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Histological Features of Uterine Myometrial Dysfunction:Possible Involvement of Localized Inflammation

Current Medical Science 2024年第3期44卷 633-641页

作者： Sheng-lan ZHU Hui-ting ZHANG yuan-yuan du Yi JIANG Shao-shuai WANG Wen-cheng DING Ling FENG National Clinical Research Center for Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective The latest perspective suggests that elevated levels of inflammation and cytokines are implicated in atonic postpartum ***(LPS)has been widely used to induce inflammation in animal ***,this study aimed to induce uterine inflammation using LPS to investigate whether local inflammation triggers dysfunction and atrophy in the myometrium,as well as the potential underlying molecular mechanisms *** In vivo,an animal model was established by intraperitoneal injection of 300μg/kg LPS in rats on gestational day ***-eosin(H&E)staining and Masson staining were employed to determine morphological changes in the rat uterine smooth ***-linked immunosorbent assay(ELISA)was used to detect inflammatory ***,tissue fluorescence,and Western blotting were conducted to assess the expression levels of the uterine contraction-related proteins Toll-like receptor 4(TLR4)and the nuclear factor kappa-B(NF-κB)signaling *** vitro,human uterine smooth muscle cells(HUtSMCs)were exposed to 2μg/mL LPS to further elucidate the involvement of the TLR4/NF-κB signaling pathway in LPS-mediated *** In this study,LPS induced uterine myometrial dysfunction in rats,leading to a disorganized arrangement,a significant increase in collagen fiber deposition,and widespread infiltration of inflammatory *** both in vivo animal models and in vitro HUtSMCs,LPS elevated IL-6,IL-1β,and TNF-αlevels while concurrently suppressing the expression of connexin 43(Cx43)and oxytocin receptor(OXTR).Mechanistically,the LPS-treated group exhibited TLR4 activation,and the phosphorylation levels of p65 and IκBαwere notably *** LPS triggered the TLR4/NF-κB signaling pathway,inducing an inflammatory response in the myometrium and leading to uterine myometrial dysfunction and uterine atony.

关键词： lipopolysaccharide inflammatory response TLR4 NF-κB myometrium

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Recent Progress in Fabrication and Structural Design of Thermal Conductive Polymer Composites

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Chinese Journal of Polymer Science 2024年第3期42卷 277-291,I0004页

作者： yuan-Kai du Zheng-Xue Shi Shan Dong Hui Jin Xue Ke Pei Zhao Bing-Bing Jiang Feng You Hubei Key Laboratory of Plasma Chemistry and Advanced Materials School of Material Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Key Laboratory of Green Preparation and Application of Functional Materials Ministry of EducationHubei UniversityWuhan 430062China Institute of Molecular Aggregation Science Tianjin UniversityTianjin 300072China

In recent years, the demand direction for electronic equipment has expanded into embedded and miniaturized devices. The heat radiation problem has become one of the most significant factors for hindering the development of electronic devices. Since heat radiation material is one of the important components in electronic devices, the demand for enhancing thermal conductivity is also increasingly urgent. Research on thermal conductive polymer composites has become a major direction for developing functional composites. This work reviewed the recent progress in the fabrication of thermal conductive polymer composites. Five different structures are presented, including the using of single fillers,hybrid fillers, double threshold percolation structure, segregated structure and other complex multiphase structures. Specifically, the preparation of high-performance thermal conductive polymer composites was introduced through the combination of various thermal conductive ***, the development direction of high thermal conductive polymer composites was briefly explored.

关键词： Thermal conductive polymer Hybrid fillers Polymer composite Thermal resistance

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Predicting the Risk of Arterial Stiffness in Coal Miners Based on Different Machine Learning Models

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Biomedical and Environmental Sciences 2024年第1期37卷 108-111页

作者： CHEN Qian Wei HUANG Xue Zan DING Yu ZHU Feng Ren WANG Jia ZOU yuan Jie du yuan Zhen ZHANG Ya Jun HUI Zi Wen ZHU Feng Lin MU Min The Project was supported by Open Research Grant of Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining Anhui University of Science and TechnologyHefei 232001AnhuiChina School of Public Health Anhui University of Science and TechnologyHefei 232001AnhuiChina Key Laboratory of Industrial dust Prevention and Control Occupational Safety and HealthMinistry of EducationAnhui University of Science and TechnologyHefei 232001AnhuiChina Anhui Institute of Occupational Safety and Health Anhui University of Science and TechnologyHefei 232001AnhuiChina Joint Research Center of Occupational Medicine and Health Institute of Grand HealthHefei Comprehensive National Science CenterAnhui University of Science and TechnologyHefei 232001AnhuiChina Department of Occupational&Environmental Health School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Key Laboratory of Environment and Health Ministry of Education&Ministry of Environmental Protectionand State Key Laboratory of Environmental Health(Incubating)School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina

Coal is one of the world’s main energy resources,accounting for approximately 68%of China’s current total power ***,several studies have demonstrated that dust,exhaust fumes,and other harmful factors in coal mines increase the risk of cardiovascular disease(CVD)among miners^([1]).Arterial stiffness(AS)is an independent risk factor of CVD,and epidemiological studies have shown that AS plays a vital role in assessing the risk of CVD^([2]).

关键词： Arterial cardiovascular assessing

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A Wave Superposition–Finite Element Method for Calculating the Radiated Noise Generated by Volumetric Targets in Shallow Water

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China Ocean Engineering 2024年第5期38卷 845-854页

作者： TANG Yu-hang ZHAO Zhe LI Hai-chao PANG Fu-zhen TANG Yang du yuan Naval Research Institute College of Shipbuilding Engineering Harbin Engineering University School of Marine Engineering and Technology Sun Yat-sen University

A combined method of wave superposition and finite element is proposed to solve the radiation noise of targets in shallow sea. Taking the sound propagation of spherical sound source in shallow sea as an example, the radiation sound field of the spherical sound source is equivalent to the linear superposition of the radiation sound field of several internal point sound sources, and then the radiated noise induced by spherical sound source can be predicted *** accuracy and efficiency of the method are verified by comparing with the numerical results of finite element method, and the rapid prediction of underwater radiated noise of cylindrical shell is carried out based on the *** results show that compared with the finite element method, the relative error of the calculation results under different simulation conditions does not exceed 0.1%, and the calculation time is about 1/10 of the finite element method, so this method can be used to solve the radiated noise of shallow underwater targets.

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特殊教育普惠发展的经费投入保障格局与政策展望

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中国特殊教育 2024年第3期 12-22页

作者：杜媛北京教育科学研究院北京100036

党的二十大报告提出“强化特殊教育普惠发展”,为新时期我国特殊教育发展指明了方向。高水平的经费投入保障是特殊教育普惠发展的前提条件,本文以特殊教育经费的需求关系为基本分析框架,从总量、结构、变化趋势和区域分布四个方面综合... 详细信息

党的二十大报告提出“强化特殊教育普惠发展”,为新时期我国特殊教育发展指明了方向。高水平的经费投入保障是特殊教育普惠发展的前提条件,本文以特殊教育经费的需求关系为基本分析框架,从总量、结构、变化趋势和区域分布四个方面综合分析党的十八大以来我国特殊教育经费投入保障的总体格局,并从国家战略实施、区域协调发展和学龄特殊人口变化的视角,阐述特殊教育普惠发展的教育经费需求。“十四五”及未来一段时期,特殊教育经费投入需要坚持政府投入主体地位,完善特殊教育多渠道资金筹措机制,积极关注“中部塌陷”现象,增强特殊教育生均经费成本意识,不断提升经费投入效能。

关键词：特殊教育经费保障普惠发展

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Accuracy of FreeStyle Libre flash glucose monitoring in patients with type 2 diabetes who migrated from highlands to plains

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World Journal of Diabetes 2024年第6期15卷 1254-1262页

作者： Zeng-Mei Sun yuan-Ze du Su-yuan Wang Shu-Yao Sun Yan Ye Xue-Ping Sun Ming-Xia Li Hua He Wun-Chun Long Cheng-Hui Zhang Xuan-Yu Yao Wu-Yi Fan Ling Wang Yun-Hong Wu Department of Endocrinology and Metabolism Hospital of the People's Government of the Tibet Autonomous Region in ChengduChengdu 614000Sichuan ProvinceChina Department of Nursing Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina Department of Endocrinology Hospital of Chengdu Office of the People's Government of Tibet Autonomous RegionChengdu 610041Sichuan ProvinceChina

BACKGROUND The FreeStyle Libre flash glucose monitoring(FGM)system entered the Chinese market in 2017 to complement the self-monitoring of blood *** to its increased usage in clinics,the number of studies investigating its accuracy has ***,its accuracy has not been investigated in highland populations in *** To evaluate measurements recorded using the FreeStyle Libre FGM system compared with capillary blood glucose measured using the enzyme electrode method in patients with type 2 diabetes(T2D)who had migrated within 3 mo from highlands to *** Overall,68 patients with T2D,selected from those who had recently migrated from highlands to plains(within 3 mo),were hospitalized at the Department of Endocrinology from August to October 2017 and underwent continuous glucose monitoring(CGM)with the FreeStyle Libre FGM system for 14 *** the study period,fingertip capillary blood glucose was measured daily using the enzyme electrode method(Super GL,China),and blood glucose levels were read from the scanning probe during fasting and 2 h after all three ***,the time interval between reading the data from the scanning probe and collecting fingertip capillary blood was controlled to<5 *** accuracy of the FGM system was evaluated according to the CGM ***,the factors influencing the mean absolute relative difference(MARD)of this system were analyzed by a multiple linear regression *** Pearson’s correlation analysis showed that the fingertip and scanned glucose levels were positively correlated(R=0.86,P=0.00).The aggregated MARD of scanned glucose was 14.28±13.40%.Parker's error analysis showed that 99.30%of the data pairs were located in areas A and *** to the probe wear time of the FreeStyle Libre FGM system,MARD_(1 d) and MARD_(2-14 d) were 16.55%and 14.35%,respectively(t=1.23,P=0.22).Multiple stepwise regression analysis showed that MARD did not correlate with blood glucose when

关键词： Type 2 diabetes Flash glucose monitoring Accuracy Continuous glucose monitor High altitude

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Effects of pulmonary surfactant combined with noninvasive positive pressure ventilation in neonates with respiratory distress syndrome

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World Journal of Clinical Cases 2024年第23期12卷 5366-5373页

作者： Ze-Ning Shi Xin Zhang Chun-yuan du Bing Zhao Shu-Gang Liu Department of Pediatrics Army Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina Department of Anesthesiology Army Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina Department of Gynecology and Obstetrics Army Military Medical University Officer School Affiliated HospitalShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Neonatal respiratory distress syndrome(NRDS)is one of the most common diseases in neonatal intensive care units,with an incidence rate of about 7%among ***,it is a leading cause of neonatal death in hospitals in *** main mechanism of the disease is hypoxemia and hypercapnia caused by lack of surfactant AIM To explore the effect of pulmonary surfactant(PS)combined with noninvasive positive pressure ventilation on keratin-14(KRT-14)and endothelin-1(ET-1)levels in peripheral blood and the effectiveness in treating *** Altogether 137 neonates with respiratory distress syndrome treated in our hospital from April 2019 to July 2021 were *** these,64 control cases were treated with noninvasive positive pressure ventilation and 73 observation cases were treated with PS combined with noninvasive positive pressure *** expression of KRT-14 and ET-1 in the two groups was *** deaths,complications,and PaO_(2),PaCO_(2),and PaO_(2)/FiO_(2)blood gas indexes in the two groups were *** operating characteristic curve(ROC)analysis was used to determine the diagnostic value of KRT-14 and ET-1 in the treatment of *** The observation group had a significantly higher effectiveness rate than the control *** was no significant difference between the two groups in terms of neonatal mortality and adverse reactions,such as bronchial dysplasia,cyanosis,and shortness of *** treatment,the levels of PaO_(2)and PaO_(2)/FiO_(2)in both groups were significantly higher than before treatment,while the level of PaCO_(2)was significantly *** treatment,the observation group had significantly higher levels of PaO_(2)and PaO_(2)/FiO_(2)than the control group,while PaCO_(2)was notably lower in the observation *** treatment,the KRT-14 and ET-1 levels in both groups were significantly decreased compared with the pre-treatment *** observation group had a reduction of KRT-14 and ET-

关键词： Pulmonary surfactant Non-invasive positive pressure ventilation Neonatal respiratory distress syndrome Keratin-14 Endothelin-1

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资本结构对双重股权结构选择的影响——基于赴美上市中概股公司的经验证据

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现代财经（天津财经大学学报） 2024年第10期 74-90页

作者：杜媛毛慧娜中国海洋大学管理学院山东青岛266100 一汽解放青岛汽车有限公司财务部山东青岛266217

企业IPO时可选择使用双重股权结构的上市制度为资本结构影响股权结构的研究提供了契机。以1991—2023年赴美上市的中概股企业为样本,本文从选择原因和选择结果双重视角,经过主回归和工具变量、子样本回归等多种稳健性检验,研究发现,高... 详细信息

企业IPO时可选择使用双重股权结构的上市制度为资本结构影响股权结构的研究提供了契机。以1991—2023年赴美上市的中概股企业为样本,本文从选择原因和选择结果双重视角,经过主回归和工具变量、子样本回归等多种稳健性检验,研究发现,高杠杆企业更有可能选择以双重股权结构上市,这种趋势在短期债务占比高的企业、战略性新兴产业中表现得更为明显。从选择结果看,基于债务的治理作用,高杠杆企业选择双重股权结构后更有助于保护外部股东利益、提升股东价值;进一步研究得知,内部股东可通过设定较高的投票权倍数减轻其承担的债务风险效应,但也减弱了债务治理效应,而持有较多现金流权则能够增强债务治理效应;企业成长性越高、行业竞争度越高、重资产越多时,高杠杆企业选择双重股权结构的债务治理效应越强。独特的研究视角同时对双重股权结构和资本结构研究具有增量贡献。

关键词：双重股权结构资本结构内部股东外部股东债务治理

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Effect of Chinese Medicine in Patients with COVID-19: A Multi-center Retrospective Cohort Study

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Chinese Journal of Integrative Medicine 2024年第11期30卷 974-983页

作者： ZHAO Guo-zhen YAN Shi-yan LI Bo GUO Yu-hong SONG Shuang HU Ya-hui GUO Shi-qi HU Jing du yuan LU Hai-tian YE Hao-ran REN Zhi-ying ZHU Ling-fei XU Xiao-long SU Rui LIU Qing-quan Beijing Hospital of Traditional Chinese Medicine Capital Medical University Beijing Institute of Traditional Chinese Medicine School of Clinical Medicine Beijing University of Chinese Medicine School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese Medicine College of Integrated Chinese Medicine Tianjin University of Traditional Chinese Medicine

Objective: To evaluate the effectiveness and safety of Chinese medicine(CM) in the treatment of coronavirus disease 2019(COVID-19) in China. Methods: A multi-center retrospective cohort study was carried out, with cumulative CM treatment period of 3 days during hospitalization as exposure. Data came from consecutive inpatients from December 19, 2019 to May 16, 2020 in 4 medical centers in Wuhan, China. After data extraction, verification and cleaning, confounding factors were adjusted by inverse probability of treatment weighting(IPTW), and the Cox proportional hazards regression model was used for statistical analysis. Results:A total of 2,272 COVID-19 patients were included. There were 1,684 patients in the CM group and 588 patients in the control group. Compared with the control group, the hazard ratio(HR) for the deterioration rate in the CM group was 0.52 [95% confidence interval(CI): 0.41 to 0.64, Pduce the deterioration rate and all-cause mortality of COVID-19patients. This result can provide the new evidence to support the current treatment of COVID-19. Additional prospective clinical trial is needed to evaluate the efficacy and safety of specific CM interventions.(Registration No. ChiCTR2200062917)

关键词： Chinese medicine all-cause mortality cohort study coronavirus disease 2019 deterioration rate

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基于人工智能的缺陷图像识别算法

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微型电脑应用 2024年第4期40卷 47-49页

作者：杜媛西安职业技术学院大数据应用学院陕西西安710072

为了提高实际场景图像的缺陷识别准确度,基于人工智能、图像识别和深度学习技术,设计一种新的图像缺陷识别算法。采集缺陷图像,为缺陷目标识别做好检测分析和学习训练准备。联合分水岭分割和颜色特征分割方法,提取缺陷图像的有效特征。... 详细信息

为了提高实际场景图像的缺陷识别准确度,基于人工智能、图像识别和深度学习技术,设计一种新的图像缺陷识别算法。采集缺陷图像,为缺陷目标识别做好检测分析和学习训练准备。联合分水岭分割和颜色特征分割方法,提取缺陷图像的有效特征。基于卷积网络,充分借助其中的学习模型,采用Python开源框架,设计新的缺陷识别方法。将人工智能算法集成于开发的软件系统中,该系统功能包括相机采集、视频导入、HDMI导入、脚踏板控制等。仿真数据表明,与已有分割技术相比,所提算法具有更理想的识别准确性与鲁棒性。

关键词：缺陷图像目标识别颜色特征分割缺陷检测

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