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海藻酸钠-活性炭固定化藻菌球的制备及其对碱性橙Ⅱ的降解

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中国环境科学 2024年第2期44卷 781-792页

作者：赵联芳丁奎元于雪晴河海大学环境学院江苏南京210098 河海大学浅水湖泊综合治理与资源开发教育部重点实验室江苏南京210098

以海藻酸钠和活性炭为包埋剂、CaCl_(2)为交联剂,采用吸附-包埋法制备了固定化藻菌球,处理偶氮染料碱性橙Ⅱ.通过响应面法优化了制备条件,采用扫描电镜观察了藻菌球外部和内部的结构,并考察了其重复利用性能.结果表明,藻菌球的最佳制备... 详细信息

以海藻酸钠和活性炭为包埋剂、CaCl_(2)为交联剂,采用吸附-包埋法制备了固定化藻菌球,处理偶氮染料碱性橙Ⅱ.通过响应面法优化了制备条件,采用扫描电镜观察了藻菌球外部和内部的结构,并考察了其重复利用性能.结果表明,藻菌球的最佳制备条件为:海藻酸钠、活性炭、CaCl_(2)质量浓度分别为2.58%、0.838%、2%;固定化生物量为1.139%(质量浓度),泥和藻的质量比为2:1;固定化时间为14h.当进水染料浓度在50~250mg/L,进水pH值在6~10.5范围内,脱色率均可达到90%以上,TOC的去除率在74%~90%之间.由紫外-可见全波长扫描图谱和GC-MS扫描图谱可知,碱性橙Ⅱ中的氮氮双键、共轭体系以及苯环结构均被破坏,发生脱色降解反应,实现了对该偶氮染料的矿化.藻菌球经过5次重复利用,仍可保持较高的脱色率和TOC去除率.

关键词：藻菌共生系统固定化响应面法碱性橙Ⅱ 降解过程

Physical Simulation of Molten Slag Granulation by Rotary Disk

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Journal of Iron and Steel Research International 2013年第9期20卷 26-32页

作者： MIN Yi HUANG Jian LIU Cheng-jun JIANG Mao-fa yu xue-qing School of Materials and Metallurgy Northeastern University Benxi Steel Group Corporation

A physical model of molten slag granulation by rotary disk was developed based on the mechanism of New-tonian liquid granulation. For geometrical similarity, the radius ratio of model disk to the prototype disk was chosen as 1 ： 1. For dynamic similarity, equality of Ohnesorge number between the model and the prototype was achieved firstly by compounding rosin and paraffin wax with mass ratio of 4 ~ 1 as simulation liquid of molten blast furnace （BF） slag, and the simulation material can satisfy the similarity of liquid solid transformation during falling in the medium; then equality of Reynolds number and Weber number was obtained by controlling the volumetric flow rate and the rotary speed, respectively. Model accuracy was verified by comparing the simulation data with the results re ported in literature, which showed good agreement with the calculation results of empirical equation and the actual molten BF slag granulation from the view point of particle size. Furthermore, influences of disk radius, rotary speed and liquid flow rate on granulation were discussed using the developed model, and the Kitamura equation was modi-fied according to the simulation data which can predict particle size more accurately. Using the modified equation, the operation parameters were predicted according to the flow rate of molten industrial BF slag.

关键词： physical model simulation liquid molten slag granulation rotary disk

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IgA肾病研究的现状、问题与对策

实用医院临床杂志 2024年第1期21卷 1-4页

作者：李明司美君蔡凤桃余学清广东省人民医院广东省医学科学院

IgA肾病是全球范围内最常见的原发性肾小球肾炎，是终末期肾脏病的主要病因之一。种族和地域差异及家族聚集性均提示遗传因素在IgA肾病的发病中起着一定的作用，同时免疫系统异常及糖基化缺失IgA1的产生也与IgA肾病的发病密切相关。研究... 详细信息

IgA肾病是全球范围内最常见的原发性肾小球肾炎，是终末期肾脏病的主要病因之一。种族和地域差异及家族聚集性均提示遗传因素在IgA肾病的发病中起着一定的作用，同时免疫系统异常及糖基化缺失IgA1的产生也与IgA肾病的发病密切相关。研究IgA肾病的病因及发病机制对IgA肾病的诊断、治疗和预后有重要意义。本文对IgA肾病的遗传学研究、发病机制、微生物及代谢物组学及靶向药物等方面进行了相关的综述。

关键词： IgA肾病糖基化缺失IgA1 遗传学研究微生物及代谢物靶向药物

Kidney disease in China： recent progress and prospects

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Chinese Medical Journal 2009年第17期122卷 2048-2053页

作者： yu xue-qing WEI Jia-li Department of Nephrology First Affiliated Hospital of Sun Yat-senUniversity Guangzhou Guangdong 510080 China

Kidney disease is a worldwide public health *** prevalence of end-stage renal disease （ESRD）, a final outcome of kidney disease, has increased progressively in the past decades and has emerged as a great burden to the healthcare system in China. Glomerulonephritis is still the most common cause of ESRD in China. However, the prevalence of diabetes and hypertension are increasing dramatically. There are modifiable risk factors for the development of progressive renal dysfunction. The challenge is to identify the disease and deliver effective therapies at the right time with the right tools. In the last two years,

关键词： kidney disease progress China

Open-Shell Oligomers and Polymers: Theory, Characterization Methods, Molecular Design, and Applications

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Chinese Journal of Polymer Science 2024年第4期42卷 417-436页

作者： xue-qing Wang Cheng Song Ting Lei Key Laboratory of Polymer Chemistry and Physics(Ministry of Education) School of Materials Science and EngineeringPeking UniversityBeijing100871China

Open-shell oligomers and polymers have exhibited intriguing electronic and magnetic properties, making them highly desirable for a wide range of applications, including ambipolar organic field-effect transistors (OFETs), photodetectors, organic thermoelectrics, and spintronics. Although open-shell ground states have been observed in certain small molecules and doped organic semiconductors, the exploration of open-shell ground-state conjugated polymers is still limited, and the strategies for designing these polymers remain obscure. This review aims to briefly introduce the theory and characterization methods of open-shell conjugated polymers, along with an overview of recent progress and applications. The objective is to stimulate further advancements and investigations in this promising area by shedding light on the potential of open-shell conjugated polymers and the challenges that lie ahead.

关键词： Conjugated polymers Open-shell molecules High-spin ground state Donor-acceptor(D-A)polymers Optoelectronic and magnetic properties

Long non-coding RNAs as novel diagnostic and therapeutic targets in kidney disease

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Chronic Diseases and Translational Medicine 2019年第4期5卷 252-257页

作者： Qin Zhou Wei Chen xue-qing yu Department of Nephrology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China National Health Commission Key Laboratory of Nephrology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China Guangdong Provincial Key Laboratory of Nephrology The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong 510080China Guangdong General Hospital GuangzhouGuangdong510080China

Long non-coding RNAs(IncRNAs)have critical roles in the development of many diseases including kidney *** increasing number of studies have shown that IncRNAs are involved in kidney development and that their dysregulation can result in distinct disease processes,including acute kidney injury(AKI),chronic kidney disease(CKD),and renal cell carcinoma(RCC).Understanding the roles of IncRNAs in kidney disease may provide new diagnostic and therapeutic opportunities in the *** review provides an overview of IncRNA characteristics,biological function and discusses specific studies that provide insight into the function and potential application of IncRNAs in kidney disease treatment.

关键词： Long non-coding RNAs Kidney disease Renal inflammation Renal fibrosis Diabetic nephritis Renal cell carcinoma

All types of base conversions allowed by base editors

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Science China(Life Sciences) 2024年第2期67卷 431-433页

作者： Shun-qing Liang Wen xue RNA Therapeutics Institute UMass Chan Medical SchoolWorcester 01655USA Department of Molecular Cell and Cancer BiologyUMass Chan Medical SchoolWorcester 01655USA Department of Molecular Medicine UMass Chan Medical SchoolWorcester 01655USA Li Weibo Institute for Rare Diseases Research UMass Chan Medical SchoolWorcester 01655USA

Base editors(BEs) hold great promise as tools for introducing single-base-pair changes in both basic research and therapeutic applications(Rees and Liu,2018).Base editors are composed of a Cas9 nickase fused to a DNA-modifying enzyme,which chemically modifies nucleobases within a specific targeting window near the Cas9-binding site.

关键词： base bases allowed

Features and formulae of sediment incipient motion in vegetated flow environment

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Journal of Hydrodynamics 2024年第2期36卷 331-339页

作者： yu-xuan Xu Wei-jie Wang Shi-bao Zhang Han-qing Zhao xue-kai Chen Hai-ping Zhang School of Water Conservancy North China University of Water Resources and Electric PowerZhengzhou450045China State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin China Institute of Water Resources and Hydropower ResearchBeijing100038China China Three Gorges Corporation Wuhan430010China

Aquatic vegetation is a vital component of natural river ecosystems,playing a crucial role in maintaining ecological balance,providing habitat and improving water ***,the presence of vegetation results in increased resistance in vegetated channels compared with non-vegetated channels,rendering traditional sediment movement predictions inadequate for the ***,the concept of a vegetation influence factor,denoted by CDah,has been proposed by previous researchers to represent the effect of vegetation on sediment movement in *** this study,we focus on exploring the vegetation resistance coefficient(CD)among the vegetation influence factors,evaluating two different calculation methods for vegetation resistance coefficient,and presenting two expressions through genetic algorithm analysis to predict the incipient flow velocity of sediment in vegetated *** predicted values from the new formulae show excellent agreement with measured data,highlighting the high accuracy of the proposed methods in predicting the incipient flow velocity of *** results provide a solid theoretical basis for understanding the influence of aquatic vegetation on sediment particle movement.

关键词： Vegetation flow vegetation resistance coefficient genetic algorithm sediment initiation

A Predictive Model for Estimation Risk of Proliferative Lupus Nephritis

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Chinese Medical Journal 2018年第11期131卷 1275-1281页

作者： Dong-Ni Chen Li Fan yu-Xi Wu Qian Zhou Wei Chen xue-qing yu Department of Nephrology The First Affiliated Hospital Sun Yat-sen University Key Laboratory of Nephrology Ministry of Health and Guangdong Province Guangzhou Guangdong 510080 China Clinical Trials Unit The First Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510080 China Department of Nephrology The First Affiliated Hospital Sun Yat-sen University Guangdong 510080 Key Laboratory of Nephrology Ministry of Health and Guangdong Province Guangzhou Guangdong 510080 Guangdong Medical University Zhanjiang Guangdong 524023 China

Background： Lupus nephritis （LN） is classified by renal biopsy into proliferative and nonproliferative forms, with distinct prognoses, but renal biopsy is not available for every LN patient. The present study aimed to establish an alternate tool by building a predictive model to evaluate the probability of proliferative LN. Methods： In this retrospective cohort with biopsy-proven LN, 382 patients in development cohort, 193 in internal validation cohort, and 164 newly diagnosed patients in external validation cohort were selected. Logistic regression model was established, and the concordance statistics （C-statistics）, Akaike information criterion （AIC）, integrated discrimination improvement, Hosmer-Lemeshow test, and net reclassification improvement were calculated to evaluate the performance and validation of models. Results： The prevalence of proliferative LN was 77.7% in the whole cohort. A model, including age, gender, systolic blood pressure, hemoglobin, proteinuria, hematuria, and serum C3, performed well on good-of-fit and discrimination in the development chohort to predict the risk of proliferative LN （291 for AIC and 0.84 for C-statistics）. In the internal and external validation cohorts, this model showed good capability for discrimination and calibration （0.84 and 0.82 for C-statistics, and 0.99 and 0.75 for P values, respectively）. Conclusion： This study developed and validated a model including demographic and clinical indices to evaluate the probability of presenting proliferative LN to guide therapeutic decisions and outcomes.

关键词： Biopsy Lupus Nephritis Nomogram Predictive Value of Tests Risk Factors