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MULTIPHOTON MICROSCOPY:A NEW APPROACH IN PHYSIOloGICAL STUDIES AND PATHOloGICAL DIAGNOSIS FOR OPHTHALMOloGY

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Journal of Innovative Optical Health Sciences 2009年第1期2卷 45-60页

作者： CHIU-MEI HSUEH WEN lo SUNG-JAN LIN TSUNG-JEN WANG FUNG-RUNG HU HSIN-yuan TAN CHEN-yuan DONG Department of Physics National Taiwan University Taipei 106 Taiwan Institute of Biomedical Engineering National Taiwan University Taipei 106 Taiwan Department of Dermatology National Taiwan University Hospital Taipei 100 Taiwan Department of Ophthalmology Taipei Medical University Hospital Taipei 100 Taiwan Department of Ophthalmology National Taiwan University College of Medicine and Hospital Taipei 100Taiwan Department of Ophthalmology Chang-Gung University Linko 333 Taiwan Institute of Biomedical Engineering National Taiwan University Taipei 100 Taiwan

Multiphoton microscopy(MPM),with the advantages of improved penetration depth,decreased photo-damage,and optical sectioning capability,has become an indispensable tool for biomedical *** combination of multiphoton fluorescence(MF)and second-harmonic generation(SHG)microscopy is particularly effective in imaging tissue structures of the ocular *** work is intended to be a review of advances that MPM has made in ophthalmic *** MPM not only can be used for the label-free imaging of ocular structures,it can also be applied for investigating the morphological alterations in corneal pathologies,such as keratoconus,infected keratitis,and corneal ***,the corneal wound healing process after refractive surgical procedures such as conductive keratoplasty(CK)can also be studied with ***,qualitative and quantitative SHG microscopy is effective for characterizing corneal thermal *** additional development,multiphoton imaging has the potential to be developed into an effective imaging technique for in vivo studies and clinical diagnosis in ophthalmology.

关键词： Multiphoton microscopy fluorescence second harmonic generation cornea sclera

Observations of Passenger Flow and Verification of a Crowd Dynamics Model

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Wuhan University Journal of Natural Sciences 2008年第2期13卷 195-200页

作者： yuan Jianping FANG Zheng lo Siuming XIE Lilin HUANG Danguang School of Civil Engineering Wuhan University Wuhan430072 Hubei China Department of Building and Construction City Universityof Hong Kong Hong Kong China

This paper reports observations of passenger flow in the Wuchang railway station in Wuhan, China during the Chinese Traditional Spring Festival in 2006. The data collected are used to verify a crowd dynamics model previously developed. The crowd dynamics model is based on simulating the global movement of each individual under the influence of the surrounding crowd, and the good agreement between the predictions and observations validates the prediction model. The crowd dynamics model suggests that the crowd movement speed is dominated by two factors： the front-back inter-person effect, and the pedestrian＇s self-motive. The first effect gives logarithmic relationship between the crowd speed and crowd density. The second factor depends on the individual motive driven with which people try to divorce themselves from the control of the crowd movement. The prediction model are helpful to guide the design of public traffic systems for effective crowd dispersal.

关键词： crowd dynamics model observation mathematical modeling evacuation traffic planning

Laboratory Observations on Internal Solitary Wave Evolution over A Submarine Ridge

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China Ocean Engineering 2006年第1期20卷 61-72页

作者： Chen-yuan CHEN John Rong-Chung HSU Ching-Feng KUO Hsin-Hsun CHEN Min-hung CHENG Department of Marine Environment and Engineering National Sun Yat-sen University Kaohsiung 80424 Taiwan China Honorary Research Fellow School of Civil and Resource Engineering University of Western Australia WA 6009 Australia Institute of Physical Oceanography National Sun Yat-sen University Kaohsiung 80424 Taiwan China

Laboratory experiments were conducted in a wave flume on internal solitary wave （ISW） of depression and elevation types propagating over a submarine ridge in semicircular/triangular shape. Tests were arranged in series for combinations of submarine ridges of different heights and ISW of different amplitudes. The resuhant wave motions were found differing from thee of surface gravity waves. In deeper water, where an ISW of depression-type prevailed, the process of wave breaking displayed downward motion with continuous eddy on the front face of the ridge followed by upward motion towards the apex of the obstacle. Experimental results also suggested that blockage parameter ξ could be applied to classify various degrees of ISW-ridge interaction, i.e., ξ 〈 0.5 for weak interaction, 0.5 〈 ξ 〈 0.7 for moderate interaction, and 0.7 〈 ξ for wave breaking.

关键词： internal solitary wave laboratory experiments wave dispersion energy loss profile change

Successful bailout stenting strategy against rare spontaneous retrograde dissection of partially absorbed magnesium-based resorbable scaffold:A case report

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World Journal of Clinical Cases 2021年第5期9卷 1148-1155页

作者： Zhen-Yu Liao Jer-Young Liou Shen-Chang Lin Huei-Fong hung Che-Ming Chang Lung-Ching Chen Su-Kiat Chua Huey-Ming lo Chi-Feng hung Division of Cardiology Department of Internal MedicineShin Kong Wu Ho-Su Memorial HospitalTaipei 11101Taiwan Ph.D.Program in Nutrition and Food Science Fu Jen Catholic UniversityNew Taipei 24205Taiwan School of Medicine Fu Jen Catholic UniversityNew Taipei 24205Taiwan MS Program Transdisciplinary long-Term Care Fu Jen Catholic UniversityNew Taipei 24205Taiwan Ph.D.Program in Pharmaceutical Biotechnology Fu Jen Catholic UniversityNew Taipei 24205Taiwan

BACKGROUND In the development of coronary stent technology,bioresorbable scaffolds are promising milestones in improving the clinical treatment of coronary artery ***“leave nothing behind”motto is the premise of the fourth revolution in percutaneous coronary intervention(PCI).Studies proving the safety and efficacy of the magnesium-based resorbable scaffolds(MgBRSs)include the BIOSOLVE-I and BIOSOLVE-II trials and the latest BIOSOLVE-IV ***,spontaneous retrograde dissection of a partially absorbed MgBRS may still occur,albeit *** SUMMARY We describe an unusual case of coronary artery disease in a patient who had undergone a successful PCI 8 mo earlier,where an MgBRS was implanted into the left anterior descending artery(LAD)and left circumflex artery with drug-coated balloons for a ramus intermedius branch stenosis to achieve the“leave nothing behind”therapeutic intention and was currently presenting with a gradual worsening of chest *** distal edge vascular response,during subsequent attempts with balloon angioplasty was performed ***,spontaneous retrograde dissection of a partially absorbed MgBRS in the LAD *** bailout stenting was performed with revascularization of the entry and exit sites created by spontaneous dissection and complete sealing of the intramural *** patient recovered well and was discharged after 2 d of *** followed up in August 2020(7 mo later),the patient showed uneventful *** Spontaneous retrograde dissection of a partially absorbed MgBRS was successfully treated using bailout sirolimus-eluting coronary stent strategy.

关键词： Coronary artery disease Percutaneous coronary intervention Magnesium Stents Dissection Case report

Dinosaur-bearing strata and K/T boundary in the Luanchuan-Tantou Basin of western Henan Province,China

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Science China Earth Sciences 2011年第8期54卷 1149-1155页

作者： JIANG XiaoJun LIU YongQing JI ShuAn ZHANG XingLiao XU Li JIA SongHai lo JunChang yuan ChongXi LI Ming Institute of Geology Chinese Academy of Geological Sciences Beijing 100037 China Henan Geological Museum Zhengzhou 450000 China

The sequence stratigraphy and geochronology of the terrestrial dinosaur-bearing strata,i.e.,the Qiupa Formation,were poorly studied in the Luanchuan-Tantou Basin in western Henan,*** study shows that these strata represent a complete succession from the Late Cretaceous to the early Paleogene,including the K/T boundary,in this *** we report a detailed study of the K/T boundary,especially its stratigraphic sequence,sedimentary characteristics,integrity,continuity,and geological implications.

关键词： western Henan Luanchuan-Tantou Basin dinosaurs stratigraphy K/T boundary

Solitary extraovarian primary peritoneal carcinoma with direct invasion into the liver,diaphragm and lung without peritoneal dissemination or distant metastasis

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 322-325页

作者： Billy Ho hung Cheung Wong Hoi She Siu Lun Ho Albert Chi Yan Chan Chung Mau lo Tan To Cheung Department of Surgery The University of Hong KongHong KongChina Department of Pathology The University of Hong KongHong KongChina

To the Editor:Extraovarian primary peritoneal carcinoma(EOPPC)is an uncommon malignancy with many similarities to epithelial ovarian carcinoma in histological,clinical,and etiological aspects[1].This phenomenon is explained by their common embryonal origin,in which both develop from the coelomic epithelium in the early embryological *** their similarities,the incidence of EOPPC is significantly lower than that of epithelial ovarian carcinoma(6.78 cases per million vs.120.5 cases per million)[1].

关键词： peritoneal invasion metastasis

Information Theoretic Weighted Fuzzy Clustering Ensemble

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Computers, Materials & Continua 2021年第4期67卷 369-392页

作者： Yixuan Wang Liping yuan Harish Garg Ali Bagherinia Hamïd Parvïn Kim-hung Pho Zulkei Mansor Department of Electronic Information Engineering School of Information EngineeringWuhan University of TechnologyWuhanChina School of Information Engineering Wuhan University of TechnologyWuhanChina School of Information Engineering Wuhan Huaxia University of TechnologyWuhanChina School of Mathematics Thapar Institute of Engineering and TechnologyDeemed UniversityPatialaPunjabIndia Department of Computer Science Dehdasht BranchIslamic Azad UniversityDehdashtIran Institute of Research and Development Duy Tan UniversityDa Nang550000Vietnam Faculty of Information Technology Duy Tan UniversityDa Nang550000Vietnam Department of Computer Science Nourabad Mamasani BranchIslamic Azad UniversityMamasaniIran Fractional Calculus Optimization and Algebra Research GroupFaculty of Mathematics and StatisticsTon Duc Thang UniversityHo Chi Minh CityVietnam Fakulti Teknologi dan Sains Maklumat Universiti Kebangsaan Malaysia 43600 UKM BangiSelangorMalaysia

In order to improve performance and robustness of clustering,it is proposed to generate and aggregate a number of primary clusters via clustering ensemble *** clustering ensemble approaches attempt to improve the performance of fuzzy clustering ***,in these approaches,cluster(or clustering)reliability has not paid much attention *** cluster(or clustering)reliability makes these approaches weak in dealing with low-quality base clustering *** this paper,we have utilized cluster unreliability estimation and local weighting strategy to propose a new fuzzy clustering ensemble method which has introduced Reliability Based weighted co-association matrix Fuzzy C-Means(RBFCM),Reliability Based Graph Partitioning(RBGP)and Reliability Based Hyper Clustering(RBHC)as three new fuzzy clustering consensus *** fuzzy clustering ensemble approach works based on fuzzy cluster unreliability *** unreliability is estimated according to an entropic criterion using the cluster labels in the entire *** do so,the new metric is dened to estimate the fuzzy cluster unreliability;then,the reliability value of any cluster is determined using a Reliability Driven Cluster Indicator(RDCI).The time complexities of RBHC and RBGP are linearly proportional with thnumber of data *** and robustness of the proposed method are experimentally evaluated for some benchmark *** experimental results demonstrate efciency and suitability of the proposed method.

关键词： Fuzzy clustering ensemble cluster unreliability consensus function

AN AHP MODEL FOR BRINGING EXPERTS TO CONSENSUS ON MEDICAL PAYMENT STANDARDS

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Journal of Systems Science and Systems Engineering 2006年第2期15卷 247-255页

作者： yuan-Huei HUANG Pei-Yeh CHANG Chih-Young hung Kuei-Ing WANG King-Jen CHANG Department of Surgery Hsin-Chu General HospitalTaiwanChina Department of Pediatric Surgery Chang Gung Children’s HospitalChang Gung UniversityCollege of MedicineTaiwanChina Institute of Management of Technology National Chiao Tung UniversityTaiwanChina Department of Information Management Ming Hsin University of Science and TechnologyTaiwanChina Department of Surgery National Taiwan University HospitalTaiwanChina

Many countries with health insurance systems conduct periodic payment standards reform. How to reach consensus in setting payment standards among different specialties with different agendas has become a critical issue. The purpose of this study is to construct an analytic hierarchy process （AHP） model to obtain judgments from experts about the importance of ＂factors related to establishing payment standards in the national health insurance program＂. Under this goal, the first tier contains four evaluation aspects, and the second tier contains sixteen evaluation criteria divided into four groups The AHP model was then used to collect and combine the opinions of experts through an empirical study. The results can be directly used to formulate standard values as the basis for establishing payment standards. The results of our study strongly support that an AHP model is effective in forming a consensus among surgical specialists.

关键词： National Health Insurance Analytic Hierarchy Process payment standards

CD14 promoter polymorphism in Chinese alcoholic patients with cirrhosis of liver and acute pancreatitis

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World Journal of Gastroenterology 2005年第38期11卷 6043-6048页

作者： Hsin-hung Huang Tsai-yuan Hsieh Division of Gastroenterology

AIM： To investigate the relationship between genetic polymorphism of the CD14 promoter and the occurrence of alcoholic cirrhosis and alcoholic pancreatitis, and to challenge the conclusion made earlier that the patients with acute alcoholic pancreatitis and patients with alcoholic cirrhosis of liver are two different subpopulations. METHODS： Using the polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method, we determined the polymorphism of CD14 gene and aldehyde dehydrogenase gene 2 （ALDH 2） in 335 alcoholic patients with different organ complications i.e., cirrhosis of liver （n = 100）, acute pancreatitis （n = 100）, esophageal cancer （n = 82） and avascular necrosis of hip joint （AVN）（n = 53） and 194 non-alcoholic controls in a Chinese group. RESULTS： The results showed that the carriage of T allele was not different among alcoholic patients with cirrhosis of liver, alcoholic patients with other complication and non-alcoholic controls. On the other hand, the carriage of the C allele was significantly more prevalent for alcoholic pancreatitis than for esophageal cancer （0.79 vs 0.60, P〈0.001）, alcoholic AVN （0.79 vsO.65, P〈0.025） and nonalcoholic controls （0.79 vs 0.68, P〈0.025）. Furthermore, when only subjects with ALDH2 1-1 genotype were examined, the C allele frequency was significantly more prevalent for alcoholic pancreatitis than for alcoholic liver cirrhosis （0.82 vs 0.69, P〈0.025）, esophageal cancer （0.82 vs 0.61, P〈0.01）, alcoholic AVN （0.82 vs 0.64, P〈0.01） and non-alcoholic controls （0.82 vs0.69, P〈0.05）. CONCLUSION： The C allele may be associated with some mechanism, which is important in the pathogenesis of alcoholic pancreatitis, and that alcoholic patients with acute pancreatitis and cirrhosis of liver are probably two different subpopulations.

关键词： CD14 promoter Polymorphism Alcoholic patients