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Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

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Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih hung lo Jialiu Zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

Defective lysosomal acidification:a new prognostic marker and therapeutic target for neurodegenerative diseases

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Translational Neurodegeneration 2023年第1期12卷 500-510页

作者： Chih hung lo Jialiu Zeng Lee Kong Chian School of Medicine Nanyang Technological UniversitySingapore 308232Singapore

Lysosomal acidification dysfunction has been implicated as a key driving factor in the pathogenesis of neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s *** genetic factors have been linked to lysosomal de-acidification through impairing the vacuolar-type ATPase and ion channels on the organelle *** lysosomal abnormalities are also present in sporadic forms of neurodegeneration,although the underlying pathogenic mechanisms are unclear and remain to be ***,recent studies have revealed early occurrence of lysosomal acidification impairment before the onset of neurodegeneration and late-stage ***,there is a lack of methods for organelle pH monitoring in vivo and a dearth of lysosome-acidifying therapeutic ***,we summarize and present evidence for the notion of defective lysosomal acidification as an early indicator of neurodegeneration and urge the critical need for technological advancement in developing tools for lysosomal pH monitoring and detection both in vivo and for clinical *** further discuss current preclinical pharmacological agents that modulate lysosomal acidification,including small molecules and nanomedicine,and their potential clinical translation into lysosome-targeting *** timely detection of lysosomal dysfunction and development of therapeutics that restore lysosomal function represent paradigm shifts in targeting neurodegenerative diseases.

关键词： Neurodegenerative diseases Alzheimer’s disease Parkinson’s disease Lysosomal de-acidification Autophagy dysfunction Early detection Prognostic marker Small molecules Nanomedicine Nanoparticles

Skew Derivations with Power Central Values on Commutators

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Algebra Colloquium 2015年第3期22卷 479-494页

作者： hung-yuan Chen Department of Mathematics National Changhua University of Education Changhua City 500 Taiwan

Let R be a prime ring with center Z, 5 ： R → R a nonzero skew derivation, and n a fixed positive integer. In this paper, we show that R is a commutative ring if （i） [（δ（[x, y]）, [x, y]]n = 0 for all x, y ∈ R ... 详细信息

关键词： automorphism prime ring Martindale quotient ring skew derivation Minner

Ileocolonic mucormycosis in adult immunocompromised patients:A surgeon's perspective

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World Journal of Gastroenterology 2010年第9期16卷 1165-1170页

作者： Oswens Siu-hung lo Wai-Lun Law Division of Colorectal Surgery Department of SurgeryUniversity of Hong Kong Medical CentreQueen Mary Hospital

We report three cases of ileocolic mucormycosis in adult immunocompromised patients presenting as acute *** patients underwent laparotomy but two of them died from multiorgan failure before the diagnoses were *** diagnosis of gastrointestinal mucormycosis is rarely suspected,and antemortem diagnosis is made in only 25%-50% of *** cases illustrate the difficulty encountered by surgeons in managing acute abdomen in neutropenic patients with hematological *** management of colonic mucormycosis in the published literature is also reviewed.

关键词： Gastrointestinal mucormycosis Colon Immunocompromised Surgery

TEMPERATURE RESPONSIVE METHACRYLAMIDE POLYMERS WITH ANTIBACTERIAL ACTIVITY

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Chinese Journal of Polymer Science 2010年第4期28卷 607-613页

作者：陈伯宽 Shuen-hung lo Shu-Feng Lee Department of Polymer Materials Kun Shan University

A new methacrylamide monomer, hexylamine methacrylamide （MAHA）, was synthesized and used in polymerizations. The homopolymer of MAHA and its copolymers were synthesized by free radical polymerization techniques with N-isopropyl acrylamide （NIPAAm） in two different compositions. The quatemization of the homopolymer and copolymers were carried out using 1-bromopropane. The copolymers with NIPAAm and a low MAHA content showed temperature-responsive behavior in an aqueous environment. The lower critical solution temperatures （LCSTs） of these polymers varied between 32℃ and 44℃. The LCSTs of quatemized copolymers were higher than those of neutral copolymers because they were more hydrophilic. The obtained homopolymers and copolymers were tested for antibacterial activities against S. aureus and E. coli. The quatemized water-soluble copolymers showed antibacterial activities against S. aureus. The quaternization resulted in the synthesis of both antibacterial and temperature-responsive copolymers.

关键词： Methacrvlamide: NIPAAm: Antibacterial: Temperature-rest)onsive

Smart Dynamic Resource Allocation Model for Patient-Driven Mobile Medical Information System Using C4.5 Algorithm

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Journal of Electronic Science and Technology 2019年第3期17卷 231-241页

作者： Ching-Kan lo Hsing-Chung Chen Pei-yuan Lee Ming-Chou Ku Lidia Ogiela Cheng-hung Chuang the Department of Orthopedics and the Department of Information Show-Chwan Health Care SystemChanghua 50008 the Department of Computer Science and Information Engineering and the Department of Bioinformatics and Medical Engineering Asia UniversityTaichung 41354 the Department of Orthopedics Show-Chwan Health Care SystemChanghua 50008 the Department of Applied Informatics Akademia Gorniczo-Hutnicza University of Science and TechnologyKrakow 30-059

A mobile medical information system (MMIS) is an integrated application (app) of traditional hospital information systems (HIS) which comprise a picture archiving and communications system (PACS), laboratory information system (LIS), pharmaceutical management information system (PMIS), radiology information system (RIS), and nursing information system (NIS). A dynamic resource allocation table is critical for optimizing the performance to the mobile system, including the doctors, nurses, or other relevant health workers. We have designed a smart dynamic resource allocation model by using the C4.5 algorithm and cumulative distribution for optimizing the weight of resource allocated for the five major attributes in a cooperation communications system. Weka is used in this study. The class of concept is the performance of the app, optimal or suboptimal. Three generations of optimization of the weight in accordance with the optimizing rate are shown.

关键词： Dynamic resource allocation electronic health record hospital information system mobile medical information system

Generate basic conceptual solutions for 3DPVS via utilizing TRIZ

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Bio-Design and Manufacturing 2019年第2期2卷 76-95页

作者： Haobo yuan Ke Xing hung-Yao Hsu School of Engineering University of South AustraliaMawson Lakes BlvdSalisbury 5095Australia

For cell culture scaffold innovation,3DPVS,namely 3D printed vibratory scaffold,was indicated as a future novel product,and it currently stands at conceptual development *** essential part for 3DPVS design is innovation,and TRIZ(algorithm of inventive problem solving)was studied as promising method for generating novel conceptual *** study targets designing and solving 3DPVS problems using TRIZ in the new *** aim to utilize TRIZ to conduct a multi-layer problem-solving process,which is to address design concerns of 3DPVS,especially at super-system to system *** this connection,TRIZ is used to address basic constraints and contradictions inside regarding trinity of 3D printing,3D scaffold and bio-based vibratory *** the study,five basic conceptual solutions for potential 3DPVS,namely magnetic,electric,mechanical,light and thermal based,have been generated.A brief evaluation has also been conducted,where magnetic-based 3DPVS shows the relatively highest applicability as potential *** with traditional experimental-oriented processes for biodesign,the approach of utilizing TRIZ can be inspiring and reinvigorating,which prepares a ground for future 3DPVS design to address detailed sub-system *** study might,to some extent,fill a gap in scaffold design and TRIZ literature and hopefully provide a comprehensive perspective of a timely topic.

关键词： 3DPVS 3D scaffold 3D printing Scaffold innovation Biodesign TRIZ Concept generation

Intelligent Mobile Video Surveillance System with Multilevel Distillation

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Journal of Electronic Science and Technology 2017年第2期15卷 133-140页

作者： yuan-Kai Wang hung-Yu Chen Department of Electrical Engineering Fu Jen Catholic UniversityNew Taipei City 24205 Intelligent System Lab.Fu Jen Catholic University New Taipei City 24205

This paper proposes a mobile video surveillance system consisting of intelligent video analysis and mobile communication networking. This multilevel distillation approach helps mobile users monitor tremendous surveillance videos on demand through video streaming over mobile communication networks. The intelligent video analysis includes moving object detection/tracking and key frame selection which can browse useful video clips. The communication networking services, comprising video transcoding, multimedia messaging, and mobile video streaming, transmit surveillance information into mobile appliances. Moving object detection is achieved by background subtraction and particle filter tracking. Key frame selection, which aims to deliver an alarm to a mobile client using multimedia messaging service accompanied with an extracted clear frame, is reached by devising a weighted importance criterion considering object clarity and face appearance. Besides, a spatial- domain cascaded transcoder is developed to convert the filtered image sequence of detected objects into the mobile video streaming format. Experimental results show that the system can successfully detect all events of moving objects for a complex surveillance scene, choose very appropriate key frames for users, and transcode the images with a high power signal-to-noise ratio （PSNR）.

关键词： Index Terms---Mobile video streaming moving object detection key frame extraction video surveillance video transcoding.

Rare complication of inflammatory bowel disease-like colitis from glycogen storage disease type 1b and its surgical management:A case report

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World Journal of Clinical Cases 2021年第16期9卷 4081-4089页

作者： Frederick Chi-Wai Lui Oswens Siu-hung lo Department of Surgery LKS Faculty of MedicineThe University of Hong KongHong KongChina

BACKGROUND Glycogen storage disease(GSD)is an autosomal recessive inborn metabolic *** with GSD are prone to hypoglycaemia,hyperlactacidemia and *** type 1b(GSD-1b)patients specifically can develop neutropenia,recurrent bacterial infection and inflammatory bowel disease(IBD).Documentation of the long-term outcomes of surgical management of GSD-1b has been scarce,especially for Asian *** herein describe a case of GSD-1b complicated by IBD-like colitis and coloduodenal *** patient was managed successfully with surgical *** SUMMARY A 20-year-old Chinese lady confirmed by genetic testing to have GSD-1b was initially managed with uncooked cornstarch and granulocyte-colony stimulating *** recurrent abdominal symptoms,her condition was treated as clinical“Crohn’s disease”with mesalazine,prednisolone and azathioprine *** showed a tight stricture at the hepatic *** computerized tomographic colonography revealed a phlegmon at the ileocaecal region with a suspected coloduodenal *** an exploratory laparotomy was performed and severe colitis at the ascending colon with coloduodenal fistula was *** hemicolectomy with primary anastomosis and repair of the duodenum were *** management of complications from GSD-1b associated IBD-like colitis has rarely been ***-line treatment would usually be *** intervention like hemicolectomy is mainly reserved for refractory *** Surgical management of coloduodenal fistula in GSD-1b patients is a feasible and safe option when failed conservative management.

关键词： Glycogen storage disease Coloduodenal fistula Inflammatory bowel diseaselike colitis Case report Perioperative management