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高雷诺数圆柱绕流的二维大涡模拟

水动力学研究与进展（A辑） 1992年第A12期7卷 614-622页

作者：苑明顺清华大学水电工程系北京100080

本文分析了采用大涡模拟方法和复合式柱面固壁条件对亚临界区(re=1.4×10~5)圆柱绕流进行二维数值模拟的结果。研究了在二维模型中引入涡量耗散项来模拟涡街的三维涡量耗散效应的方法,并分析对比了有关流动特征。

关键词：圆柱绕流大涡模拟高雷诺数

A multicenter prospective study on the management of hepatoblastoma in children:a report from the Chinese Children's Cancer Group

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World Journal of pediatrics 2024年第6期20卷 590-601页

作者： Meng-Jie Tang Xiao-Li Ma Xiang-Ling He Wei-Hua pan Xiao-Hong Zhang Sha-Yi Jiang Ju Gao Fu Li Wei Yao Song Gu Wei-Ling Zhang Qiang Zhao Shi-Hao Huang Yong-Jun Fang Wei Liu Hui-Zhong Niu Chun-Mei Wang Li-rong Sun Hui Gao Yun-peng Dai shun-Gen Huang Zhi-Yong Zhong Xi-Ge Wang Zhong-rong Li Liang-Chun Yang Ye-ming Wu Huan-Min Wang Xin Sun Xiao-Jun yuan department of pediatric Hematology/Oncology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineNo.1665Kongjiang RoadYangpu DistrictShanghai 200092China Medical Oncology department Pediatric Oncology CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China department of Hematology/Oncology Children's Medical CenterHunan Provincial People's HospitalThe First Affiliated Hospital of Hunan Normal UniversityChangsha 41005China department of pediatric Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China department of Hematology/Oncology Guangzhou Women and Children's Medical CenterNational Children's Medical Center for South Central RegionGuangzhou 510623China department of Hematology Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200062China department of pediatrics West China Second University HospitalSichuan UniversityChengdu 610041China department of Hematology/Oncology Qilu Children's Hospital of Shandong UniversityJinan 250022China department of pediatric Surgery Children's Hospital of Fudan UniversityShanghai 201102China department of General Surgery Shanghai Children's Medical Center(National Children's Medical Center-Shanghai)Shanghai Jiao Tong University School of MedicineShanghai 200127China department of pediatrics Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China department of pediatric Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060China department of Hematology/Oncology Children's Hospital of Nanjing Medical UniversityNanjing 210008China department of Hematology/Oncology Henan Children's HospitalZhengzhou 450018China department of pediatric General Surgery Hebei Children's Hospital of Hebei Medical UniversityShijiazhuang City 050031China Children's Hospital the First Affliated Hospital of Zhengzhou UniversityZhengzhou 450052China department of paediatric

Background This study aimed to identify survival risk factors in Chinese children with hepatoblastoma(HB)and assess the effectiveness of the new treatment protocol proposed by the Chinese Children's Cancer Group(CCCG)in *** A multicenter,prospective study that included 399 patients with HB from January 2015 to June 2020 was *** demographics,treatment protocols,and other related information were *** regression models and Kaplan-Meier curve methods were *** The 4-year event-free survival(EFS)and overall survival(OS)were 76.9 and 93.5%,*** 4-year EFS rates for the very-low-risk,low-risk,intermediate-risk,and high-risk groups were 100%,91.6%,81.7%,and 51.0%,*** 4-year 0S was 100%,97.3%,94.4%,and 86.8%,*** regression analysis found that age,tumor rupture(r+),and extrahepatic tumor extension(E+)were independent prognostic factors.A total of 299 patients had complete remission,and 19 *** with declining alpha-fetoprotein(AFp)>75%after the first two cycles of neoadjuvant chemotherapy had a better EFS and OS than those≤75%.Conclusions The survival outcome of HB children has dramatically improved since the implementation of CCCG-HB-2016 ***≥8 years,r+,and E+were independent risk factors for *** with a declining AFp>75%after the first two cycles of neoadjuvant chemotherapy had better EFS and OS.

关键词： Alpha-fetoprotein Hepatoblastoma Multicenter prospective study Survival

Effect and Safety of Herbal Medicine Foot Baths in patients with Diabetic peripheral Neuropathy:A Multicenter Double-Blind randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2024年第3期30卷 195-202页

作者： HUANG Hao-yue LIN Yu-ping WEI Hua FU Yu ZHOU Yue-hong FANG Zhao-hui QIU Xiao-tang WANG Mei LI Qing-bo LI Shan-shan WANG Shi-dong DAI Fang LIU Zhen-jie ZHAO Ling WEN Jian-xuan WU Li-yan ZENG Hui-yan ZHANG Jin-ming LU Qi-yun HE Liu SONG Wei SUN Lu LUO Lu-lu HE Jia-li XIE Wen-wen LIANG Qing-shun HUANG yuan ZHU Sheng-ling LONG Jie-er GAO Zhi-juan WEN Ze-huai LI Chun-ji OUYANG Wen-wei LI Geng WU ming-hui LI An-xiang HUANG Jin-zhu Sanjoy K paul TANG Xian-yu FAN Guan-jie department of Endocrinology Guangdong Provincial Hospital of Chinese MedicineGuangzhou510120China The Second Clinical College of Guangzhou university of Chinese Medicine Guangzhou510120China department of Endocrinology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou510120China Guangdong provincial Academy of Chinese Medical Sciences Guangzhou510120China department of Endocrinology The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou450000China department of Endocrinology Liuyang Hospital of Chinese MedicineChangsha410000China department of Endocrinology The First Affiliated Hospital of Anhui University of Chinese MedicineHefei230000China department of Endocrinology Hainan Provincial Hospital of Traditional Chinese MedicineHaikou570100China department of Endocrinology The Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang110000China department of Geriatric Luoyang No.1 Hospital of Traditional Chinese MedicineLuoyangHenan Province471000China department of Endocrinology The Second Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China department of Endocrinology Beijing University of Chinese Medicine Affiliated Dongzhimen HospitalBeijing100000China department of Endocrinology The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang550000China Melbourne EpiCentre The University of Melbourne and Melbourne HealthMelbourne3013Australia

Objective:To evaluate the effect and safety of foot baths with Tangbi Waixi Decoction(TW)in treating patients with diabetic peripheral neuropathy(DpN).Methods:It is a multicenter double-blinded randomized controlled *** with DpN were recruited between November 18,2016 and May 30,2018 from 8 hospitals in *** patients received basic treatments for glycemic *** received foot baths with TW herbal granules either 66.9 g(intervention group)or 6.69 g(control group)for 30 min once a day for 2 weeks and followed by a 2-week rest,as a therapeutic *** the Toronto Clinical Scoring System total score(TCSS-TS)6 points,the patients received a total of 3 therapeutic courses(for 12 weeks)and were followed up for 12 *** primary outcome was change in TCSS-TS score at 12 and 24 *** outcomes included changes in bilateral motor nerve conduction velocity(MNCV)and sensory nerve conduction velocity(SNCV)of the median and common peroneal *** was also ***:Totally 632 patients were enrolled,and 317 and 315 were randomized to the intervention and control groups,*** the 12-week intervention,patients in both groups showed significant declines in TCSSTS scores,and significant increases in MNCV and SNCV of the median and common peroneal nerves compared with pre-treatment(preduction of TCSS-TS score at 12 weeks and the increase of SNCV of median nerve at 24 weeks in the control group were greater than those in the intervention group(pr of adverse events did not differ significantly between groups(p>0.05),and no serious adverse event was related with ***:Treatment of TW foot baths was safe and significantly benefitted patients with DpN.A low dose of TW appeared to be more effective than a high dose.(registry *** CTr-IOr-16009331)

关键词： diabetic peripheral neuropathy herbal medicine foot baths Chinese medicine randomized controlled trial Tangbi Waixi Decoction

STATISTICAL prOpErTY OF THrESHOLD-CrOSSING FOr ZErO-MEAN-VALUED, NArrOW-BANDED GAUSSIAN prOCESSES

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Applied Mathematics and Mechanics(English Edition) 2001年第6期22卷 701-710页

作者： HE Wu-zhou(贺五洲) yuan ming-shun(苑明顺) department of hydraulic and Hydropower engineering Tsinghua University Beijing 100084 P R China Department of Hydraulic and Hydropower Engineering Tsinghua University Beijing 100084 P R China

Based on a comprehensive discussion of the calculation method for the threshold-crossing statistics of zero mean valued, narrow banded Gaussian processes of various practical engineering problems, including the threshold-crossing probability, average number of crossing events per unit time, mean threshold-crossing duration and amplitude, a new Simple numerical procedure is proposed for the efficient evaluation of mean threshold-crossing duration. A new dimensionless parameter, called the threshold-crossing intensity, is defined as a measure of the threshold-crossing severity, which is equal to the ratio of the product of average number of crossing events per unit time and mean threshold-crossing duration and amplitude over the threshold. It is found, by the calculation results for various combinations of stochastic processes and different thresholds, that the threshold-crossing intensity, irrelevant of the threshold and spectral density of the process, is dependent only on the threshold-crossing probability.

关键词： stochastic process threshold-crossing statistical property

The In-Flight realtime Trigger and Localization Software of GECAM

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research in Astronomy and Astrophysics 2024年第10期24卷 11-24页

作者： Xiao-Yun Zhao Shao-Lin Xiong Xiang-Yang Wen Xin-Qiao Li Ce Cai Shuo Xiao Qi Luo Wen-Xi peng Dong-Ya Guo Zheng-Hua An Ke Gong Jin-yuan Liao Yan-Qiu Zhang Yue Huang Lu Li Xing Wen Fei Zhang Jing Duan Chen-Wei Wang Dong-Li Shi peng Zhang Qi-Bin Yi Chao-Yang Li Yan-Bing Xu Xiao-Hua Liang Ya-Qing Liu Da-Li Zhang Xi-Lei Sun Fan Zhang Gang Chen Huan-Yu Wang Sheng Yang Xiao-Jing Liu Min Gao Mao-shun Li Jin-Zhou Wang Xing Zhou Yi Zhao Wang-Chen Xue Chao Zheng Jia-Cong Liu Xing-Bo Han Jin-Ling Qi Jia Huang Ke-Ke Zhang Can Chen Xiong-Tao Yang Dong-Jie Hou Yu-Sa Wang rui Qiao Xiang Ma Xiao-Bo Li ping Wang Xin-Ying Song Li-ming Song Shi-Jie Zheng Bing Li Hong-Mei Zhang Yue Zhu Wei Chen Jian-Jian He Zhen Zhang Jin Hou Hong-Jun Wang Yan-Chao Hao Xiang-Yu Wang Zong-yuan Yang Zhi-Long Wen Zhi Chang yuan-yuan Du rui Gao Xiao-Fei Lan Yan-Guo Li Gang Li Xu-Fang Li Fang-Jun Lu Hong Lu Bin Meng Feng Shi Hui Wang Hui-Zhen Wang Yu-peng Xu Jia-Wei Yang Xue-Juan Yang Shuang-Nan Zhang Chao-Yue Zhang Cheng-Mo Zhang Zhi-Cheng Tang Cheng Cheng Key Laboratory of particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China university of Chinese Academy of Sciences Chinese Academy of SciencesBeijing 100049China School of Information Science and Technology Southwest Jiaotong UniversityChengdu 611756China Key Laboratory of Stellar and Interstellar physics and department of physics Xiangtan UniversityXiangtan 411105China physics and Space Science College China West Normal UniversityNanchong 637002China department of Astronomy Beijing Normal UniversityBeijing 100875China Innovation Academy for Microsatellites of CAS Shanghai 201203China Changchun university of Science and Technology Changchun 130022China Chinese Academy of Sciences South America Center for Astronomy National Astronomical ObservatoriesCASBeijing 100101China

realtime trigger and localization of bursts are the key functions of GECAM,an all-sky gamma-ray monitor launched on 2020 December *** developed a multifunctional trigger and localization software operating in the CpU of the GECAM Electronic *** onboard software has the following features:high trigger efficiency for real celestial bursts with a suppression of false triggers caused by charged particle bursts and background fluctuation,dedicated localization algorithm optimized for both short and long bursts,and low time latency of the trigger information which is downlinked through the Global Short Message Communication service of the global BeiDou navigation *** paper provides a detailed description of the design and development of the trigger and localization software system for *** covers the general design,workflow,the main functions,and the algorithms used in the *** paper also includes on-ground trigger tests using simulated gamma-ray bursts generated by a dedicated X-ray tube,as well as an overview of the performance for real celestial bursts during its in-orbit operation.

关键词： telescopes instrumentation:detectors methods:observational

Comparison of the Coronal Green-line Intensities with the EUV Measurements from SDO/AIA

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research in Astronomy and Astrophysics 2022年第7期22卷 191-205页

作者： Xue-Fei Zhang Yu Liu ming-Yu Zhao Ji-Hong Liu Abouazza Elmhamdi Teng-Fei Song Zi-Han Li Hong-Bo Li Fei-Yang Sha Jing-Xing Wang Xiao-Bo Li yuan-Deng Shen shun-Qing Liu Hong-Fei Liang r.M.Al-Shammari Yunnan Observatories Chinese Academy of SciencesKunming 650011China university of Chinese Academy of Sciences Beijing 100049China Shijiazhuang university Shijiazhuang 050035China School of physical Science and Technology Southwest Jiaotong UniversityChengdu 610031China department of physics and Astronomy King Saud UniversityP.O.Box 2455Riyadh 11451Saudi Arabia Yunnan Normal university School of Physics and Electronic InformationKunming 650500China Institute of Space physics Luoyang Normal UniversityLuoyang 471934China

The intensity of the green line(Fe ⅩⅣ 5303 A) is the strongest in the visible spectrum of the solar corona,and this line has been used as long-term powerful diagnostic tools for studying the coronal configurations and hot plasma ***,it remains unclear and an open question whether there exists close relationship between the green line intensities and the coronal extreme ultraviolet(EUV) line emissions for various coronal *** this paper,we use the green-line data by the Lijiang YOGIS Lyot coronagraph and the EUV data from the Solar Dynamics Observatory/Atmospheric Imaging Assembly instruments in order to perform direct comparisons and analyses,based on two algorithms developed to extract particular features in the low *** is found that,among the correlation coefficients obtained between the intensities of 5303 A and the EUV lines,the coefficients between the green line and the 211 A wavelength for different coronal structures and different limb locations always keep the highest values(ranging from 0.89 to 0.99),which has not been reported *** result can be helpful and promising to link together the various physical processes involved at different heights in the corona by precisely tracking the bright loops or other features observed in 5303 A above the limb down to the correct surface locations revealed by the 211 A ***,the ground-based observations of the coronal green line and the space-based EUV observations at 211 A can advantageously complement each other when there is a need.

关键词： Sun:corona Sun:magnetic fields stars:coronae

Application of a hybrid multiscalar indicator in drought identification in beijing and Guangzhou,china

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Water Science and engineering 2018年第3期11卷 177-186页

作者： ming-wei Ma Wen-chuan Wang Fei yuan Li-liang ren Xin-jun Tu Hong-fei Zang School of Water Conservancy North China University of Water Resources and Electric PowerZhengzhou 450046China Collaborative Innovation Center of Water resources Efficient Utilization and protection engineering of Henan province Zhengzhou 450046China State Key Laboratory of Hydrology-Water resources and hydraulic engineering Hohai UniversityNanjing 210098China department of Water resources and Environment Sun Yat-sen UniversityGuangzhou 510275China

The palmer drought severity index(pDSI) is physically based with multivariate concepts, but requires complicated calibration and cannot easily be used for multiscale comparison. Standardized drought indices(SDIs), such as the standardized precipitation index(SpI) and standardized precipitation evapotranspiration index(SpEI), are multiscalar and convenient for spatiotemporal comparison, but they are still challenged by their lack of physical basis. In this study, a hybrid multiscalar indicator, the standardized palmer drought index(SpDI), was used to examine drought properties of two meteorological stations(the beijing and Guangzhou stations) in china, which have completely different drought climatologies. The results of our case study show that the SpDI is correlated with the well-established drought indices(SpI, SpEI, and pDSI) and presents generally consistent drought/wetness conditions against multiple indicators and literature records. relative to the pDSI, the SpDI demonstrates invariable statistical characteristics and better comparable drought/wetness frequencies over time and space. Moreover,characteristics of major drought events(drought class, and onset and end times) indicated by the SpDI are generally comparable to those detected by the pDSI. As a physically-based standardized multiscalar drought indicator, the SpDI can be regarded as an effective development of the palmer drought indices, providing additional choices and tools for practical drought monitoring and assessment.

关键词： Drought pDSI Multiscalar index SpDI Multifaceted comparison

Calcitriol attenuates liver fibrosis through hepatitis C virus nonstructural protein 3-transactivated protein 1-mediated TGF β1/Smad3 and NF-κB signaling pathways

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World Journal of Gastroenterology 2023年第18期29卷 2798-2817页

作者： Liu Shi Li Zhou ming Han Yu Zhang Yang Zhang Xiao-Xue yuan Hong-ping Lu Yun Wang Xue-Liang Yang Chen Liu Jun Wang pu Liang shun-Ai Liu Xiao-Jing Liu Jun Cheng Shu-Mei Lin department of Infectious Disease Medicine The First Hospital Affiliated to Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina china-Japan Friendship Hospital Department of Infectious Disease China-Japan Friendship HospitalBeijing 100029China Institute of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China The Division of Liver Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Institute of Liver Diseases Beijing Pan-Asia Tongze Institute of Biomedicine Co.LtdBeijing 100015China department of rehabilitation Medicine The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina beijing Key Laboratory of Emerging Infectious Diseases Peking University Ditan Teaching HospitalBeijing 100015China

BACKGrOUND Hepatic fibrosis is a serious condition,and the development of hepatic fibrosis can lead to a series of ***,the pathogenesis of hepatic fibrosis remains unclear,and effective therapy options are still *** group identified hepatitis C virus nonstructural protein 3-transactivated protein 1(NS3Tp1) by suppressive subtractive hybridization and bioinformatics analysis,but its role in diseases including hepatic fibrosis remains ***,additional studies on the function of NS3Tp1 in hepatic fibrosis are urgently needed to provide new targets for *** To elucidate the mechanism of NS3Tp1 in hepatic fibrosis and the regulatory effects of calcitriol on *** Twenty-four male C57BL/6 mice were randomized and separated into three groups,comprising the normal,fibrosis,and calcitriol treatment groups,and liver fibrosis was modeled by carbon tetrachloride(CCl4).To evaluate the level of hepatic fibrosis in every group,serological and pathological examinations of the liver were ***-β1 was administered to boost the in vitro cultivation of LX-2 ***3Tp1,α-smooth muscle actin(α-SMA),collagen I,and collagen Ⅲ in every group were examined using a Western blot and real-time quantitative polymerase chain *** activity of the transforming growth factor beta 1(TGFβ1)/Smad3 and NF-κB signaling pathways in each group of cells transfected with pcDNA-NS3Tp1 or sirNA-NS3Tp1 was *** statistical analysis of the data was performed using the Student’s t *** NS3Tp1 promoted the activation,proliferation,and differentiation of hepatic stellate cells(HSCs)and enhanced hepatic fibrosis via the TGFβ1/Smad3 and NF-κB signaling pathways,as evidenced by the presence of α-SMA,collagen I,collagen Ⅲ,p-smad3,and p-p65 in LX-2 cells,which were upregulated after NS3Tp1 overexpression and downregulated after NS3Tp1 *** proliferation of HSCs was lowered after NS3Tp1 interference and elevated after

关键词： Nonstructural protein 3-transactivated protein 1 Calcitriol Liver fibrosis Hepatic stellate cells Mouse model TGFβ1/Smad3 NF-κB Signaling pathway

Direct reprogramming of porcine fibroblasts to neural progenitor cells

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protein & Cell 2014年第1期5卷 4-7页

作者： Xiu-Ling Xu Ji-ping Yang Li-Na Fu ruo-Tong ren Fei Yi Keiichiro Suzuki Kai Liu Zhi-Chao Ding Jing Qu Wei-Qi Zhang Ying Li Ting-Ting yuan Guo-Hong yuan Li-Na Sui Di Guan shun-Lei Duan Hui-Ze pan ping Wang Xi-ping Zhu Nuria Montserrat ming Li rui-Jun Bai Lin Liu Juan Carlos lzpisua Belmonte Guang-Hui Liu National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of Sciences department of Molecular and Cellular physiology tanford University School of MedicineStanfordCA 94305USA Gene Expression Laboratory Salk Institute for Biological Studies10010 North Torrey Pines RoadLa JollaCA 9207USA State Key Laboratory of Medicinal Chemical Biology College of Life SciencesNankai University Center for regenerative Medicine in Barcelona Dr.Aiguader 8808003 BarcelonaSpain beijing Institute for Brain Disorders

Dear Editor,Neural progenitor cells(NpCs)have proven potential to facilitate mechanistic studies of neurological disorders in vitro,as well as the discovery of new *** addition,NpCs have been proposed as promising cell sources for cell replacement therapy of neurological diseases(Liu et al.,2012b).For these areas of study,experimental animals are indispensable *** the possible animal species,pigs are advantageous compared to rodents because of their physiological and anatomical similarities to

关键词： Neural progenitor Cell Neural Differentiation Sodium Butyrate Direct reprogram Episomal Vector