Molecular recognition and homochirality preservation of guanine tetrads in the presence of melamine
作者机构：Condensed Matter Science and Technology InstituteSchool of Instrumentation Science and Engineerinz Harbin Institute of TechnologryHarbin 150001China State Key Laboratory of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute oj TechnologyHarbin 150001China Department of PhysicsKings College LondonLondon WC2R 2LSUK Interdisciplinary Nanoscience CenterAarhus UniversityAarhus 8000Denmark
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2020年第13卷第9期
页 面：2427-2430页
核心收录：
学科分类：0710[理学-生物学] 0808[工学-电气工程] 07[理学] 0809[工学-电子科学与技术（可授工学、理学学位）] 071007[理学-遗传学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：This work was financially supported by the National Natural Science Foundation of China(Nos.21473045 and 51772066) State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology(No.2018DX04).
主 题：molecular recognition guanine-tetrad base pairing homcxjhirality biochemical synthesis
摘 要：Molecular recognition between nucleobases plays a crucial role in all kinds of biological processes.However,real-space investigation of the recognition capability of nucleobases in the presence of interfering compounds remains unexplored.Herein,based on the combination of scanning tunneling microscopy imaging and density functional theory modeling,we report the impact of the presence of melamine(M)on the formation and chirality of guanine(G)-tetrads on Au(111).Although M can interact with G by double hydrogen bonding,the Hoogsteen base pairing of G is not compromised,forming identical individual G-tetrads as would have happened without the presence of M.G-tetrads coexist with M on the surface not only in separate domains,but also within the mixture network of G-tetrads and M-dimers.Although the adsorption orientation of G-tetrads in the mixture network diversifies into two distinct angles,all G-tetrads in the network keep the same chirality,emphasizing the high preference of homochirality in such biochemical systems.
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