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Super Tough Hydrogels with Self-adaptive Network Facilitated by liquid Metal

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Chinese Journal of Polymer Science 2023年第6期41卷 866-873,I0006页

作者： Rong-Ze Gao yu-xi li Jian-Hui Yan Xue-Rui Ma Xu-Ming xie Key Laboratory of Advanced Materials(MOE) Department of Chemical EngineeringTsinghua UniversityBeijing 100084China

liquid metals(LM)refer to Ga-based alloys with low melting points such as Eutectic GaInSn alloys(EGaInSn),which have excellent fluidity,flexibility and low toxicity at room *** this work,by incorporating EGaInSn into poly(acrylic acid)(PAA)hydrogels as dynamic crosslinkers and effective energy-dissipating units,tough and strong PAA-LM hydrogels are prepared through the interactions between the oxide layers on the surface of LM and carboxyl groups of PAA ***,owing to the fluidity of LM,one LM droplet as a cross-linking point may change its shape or break into more and smaller droplets in the hydrogels upon *** hydrogels with self-adaptive networks can be fabricated by mechanical training through cyclic stretch at a certain ***,the networks of the hydrogels are further homogenized,and the hydrogels are significantly toughened during the training due to the increased cross-linking density from the larger number of smaller LM *** a 5-cycle training at the maximum strain of 500%and 24 h recovering,the tensile strength and initial modulus of the PAA-LM hydrogels can be increased from 355 kPa to 597 kPa and 71 kPa to 166 kPa,respectively,while the elongation at break only decreases from 1491%to 1034%.

关键词： temperature. linking stretching

Anti-N-methyl-D-aspartate-receptor antibody encephalitis combined with syphilis:A case report

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World Journal of Clinical Cases 2020年第12期8卷 2603-2609页

作者： xi-yu li Zhi-Hong Shi Ya-lin Guan Yong Ji Graduate School Tianjin Medical CollegeTianjin 300070China Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases Tianjin Dementia InstituteDepartment of NeurologyTianjin Huanhu HospitalTianjin 300350China China National Clinical Research Center for Neurological Diseases Department of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACKGROUND Anti-N-methyl-D-aspartate-receptor(NMDAR)encephalitis is a common type of autoimmune encephalitis characterized by complex clinical signs and variable imaging *** pathogenesis of the disease is *** is an infectious disease caused by Treponema pallidum that can invade the nervous and immune systems and cause systemic *** are few reports of anti-NMDAR encephalitis with syphilis,and the association between them is unknown;both diseases are related to immune system *** report a case of anti-NMDAR encephalitis with *** SUMMARY A 32-year-old man was admitted to our hospital with complaints of cognitive decline,diplopia,and walking instability during the previous 6 *** developed dysarthria,difficulty swallowing,and involuntary shaking of his head,neck,and limbs during the month prior to *** magnetic resonance imaging showed symmetrical abnormal signals in the pons,midbrain,and bilateral basal ganglia,and inflammatory demyelination was *** diagnosis of syphilis was confirmed based on the syphilis diagnosis test and the syphilis rapid *** was given anti-syphilis treatment,but the above symptoms gradually ***-NMDAR antibody was positive in cerebrospinal fluid but was negative in *** to the cerebrospinal fluid findings,anti-NMDAR encephalitis was a *** to the patient’s weight,he was treated with intravenous methylprednisolone 1 g QD for 5 d,with the dose gradually decreased for 6 mo,and immunoglobulin 25 g QD for 5 d;his symptoms improved after *** This case shows that anti-NMDAR encephalitis may be combined with syphilis,which should be recognized to avoid misdiagnosis and treatment delay.

关键词： Anti-N-methyl-D-aspartate receptor encephalitis Syphilis Imaging manifestations Treatment Methylprednisolone Immunoglobulin Case report

Cyanidin-3-O-glucoside alleviates trimethyltin chloride-induced neurodegeneration by maintaining glutamate homeostasis through modulation of the gut microbiota

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Food Science and Human Wellness 2024年第2期13卷 1093-1107页

作者： yu xi Wenhui li Junru Wang Meihong yu xiangquan Zeng He li Jian li Key Laboratory of Green and Low-Carbon Processing Technology for Plant-Based Food of China National light Industry Council Beijing Advanced Innovation Center for Food Nutrition and Human HealthBeijing Technology and Business UniversityBeijing 100048China

Trimethyltin chloride(TMT)is a potent neurotoxin to cause neurodegeneration,especially in *** study aimed to identify dietary components that can effectively attenuate TMT-induced neurodegeneration in *** predominant anthocyanin in human diets,cyanidin-3-O-glucoside(C3G,5 or 50 mg/kg),was given to mice for 16 days,and TMT(2.7 mg/kg)was injected intraperitoneally once on the eighth day.C3G(50 mg/kg)significantly alleviated TMT-induced seizures and subsequent cognitive impairment by ameliorating hippocampal neurodegeneration and synaptic ***,C3G treatment restored glutamate homeostasis in brain and reversed glutamine synthetase(GS)inhibition in reactive astrogliosis and neuroinflammation,which are critical for C3G's neuroprotective ***,C3G decreased the lipopolysaccharide,tumor necrosis factor-α,interleukin-6,and interleukin-1βlevels in the mice,which potentially by modulating the relative abundance of Atopobiaceae and Lachnospiraceae in the gut.C3G may be a promising and practical dietary component for reducing TMT-induced neurodegeneration.

关键词： Cyanidin-3-O-glucoside Trimethyltin Neurodegeneration Glutamatergic pathway Gut microbiota

Corrosion behavior of thermal-sprayed WC cermet coatings in SO_4^(2-) environment

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Rare Metals 2014年第3期33卷 318-323页

作者： Yan liu xiao-Min Wang Sheng-bo Cen Guo-Qing Gou li-Jun Wang Hui Chen Ming-Jing Tu yu-xi li School of Materials Science and Engineering Sichuan University School of Materials Science and Engineering Southwest Jiaotong University Zigong Tungsten Carbide Co. Ltd

A series of the electrochemical and long-term corrosion tests was carried out in a 3.5 wt% Na2SO4 solution on thermal-sprayed WC-17Co and WC-10Co-4Cr cermet coatings in order to examine the effect of composition of binder materials on the corrosion behavior. The results reveal that the overall corrosion resistance of the WC-17Co coating is inferior to that of the WC-Co-Cr coatings due to the corrosion of binder materials which induce WC particles to fall off. CoO and WO3 oxide films form on the surface of WC-17Co coating in Na2SO4 solution electrochemical corrosion process, which will protect the coating in the process of corrosion. Cr2O3 oxide film formed on the WC-10Co-4Cr coating surface has a strong hindered role to corrosion. The corrosion mechanism of WC-17Co coating in Na2SO4 solution is entire corrosion of Co matrix, while it is film-hole corrosion mechanism for WC-10Co-4Cr coating.

关键词： WC-Co WC-Co-Cr Corrosion Electrochemical

Application of GNSS-PPP on Dynamic Deformation Monitoring of Offshore Platforms

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China Ocean Engineering 2024年第2期38卷 352-361页

作者： yu li-na xiONG Kuan GAO xi-feng li Zhi FAN li-long ZHANG Kai Institute of Ocean Energy and Intelligent Construction Tianjin University of TechnologyTianjin 300384China China Railway Construction Bridge Engineering Bureau Group Co.LTD Tianjin 300300China School of Civil Engineering Tianjin UniversityTianjin 300072China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Precision Blasting Jianghan UniversityWuhan 430056China

The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe *** Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)has been considered for this purpose,its monitoring accuracy is relatively ***,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains ***,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore *** address these concerns,vibration table tests with different amplitudes and frequencies are *** results demonstrate that GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with ***,the spectral characteristic of background noise in GNSS-PPP is similar to that of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)has been proposed to de-noise the data and enhance the dynamic monitoring accuracy of *** monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN *** comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed that the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load *** research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms.

关键词： GNSS-PPP offshore platform dynamic deformation monitoring improved CEEMDAN de-noising

Pseudo-Wellens syndrome secondary to postexercise syncope

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World Journal of Emergency Medicine 2022年第4期13卷 334-336页

作者： Shu Fang Zhi-hao liu Qi Jin yu-xi li Wen-hui Ding Hao-yu Weng Tie-ci Yi Jian-ping li Department of Cardiology Peking University First HospitalBeijing 100034China Department of Cardiology Xiamen Cardiovascular HospitalXiamen UniversityXiamen 361004China Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghai 200032China Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education Health Science CenterPeking UniversityBeijing 100034China

Dear editor,Wellens syndrome is characterized by electrocardiography(ECG)patterns of the biphasic or inverted T wave in the precordial leads with normal R wave progression and absence of Q waves,[1,2]which indicates occlusive lesions of the proximal left anterior descending(LAD)coronary artery and warrants.[1]These ECG changes usually occur during a pain-free interval and turn to a fatal consequence if without urgent intervention therapy.[1,3]However,in some cases,coronary stenosis was absent and ECG patterns manifested as Wellens syndrome,which was defined as pseudo-Wellens syndrome.

关键词： coronary editor consequence

Influence of electroacupuncture on ghrelin and the phosphoinositide 3-kinase/protein kinase B/endothelial nitric oxide synthase signaling pathway in spontaneously hypertensive rats

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Journal of Integrative Medicine 2022年第5期20卷 432-441页

作者： yue Zhang Dong-ling Zhong Ya-ling Zheng yu-xi li Yi-jie Huang Yi-jing Jiang Rong-jiang Jin Juan li School of Health Preservation and Rehabilitation Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Rehabilitation Medicine The Second People’s Hospital of ChengduChengdu 610017Sichuan ProvinceChina Department of Rehabilitation Medicine The Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107Guangdong ProvinceChina Department of Rehabilitation Medicine Rehabilitation Hospital Affiliated to Fujian University of Traditional Chinese MedicineFuzhou 350003Fujian ProvinceChina

Objective To investigate the influence of electroacupuncture(EA)on ghrelin and the phosphoinositide 3-kinase/protein kinase B/endothelial nitric oxide synthase(PI3K/Akt/eNOS)signaling pathway in spontaneously hypertensive rats(SHRs).Methods Eight Wistar-Kyoto rats were used as the healthy blood pressure(BP)control(normal group),and 32 SHRs were randomized into model group,EA group,EA plus ghrelin group(EA+G group),and EA plus PF04628935 group(a potent ghrelin receptor blocker;EA+P group)using a random number *** in the normal group and model group did not receive treatment,but were immobilized for 20 min per day,5 times a week,for 4 continuous *** in the EA group,EA+G group and EA+P group were immobilized and given EA treatment in 20 min sessions,5 times per week,for 4 ***,1 h before EA,SHRs in the EA+G group and EA+P group were intraperitoneally injected with ghrelin or PF04628935,respectively,for 4 *** tail-cuff method was used to measure *** the 4-week intervention,the rats were sacrificed by cervical dislocation,and pathological morphology of the abdominal aorta was observed using hematoxylin-eosin(HE)***-linked immunosorbent assay(EliSA)was used to detect the levels of ghrelin,nitric oxide(NO),endothelin-1(ET-1)and thromboxane A2(TXA2)in the *** thoracic aortic ring experiment was performed to evaluate *** blot was used to measure the expression of PI3K,Akt,phosphorylated Akt(p-Akt)and eNOS proteins in the abdominal ***,quantitative real-time polymerase chain reaction(qRT-PCR)was conducted to measure the relative levels of mRNA expression for PI3K,Akt and eNOS in the abdominal *** EA significantly reduced the systolic BP(SBP)and diastolic BP(DBP)(Plium to some *** of EliSA indicated that higher concentrations of ghrelin and NO,and lower concentrations of ET-1 and TXA2 we

关键词： Electroacupuncture Hypertension Vascular endothelial dysfunction Ghrelin PI3K/Akt/eNOS signaling pathway

Food-derived protein hydrolysates and peptides:anxiolytic and antidepressant activities,characteristics,and mechanisms

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Food Science and Human Wellness 2024年第3期13卷 1168-1185页

作者： Wenhui li yu xi Junru Wang Yinxiao Zhang He li xinqi liu Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Engineering and Technology Research Center of Food AdditivesNational Soybean Processing Industry Technology Innovation CenterBeijing Technology and Business UniversityBeijing 100048China

Globally,the prevalence of anxiety and depression has reached epidemic ***-derived protein hydrolysates and peptides delivered through dietary supplementation can avoid the negative risks associated with traditional pharmaceuticals while delivering superior anxiolytic and antidepressant *** review summarizes current research on food-derived anxiolytic and antidepressant protein hydrolysates and peptides,and subsequently analyses their physicochemical characteristics and elaborates on their *** aim of this work is to contribute to the in-depth study and provide a theoretical foundation for the development of related products to better serve patients with anxiety and depression.

关键词： Anxiolytic Antidepressant Peptides Protein hydrolysates Neurotransmitter

Suppressed Internal Intrinsic Stress Engineering in High-Performance Ni-Rich Cathode Via Multi layered In Situ Coating Structure

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Energy & Environmental Materials 2024年第2期7卷 58-66页

作者： Jiachao Yang yunjiao li xiaoming xi Junchao Zheng Jian yu Zhenjiang He School of Metallurgy and Environment Central South UniversityChangsha 410083China Engineering Research Center of the Ministry of Education for Advanced Battery Materials Central South UniversityChangsha 410083China Changsha Research Institute of Mining and Metallurgy Changsha 410083China Ningbo Ronbay New Energy Technol Co Ltd Tanjialing East Rd 39Ningbo 315400China

liNi_(x)Co_(y)Al_(z)O_(2)(NCA)cathode materials are drawing widespread attention,but the huge gap between the ideal and present cyclic stability still hinders their further commercial application,especially for the Ni-rich liNi_(x)Co_(y)Al_(z)O_(2)(x>0.8,x+y+z=1)cathode material,which is owing to the structural degradation and particles'intrinsic *** tackle the problems,li_(0.5)La_(2)Al_(0.5)O_(4)in situ coated and Mn compensating doped multilayer liNi_(0.82)Co_(0.14)Al_(0.04)O_(2)was *** refinement indicates that La-Mn co-modifying could realize appropriate li/Ni disorder *** results and in situ XRD patterns reveal that the LLAO coating layer could effectively restrain crack in secondary particles benefited from the suppressed internal *** further improves as NCA-LM2 has superior mechanical *** SEM,TEM,XPS tests indicate that the cycled cathode with LLAO-Mn modification displays a more complete morphology and less side reaction with *** was used to further investigate cathode-electrolyte interface which was reflected by gas ***-LM2 releases less CO_(2)than NCA-P indexing on a more stable *** modified material presents outstanding capacity retention of 96.2%after 100 cycles in the voltage range of 3.0-4.4 V at 1C,13%higher than that of the pristine and 80.8%at 1 C after 300 *** excellent electrochemical performance could be attributed to the fact that the high chemically stable coating layer of li_(0.5)La_(2)Al_(0.5)O_(4)(LLAO)could enhance the interface and the Mn doping layer could suppress the influence of the lattice mismatch and *** believe that it can be a useful strategy for the modification of Ni-rich cathode material and other advanced functional material.

关键词： compensating doped in situ coating multilayer material Ni-rich cathode materials suppressed internal strain