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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu Yi-Hua Wang Yi-xin Liu Lu Xu Lin Fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

Nonlinear vibration of functionally graded graphene platelet-reinforced composite truncated conical shell using first-order shear deformation theory

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Applied Mathematics and Mechanics(English Edition) 2021年第7期42卷 981-998页

作者： Shaowu YANG yuxin HAO Wei ZHANG Li YANG Lingtao LIU College of Mechanical Engineering Beijing Information Science and Technology UniversityBeijing 100192China Beijing Key Laboratory of Nonlinear Vibrations and Strength of Mechanical Structures College of Mechanical EngineeringBeijing University of TechnologyBeijing 100124China

In this study,the first-order shear deformation theory(FSDT)is used to establish a nonlinear dynamic model for a conical shell truncated by a functionally graded graphene platelet-reinforced composite(FG-GPLRC).The vibration analyses of the FG-GPLRC truncated conical shell are *** the graphene platelets(GPLs)of the FG-GPLRC truncated conical shell with three different distribution patterns,the modified Halpin-Tsai model is used to calculate the effective Young’s ***’s principle,the FSDT,and the von-Karman type nonlinear geometric relationships are used to derive a system of partial differential governing equations of the FG-GPLRC truncated conical *** Galerkin method is used to obtain the ordinary differential equations of the truncated conical ***,the analytical nonlinear frequencies of the FG-GPLRC truncated conical shell are solved by the harmonic balance *** effects of the weight fraction and distribution pattern of the GPLs,the ratio of the length to the radius as well as the ratio of the radius to the thickness of the FG-GPLRC truncated conical shell on the nonlinear natural frequency characteristics are *** study culminates in the discovery of the periodic motion and chaotic motion of the FG-GPLRC truncated conical shell.

关键词： nonlinear free vibration harmonic balance method functionally graded graphene platelet-reinforced composite(FG-GPLRC) truncated conical shell chaos

NEW ORGANIC SYSTEM FOR PHOTON-GATED PERSISTENT SPECTRAL HOLE BURNING

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Chinese Physics Letters 1990年第12期7卷 556-559页

作者： WANG Duoyuan HU Lingzhi HE Huizhu XIE Jie ZHANG Junyi ZHAO Lizeng ZHANG Xiulan ZHANG Dongxiang MI xin NIE yuxin YE Peixian Institute of Photographic Chemistry Academia SinicaBeijing 100101 Institute of Physics Academia SinicaBeijing 100080

We report a new system of organic materials for photon-gated persistent spectral hole burning by donor-acceptor electron transfer:a tetrabenzoporphyrin derivative as donor and one of several aromatic cyanides as an acceptor in a poly(methyl methacrylate)(FMMA)host *** to 50C%deep spectral holes in transmission were burnt and appeared very high hole burning efficiency.

关键词： methacrylate matrix. donor

Clinical characteristics of 310 SARS-CoV-2 Omicron variant patients and comparison with Delta and Beta variant patients in China

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Virologica Sinica 2022年第5期37卷 704-715页

作者： Wei Yang Songliu Yang Lei Wang yuxin Zhou Yu xin Hongxu Li Wenjing Mu Qi Wu Lei Xu Mingyan Zhao Changsong Wang Kaijiang Yu Department of Critical Care Medicine The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001China Department of Critical Care Medicine The Cancer Hospital of Harbin Medical UniversityHarbin 150081China Respiratory Department Haihe Hospital of TianjinTianjin 300222China Department of Critical Care Medicine Tianjin Third Central HospitalTianjin 300170China

Although the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant has spread,data on the clinical characteristics of infected patients are *** this study,the demographic,clinical characteristics,and laboratory data of 310 SARS-CoV-2 Omicron variant patients treated at Haihe Hospital of Tianjin were collected and *** on these patients was compared to 96 patients with the Delta variant of concern(VOC)and 326 patients with the Beta VOC during the previous coronavirus disease 2019(COVID-19)outbreak in *** the 310 patients infected with the Omicron variant,the median age was 35 *** patients were clinically classified as mild(57.74%),and the most common symptoms were cough(48.71%),fever(39.35%),and sore throat(38.26%).The results for different vaccination groups in the Omicron group showed that the median of“SARS-CoV-2 specific IgG”after 2 or 3 doses of vaccination was higher than the unvaccinated group(all Ps<0.05).Older age was associated with a higher proportion of moderate cases and lower asymptomatic and mild cases based on clinical *** to the Delta and Beta groups,the median age of the Omicron group was *** total number of asymptomatic patients and mild patients in the Omicron virus group was higher than the Delta and Beta groups(60.97%vs.54.17%vs.47.55%).This study presented the clinical characteristics of the first group of patients infected with the Omicron variant in Tianjin,China,and compared their clinical features with patients infected by the Delta and Beta variants,which would increase our understanding of the characteristics of SARS-CoV-2 Omicron variant.

关键词： SARS-CoV-2 Omicron Clinical features Vaccine Age Disease severity

基于乳脂肪球膜结构以提高液态乳体系的稳定性:乳脂肪球膜构建机制综述

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食品科学 2025年第2期46卷 308-316页

作者：王鑫于景华赵亭亭刘晓辉天津科技大学食品科学与工程学院食品营养与安全国家重点实验室天津300457 河北省功能油脂微胶囊化技术创新中心河北石家庄052160

乳脂肪球起源于乳腺上皮细胞,脂肪球膜中的脂质和蛋白质通过静电斥力和空间位阻维持脂肪球的稳定性,同时膜上的成分具有特定的营养特性。脂肪球界面的重新构建对液态乳制品的品质至关重要,本文对近年来加工中乳脂肪球界面构建机制的研... 详细信息

乳脂肪球起源于乳腺上皮细胞,脂肪球膜中的脂质和蛋白质通过静电斥力和空间位阻维持脂肪球的稳定性,同时膜上的成分具有特定的营养特性。脂肪球界面的重新构建对液态乳制品的品质至关重要,本文对近年来加工中乳脂肪球界面构建机制的研究进行总结并发掘共通之处。均质会破坏脂肪球膜的原生结构,导致膜结构重新排列。此外,热处理也会改变蛋白质的结构,并引起脂质结构域的侧向分离。同时,脂肪球膜上蛋白质和脂质的热响应会导致原始膜成分的损失。外源添加物通过改善油水界面和增强脂肪球的稳定性,参与体系稳定化的重构建。未来需深入研究脂肪球膜构建机制与宏观体系的联系,并优化特定的加工条件,以获得更高品质的乳制品。

关键词：脂肪球脂肪球膜脂肪球膜蛋白脂质域重构建

Isolation and identification of a novel STR(D17S2204)in the vicinity of NF1 locus

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Chinese Science Bulletin 1999年第7期44卷 627-631页

作者： Xiyuan Sun Long Yu Qiping Zheng Yurong xin Liemin Zhou yuxin Fan Ying Jiang Jiahui Xia Zhuolin Liu Shouyuan Zhao Fudan Univ Inst Genet State Key Lab Genet Engn Shanghai 200433 Peoples R China Sun Yatsen Univ Med Sci Affiliated Hosp 1 Dept Neurol Guangzhou 510089 Peoples R China Hunan Med Univ State Key Lab Med Genet Changsha 410078 Peoples R China

Using a synthetic oligonucleotide （dA-dC）15 as a probe to screen a probe pool made by microdissected human chromosome band 17q11-q12, a DNA fragment containing （CA）16 was isolated, which is a novel short tandem repeat （STR） determined by searching in the GenBank and GDB. It has 8 allelic types with a PIC value of 0.61. The novel STR is conformed with Mendelian segregation according to the linkage analysis of a three-generation neurofibromatosis type Ⅰ （NF1） pedigree. The STR was localized at chromosome band 17q11-q12 in the vicinity of NF1 gene by FISH analysis. The accession number of the STR in GenBank and GDB is G32112 and D17S2204 respectively.

关键词： chromosome 17q11-q12 short tandem repeats (STR) D17S2204 neurofibromatosis type Ⅰ (NF1).

Genetic Polymorphism and Relationship Analyses of Standard Poodle and Bichon Frise Groups Based on 19 Short Tandem Repeat Loci

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Journal of Forensic Science and Medicine 2023年第4期9卷 331-339,I0013-I0015页

作者： Shuyan Mei Jinlong Yang Jianping Li xin Xiong Menglei Wang Zhichao Zhao yuxin Guo Yajun Deng College of Basic Medicine and Forensic Medicine Henan University of Science and TechnologyHenanChina Guangzhou Key Laboratory of Forensic Multi‑Omics for Precision Identification School of Forensic MedicineSouthern Medical UniversityGuangzhouChina Beijing Zhongzheng DNA Evidence Institute BeijingChina Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’AnChina Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases College of StomatologyXi’an Jiaotong UniversityXi’AnChina

Context:As the increasing number of pet canines,the identification of canine has attracted much attentions in the forensic field,however,the genetic diversities of pet canines still remained ***:To explore genetic polymorphisms of 19 short tandem repeat(STR)loci and genetic relationships between the two studied canine groups and reference *** and Methods:In the present study,genetic polymorphisms of 19 STR loci and a sex-linked zinc finger locus were analyzed in a total of 594 canines in Standard Poodle and Bichon Frise groups from ***:A total of 166,159 alleles were observed in the Standard Poodle,Bichon Frise groups with the corresponding allelic frequencies ranging from 0.0030-0.6108 to 0.0012-0.6148,*** combined discrimination power and probability of exclusion of 19 STR loci in Standard Poodle and Bichon Frise groups were 0.9999999999999497,0.999962884;and 0.99999999999999995,0.999965955,***,the genetic distances between the two canine groups and Labrador retriever group were calculated,and the results indicated that Standard Poodle and Bichon Frise groups showed a closer genetic relationship,while the two canine groups had distant genetic relationships with Labrador retriever *** result of population genetic structure revealed that genetic component distributions in the three canine groups were *** predicted accuracies of the constructed random forest prediction model for three validation sets(25%individuals randomly selected from three populations with 808 individuals)were higher than 0.9,especially for the individuals in validation set from the Bichon Frise group is ***:The 19 STR loci could be used for individual identification,canine breed identification and paternity testing in the two canine groups.

关键词： Short tandem repeat Standard Poodle Bichon Frise forensic parameter canine genetic polymorphism

Comparison of sequencing-based and array-based genotyping platforms for genomic prediction of maize hybrid performance

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The Crop Journal 2023年第2期11卷 490-498页

作者： Guangning Yu Yanru Cui yuxin Jiao Kai Zhou xin Wang Wenyan Yang Yiyi Xu Kun Yang Xuecai Zhang Pengcheng Li Zefeng Yang Yang Xu Chenwu Xu Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding/Jiangsu Co-Innovation Center for Modern Production Technology of Grain Crops College of AgricultureYangzhou UniversityYangzhou 225009JiangsuChina State Key Laboratory of North China Crop Improvement and Regulation Hebei Agricultural UniversityBaoding 071001HebeiChina International Maize and Wheat Improvement Center(CIMMYT) 06600 Mexico D.F.Mexico

Genomic selection(GS)is a powerful tool for improving genetic gain in maize ***,its routine application in large-scale breeding pipelines is limited by the high cost of genotyping *** sequencing-based and array-based genotyping platforms have been used for GS,few studies have compared prediction performance among *** this study,we evaluated the predictabilities of four agronomic traits in 305 maize hybrids derived from 149 parental lines subjected to genotyping by sequencing(GBS),a 40K SNP array,and target sequence capture(TSC)using eight GS *** GBS marker dataset yielded the highest predictabilities for all traits,followed by TSC and SNP array *** investigated the effect of marker density and statistical models on predictability among genotyping platforms and found that 1K SNPs were sufficient to achieve comparable predictabilities to 10K and all SNPs,and BayesB,GBLUP,and RKHS performed well,while XGBoost performed poorly in most *** also selected significant SNP subsets using genome-wide association study(GWAS)analyses in three panels to predict hybrid *** facilitated selecting effective SNP subsets for GS and thus reduced genotyping cost,but depended heavily on the GWAS *** conclude that there is still room for optimization of the existing SNP array,and using genotyping by target sequencing(GBTS)techniques to integrate a few functional markers identified by GWAS into the 1K SNP array holds great promise of being an effective strategy for developing desirable GS breeding arrays.

关键词： Genomic selection Maize GBS SNP array Marker density

Gut-brain axis as a bridge in obesity and depression:Mechanistic exploration and therapeutic prospects

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World Journal of Psychiatry 2025年第1期15卷 12-20页

作者： Rui-Ying Fang Xiao-Rui Pan xin-xing Zeng Zheng-Zheng Li Bo-Fan Chen Hai-Min Zeng Jie Peng The Second Clinical Medical College The Second Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

A recent study by Wang et al,published in the World Journal of Psychiatry,provided preventative and therapeutic strategies for the comorbidity of obesity and *** gut-brain axis,which acts as a two-way communication system between the gastrointestinal tract and the central nervous system,plays a pivotal role in the pathogenesis of these *** suggests that metabolic byproducts,such as short-chain fatty acids,lipopolysaccharide and bile acids,which are generated by the gut microbiota,along with neurotransmitters and inflammatory mediators within the gut-brain axis,modulate the host's metabolic processes,neuronal regulation,and immune responses through diverse *** interaction between obesity and depression via the gut-brain axis involves disruptions in the gut microbiota balance,inflammatory immune responses,and alterations in the neuroendocrine *** the gut-brain axis,for example,through a ketogenic diet,the use of probiotics,and the supplementation of antioxidants,offers new remedial approaches for obesity and *** research that explores the mechanisms of the gut-brain axis is needed to provide more evidence for clinical treatment.

关键词： Gut-brain axis Obesity Depression Gut microbiota Mechanism