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Enantioseparation of Dencichine and D-Isomer on L-Cysteine Derivative Phase by Ligand-exchange Chromatography

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Chinese Chemical Letters 2006年第6期17卷 807-808页

作者： Yan Shun MA Qing Hua MENG Hong yu shi yuan De LONG Tian Bao HUANG Chengdu Institute of Organic Chemistry Chinese Academy of Sciences Chengdu 610041 Graduate School of the Chinese Academy of Sciences Beijing 100049

The enantioseparation of dencichine and its D-isomer was achieved on a novel chiral stationary phase via coating N-（2-hydroxyl-3-octoxyl） propyl-S-benzyl-（L）-cysteine on YWG-C18 phase by ligand exchange chromatogr... 详细信息

关键词： Dencichine enantioseparation ligand exchange chromatography chiral stationaryphase.

Targeted Antagonism of Vascular Endothelial Growth Factor Reduces Mortality of Mice with Acute Respiratory Distress Syndrome

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Current Medical Science 2020年第4期40卷 671-676页

作者： Zhao ZHANG Dong-shi LU Dan-qing ZHANG Xin WANG yu MING Zhou-yang WU Department of Anesthesiology Union HospitalTongji Medical CollegeHuazhong Universiry of Science and TechnologyWuhan 430022.China Department of Senior Cadre No.989 HospitalThe Joint Logistics Support Force of the Chinese People's Liberation ArmyLuoyang 471003China College of Health Science and Nursing Withan Polytechnic UniversityWiuhan 430032China

Summary:Acute respiratory distress syndrome(ARDS)is associated with a mortality of 45%.Our previous rescarch indicated that anti-vascular endothelial growth factor(VEGF)could maintain the normal structure and function of the respiratory ***,systemic application of VEGF antagonists would lead to animal *** study attempts to study the targeted drug delivery for *** this study,we used soluble fims-like tyrosine kinase-1(sFlt)-targeted ultrasound microbubbles to antagonize the effect of VEGF on lung *** male BALB/C mice were randomly assigned to 6 groups:phosphate buffer saline(PBS)group(PBS+PBS);blank group(PBS+empty microbubbles);lipopolysaccharide(LPS)group(LPS+PBS);ARDS group(LPS tempty microbubbles);control group(PBS+sFlt microbubbles);and treatment group(LPS+sFIt microbubbles).After administration of LPS or PBS in the corresponding groups,the sFlt-targeted microbubbles or empty microbubbles were injected into the blood *** the lungs were irradiated with ultrasound,which ruptured the drug-loaded microbubbles and helped release drugs to the lung tissues *** lung injury score,lung wet/dry ratio(W/D),liver and kidney functions,and the mortality of the mice in all groups were investigated at the predetermined time *** difference in mortality between groups was examined by Fisher *** data were analyzed by onc-way analysis of variance(ANOVA).A value of P<0.05 indicates that the difference was *** results showed that the PaO2 levels were normal in the PBS group,the blank group,and the control *** LPS group and ARDS group showed significant ***2 was improved significantly in the treatment *** lung injury score and W/D were normal in the PBS group,the blank group,and the control *** lung injury score and W/D increased significantly in the LPS group and ARDS group and decreased in the treatment group(P<0.05).The mortality rate of the ARDS model was 60%(95%confidence inte

关键词： acute respiratory distress syndrome vascular endothelial growth factor soluble fims-like tyrosine kinase-1 ultrasound microbubble lipopolysaccharide

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浅析生乳滋气味管控

中国奶牛 2024年第2期 7-11页

作者：于有利黎玉琼时发亿陈松睿从志鹏宁夏农林科学院银川750002 固原市职业技术学校固原756000 西北农林科技大学杨凌712000

本文以生乳的气味为主要研究对象。通过对奶牛场生产过程中数据的研究和分析,对奶牛场的整个生产过程进行跟踪,检测出异常气味牛奶中的差异代谢产物。目的是阐明牛奶异味的概念、原因和解决方案,从而为减少乳制品生产中异常奶味和异味... 详细信息

本文以生乳的气味为主要研究对象。通过对奶牛场生产过程中数据的研究和分析,对奶牛场的整个生产过程进行跟踪,检测出异常气味牛奶中的差异代谢产物。目的是阐明牛奶异味的概念、原因和解决方案,从而为减少乳制品生产中异常奶味和异味的发生提供依据。

关键词：生乳滋气味产生原因预防解决方案

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《矛盾论》的时代意义

湘潭大学学报（哲学社会科学版） 2021年第5期45卷 177-182页

作者：荆世群湘潭大学马克思主义学院湖南湘潭411105

《矛盾论》在深刻总结中国革命历史经验的基础上,根据马克思主义经典作家的重要论述,结合中国传统辩证法思想,系统地阐述了对立统一规律这一唯物辩证法的实质内容和根本方法,实现了马克思主义中国化和中华优秀传统辩证法思想的现代化,... 详细信息

《矛盾论》在深刻总结中国革命历史经验的基础上,根据马克思主义经典作家的重要论述,结合中国传统辩证法思想,系统地阐述了对立统一规律这一唯物辩证法的实质内容和根本方法,实现了马克思主义中国化和中华优秀传统辩证法思想的现代化,成为马克思主义中国化的哲学经典。《矛盾论》是毛泽东哲学思想成熟的重要标志,不仅阐明了中国革命的哲学逻辑,而且为中国特色社会主义奠定了哲学基础,提供了方法论指导,已成为中国共产党人学习马克思主义哲学的入门书和提高自身辩证思维能力、掌握看家本领的必修课。新时代坚持和发展中国特色社会主义必须继续学习、运用和发展《矛盾论》的观点和方法。

关键词：《矛盾论》对立统一规律矛盾分析方法

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水利团体标准质量与实施效果评估初探

中国标准化 2024年第20期 35-39,48页

作者：董长娟汝楠蒋雨彤施克鑫水利部科技推广中心水利部国际合作与科技司水利部南京水利水文自动化研究所

培育发展团体标准是国家标准化改革的一项重大举措。近年来,我国水利团体标准发展迅速,为贯彻落实《国家标准化发展纲要》等有关要求,进一步加强水利团体标准监管,结合水利团体标准发展实际,本文探索并首次建立了《水利团体标准评估指... 详细信息

培育发展团体标准是国家标准化改革的一项重大举措。近年来,我国水利团体标准发展迅速,为贯彻落实《国家标准化发展纲要》等有关要求,进一步加强水利团体标准监管,结合水利团体标准发展实际,本文探索并首次建立了《水利团体标准评估指标体系(试行)》,对发布满3年的水利团体标准开展了质量与实施效果评估,并对下一步如何有效提升水利团体标准质量和水平提出了意见建议,以期为促进水利团体标准规范优质发展,扎实推进水利高质量发展提供一定支撑。

关键词：水利团体标准评估指标体系高质量发展

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A Facile Synthsis of ω-Bromo-Diene Via Solid/LiquidTransferred Wittig Reactions of ω-Bromobutyltriphenylphosphonium Salts With α.β -Unsaturated Aldehydes

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Chinese Chemical Letters 1999年第11期10卷 911-914页

作者： De Qing shi Ru yu CHEN(Research Institute of Elemento Organic Chemistry, NanKai University,Tianjin 300071) Res. Inst. of Elemento Organ. Chem. NanKai University Tianjin 300071 China

A new approach to the synthesis of co -bromo-dienes was carried out by usingsolid/liquid transferred Wittig reactions between in -bromobutyltriphenylphosphoniumsalt and Q. 6 -unsaturated aldehydes.

关键词： Wittig reactions w -bromoalkyltriphenylphosphonium salts synthesis w- bromo-dienes stereoselectivity.

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成年期视皮层神经元数量减少降低突触连接

现代生物医学进展 2024年第18期24卷 3401-3406页

作者：蓝志达王兆龙谢先屿赵乐文方伟群上海交通大学基础医学院解剖学与生理学系上海200025

目的:探究成年期视皮层神经元数量减少对突触连接的改变,为解析创伤性脑损伤导致的视觉功能障碍提供实验依据。方法:采用立体定位技术,以腺相关病毒(Adeno-associated viruses,AAVs)稀疏感染方式于8周龄C57BL/6小鼠初级视皮层(Primary v... 详细信息

目的:探究成年期视皮层神经元数量减少对突触连接的改变,为解析创伤性脑损伤导致的视觉功能障碍提供实验依据。方法:采用立体定位技术,以腺相关病毒(Adeno-associated viruses,AAVs)稀疏感染方式于8周龄C57BL/6小鼠初级视皮层(Primary visual cortex,V1)中表达白喉毒素A片段蛋白(Diphtheria toxin A,DTA),引发神经元凋亡。4周后,通过免疫荧光染色、高尔基染色及共聚焦显微镜成像,分析视皮层第2-4层神经元数量以及幸存锥体神经元的树突棘形态特征。结果:通过注射不同滴度(E+11-13)的DTA表达病毒,成功构建了不同水平(14~85%)的视皮层神经元减少小鼠模型。结果发现低滴度(E+11)DTA表达病毒导致中等程度神经元减少(~18%,P<0.01),模拟了轻度创伤性脑损伤患者的皮层神经元丢失水平(16.5~22.9%),并发现该小鼠锥体神经元的树突棘密度与对照组没有差异,而树突棘成熟比例减少~19%(P<0.0001)。结论:成年期视皮层神经元数量减少损害突触连接,可能导致大脑的视觉功能障碍。

关键词：视皮层神经元神经元数量树突棘

A nested case-control study of maternal-neonatal transmission of hepatitis B virus in a Chinese population

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World Journal of Gastroenterology 2011年第31期17卷 3640-3644页

作者： Li-Zhang Chen Wen-Qi Zhou Shu-Shan Zhao Zhi-yu Liu shi-Wu Wen School of Public Health Central South UniversityChangsha 410078Hunan ProvinceChina Eight-Year Program Xiangya School of MedicineCentral South University410008 ChangshaHunan ProvinceChina Maternal and Child Health Hospital of Hunan Province Changsha 410008Hunan ProvinceChina The OMNI Research Group Department of Obstetrics and GynecologyUniversity of Ottawa501 Smyth RoadBox 241Ottawa K1H 8L6Canada Ottawa Health Research Institute Clinical Epidemiology Program Canada Department of Epidemiology and Community Medicine University of OttawaK1H 8L6Canada

AIM:To examine the determinants of maternal-neonatal transmission of hepatitis B virus(HBV) METHODS:A nested case-control study was conducted in Changsha,Hunan,People's Republic of China from January 1,2005 to September 31,2006 To avoid potential maternal blood contamination,we collected vein blood of newborns immediately after birth and before initial hepatitis B vaccination to determine the HBV infection status of the newborn For each HBsAg-positive infant,one HBsAg-negative infant born to an HBsAg-positive mother was matched by hospital at birth(same),gender(same),and date of birth(within 1 mo) A faceto-face interview was conducted to collect clinical and epidemiological data Conditional logistic regression analysis was used to estimate the independent effects of various determinants on maternal-neonatal transmission of HBV RESULTS:A total of 141 HBsAg-positive infants and 141 individually matched HBsAg-negative infants were included in the final analysis Maternal first-degree family history of HBV infection,intrahepatic cholestasis,and premature rupture of membranes were risk factors for perinatal transmission of HBV,whereas systematic treatment and HBV immunoglobulin injections for mothers with HBV infection were protective factors for maternal-neonatal transmission of HBV,after adjustment for potential confounding factors CONCLUSION:For HBsAg-positive mothers,systematic treatment,HBV immunoglobulin administration,and controlling intrahepatic cholestasis and pregnancy complications may reduce the incidence of perinatal transmission of HBV.

关键词： HBsAg-positive Hepatitis B virus Perinatal transmission:Nested case-control study

Efficacy and safety of acupuncture for polycystic ovary syndrome:An overview of systematic reviews

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Journal of Integrative Medicine 2023年第2期21卷 136-148页

作者： Han Yang Zhi-yong Xiao Zi-han Yin Zheng yu Jia-jia Liu Yan-qun Xiao Yao Zhou Juan Li Jie Yang Fan-rong Liang Acupuncture and Tuina School Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina College of Medical Information and Engineering Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Traditional Chinese Medicine Department Chengdu Xinan Gynecological HospitalChengdu 610051Sichuan ProvinceChina Infertility Clinic Chengdu Xinan Gynecological HospitalChengdu 610051Sichuan ProvinceChina Health Preservation and Rehabilitation School Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina

Background:Polycystic ovary syndrome(PCOS)is the primary cause of anovulatory infertility,bringing serious harm to women’s physical and mental *** may be an effective treatment for ***,systematic reviews(SRs)on the efficacy and safety of acupuncture for PCOS have reported inconsistent results,and the quality of these studies has not been adequately ***:To summarize and evaluate the current evidence on the efficacy and safety of acupuncture for PCOS,as well as to assess the quality and risks of bias of the available *** strategy:Nine electronic databases(Cochrane Library,MEDLINE,Embase,PsycINFO,CINAHL,Chinese National Knowledge Infrastructure,Wanfang Data,Chongqing VIP Chinese Science and Technology Periodical Database,and China Biology Medicine disc)were searched from their establishment to July 27,*** on the principle of combining subject words with text words,the search strategy was constructed around search terms for“acupuncture,”“polycystic ovary syndrome,”and“systematic review.”Inclusion criteria:SRs of randomized controlled trials that explored the efficacy and(or)safety of acupuncture for treating patients with PCOS were *** extraction and analysis:Two authors independently extracted study data according to a predesigned *** for evaluating the methodological quality,risk of bias,reporting quality,and confidence in study outcomes,including A Measurement Tool to Assess Systematic Reviews 2(AMSTAR 2),Risk of Bias in Systematic Reviews(ROBIS),Preferred Reporting Items for Systematic Reviews and Metaanalyses for Acupuncture(PRISMA-A),and the Grading of Recommendations Assessment,Development and Evaluation(GRADE),were used to score the included ***:A total of 885 studies were retrieved,and 11 eligible SRs were finally included in this *** methodological quality of 2 SRs(18.18%)was low,while the other 9 SRs(81.82%)were scored as extremely *** SRs(36.36%)were considered to be of

关键词： Acupuncture Polycystic ovary syndrome Systematic review Meta-analysis