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Coupling action of rainfall and vehicle loads impact on the stability of loess slopes based on the iso-water content layer

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Earthquake Research Advances 2022年第3期2卷 67-76页

作者： yu Zhang Hongjian Jiang Gexue Bai Bingbing han School of Traffic and Transportation Lanzhou Jiaotong UniversityLanzhou730070China Gansu Institute of Engineering Geology Lanzhou730000China

To clarify the changes in slope stability of loess slopes under the coupling action of rainfall and vehicle *** with different water contents under different environmental conditions were carried out indoors,and the relationship function between water content and shear strength parameters was obtained;based on Geostudio,an equivalent layered calculation model of water content-strength parameters of loess slope was established,the variation law of soil sample matrix suction with volumetric water content was measured by volumetric pressure plate ***,by using a combination of finite element analysis of saturated/unsatu-rated seepage and limit equilibrium analysis of slope stability,the SLOPE/W module in the modeling software GeoStudio is used to calculate and analyze the effects of vehicle loads,rainfall intensity,rainfall duration,and other working conditions on the stability of loess slopes,*** results show that when the lane is in the middle of the slope,the vehicle load parameters have little effect on the uphill stability,but have a greater impact on the downhill;With the increase in rainfall,the change curves of the slope safety coefficient gradually overlap when the vehicle loads are four-axis,five-axis,and *** shows that when studying the change of slope safety factor under the dual influence of vehicle loads and rainfall,rainfall is the main cause of slope stability;The change rate of slope safety factor increases gradually with the increase of rainfall,and the change trends of the upper,lower and overall parts of the slope are similar.

关键词： Loess Coupling action Slope stability Iso-water content layer

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褐飞虱唾液内生菌对抗虫水稻过氧化氢酶的影响

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广州化工 2024年第9期52卷 65-67页

作者：王寒玉陈鹏宇李烨林王小兰新疆农业大学动物医学学院新疆乌鲁木齐830052 广州大学生命科学学院广东广州510006

为了解褐飞虱唾液内生菌是否引起植物体内过氧化氢酶活性的改变,采用褐飞虱直接刺吸和人工模拟褐飞虱刺吸的方法处理感虫水稻和抗虫水稻,提取并测定了水稻过氧化氢酶的活性。结果表明,在最初的4 h,褐飞虱直接取食水稻,表现出降低抗虫水... 详细信息

为了解褐飞虱唾液内生菌是否引起植物体内过氧化氢酶活性的改变,采用褐飞虱直接刺吸和人工模拟褐飞虱刺吸的方法处理感虫水稻和抗虫水稻,提取并测定了水稻过氧化氢酶的活性。结果表明,在最初的4 h,褐飞虱直接取食水稻,表现出降低抗虫水稻的CAT活性;而无菌唾液模拟刺吸则使得抗虫水稻B5叶片部位的CAT酶活升高。说明褐飞虱唾液中的某些内生菌能抑制水稻的CAT酶活。本研究结果将为进一步明确植物-昆虫-内生菌的互作提供实验依据。

关键词：褐飞虱唾液抗虫水稻内生菌过氧化氢酶

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甘蓝型油菜种子硫苷含量全基因组关联分析

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生物技术通报 2024年第1期40卷 222-230页

作者：周会汶吴兰花韩德鹏郑伟余跑兰吴杨肖小军九江学院江西油茶研究中心药学与生命科学学院九江332005 江西省红壤及种质资源研究所国家红壤改良工程技术研究中心江西省红壤耕地保育重点实验室南昌330045

【目的】挖掘与种子硫苷含量显著关联的SNP位点及候选基因,有助于油菜品质改良和培育高品质油菜品种。【方法】以300份甘蓝型油菜自交系为材料,考察了江西农业大学试验地和江西省红壤及种质资源研究所试验地2种环境下种子硫苷含量,采用... 详细信息

【目的】挖掘与种子硫苷含量显著关联的SNP位点及候选基因,有助于油菜品质改良和培育高品质油菜品种。【方法】以300份甘蓝型油菜自交系为材料,考察了江西农业大学试验地和江西省红壤及种质资源研究所试验地2种环境下种子硫苷含量,采用前期开发的201817个SNP(singlenucleotidepolymorphism,SNP)标记对油菜种子硫苷含量进行全基因组关联分析(genome-wide association study,GWAS),搜寻显著位点两侧100 kb范围内的候选基因并进行功能注释。【结果】300份甘蓝型油菜种子硫苷含量在两地均表现出表型差异;基于一般线性模型和混合线性模型检测到209个硫苷含量显著关联SNP位点,其中两地两种方法重复检测到41个SNP位点,分别在A05(1个)、A09(36个)、C09(4个)3条染色体上。候选基因功能注释结果显示,有8个候选基因参与硫苷生物合成途径(GO:0019761),包含调控硫苷合成相关基因MYB28(BnaC09g05290D、BnaC09g05300D)、MYB34(BnaA09g05480D)和编码硫苷转运蛋白2相关基因(BnaA09g06180D、BnaA09g06190D)。【结论】通过两种方法在两地检测到多个与硫苷显著关联的SNP位点,并在显著性位点附近挖掘到相关候选基因,研究结果有助于解析甘蓝型油菜硫苷含量的遗传变异,为低硫苷含量油菜新品种的遗传改良提供基础。

关键词：甘蓝型油菜硫苷全基因组关联分析 MYB转录因子硫苷转运蛋白2

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Corrigendum to“Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration”[Journal of Genetics and Genomics(2022)49,1114-1126]

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Journal of Genetics and Genomics 2024年第5期51卷 578-578页

作者： xi Chen Xuran Niu Yang Liu Rui Zheng Lei Yang Jian Lu Shuming Yin yu Wei Jiahao Pan Ahmed Sayed Xueyun Ma Meizhen Liu Fengxiang Jing Mingyao Liu Jiazhi Hu Liren Wang Dali Li Shanghai Frontiers Science Center of Genome Editing and Cell Therapy Shanghai Key Laboratory of Regulatory BiologyInstitute of Biomedical Sciences and School of Life SciencesEast China Normal UniversityShanghai 200241China The MOE Key Laboratory of Cell Proliferation and Differentiation Genome Editing Research CenterSchool of Life SciencesPeking-Tsinghua Center for Life SciencesPeking UniversityBeijing 100871China xinhua Hospital Shanghai Jiao Tong University School of MedicineShanghai 200092China Biochemistry Laboratory Chemistry DepartmentFaculty of ScienceAssiut UniversityAssiut 71516Egypt Shanghai Turtle Technology Co. Shanghai 201900China

The authors regret that the grant number“21CJ1402200”in the Acknowledgments session should be replaced as“21JC1402200”.The corrected contents areprovided as follows.

关键词： CRISPR/Cas9 correction ledgment

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水杨梅根的化学成分及α-葡萄糖苷酶抑制活性研究

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天然产物研究与开发 2024年第8期36卷 1307-1319,1297页

作者：李茹陈雪林王寒蕾张振男赵霞张昆张玉梅中国科学院西双版纳热带植物园中国科学院热带植物资源可持续利用重点实验室昆明650223 中国科学院大学北京100049

对水杨梅(Adina rubella)根的化学成分及其α-葡萄糖苷酶抑制活性进行研究。通过硅胶、Sephadex LH-20和半制备HPLC等多种色谱分离技术,从水杨梅根的乙酸乙酯部位中分离得到25个化合物,并运用现代波谱学方法鉴定为奎诺酸(1)、奎诺酸-3-O... 详细信息

对水杨梅(Adina rubella)根的化学成分及其α-葡萄糖苷酶抑制活性进行研究。通过硅胶、Sephadex LH-20和半制备HPLC等多种色谱分离技术,从水杨梅根的乙酸乙酯部位中分离得到25个化合物,并运用现代波谱学方法鉴定为奎诺酸(1)、奎诺酸-3-O-β-D-吡喃葡萄糖苷(2)、奎诺酸-3-O-β-D-岩藻糖苷(3)、奎诺酸-3-O-β-D-吡喃葡萄糖-28-O-β-D-吡喃葡萄糖酯(4)、gongganoside C(5)、gongganoside A(6)、奎诺酸-3-O-β-D-岩藻糖-28-O-β-D-吡喃葡萄糖酯(7)、奎诺酸-3-O-β-D-奎诺糖-28-O-β-D-吡喃葡萄糖酯(8)、齐墩果酸(9)、芥子醛(10)、松柏醛(11)、3,5-O-二咖啡酰基奎宁酸甲酯(12)、3,4-O-二咖啡酰基奎宁酸甲酯(13)、methyl-4,5-di-caffeoyl-quinate(14)、大花葵苷(15)、undulatoside A(16)、5,7-dihydroxy-2-methylchromone-7-O-β-D-apiosyl-(1→6)-O-β-D-glucoside(17)、马钱苷(18)、马钱苷酸(19)、谷甾醇(20)、6′-O-乙酰基-β-胡萝卜苷(21)、胡萝卜苷(22)、丁香醛(23)、3,4,5-trimethoxyphenyl-1-O-β-D-apiofuranosyl-(1′′→6′)-O-β-D-glucopyranoside(24)、栗柄醇(25)。化合物2~8、10~14、16、17、19、21、23~25为首次从水杨梅根中分离得到。α-葡萄糖苷酶抑制活性测试结果显示,化合物12、13具有显著的α-葡萄糖苷酶抑制活性,IC 50值分别为8.83±0.54、8.36±1.01μmol/L。酶动力学分析表明化合物12、13对α-葡萄糖苷酶的抑制类型为混合竞争性抑制,随后分子对接及分子动力学模拟结果表明化合物12、13对α-葡萄糖苷酶具有较强的亲和力,对接结合能分别为-10.08、-10.65 kcal/mol,化合物12、13具有显著的α-葡萄糖苷酶抑制活性,可能为水杨梅根乙酸乙酯部位发挥α-葡萄糖苷酶抑制活性的物质基础。

关键词：水杨梅化学成分降糖 α-葡萄糖苷酶分子对接

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Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhance the Osteoblastic Differentiation of Periodontal Ligament Stem Cells Under High Glucose Conditions Through the PI3K/AKT Signaling Pathway

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Biomedical and Environmental Sciences 2022年第9期35卷 811-820页

作者： YANG Shuo ZHU Biao TIAN xiao yu yu han Ying QIAO Bo ZHAO Li Sheng ZhanG Bin Department of Stomatology The First Medical CenterChinese PLA General HospitalBeijing 100853China Department of Stomatology Fuxing HospitalCapital Medical UniversityBeijing 100038China

Objective High glucose(HG)can influence the osteogenic differentiation ability of periodontal ligament stem cells(PDLSCs).Human umbilical cord mesenchymal stem cell-derived exosomes(hUCMSC-exo)have broad application prospects in tissue *** current study aimed to explore whether hUCMSC-exo could promote the osteogenic differentiation of hPDLSCs under HG conditions and the underlying *** We used a 30 mmol/L glucose concentration to simulate HG ***-8 assay was performed to evaluate the effect of hUCMSC-exo on the proliferation of *** phosphatase(ALP)staining,ALP activity,and qRT-PCR were performed to evaluate the pro-osteogenic effect of hUCMSC-exo on *** blot analysis was conducted to evaluate the underlying *** The results of the CCK-8 assay,ALP staining,ALP activity,and qRT-PCR assay showed that hUCMSC-exo significantly promoted cell proliferation and osteogenic differentiation in a dosedependent *** Western blot results revealed that hUCMSC-exo significantly increased the levels of p-PI3K and p-AKT in cells,and the effect was inhibited by LY294002(PI3K inhibitor)or MK2206(AKT inhibitor),***,the increases in osteogenic indicators induced by hUCMSC-exo were significantly suppressed by LY294002 and *** hUCMSC-exo promote the osteogenic differentiation of hPDLSCs under HG conditions through the PI3K/AKT signaling pathway.

关键词： Exosomes Human umbilical cord mesenchymal stem cell Periodontal ligament stem cell Osteogenic differentiation High glucose PI3K/AKT

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Synthesis, Crystal Structure and Bioactivity of Ethyl 1-((2-Bromophenyl)carbamoyl)-2-(3,4,5-trimethoxyphenyl) cyclopropanecarboxylate

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Chinese Journal of Structural Chemistry 2019年第12期38卷 2070-2076页

作者： JIA Hui ZHONG han-yu ZhanG Jing-Yi Department of Pharmacy General Hospital of Shenyang Military CommandShenyang 110016China Department of Pharmacy First Affiliated HospitalChina Medical UniversityShenyang 110001China

Many small-molecule compounds were reported as microtubule-inhibitor with potential anticancer activities, such as combretastatin-A4（CA-4） analogue. The title compound which is one novel cyclopropylamide analogue of CA-4, namely as ethyl 1-（（2-bromophenyl）carbamoyl）-2-（3,4,5-trimethoxyphenyl）cyclopropanecarboxylate, has been synthesized and its crystal structure was characterized by X-ray single-crystal diffraction. The crystal belongs to monoclinic, space group P21/n with a = 8.8002（6）, b = 11.4525（8）, c = 21.7870（16） ?, b = 93.810（3）o, V = 2190.9（3） ?3, Z = 4, C22H23BrNO6, Mr = 477.32, Dc = 1.447 Mg/cm3, F（000） = 980, λ（Cu Kα） = 1.54178 ?, μ = 2.883 mm–1, R = 0.0691 and wR = 0.1958 for 6420 observed reflections（I > 2σ（I））. Importantly, the compound revealed potential anticancer activities in six cancer cells and could stimulate tubulin polymerization in vitro, indicating that the small-molecule could be selected as a lead compound for the development of microtubule stimulator.

关键词： cycolpropylamide analogues synthesis bioactivity microtubule-stabilizing agents

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南秦岭镇安西部钨钼矿集区成矿物质来源研究

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黄金科学技术 2024年第1期32卷 13-30页

作者：韩珂杨兴科中煤科工西安研究院(集团)有限公司陕西西安710077 长安大学地球科学与资源学院陕西西安710054

为了查明南秦岭镇安西部大型钨钼多金属矿集区成矿物质来源,在矿床基础地质研究的基础上,运用岩石地球化学、硫化物单矿物硫同位素地球化学和锆石U-Pb同位素、辉钼矿Re-Os同位素地球化学等方法,对复式中酸性侵入体与钨钼成矿的时空关系... 详细信息

为了查明南秦岭镇安西部大型钨钼多金属矿集区成矿物质来源,在矿床基础地质研究的基础上,运用岩石地球化学、硫化物单矿物硫同位素地球化学和锆石U-Pb同位素、辉钼矿Re-Os同位素地球化学等方法,对复式中酸性侵入体与钨钼成矿的时空关系和成因联系进行深入研究。结果表明:懒板凳岩体田湾单元、王家坪隐伏岩体和花岗细晶岩脉富集Si元素,且Mg#值和稀土总量较低,稀土元素配分曲线呈明显的四分组效应并具有强负Eu异常,岩浆分异结晶程度高;懒板凳岩体九间屋单元和王家坪隐伏岩体锆石U-Pb同位素年龄分别为(222.7±2.6)Ma和(201.6±4.7)Ma,棋盘沟钨矿床和江口钼矿床中辉钼矿Re-Os同位素模式年龄分别为(199.7±3.9)Ma和(198.7±3.9)Ma;钨钼矿床中硫化物单矿物δ34S值为3.6‰~10.2‰,推测成矿物质来源于复式岩体晚阶段形成于190~200Ma之间的高分异演化酸性侵入体。

关键词：钨钼矿集区成矿物质来源复式岩体镇安西部南秦岭

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Digital bunch-by-bunch transverse feedback system at SSRF

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Science China(Physics,Mechanics & Astronomy) 2011年第S2期54卷 305-308页

作者： yuAN Renxian LENG YongBin yu LuYang han LiFeng YE KaiRong Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China

In order to suppress multi-bunch couple instabilities caused by transverse impedance, a bunch-by-bunch transverse feedback system based on a FPGA digital processor is commissioned at SSRF storage ring. The RF front end has two COD pre-rejected attenuators for increasing the system arrangement and signal noise ratio, and the 3*RF Local signal comes from the BPM's sum signal using a FIR filter for avoiding the effect of longitudinal oscillation. The digital processor receives the coupled horizontal and vertical oscillation signals in the base band and transforms the coupled signals to the horizontal and vertical feedback signals with two series double-zeroes FIR filters. A matlab GUI is applied for producing the FIR coefficients when the tune is shifted. The horizontal and vertical Kickers have a special design for increasing the shunt impedance. Then the multi-bunch instabilities are suppressed respectively and the minimum damping time is about 0.4 ms.

关键词： transverse feedback multi-bunch instability

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First detection and complete genome of Soybean chlorotic mottle virus naturally infecting soybean in China by deep sequencing

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Journal of Integrative Agriculture 2019年第11期18卷 2664-2667页

作者： HU Qian-qian LIU Xue-jian han Xue-dong LIU Yong JIANG Jun-xi xiE Yan State Key Laboratory of Rice Biology Institute of BiotechnologyZhejiang UniversityHangzhou 310058P.R.China Hunan Plant Protection Institute Changsha 410125P.R.China College of Agriculture Jiangxi Agricultural UniversityNanchang 330000P.R.China

Soybean chlorotic mottle virus(SbCMV)was first detected from soybean plants in Jiangxi Province of China by high throughput sequencing and was confirmed by *** complete nucleotide sequence of NC113 was determined to be 8210 nucleotides,and shared the highest similarity(91.7%)with sequences of SbCMV that was only reported in *** encodes nine putative open reading frames(ORFs Ia,Ib and Ⅱ-Ⅷ),and contains a large intergenic region located at nucleotide 5976-6512 between ORFs VI and *** analysis and phylogenetic tree indicated that NC113 is an isolate of SbCMV,and is more related to the soymoviruses Blueberry red ringspot virus(BRRSV),Peanut chlorotic streak virus(PCSV)and Cestrum yellow leaf curling virus(CmYLCV)than to other representative members in the Caulimoviridae *** survey of 472 legume plants from Jiangxi and Zhejiang provinces showed SbCMV was only detected from soybean in Nanchang City with a low incidence *** is the first report of Soybean chlorotic mottle virus identified in China.

关键词： Soybean chlorotic mottle virus Soymovirus genome sequence sequence analysis

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