Anti-N-methyl-D-aspartate-receptor antibody encephalitis combined with syphilis:A case report
作者机构：Graduate SchoolTianjin Medical CollegeTianjin 300070China Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative DiseasesTianjin Dementia InstituteDepartment of NeurologyTianjin Huanhu HospitalTianjin 300350China China National Clinical Research Center for Neurological DiseasesDepartment of NeurologyBeijing Tiantan HospitalCapital Medical UniversityBeijing 100070China
出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)
年 卷 期：2020年第8卷第12期
页 面：2603-2609页
核心收录：
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 100206[医学-皮肤病与性病学] 10[医学]
基 金：Supported by the National Natural Science Foundation of China,No.81571057 Tianjin Science and Technology Project,No.16ZXMJSY00010
主 题：Anti-N-methyl-D-aspartate receptor encephalitis Syphilis Imaging manifestations Treatment Methylprednisolone Immunoglobulin Case report
摘 要：BACKGROUND Anti-N-methyl-D-aspartate-receptor(NMDAR)encephalitis is a common type of autoimmune encephalitis characterized by complex clinical signs and variable imaging *** pathogenesis of the disease is *** is an infectious disease caused by Treponema pallidum that can invade the nervous and immune systems and cause systemic *** are few reports of anti-NMDAR encephalitis with syphilis,and the association between them is unknown;both diseases are related to immune system *** report a case of anti-NMDAR encephalitis with *** SUMMARY A 32-year-old man was admitted to our hospital with complaints of cognitive decline,diplopia,and walking instability during the previous 6 *** developed dysarthria,difficulty swallowing,and involuntary shaking of his head,neck,and limbs during the month prior to *** magnetic resonance imaging showed symmetrical abnormal signals in the pons,midbrain,and bilateral basal ganglia,and inflammatory demyelination was *** diagnosis of syphilis was confirmed based on the syphilis diagnosis test and the syphilis rapid *** was given anti-syphilis treatment,but the above symptoms gradually ***-NMDAR antibody was positive in cerebrospinal fluid but was negative in *** to the cerebrospinal fluid findings,anti-NMDAR encephalitis was a *** to the patient’s weight,he was treated with intravenous methylprednisolone 1 g QD for 5 d,with the dose gradually decreased for 6 mo,and immunoglobulin 25 g QD for 5 d;his symptoms improved after *** This case shows that anti-NMDAR encephalitis may be combined with syphilis,which should be recognized to avoid misdiagnosis and treatment delay.
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