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Two new dammarane-type sapogenins from Gynostemma pentaphyllum

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Chinese Chemical Letters 2011年第12期22卷 1461-1464页

作者： Xia Li Jia qing Cao Lin Shi yu qing zhao School of Traditional Chinese Materia Medica Shenyang Pharmaceutical UniversityShenyang 110016China College of Food Science Shenyang Agriculture UniversityShenyang 110866China

Two new sapogenins,named（20S,24R）-3β,20,21β,25-tetrahydroxy-21,24-cyclodammarane（1）and 3β-hydroxyetio-17β-dammaranic acid（2）,were isolated from the alkaline hydrolysate of Gynostemma pentaphyllum *** structu... 详细信息

关键词： Gynostemma pentaphyllum Sapogenin Alkaline hydrolysate

A new triterpene saponin from Panax japonicus *** var major(Burk.) *** et ***

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Chinese Chemical Letters 2010年第10期21卷 1216-1218页

作者： Hong zhao Lin Shi Jia qing Cao Wei Li Xia Wen yu qing zhao Heilongjiang University of Traditional Chinese Medicine Haerbin 150040 China Dalian University Dalian 116622 China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang 110016 China No. 1 Hospital of Dalian Jinzhou Dalian 116016 China

One new Iriterpene saponin was isolated from Panaxjaponicus C. A. Meyer var major （Burk.） C. Y. Wu et K. M. Feng, and established as oleanolic acid 3-O-[β-D-glucopyranosyl-（1 →2）-β-D-glucuronopyranosyl-6＇-O-n-butyl ester] which showed mod- erate antitumor activities against the A2780 cells and OVCAR-3 cells. Its structure was established by means of spectral data, particularly NMR, including HSQC and HMBC techniques.

关键词： Oleanolic acid 3-O-[β-D-glucopyranosyl-(1 → 2)-β-D-glucuronopyranosyl-6'-O-n-butyl ester] Antitumor Panax japonicus C. A.Meyer vat major (Burk) C Y wu et K. M Feng Triterpene saponin

Two-dimensional metallic CoTe_(2)flakes for electrocatalytic hydrogen evolution

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Rare Metals 2024年第11期43卷 5860-5867页

作者： yu-qing zhao Qian Liu Bo-Jian Zhou Guang Yang Shao-Long Jiang School of Physics and Electronics Science Hunan University of Science and TechnologyXiangtan 411201China College of Metallurgy and Energy North China University of Science and TechnologyTangshan 063210China Department of Physics Southern University of Science and TechnologyShenzhen 518055China School of Integrated Circuit Science and Engineering Beihang UniversityBeijing 100191China Quantum Science Center of Guangdong-Hong Kong-Macao Greater Bay Area(Guangdong) Shenzhen 518045China

Two-dimensional(2D)metallic 1T-CoTe_(2)has attracted considerable attention due to its fascinating physical properties and promising applications in electronics and ***,the production of highquality 2D 1T-CoTe_(2)still remains ***,we demonstrate a methodology to realize the facile synthesis of ultrathin,high-quality CoTe_(2)flakes with a thickness down to 2.3 nm on mica substrates by an ambient-pressure chemical vapor deposition(CVD)*** atomic arrangement is verified by scanning transmission electron *** theoretical calculations uncover the metallic characteristic of 1T-CoTe_(2)in the 2D ***,the CVD-derived 2D metallic CoTe_(2)flakes for the hydrogen evolution reaction(HER)catalyst exhibit admirable performance,such as an overpotential of186 mV at 10 mA·cm^(-2),a Tafel slope of 78 mV·dec^(-1),an exchange current density of 69μA·cm^(-2),and negligible performance degradation after 1000 *** results establish novel approaches for the synthesis and HER application of 2D metallic 1T-CoTe_(2).

关键词： 2D metallic material 1T-CoTe_(2) Chemical vapor deposition Electrochemical hydrogen evolution

Efficient synthesis of panaxadiol derivatives using continuous-flow microreactor and evaluation of anti-tumor activity

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Chinese Chemical Letters 2015年第3期26卷 334-338页

作者： Yan Wu Wei-Qi Chen yu-qing zhao Hu-Ri Piao Key Laboratory of Natural Resources and Functional Molecules of the Changbai Mountain Affiliated Ministry of EducationYanbian University College of Pharmacy Department of Chemistry Fudan University School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University

An efficient method has been developed for the synthesis of a series of（20R）-panaxadiol derivatives（4a–w） using a continuous-flow *** antitumor activities of the newly synthesized compounds were evaluated in vitro in two human prostate adenocarcinoma tumor cell lines（i.e.,PC-3and LNCa P cells）,and their cytotoxicities were evaluated using a standard MTT *** 4c,4h,4p,4q and 4s exhibited higher antitumor activities toward PC-3 cell line than panaxadiol,which was used as a reference standard.

关键词： antitumor adenocarcinoma toward silica batch shorter spectrometer incubated equiv acetate

Synthesis and mesomorphic properties of novel tolane-type liquid crystals

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Chinese Chemical Letters 2009年第11期20卷 1283-1286页

作者： Dong yu zhao qing Yong Meng Xiao Peng Cui Huai Yang Department of Materials Physics and Chemistry School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China

Two series of novel tolane-type liquid crystals （LCs） comprising of hydrogen-bonded organic acids were synthesized. The formation of dimerized H-bond LCs was confirmed by IR spectroscopy, and mesomorphic properties of the LCs were investigated by differential scanning calorimetry （DSC） and polarizing optical microscopy （POM）. It was found that the end groups of the liquid crystals as well as the unsaturated rigid core had effect on the mesomorphic properties.

关键词： Tolane Hydrogen-bonded liquid crystal Mesomorphic properties Synthesis

Polycaprolactone/polysaccharide functional composites for lowtemperature fused deposition modelling

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Bioactive Materials 2020年第2期5卷 185-191页

作者： yu-qing zhao Ji-Hao Yang Xiaokang Ding Xuejia Ding Shun Duan Fu-Jian Xu State Key Laboratory of Chemical Resource Engineering Key Lab of Biomedical Materials of Natural Macromolecules(Beijing University of Chemical Technology)Ministry of EducationBeijing Laboratory of Biomedical MaterialsBeijing University of Chemical TechnologyBeijing100029China

Fused deposition modelling(FDM)is a commonly used 3D printing *** development of FDM materials was essential for the product quality of *** this work,a series of polycaprolactone(PCL)-based composites for low-temperature FDM were *** melt blending technique,different ratios of starch were added into PCL to improve the performances of FDM,and the printability,tensile strength,rheological properties,crystallization behaviors and biological performances of the composites were *** PCL/starch composite had the best performance in FDM process with the starch ratio of 9 ph at 80–90°*** melting strength and solidification rate of PCL/starch composites were *** starch also increased the crystallization temperature,degree of crystallinity and crystallization rate of PCL/starch composites,while had no negative effects on the tensile strength of *** to the low printing temperature,various kinds of bioactive components were added into PCL/starch composites for preparation of antibacterial and biocompatible materials for *** present work provides a new method to develop novel low-temperature FDM materials with various functions.

关键词： Fused deposition modelling Melt blending Polycaprolactone Composite Antibacterial

A New Homogenizing Technology to Obtain Rosmarinic Acid from Perilla Oil Meal

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Chinese Herbal Medicines 2012年第1期4卷 70-73页

作者： Wei-zhuo TANG[a] Yan-ze LIU[b][c] yu-qing zhao[a][d] Shenyang Pharmaceutical University Shenyang 110016 China Bio-Organic and Natural Product Laboratory MRC 311 McLean Hospital/Harvard Medical School MA 02478 USA Institute of Medicinal Plant Development Chinese Academy of Medical Sciences Beijing 100193 Shenyang Pharmaceutical University Shenyang 110016 China Key Laboratory of Structure-Based Drug Design & Discovery Ministry of Education Shenyang Pharmaceutical University Shenyang 110016 China

Objective To optimize the extraction technology of the active component, rosmarinic acid, an ester of caffeic acid and 3,4-dihydroxyphenyllactic acid, in perilla oil meal for the first time by a new homogenizing technology called smashing tissue extraction (STE). Methods Orthogonal design was used to optimize the extraction condition. The content of rosmarinic acid was quantified from the methanol crude extract with the help of HPLC. Results The optimization of STE process to get rosmarinic acid from the perilla oil meal was the ratio of liquid to solid material at 10:1 and the power of extraction at 150 V, extracting twice (2 min for each time). Conclusion STE could be applied to extracting the active ingredients from the oil meals due to its high extraction efficiency. This new homogenizing technology has advantages on saving extraction time, raising extraction efficiency, and maintaining the temperature sensitive constituents.

关键词： HPLC perilla oil meal rosmarinic acid smashing tissue extraction tissue homogenizing technology

Optimization of Smashing Tissue Extraction Technology of Schisandra chinensis Fruits by Orthogonal Test

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Chinese Herbal Medicines 2012年第3期4卷 259-262页

作者： yun TANG[a] Yan-ze LIU[b][c] Ling HAN[d] yu-qing zhao[a][e] Shenyang Pharmaceutical University Shenyang 110016China Institute of Medicinal Plant DevelopmentChinese Academy of Medical SciencesBeijing 100193China Bio-organic and Natural Product Laboratory McLean Hospital/Harvard Medical SchoolMA 02478USA Shenyang Pharmaceutical UniversityShenyang 110016China Key Laboratory of Structure-Based Drug Design & Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China

Objective To optimize the extract technology of active lignins from the fruits of Schisandra chinensis. Methods The content of schizandrin, gomisin A, and deoxyschizandrin were selected as standards to evaluate the efficiency of smashing tissue extraction (STE). Solid-liquid ratio, extracting times, ethanol concentration, and extracting time were investigated through orthogonal test. Results The optimized conditions for STE were ten times amount of 80% EtOH, extracting for three times, and 2 min for each time. Conclusion STE could obtain relatively higher yield, simplicity of operation, and benefit for environment protection. It could be better choice for the extraction of S. chinensis.

关键词： deoxyschizandrin gomisin A orthogonal test Schisandra chinensis schizandrin smashing tissue extraction

Progress in preventive effects of cordyceps sinensis on ischemic brain

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中国药理学与毒理学杂志 2017年第10期31卷 985-986页

作者： Xue BAI yu-qing zhao Chao-feng LI Yi-bo TANG Zhen-quan LIU Beijing University of Chinese Medicine Beijing 100029

Cerebral ischemia is due to cerebral blood supply disorders caused by ischemia and hypoxia resulting in localized ischemic brain necrosis or brain softening of the disease,leading to irreversible brain damage and subsequent loss of neuronal function is a serious threat to human health One of several *** patients with cerebral ischemia,often the lack of effective and extensive *** addition,cerebral ischemia with morbidity,morbidity and mortality are characterized by high,so by the medical profession at home and abroad *** a traditional Chinese medicine,cordyceps sinensis(CS)is a complex of ergot fungus,which is parasitized on the larvae of the bat-moth *** compound is composed of cordycepin,cordyceps polysaccharide,cordyceps sinensis peptides,ergosterol,mannitol,fatty acids and trace elements such as a variety of ingredients,with a wide range of pharmacological *** the years,domestic and foreign scholars on the pharmacological effects of cordyceps sinensis were more comprehensive study of its prevention and treatment of cerebral ischemia is also deepening,found that cordyceps sinensis on cerebral ischemia with anti-inflammatory,reduce oxidative damage and neuronal ischemia damage,reduce neuronal apoptosis,improve memory cognition,reduce thrombosis,inhibit NO production,enhance mitochondrial energy supply,scavenging free radicals and other prevention and *** no relevant *** this paper,the domestic and foreign literatures on the prevention and treatment of cerebral ischemia by cordyceps sinensis were summarized,analyzed and summarized in order to provide useful information for the research and further development of cordyceps sinensis.

关键词： cordyceps sinensis cerebral ischemia preventive effect progress