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加减益肾蠲痹汤治疗早期活动性强直性脊柱炎肾虚督寒证的临床疗效观察

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中医药信息 2024年第2期41卷 62-67页

作者：张利鹏杨薇张玉涛王起云孙晓伟李洪涛黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第一医院黑龙江哈尔滨150040

目的:观察加减益肾蠲痹汤对于早期活动性强直性脊柱炎(AS)肾虚督寒证的临床疗效。方法:选取符合纳入标准的肾虚督寒证AS患者52例,使用区组随机分组法将其随机分为对照组及观察组,每组各26例。对照组口服双氯芬酸钠缓释片,1次/d,75 mg/次... 详细信息

目的:观察加减益肾蠲痹汤对于早期活动性强直性脊柱炎(AS)肾虚督寒证的临床疗效。方法:选取符合纳入标准的肾虚督寒证AS患者52例,使用区组随机分组法将其随机分为对照组及观察组,每组各26例。对照组口服双氯芬酸钠缓释片,1次/d,75 mg/次;柳氮磺吡啶肠溶片,3次/d,75 mg/次,同时口服安慰汤剂。观察组在对照组治疗方案基础上服用加减益肾蠲痹汤治疗;两组均治疗4周。比较两组治疗前后MASEI评分、骶髂关节血流分级、RI指数、BASDAI评分及中医证候积分变化情况,监测不良反应发生情况并比较两组临床疗效。结果:观察组总有效率96.2%(25/26)优于对照组总有效率73.1%(19/26),差异具有统计学意义(P0.05)。结论:加减益肾蠲痹汤可有效缓解早期活动性AS肾虚督寒证患者的附着点炎,改善骶髂关节炎症,降低疾病活动度,且安全性较高。

关键词：强直性脊柱炎加减益肾蠲痹汤附着点炎骶髂关节炎超声学

CRISPR/Cas9-mediated NlInR2 mutants:Analyses of residual mRNA and truncated proteins

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Journal of Integrative Agriculture 2024年第6期23卷 2006-2017页

作者： Jun Lü Jingxiang Chen yutao Hu Lin Chen Shihui Li Yibing zhang Wenqing zhang State Key Laboratory of Biocontrol/School of Life Sciences Sun Yat-sen UniversityGuangzhou 510275China Development of Food Science and Engineering Moutai InstituteRenhuai 564507China

CRISPR/Cas9 technology is a powerful genome manipulation tool in ***,little is known about whether mRNA and protein of a target gene are completely cleared in homozygous *** study generated homozygous mutants of the insulin receptor gene 2(NlInR2)in the brown planthopper(Nilaparvata lugens)using CRISPR/Cas9 genome *** frameshift mutants,E5_D17 and E6_I7,differentiated towards long wings,but there were differences in wing morphology,with E5_D17 showing wing *** investigations revealed the presence of residual expression of NlInR2 mRNA in both mutants,as well as the occurrence of spliceosomes featuring exon skipping splicing in E5_***,the E5_D17 exhibited the detection of N-terminally truncated NlInR2 *** interference experiments indicated that the knockdown of NlInR2 expression in the E5_D17 mutant line increased the proportion of wing deformities from 11.1 to 65.6%,suggesting that the residual NlInR2 mRNA of the E5_D17 mutant might have retained some genetic *** results imply that systematic characterization of residual protein expression or function in CRISPR/Cas9-generated mutant lines is necessary for phenotypic interpretation.

关键词： CRISPR/Cas9 Nilaparvata lugens residual mRNA skipping exon truncated protein

Mushroom Poisoning Outbreaks -China, 2022

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China CDC weekly 2023年第3期5卷 45-50,I0001-I0005页

作者： Haijiao Li Yizhe zhang Hongshun zhang Jing Zhou Jiaqi Liang Yu Yin Qian He Shaofeng Jiang yutao zhang Yuan Yuan Nan Lang Bowen Cheng Mei Wang Chengye Sun National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina

Mushroom poisoning has become a serious food safety issue in *** the support of the government,over the past decade,China has gradually established a mushroom poisoning prevention and treatment system involving experts in disease prevention and control,clinical diagnosis and treatment,fungal classification,and basic medicine(1–3).

关键词： prevention diagnosis treatment

Mushroom Poisoning Outbreaks--China,2019

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China CDC weekly 2020年第2期2卷 19-24页

作者： Haijiao Li Hongshun zhang Yizhe zhang Kaiping zhang Jing Zhou Yu Yin Shaofeng Jiang Peibin Ma Qian He yutao zhang Ke Wen Yuan Yuan Nan Lang Junjia Lu Chengye Sun National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?Mushroom poisoning is becoming one of the most serious food safety issues in China,which is responsible for nearly a half of all oral poisoning *** is added by this report?In China,many mushrooms were previously“recorded”as *** this study,about 70 species obtained from mushroom poisoning incidents including several new records were confirmed accurately by morphological and molecular evidence in 2019,and spatial and temporal distribution characters of 13 lethal mushrooms were summarized *** are the implications for public health practice?Precise and timely species identification is of pivotal importance in mushroom *** efforts and cooperation are continued to be needed urgently for the governments,CDC staff,doctors and mycologists in future.

关键词： summarized continued becoming

Higher ambient temperatures may worsen obstructive sleep apnea:A nationwide smartwatch-based analysis of 6.2 million person-days

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Science Bulletin 2024年第13期69卷 2114-2121页

作者： Anni Li Qingli zhang Yuan Yao Xinlei Zhu Cong Liu yutao Guo Haidong Kan Renjie Chen School of Public Health Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology AssessmentFudan UniversityShanghai 200032China Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Pulmonary Vessel and Thrombotic Disease Sixth Medical CenterChinese PLA General HospitalBeijing 100048China Institute for Hospital Management Research Chinese PLA General HospitalBeijing 100048China Children’s Hospital of Fudan University National Children’s Medical CenterShanghai 201102China School of Public Health Hengyang Medical SchoolUniversity of South ChinaHengyang 421001China

Obstructive sleep apnea(OSA)is a serious type of sleep disorder that can lead to cardiometabolic and neurocognitive *** utilized smart device-based photoplethysmography technology to collect sleep data from the Chinese population from 2019 to *** lag nonlinear models combined with a generalized nonlinear model or a linear mixed effects model were used to investigate the shortterm associations between daily temperature and indicators of OSA *** included a total of 6,232,056 d of sleep monitoring data from 51,842 participants with moderate to severe risk of OSA from 313 Chinese *** relationships between ambient temperature and OSA exacerbation,apneahypopnea index(AHI),and minimum oxygen saturation(MinSpO_(2))were almost linear and present only on the same *** temperatures were associated with a greater risk of OSA exacerbation,with an 8.4%(95%confidence interval(CI):7.6%–9.3%)increase per 10℃increase in temperature.A 10℃increase in daily temperature corresponded to an AHI increase of 0.70 events/h(95%CI:0.65–0.76)and a MinSpO_(2)decrease of 0.18%(95%CI:0.16%–0.19%).Exposure to elevated temperatures during the night can also lead to adverse *** effects of higher temperatures on OSA severity were stronger among men,participants with a body mass index24 kg/m2,those aged 45 years and older,individuals with a history of hypertension and diabetes,and during the cold *** large-scale,nationwide,longitudinal study provides robust evidence suggesting that higher ambient temperatures may immediately worsen OSA.

关键词： Obstructive sleep apnea Temperature Apnea-hypopnea index Oxygen saturation Smart device

天山北坡中段雪岭云杉人工林碳汇随林龄的动态变化

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新疆大学学报（自然科学版）（中英文） 2024年第1期41卷 110-120页

作者：马媛常顺利王冠正张毓涛孙雪娇李吉玫新疆大学生态与环境学院绿洲生态教育部重点实验室新疆乌鲁木齐830017 新疆天山森林生态系统国家定位观测研究站新疆乌鲁木齐830063 新疆林业科学院森林生态研究所新疆乌鲁木齐830063

人工林是森林固碳增汇的重要组成部分,其碳汇动态随林龄的增长存在较大差异.以天山林区广泛分布的单一人工林雪岭云杉(Picea schrenkiana)为研究对象,选取未抚育的各龄级人工林样地并以无林地为对照,通过样地调查与取样,计算植被地上、... 详细信息

人工林是森林固碳增汇的重要组成部分,其碳汇动态随林龄的增长存在较大差异.以天山林区广泛分布的单一人工林雪岭云杉(Picea schrenkiana)为研究对象,选取未抚育的各龄级人工林样地并以无林地为对照,通过样地调查与取样,计算植被地上、植被地下、枯落物和土壤碳密度,采用空间代替时间的方法量化了人工林碳汇量和造林后固碳量特征随林龄的变化规律.结果表明:1)不同龄组雪岭云杉人工林植被地上碳密度为1.82~119.34 t·hm^(-2),植被地下碳密度为1.26~27.77 t·hm^(-2),树干累积了植被46.4%~62.0%的碳,随林龄增加,碳密度(造林固碳量)呈现明显的异速增长,碳汇量则表现为先升高后降低的趋势.2)凋落物碳密度介于0.42~1.74 t·hm^(-2)之间,碳汇量在各龄组间差异不大,发挥了0.23~0.42 t·hm^(-2)·10 a的碳汇功能,造林后固碳量随林龄成线性增长趋势.3)造林前期,土壤深层碳密度显著增大;造林后期,表层土壤碳在凋落物分解输入作用下逐渐累积,显著大于10~60 cm;造林能够有效提高土壤碳汇,平均碳汇量达51.66 t·hm^(-2)·10 a;造林后土壤固碳量与无林地相比提升较明显,21~30 a林龄时达最大值101.83t·hm^(-2),固碳量随林龄表现为先增后降的二项式分布.4)雪岭云杉人工林总碳汇呈非匀速增长趋势,其中60 a人工林碳汇潜力较高,总碳汇累积量可达488.60 t·hm^(-2);雪岭云杉人工林植被地上部和地下部碳汇在生态系统总碳汇的占比不断增加,由10~20 a林龄的4.6%增加至51~60 a林龄的67.7%,同时土壤碳汇在生态系统总碳汇的占比不断降低.

关键词：人工林林龄碳密度碳汇云杉森林

Mushroom Poisoning Outbreaks — China, 2021

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China CDC weekly 2022年第3期4卷 35-40,I0001-I0003页

作者： Haijiao Li Hongshun zhang Yizhe zhang Jing Zhou Yu Yin Qian He Shaofeng Jiang Peibin Ma yutao zhang Yuan Yuan Nan Lang Bowen Cheng Mei Wang Chengye Sun National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Mushroom poisoning is one of the most serious food safety issues in *** poisoning incidents resulted from eating mushrooms causing gastroenteritis and psycho-neurological disorder from which patients usually could fully *** deaths resulted from species causing acute liver failure and rhabdomyolysis,and the remaining deaths were attributed to acute renal failure and *** is added by this report?In 2021,the total number of investigations was 327 from 25 provincial-level administrative divisions,involving 923 patients and 20 deaths,and the overall mortality was 2.17%.Overall,74 poisonous mushrooms causing 6 different clinical syndromes were successfully identified,15 of which were newly recorded in China as poisonous *** are the implications for public health practice?Considering the potential huge risks for collecting and eating wild mushrooms,we strongly advise not collecting and eating unfamiliar wild *** knowledge about poisonous mushrooms is essential and urgent to reduce mushroom *** species identification timely after mushroom poisoning is important for appropriate diagnosis and *** deaths were ascribed to delayed hospitalization.

关键词： diagnosis attributed poisoning

“Three-in-one” strategy of trifluoromethyl regulated blood-brain barrier permeable fluorescent probe for peroxynitrite and antiepileptic evaluation of edaravone

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Chinese Chemical Letters 2024年第10期35卷 360-363页

作者： Lei Shen Hongmei Liu Ming Jin Jinchao zhang Caixia Yin Shuxiang Wang yutao Yang Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of the Ministry of Education Chemical Biology Key Laboratory of Hebei ProvinceState Key Laboratory of New Pharmaceutical Preparations and ExcipientsCollege of Chemistry and Materials ScienceHebei UniversityBaoding 071002China Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Institute of Molecular ScienceShanxi UniversityTaiyuan 030006China

Epilepsy,as a chronic neurological disease of the brain,is closely related to oxidative stress,and the peroxynitrite(ONOO-)significantly rise up in this ***,ONOO-is considered as a potential biomarker for early prediction of ***,some potential diagnostic reagents for epilepsy are hindered by the blood-brain barrier(BBB).Meanwhile,“drug repurposing”is attracting a growing ***(EDA),as a first-line drug in the clinical treatment of cerebral ischemia,plays antioxidant roles in scavenging free radicals,promising potential antiepileptic ***,it is imperative to develop fluorescent probes for monitoring ONOO-fluctuations in the epileptic ***,we proposed a novel fluorescent probe with the thiocarbonate as the promising recognition unit for ONOO-and dicyanoisophorone derivative as the ***,by the“three-in-one”strategy,the introduction of trifluoromethyl into DCI-ONOO-3 can extend the emission wavelength of the fluorophore,shorten the response and increase ***,DCI-ONOO-3 was used for monitoring ONOO-fluxes in brain of epileptic mice and evaluating the antiepileptic efficacy of *** opens up a new way for the design of BBB permeable fluorescent probes,and provides a convincing new method for the diagnosis and treatment of epilepsy.

关键词： Fluorescent probe Blood-brain barrier Peroxynitrite Epilepsy Drug repurposing

Mushroom Poisoning Outbreaks-China,2020

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China CDC weekly 2021年第3期3卷 41-45,I0002-I0006页

作者： Haijiao Li Hongshun zhang Yizhe zhang Jing Zhou Yu Yin Qian He Shaofeng Jiang Peibin Ma yutao zhang Ke Wen Yuan Yuan Nan Lang Bowen Cheng Junjia Lu Chengye Sun National Institute of Occupational Health and Poison Control Chinese Center for Disease Control and PreventionBeijingChina

What is already known about this topic?Acute liver failure,rhabdomyolysis,acute renal failure,and hemolysis caused by poisonous mushrooms are the most important mushroom poisoning threats to the Chinese *** most notorious lethal mushrooms are the species from genera Amanita,Lepiota,and Galerina that cause acute liver failure,and Russula subnigricans that leads to *** is added by this report?In 2020,the total number of investigations reached 676,involving an estimated 102 species of poisonous mushrooms,24 of which were newly recorded in *** venenata was newly discovered in incidents in Yunnan and Guizhou provinces and were the first reported poisonings due to gyromitrins in China since *** rare poisoning Shiitake mushroom dermatitis was recorded in *** poisoning caused by Paxillus involutus was recorded for the second time since the beginning of the new century,resulting in one death in Inner Mongolia Autonomous *** are the implications for public health practice?Promoting knowledge about safe consumption of mushrooms is essential to reduce mushroom *** is not wise to collect and eat wild *** southwestern provinces such as Yunnan,especially,caution must be exercised with unfamiliar mushroom species.

关键词： acute Acute population