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Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2716-2726页

作者： Cai-Jing Mo Xiao-yuan Deng Ru-lan Ma Kun Zhu Lei Shi Kang Li Department of Surgical Oncology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND The role of Sm-like 5(LSM5)in colon cancer has not been *** this study,we investigated the role of LSM5 in progression of colon cancer and the potential underlying mechanism *** To determine the role of LSM5 in the progression of colon cancer and the potential underlying mechanism *** The Gene Expression Profiling Interactive Analysis database and the Human Protein Atlas website were used for LSM5 expression analysis and prognosis ***-time quantitative polymerase chain reaction and Western blotting were utilized to detect the expression of mRNAs and proteins.A lentivirus targeting LSM5 was constructed and transfected into colon cancer cells to silence LSM5 *** and apoptosis assays were also conducted to evaluate the growth of the colon cancer *** GeneChip assay and bioinformatics analysis were performed to identify the potential underlying mechanism of LSM5 in colon *** LSM5 was highly expressed in tumor tissue and colon cancer cells.A high expression level of LSM5 was related to poor prognosis in patients with colon *** of LSM5 suppressed proliferation and promoted apoptosis in colon cancer *** of LSM5 also facilitates the expression of p53,cyclin-dependent kinase inhibitor 1A(CDKN1A)and tumor necrosis factor receptor superfamily 10B(TNFRSF10B).The inhibitory effect of LSM5 knockdown on the growth of colon cancer cells was associated with the upregulation of p53,CDKN1A and *** LSM5 knockdown inhibited the proliferation and facilitated the apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B.

关键词： Sm-like 5 Colon cancer Proliferation Apoptosis Knockdown

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Analyzing the surface passivity effect of germanium oxynitride:a comprehensive approach through first principles simulation and interface state density

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Nuclear Science and Techniques 2024年第5期35卷 74-84页

作者： Sheng-Jie Du Xiu-Xia Li Yang Tian yuan-yuan Liu Ke Jia Zhong-Zheng Tang Jian-Ping Cheng Zhi Deng Yu-lan Li Zheng-Cao Li Sha-Sha Lv College of Nuclear Science and Technology Joint Laboratory of Jinping Ultra‑Low Radiation Background Measurement of Ministry of Ecology and Environment Key Laboratory of Beam Technology of Ministry of Education Beijing Normal UniversityBeijing Normal UniversityBeijing 100875China Joint Research Center Nuctech Company LimitedBeijing 100084China Department of Engineering Physics Key Laboratory of Particle&Radiation Imaging of Ministry of EducationTsinghua UniversityBeijing 100084China Key Laboratory of Advanced Materials(MOE) School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

High-purity germanium(HPGe)detectors,which are used for direct dark matter detection,have the advantages of a low threshold and excellent energy *** surface passivation of HPGe has become crucial for achieving an extremely low energy *** this study,first-principles simulations,passivation film preparation,and metal oxide semiconductor(MOS)capacitor characterization were combined to study surface *** calculations of the energy band structure of the -H,-OH,and -NH_(2) passivation groups on the surface of Ge were performed,and the interface state density and potential with five different passivation groups with N/O atomic ratios were accurately analyzed to obtain a stable surface *** on the theoretical calculation results,the surface passivation layers of the Ge_(2)ON_(2) film were prepared via magnetron sputtering in accordance with the optimum atomic ratio *** microstructure,C-V,and I-V electrical properties of the layers,and the passivation effect of the Al/Ge_(2)ON_(2)/Ge MOS were characterized to test the interface state *** mean interface state density obtained by the Terman method was 8.4×10^(11) cm^(-2) eV^(-1).The processing of germanium oxynitrogen passivation films is expected to be used in direct dark matter detection of the HPGe detector surface passivation technology to reduce the detector leakage currents.

关键词： Surface passivation High purity germanium detector Germanium nitrogen oxide Interface state density

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Wettability and corrosion behavior between alkaline slag from sodium smelting of vanadium-titanium magnetite and refractory substrates

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Journal of Iron and Steel Research International 2024年第6期31卷 1399-1410页

作者： Fei Zhao Zhi-wei Bian Hong-xin Zhao De-sheng Chen Zhang-fu yuan Yu-lan Zhen Li-na Wang Tao Qi Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China National Engineering Research Center of Green Recycling for Strategic Metal Resources Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Hebei Zhongke Tongchuang Vanadium&Titanium Technology Co. Ltd.Hengshui 053000HeheiChina

The sodium smelting of vanadium-titanium magnetite can achieve the comprehensive utilization of Fe,V,and ***,the generation of alkaline slag during this process may cause damage to refractory *** wettability and corrosion behavior of alkaline slag on three types of refractory(MgO-C,SiC,and high alumina refractory)substrates were investigated at temperatures up to 1200℃.The effects of duration on the wettability of molten slag on SiC substrates were also *** showed that the high alumina refractory exhibited better wettability with the molten slag than the others,and thus,it is easier to be *** results of scanning electron microscopy coupled with energy dispersive spectroscopy showed that MgO-C and high alumina refractory substrates were severely *** was a visible and regular interfacial reaction layer between the slag and SiC refractory substrate,which was produced by the redox reaction between the metal oxides in the slag and the SiC refractory *** the increase in holding time,the interface layer expands and silico-ferrite phases are generated at the *** redox reaction between Fe_(2)O_(3) and SiC substrate is the main reason for the *** comparing the differences in wettability and corrosion behavior between the alkaline slag from sodium smelting of vanadium-titanium magnetite and MgO-C,SiC and high alumina refractories,it is concluded that SiC refractory has good corrosion resistance to the *** oxides in the slag accelerate the oxidation rate of SiC refractory.

关键词： Wettability Corrosion Alkaline slag-Contact angle Vanadium-titanium magnetite Refractory

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Association between inflammatory bowel disease and all-cause dementia:A two-sample Mendelian randomization study

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World Journal of Psychiatry 2024年第1期14卷 15-25页

作者： Ou-lan Liao Si-yuan Xie Jun Ye Qin Du Guo-Chun Lou Department of Gastroenterology The Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009Zhejiang ProvinceChina Department of Gastroenterology The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina

BACKGROUND Numerous observational studies have documented a correlation between inflammatory bowel disease(IBD)and an increased risk of ***,the causality of their associations remains *** To assess the causal relationship between IBD and the occurrence of all-cause dementia using the two-sample Mendelian randomization(MR)*** Genetic variants extracted from the large genome-wide association study(GWAS)for IBD(the International IBD Genetics Consortium,n=34652)were used to identify the causal link between IBD and dementia(FinnGen,n=306102).The results of the study were validated via another IBD GWAS(United Kingdom Biobank,n=463372).Moreover,MR egger intercept,MR pleiotropy residual sum and outlier,and Cochran's Q test were employed to evaluate pleiotropy and ***,multiple MR methods were performed to estimate the effects of genetically predicted IBD on dementia,with the inverse variance weighted approach adopted as the primary *** The results of the pleiotropy and heterogeneity tests revealed an absence of significant pleiotropic effects or heterogeneity across all genetic variants in outcome *** evidence of a causal effect between IBD and the risk of dementia was identified in the inverse variance weighted[odds ratio(OR)=0.980,95%CI:0.942-1.020,P value=0.325],weighted median(OR=0.964,95%CI:0.914-1.017,P value=0.180),and MR-Egger(OR=0.963,95%CI:0.867-1.070,P value=0.492)*** results were observed in validation *** MR analysis also showed no effect of dementia on the development of ***,MR analysis suggested that IBD and its subtypes did not causally affect allcause dementia and its four subtypes,including dementia in Alzheimer's disease,vascular dementia,dementia in other diseases classified elsewhere,and unspecified *** Taken together,our MR study signaled that IBD and its subentities were not genetically associated with all-cause dementia or its

关键词： Inflammatory bowel disease All-cause dementia Mendelian randomization Causal effect Risk factor©The

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基于星间测距和地面发射源的导航星座整网自主定轨

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国防科技大学学报 2009年第2期31卷 15-19,30页

作者：朱俊廖瑛文援兰国防科技大学航天与材料工程学院湖南长沙410073

导航卫星星座自主定轨技术是我国新一代卫星导航系统的关键技术之一。但是仅仅依靠星间相互测距定轨会因缺少地面基准而出现基准秩亏现象。针对这个问题,提出利用少量地面发射源随机工作的方式提供地面基准,将星间测距和地面发射源信息... 详细信息

导航卫星星座自主定轨技术是我国新一代卫星导航系统的关键技术之一。但是仅仅依靠星间相互测距定轨会因缺少地面基准而出现基准秩亏现象。针对这个问题,提出利用少量地面发射源随机工作的方式提供地面基准,将星间测距和地面发射源信息融合起来进行星座整网定轨,进一步提高定轨精度。最后利用仿真实验对该方法的合理有效性进行了验证。

关键词：导航系统自主定轨星间测量地面发射源

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Fe/S oxidation-coupled arsenic speciation transformation mediated by AMD enrichment culture under different pH conditions

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Journal of Environmental Sciences 2024年第3期137卷 681-700页

作者： Yu-hang Zhou Wei-xi Huang Zhen-yuan Nie Hong-chang Liu Yue Liu Can Wang Jin-lan Xia Wen-sheng Shu Key Lab of Biometallurgy of Ministry of Education of China School of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China School of Life Sciences South China Normal UniversityGuangzhou 510631China

Arsenic(As)speciation transformation in acid mine drainage(AMD)is comprehensively affected by biological and abiotic factors,such as microbially mediated Fe/S redox reactions and changes in environmental conditions(pH and oxidation-reduction potential).However,their combined impacts on arsenic speciation transformation remain poorly ***,we explored arsenic transformation and immobilization during pyrite dissolution mediated by AMD enrichment culture under different acidic pH *** results for incubation and mineralogical transformation of solid residues show that in the presence of AMD enrichment culture,pH 2.0,2.5,and 3.0 are more conducive to the formation of jarosites and ferric arsenate,which could immobilize high quantities of dissolved arsenic by adsorption and *** pH conditions significantly affect the initial adsorption of microbial cells to the minerals and the evolution of microbial community structure,further infuencing the biodissolution of pyrite and the release and oxidation process of Fe/*** results of Fe/S/As speciation transformation of the solid residues show that the transformation of Fe,S,and As in solution is mainly regulated by pH and potential values,which imposed significantly different effects on the formation of secondary minerals and thus arsenic oxidation and *** above results indicated that arsenic transformation is closely related to the Fe/S oxidation associated with pyrite bio-oxidation,and this correlation is critically regulated by the pH conditions of the system.

关键词： Acid mine drainage(AMD) pH conditions Fe/S/As speciation transformation Microbial community structure

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Synthesis and Properties of Ferrocene Conjugated Macrocycles with Illusory Topology of the Penrose Stairs

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CHEMICAL RESEARCH IN CHINESE UNIVERSITIES 2024年第5期40卷 881-886页

作者： Xu, Jindong lan, Bin Zhu, Lingyun Xu, Hui Chen, Xinyu Li, Wenjuan yuan, Yaofeng Yan, Jianfeng Li, yuanming Fuzhou Univ Fujian Prov Univ Coll Chem Key Lab Mol Synth & Funct Discovery Fuzhou 350108 Peoples R China Shangqiu Normal Univ Coll Chem & Chem Engn Henan Key Lab Biomol Recognit & Sensing Shangqiu 476000 Peoples R China

Polyferrocene macrocycles hold immense potential in the fields of molecular electronics and electrochemistry, primarily due to their multiple metal centers. However, developing highly efficient synthetic strategies for constructing these rings remains a significant challenge. In this study, we successfully synthesized triferrocenyl macrocycles using Pt-mediated coupling strategy and determined their configuration using single-crystal X-ray diffraction analysis, revealing a structure reminiscent of the Penrose Stair. We comprehensively investigated the macrocycle's structure, photophysical properties, and employed density functional theory (DFT) calculations to gain further insights. Notably, this macrocycle exhibits several advantageous features, including a flexible structure, good solubility, and a highly efficient synthetic pathway.

关键词： Conjugated macrocycle Organometallic macrocycle Pt-template method BENZENE CARBON NANOCAGES METALLOCENE TRIAD

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Rectangular Ring Congruences on an E-inversive Semiring

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Chinese Quarterly Journal of Mathematics 2014年第4期29卷 529-538页

作者： CHENG Zi-qiang ZHOU yuan-lan PAN Shi-ju Department of Mathematics Jiangxi Normal University Nanchang 330022 China

In this paper, we discussed the property of rectangular band semiring congruence and ring congruence on a semiring and gave some characterizations and structure of rectangular ring congruence on an E-inversive semiring.

关键词： congruence band semiring E-inversive semiring

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Identification of Two Disease-causing Genes TJP2 and GJB2 in a Chinese Family with Unconditional Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment

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Chinese Medical Journal 2015年第24期128卷 3345-3351页

作者： Hong-YangWang Ya-Li Zhao Qiong Liu Hu yuan Yun Gao lan lan Da-Yong Wang Jing Guan Qiu-Ju Wang Department of Otolaryngology-Head and Neck Chinese People's Liberation Army Institute of Otolaryngology Chinese People's Liberation Army General Hospital Beijing 100853 China

Background： There are more than 300 genetic loci that have been found to be related to hereditary hearing impairment （HHI）, including 92 causative genes for nonsyndromic hearing loss, among which 34 genes are related to autosomal dominant nonsyndromic HHI （ADNSHH 1）. Traditional linkage analysis and candidate gene sequencing are not effective at detecting the ADNSHHI, especially for the unconditional families that may have more than one pathogenic cause. This study identified two disease-causing genes TJP2 and GJB2 in a Chinese family with unconditional ADNSHHI. Methods： To decipher the genetic code of a Chinese family （family 686） with ADNSHHI, different gene screening techniques have been performed, including linkage analysis, candidate genes screening, high-throughput sequencing and Sanger sequencing. These techniques were done on samples obtained from this family over a period of 10 years. Results： We identified a pathogenic missense mutation, c. 2081G〉A （p.G694E）, in TJP2, a gene that plays a crucial role in apoptosis and age-related hearing loss （ARHL）. The mutation was co-segregated in this pedigree in all, but not in the two patients who presented with different phenotypes from the other affected family members. In one of the two patients, we confirmed that the compound heterozygosity for p.Y136^＊ and p.G45E in the GJB2 gene may account for the phenotype shown in this patient. Conclusions： We identified the co-occurrence of two genetic causes in family 686. The possible disease-causing missense mutation of TJP2 in family 686 presents an opportunity for further investigation into ARHL. It is necessary to combine various genes screening methods, especially for some unconventional cases.

关键词： Autosomal Dominant Nonsyndromic Hereditary Hearing Impairment GJB2 TJP2

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Schlemm管切开加黏弹剂扩张术治疗开角型青光眼的临床研究现状

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中华眼科杂志 2013年第8期49卷 749-751页

作者：宗媛袁志兰南京医科大学第一附属医院眼科 210029

Schlemm管切开加黏弹剂扩张术（VCO）是一种治疗开角型青光眼的手术。它通过手术后遗留下的小梁网一后弹力层窗实现缓慢滤过，从而避免了眼压骤降，大大减少了术后的并发症。近来，许多术者对VCO手术不断地改进，如联合超声乳化白内障... 详细信息

Schlemm管切开加黏弹剂扩张术（VCO）是一种治疗开角型青光眼的手术。它通过手术后遗留下的小梁网一后弹力层窗实现缓慢滤过，从而避免了眼压骤降，大大减少了术后的并发症。近来，许多术者对VCO手术不断地改进，如联合超声乳化白内障吸除术，术中使用植入物等。这些方法增强了VCO术降眼压的力度，使得术后成功率明显提高。本文对VCO手术的历史进行了回顾，着重阐述了VCO手术的方式、效果、创新发展及未来趋势。

关键词：青光眼,开角型巩膜造口术青光眼引流植入物透明质酸抗菌药

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