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Efficacy of combined therapy in patients with hepatitis B virus-related decompensated cirrhosis

World Journal of Gastroenterology 2013年第22期19卷 3481-3486页

作者： Guo-Cai Lv Jin-Mei Yao Yi-Da yang Lin Zheng Ji-Fang sheng yu Chen Lan-Juan Li Clinical Laboratory First Affiliated Hospital of Zhejiang University School of Medicine State Key Laboratory for Diagnosis and Treatment of Infectious Diseases First Affiliated Hospital of Zhejiang University School of Medicine

AIM: To investigate the efficacy and safety of combined de novo lamivudine (LAM) and adefovir dipivoxil (ADV) therapy in hepatitis B virus (HBV)-related decompensated liver cirrhosis patients. METHODS: One hundred and forty patients with HBVrelated decompensated cirrhosis were recruited, 70 patients were treated with combined LAM and ADV de novo therapy, and the other 70 patients were treated with LAM alone as controls. The follow-up period was 144 wk. All patients with LAM resistance were shifted to ADV. RESULTS: The percentage of HBV-related decompensated cirrhosis patients with undetectable HBV DNA inde novo combination group was 51.6% (33/64), 84.2% (48/57), and 92.3% (49/53) by weeks 48, 96, and 144, respectively. In monotherapy group, HBV DNA negativity rate was 46.1% (30/65), 56.1% (32/57), and 39.2% (20/51) by weeks 48, 96 and 144, respectively. There was a significant difference between the two groups by weeks 96 and 144 (P = 0.012 and 0.001). The hepatitis B e antigen seroconversion rate was 28.1% (9/32), 40.0% (12/30), and 53.6% (15/28) in the combination group by weeks 48, 96 and 144, respectively, and 24.2% (8/33), 31.0% (9/29), and 37.0% (10/27) by weeks 48, 96 and 144, respectively, in monotherapy group. A total of 68.6% (44/64), 84.2% (48/57), and 92.5% (49/53) patients achieved alanine aminotransferase (ALT) normalization by weeks 48, 96 and 144, respectively in the combination group. In monotherpy group, the ALT normalization rate was 64.6% (42/65) by week 48, 73.7% (42/57) by week 96, and 80.4% (41/51) by week 144. No patients in the combination group exhibited detectable resistance for at least 144 wk. The cumulative resistance rate in monotherapy group at weeks 48, 96, and 144 was 20.0%, 36.8%, and 56.9%. Both combination group and monotherapy group demonstrated an improvement in Child-Turcotte Pugh and Model for End-Stage Liver Disease scores at weeks 48, 96, and 144. All patients tolerated both combination and monotherapy. The ceratinine level

关键词： Liver cirrhosis Lamivudine Adefovir dipivoxil Efficacy Alanine transaminase

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柠檬酸稳定的水溶性CdSe和CdSe/CdS量子点的荧光特性

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无机化学学报 2008年第5期24卷 701-707页

作者：邓大伟于俊生南京大学化学化工学院教育部生命分析化学重点实验室南京210093

用柠檬酸(citrate)作为稳定剂合成了尺寸分布集中、荧光性质良好的水溶性CdSe量子点。通过调节合成温度可以调控CdSe量子点的尺寸及相应的最大荧光发射波长。当温度由20℃增加到95℃时,合成的CdSe量子点的平均尺寸由2.0nm增加到3.2nm,... 详细信息

用柠檬酸(citrate)作为稳定剂合成了尺寸分布集中、荧光性质良好的水溶性CdSe量子点。通过调节合成温度可以调控CdSe量子点的尺寸及相应的最大荧光发射波长。当温度由20℃增加到95℃时,合成的CdSe量子点的平均尺寸由2.0nm增加到3.2nm,相应的荧光发射峰由500nm红移到570nm,展现出明显的量子尺寸效应。进一步制备了CdSe/CdS核壳量子点,其荧光量子产率比CdSe增加了5～10倍。系统地研究了S/Se物质的量的比对CdSe/CdS量子点荧光特性的影响,通过XPS证实了CdSe/CdS量子点中CdS壳层的存在。利用红外光谱和核磁共振波谱表征了柠檬酸分子中的羧基和羟基氧原子与CdSe量子点表面的Cd离子的配位作用,进而揭示了柠檬酸分子对水溶性CdSe量子点溶液的稳定作用。

关键词： CdSe CdSe/CdS 半导体量子点柠檬酸三钠

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Effect of Aluminum Hydroxide Adjuvant on the Immunogenicity of the 2009 Pandemic Influenza A/H1N1 Vaccine:Multi-level Modeling of Data with Repeated Measures

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Biomedical and Environmental Sciences 2011年第6期24卷 624-629页

作者： YIN Da Peng ZHU Bao Ping WANG Hua Qing CAO Lei WU Wen Di JIANG Ke yu XIA Wei ZHANG Guo Min ZHENG Jing Shan CAO Ling sheng LIANG Xiao Feng Chinese Center for Disease Control and Prevention Beijing 100050 China Chinese Field Epidemiology Training Program Beijing 100050 China

Objective To evaluate the effect of the aluminum hydroxide （Al-OH） adjuvant on the 2009 pandemic influenza A/H1N1 （pH1N1） vaccine. Methods In a multicenter, double-blind, randomized, placebo-controlled trial, participants received two doses of split-virion formulation containing 15 ug hemagglutinin antigen, with or without aluminum hydroxide （N-OH）. We classified the participants into six age categories （〉61 years, 41-60 years, 19-40 years, 13-18 years, 8-12 years, and 3-7 years） and obtained four blood samples from each participant on days 0, 21, 35, and 42 following the first dose of immunization. We assessed vaccine immunogenicity by measuring the geometric mean titer （GMT） of hemagglutination inhibiting antibody. We used a two-level model to evaluate the fixed effect of aluminum Al-OH and other factors, accounting for repeated measures. Results The predictions of repeated measurement on GMTs of formulations with or without Al-OH, were 80.35 and 112.72, respectively. Al-OH significantly reduced immunogenicity after controlling for time post immunization, age-group and gender. Conclusion The Al-OH adjuvant does not increase but actually reduces the immunogenicity of the split-virion pH1N1 vaccine.

关键词： Aluminum hydroxide Adjuvant Immunogenicity 2009 pandemic influenza A/H1N1 vaccine Multi-level model

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医学显微图像自动拼接的方法研究

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中国生物医学工程学报 2005年第2期24卷 173-178页

作者：聂生东司京玉上海理工大学医疗器械学院上海200093 株式会社东芝三广医疗上海200025

图像拼接技术能够很好地解决显微镜高倍镜下图像视野减小的问题。本研究针对医学显微图像的特点 ,提出了降低分辨率全图搜索算法 ,并具体讨论了拼接缝处理和图像显示等问题。实验证明 ,采用该算法人工参与少 ,客观性好 ,硬件依赖性小 ,... 详细信息

图像拼接技术能够很好地解决显微镜高倍镜下图像视野减小的问题。本研究针对医学显微图像的特点 ,提出了降低分辨率全图搜索算法 ,并具体讨论了拼接缝处理和图像显示等问题。实验证明 ,采用该算法人工参与少 ,客观性好 ,硬件依赖性小 ,速度快 ,能够得到满意的拼接结果。

关键词：医学显微图像图像拼接技术图像视野图像显示显微镜分辨率客观性依赖性算法

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基于稀疏主成分和熵值法的中国上市银行风险评价

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湖南大学学报（社会科学版） 2019年第2期33卷 77-81页

作者：喻胜华阳林芝湖南大学经济与贸易学院湖南长沙410079

利用稀疏主成分分析方法和熵值法对中国25家上市银行风险进行多指标的量化分析和综合评价。在选择惩罚系数λ_1时,同时兼顾了主成分的稀疏度和主成分对于原解释变量的解释程度。结果显示,我国上市银行中,国有商业银行风险系数最低,其次... 详细信息

利用稀疏主成分分析方法和熵值法对中国25家上市银行风险进行多指标的量化分析和综合评价。在选择惩罚系数λ_1时,同时兼顾了主成分的稀疏度和主成分对于原解释变量的解释程度。结果显示,我国上市银行中,国有商业银行风险系数最低,其次是城市商业银行,股份制银行风险系数最高。最后,根据不同风险类型给出了防范建议。

关键词：稀疏主成分熵值法上市银行风险评价

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Partial improvement in performance of patients with severe Alzheimer's disease at an early stage of fornix deep brain stimulation

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Neural Regeneration Research 2018年第12期13卷 2164-2172页

作者： Zhi-Qi Mao Xin Wang Xin Xu Zhi-Qiang Cui Long-sheng Pan Xiao-Jing Ning Bai-Xuan Xu Lin Ma Zhi-Pei Ling Jian-Jun Jia Xin-Guang yu Department of Neurosurgery Chinese PLA General Hospital School of Medicine Nankai University Department of Nuclear Medicine Chinese PLA General Hospital Department of Radiology Chinese PLA General Hospital Department of Neurology Chinese PLA General Hospital

Deep brain stimulation is a therapy for Alzheimer＇s disease（AD） that has previously been used for mainly mild to moderate cases. This study provides the first evidence of early alterations in performance induced by stimulation targeted at the fornix in severe AD patients. The performance of the five cases enrolled in this study was scored with specialized assessments including the Mini-Mental State Examination and Clinical Dementia Rating, both before and at an early stage after deep brain stimulation. The burden of caregivers was also evaluated using the Zarit Caregiver Burden Interview. As a whole, the cognitive performance of patients remained stable or improved to varying degrees, and caregiver burden was decreased. Individually, an improved mental state or social performance was observed in three patients, and one of these three patients showed remarkable improvement in long-term memory. The conditions of another patient deteriorated because of inappropriate antipsychotic medications that were administered by his caregivers. Taken together, deep brain stimulation was capable of improving some cognitive aspects in patients with severe AD, and of ameliorating their emotional and social performance, at least at an early stage. However, long-term effects induced by deep brain stimulation in patients with severe AD need to be further validated. More research should focus on clarifying the mechanism of deep brain stimulation. This study was registered with ***（NCT03115814） on April 14, 2017.

关键词： Alzheimer's disease deep brain stimulation fornix cognition memory mood performance early stage functional neurosurgery dementia

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Multifunctional disk device for optical switch and temperature sensor

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Chinese Physics B 2015年第10期24卷 518-521页

作者：卞振宇梁瑞生张郁靖易丽璇赖根赵瑞通 Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices School for Information and Optoelectronic Science and EngineeringSouth China Normal University

A multifunctional surface plasmon polariton disk device coupled by two metal-insulator-metal（MIM） waveguides is proposed and investigated numerically with finite-difference time-domain simulation. It can be used as optical switch and temperature sensor by filling disk with liquid crystal and ethanol, respectively. The simulation results demonstrate that the transmission characteristics of an optical switch can be manipulated by adjusting the radius of disk and the slit width between disk and MIM waveguides. The transmittance and modulation depth of optical switch at 1550 nm are up to 64.82% and 17.70 d B, respectively. As a temperature sensor, its figure of merit can reach 30.46. In this paper, an optical switch with better efficiency and a temperature sensor with better sensitivity can be achieved.

关键词： surface plasmon polaritons optical switch modulation depth temperature sensor figure of merit

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Anti-Helicobacter pylori therapy followed by celecoxib on progression of gastric precancerous lesions

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World Journal of Gastroenterology 2009年第22期15卷 2731-2738页

作者： Li-Jing Zhang Shi-Yan Wang Xiao-Hui Huo Zhen-Long Zhu Jian-Kun Chu Jin-Cheng Ma Dong-sheng Cui Ping Gu Zeng-Ren Zhao Ming-Wei Wang Jun yu Department of Gastroenterology the First Affiliated Hospital of Hebei Medical University Shijiazhuang 050051 Hebei Province China Department of Medicine and Therapeutics the Prince of Wales Hospital the Chinese University of Hong Kong Hong Kong China Department of Pathology the First Affiliated Hospital of Hebei Medical University Shijiazhuang 050051 Hebei Province China Department of Neurology the First Affiliated Hospital of Hebei Medical University Shijiazhuang 050051 Hebei Province China Department of Surgery the First Affiliated Hospital of Hebei Medical University Shijiazhuang 050051 Hebei Province China

AIM： To evaluate whether celecoxib, a selective cyclooxygenase 2 （COX-2） inhibitor, could reduce the severity of gastric precancerous lesions following Hel/cobacter pylori （H pylorl） eradication. METHODS： H pylori-eradicated patients with gastric precancerous lesions randomly received either celecoxib （n = 30） or placebo （n = 30） for up to 3 mo. COX-2 expression and activity was determined by immunostaining and prostaglandin E2 （PGE2） assay, cell proliferation by Ki-67 immunostaining, apoptosis by TUNEL staining and angiogenesis by microvascular density （MVD） assay using CD31 ***： COX-2 protein expression was significantly increased in gastric precancerous lesions （atrophy, intestinal metaplasia and dysplasia, respectively） compared with chronic gastritis, and was concomitant with an increase in cell proliferation and angiogenesis. A significant improvement in precancerous lesions was observed in patients who received celecoxib compared with those who received placebo （P 〈 0.001）. Of these three changes, 84.6% of sites with dysplasia regressed in patients treated with celecoxib （P = 0.002） compared with 60% in the placebo group, suggesting that celecoxib was effective on the regression of dysplasia. COX-2 protein expression （P 〈 0.001） and COX-2 activity （P 〈 0.001） in the gastric tissues were consistently lower in celecoxib-treated patients compared with the placebo-treated subjects. Moreover, it was also shown that celecoxib suppressed cell proliferation （P 〈 0.01）, induced cell apoptosis （P 〈 0.01） and inhibited angiogenesis with decreased MVD （P 〈 0.001）. However, all of these effects were not seen in placebo-treated subjects. Furthermore, COX-2 inhibition resulted in the up-regulation of PPARy expression, a protective molecule with anti-neoplastic effects. CONCLUSION： H pylori eradication therapy followed by celecoxib treatment improves gastric precancerous lesions by inhibiting COX-2 activity, inducing apoptosis, and suppressing cell proliferation

关键词： Apoptosis Cyclooxygenase 2 Gastric precancerous lesions Helicobacter pylori Microvessel density Proliferation

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Caffeic acid ameliorates early and delayed brain injuries after focal cerebral ischemia in rats

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Acta Pharmacologica Sinica 2006年第9期27卷 1103-1110页

作者： yu ZHOU San-hua FANG Yi-lu YE Li-sheng CHU Wei-ping ZHANG Meng-ling WANG Er-qing WEI~2 Department of Pharmacology,School of Medicine,Zhejiang University,Hangzhou 310031,China Department of Pharmacology School of Medicine Zhejiang University Hangzhou China

Aim:To investigate the effects of caffeic acid on early and delayed injuries afterfocal cerebral ischemia in rats,and the possible relation to ***:Transient focal cerebral ischernia was induced by middlecerebral artery occlusion in Sprague-Dawley *** acid(10 and 50 mg/kg)was ip injected for 5 d after *** brain injuries were observed,and thelevels of cysteinyl leukotrienes and leukotriene B4in the brain tissue ***:Caffeic acid(50 mg/kg)ameliorated neurological dysfunctionand neuron loss,and decreased infarct volume 24 h after ischemia;it attenuatedbrain atrophy,infarct volume,and particularly astrocyte proliferation 14 d *** addition,it reduced the production of leukotrienes(5-lipoxygenasemetabolites)in the ischemic hemispheres 3 h and 7 d after ***:Caffeic acid has protective effect on both early and delayed injuries after focalcerebral ischemia in rats;and this effect may partly relate to 5-lipoxygenaseinhibition.

关键词： caffeic acid focal cerebral ischemia neuron astrocyte 5-lipoxygenase leukotriene

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The high diversity of SARS-CoV-2-related coronaviruses in pangolins alerts potential ecological risks

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Zoological Research 2021年第6期42卷 834-844页

作者： Min-sheng Peng Jian-Bo Li Zheng-Fei Cai Hang Liu Xiaolu Tang Ruochen Ying Jia-Nan Zhang Jia-Jun Tao Ting-Ting Yin Tao Zhang Jing-yang Hu Ru-Nian Wu Zhong-Yin Zhou Zhi-Gang Zhang Li yu Yong-Gang Yao Zheng-Li Shi Xue-Mei Lu Jian Lu Ya-Ping Zhang State Key Laboratory of Genetic Resources and Evolution Yunnan Laboratory of Molecular Biology of Domestic AnimalsKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China Kunming College of Life Science University of Chinese Academy of SciencesKunmingYunnan 650204China KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650201China State Key Laboratory for Conservation and Utilization of Bio-resources in yunnan Yunnan UniversityKunmingYunnan 650091China State Key Laboratory of Protein and Plant Gene Research Center for BioinformaticsSchool of Life SciencesPeking UniversityBeijing 100871China Molbreeding Biotechnology Co. Ltd.ShijiazhuangHebei 050035China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences&yunnan Province Kunming Institute of ZoologyKunmingYunnan 650201China CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhanHubei 430071China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunmingYunnan 650201China

Understanding the zoonotic origin and evolution history of SARS-CoV-2 will provide critical insights for alerting and preventing future outbreaks.A significant gap remains for the possible role of pangolins as a reservoir of SARS-CoV-2 related coronaviruses(SC2r-CoVs).Here,we screened SC2r-CoVs in 172 samples from 163 pangolin individuals of four species,and detected positive signals in muscles of four Manis javanica and,for the first time,one *** analysis of pangolin mitochondrial DNA traced their origins from Southeast *** in-solution hybridization capture sequencing,we assembled a partial pangolin SC2r-CoV(pangolin-CoV)genome sequence of 22895 bp(MP20)from the *** *** analyses revealed MP20 was very closely related to pangolin-CoVs that were identified in *** seized by Guangxi Customs.A genetic contribution of bat coronavirus to pangolin-CoVs via recombination was *** analysis revealed that the genetic diversity of pangolin-CoVs is substantially higher than previously *** the potential infectivity of pangolin-CoVs,the high genetic diversity of pangolin-CoVs alerts the ecological risk of zoonotic evolution and transmission of pathogenic SC2r-CoVs.

关键词： SARS-CoV-2 Pangolin Recombination Diversity Sequencing mtDNA

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