heat at high temperatures,while at low temperatures,it can slow down the heat dissipation rate and prevent the human from becoming too *** addition,the fabric has UV shielding and photodynamic antibacterial properties through depositing graphitic carbon nitride nanosheets on the hydrophilic *** smart fabric offers an innovative approach to maximizing personal comfort in environments with significant temperature variations.

关键词： Directional water transport Cotton fabric Anti-gravity directional liquid transportation Janus wettability

VIENNA结构在阻焊逆变电源中的应用仿真

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电焊机 2012年第12期42卷 59-62,101页

作者：张勇袁旭超腾辉谢红霞西北工业大学陕西省摩擦焊接重点实验室陕西西安710072

针对大功率阻焊逆变电源网侧输入电流谐波含量高、功率因数低的缺点,应用PSPICE电路仿真软件仿真研究了其功率因数补偿电路。仿真结果表明,采用三相三开关三电平结构(VIENNA结构)功率因数校正电路能够有效降低阻焊逆变电源网侧输入电流... 详细信息

针对大功率阻焊逆变电源网侧输入电流谐波含量高、功率因数低的缺点,应用PSPICE电路仿真软件仿真研究了其功率因数补偿电路。仿真结果表明,采用三相三开关三电平结构(VIENNA结构)功率因数校正电路能够有效降低阻焊逆变电源网侧输入电流的谐波含量,同时满足国际阻焊电源电磁兼容标准(IEC-62135-2标准),功率因数达97%以上,并且开关管关断时承受的反向电压仅为输出电压的一半,VIENNA结构功率因数校正电路应用于阻焊逆变电源具有很强的实用性与优越性。

关键词：电阻焊逆变电源功率因数校正仿真

热时间常数在QBe2箔与Cr20Ni80丝电容储能点焊中的应用

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电焊机 2011年第7期41卷 68-70,73页

作者：方飞张勇袁旭超谢红霞李星西北工业大学陕西省摩擦焊重点实验室陕西西安710072

为了满足微型电机电刷零部件的使用要求,根据计算所得的热时间常数τ及其与焊点中心部分温度上升的关系曲线,确定了QBe2铍青铜箔与Cr20Ni80镍铬丝微型件电容储能点焊工艺参数的选取原则。根据所选的工艺参数,采用电容储能点焊机对试样... 详细信息

为了满足微型电机电刷零部件的使用要求,根据计算所得的热时间常数τ及其与焊点中心部分温度上升的关系曲线,确定了QBe2铍青铜箔与Cr20Ni80镍铬丝微型件电容储能点焊工艺参数的选取原则。根据所选的工艺参数,采用电容储能点焊机对试样进行焊接,并对焊接接头的金相组织、微区成分进行了分析试验。结果表明,利用热时间常数选取的工艺参数,可以获得良好的固相连接接头,但焊接界面铍青铜一侧有晶界局部熔化现象,镍铬合金中的镍与铬元素向铍青铜一侧有较明显的扩散。由此可知,根据热时间常数选取焊接工艺参数的原则是合理可行的。

关键词：热时间常数铍青铜镍铬丝电容储能点焊

加味百合固金汤对肺胀(肺肾气阴两虚证)患者的疗效及呼吸功能和活动耐力的影响

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海南医学 2022年第12期33卷 1531-1533页

作者：陈昭萌袁旭潮郑威普宁市中医医院内科广东揭阳515300

目的探讨加味百合固金汤对肺胀(肺肾气阴两虚证)患者的疗效及呼吸功能和活动耐力的影响。方法选择2020年1月至2021年1月普宁市中医医院内科收治的80例肺胀(肺肾气阴两虚证)患者为研究对象,按照随机数表法将患者分为观察组和对照组各40... 详细信息

目的探讨加味百合固金汤对肺胀(肺肾气阴两虚证)患者的疗效及呼吸功能和活动耐力的影响。方法选择2020年1月至2021年1月普宁市中医医院内科收治的80例肺胀(肺肾气阴两虚证)患者为研究对象,按照随机数表法将患者分为观察组和对照组各40例。对照组患者给予多索茶碱片、沙美特罗替卡松粉吸入剂常规治疗,观察组患者在对照组治疗基础上联合加味百合固金汤治疗,持续治疗3个月,比较两组患者的临床疗效以及治疗前后最大呼气第一秒呼出的气量的容积(FEV_(1))、FEV_(1)/用力肺活量(FEV_(1)/FVC)、慢性阻塞性肺疾病评估量表(CAT)评分、6 min步行距离,同时比较两组患者治疗期间不良反应发生情况。结果治疗后,观察组患者的临床疗效总有效率为92.50%,明显高于对照组的75.00%,差异有统计学意义(P0.05)。结论加味百合固金汤可有效改善肺胀(肺肾气阴两虚证)患者的呼吸功能及活动耐力,临床应用效果显著,值得推广应用。

关键词：肺胀肺肾气阴两虚证加味百合固金汤呼吸功能活动耐力疗效

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Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： Xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong yuan Liangwei xu Chang Lin Xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine