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Detection of Syndecan-1 and Heparanase-1 Genes in Esophageal Carcinoma by Quantitative RT-PCR

Clinical oncology and cancer researeh 2010年第4期7卷 253-258页

作者： Jun-li SI yu-qin qi Jing-yuan CUI Song-mei WANG He WANG Mei LU Department of Gastroenterology Affiliated Qingdao Municipal Hospital of Qingdao University Medical College Qingdao 266011 Shan- dong Province China. Department of General Surgery Affiliated Qingdao Municipal Hospital of Qingdao University Medical College Qingdao 266011 Shandong Province China. Department of Hepatology Qingdao Infectious Diseases Hospital Qingdao 266033 Shandong Province China.

OBJECTIVE To quantitatively explore the expression of Syndecan-1 and heparanase-1 in esophageal cancer tissue as well as their relationship with the clinicopathological factors, in order to evaluate their roles in tumor invasion and *** Real-time fluorescence quantitative PCR （Q-PCR） was used to analyze the expression levels of Syndecan-1 and heparanase-1 genes￡？participants included 67 cases with esophageal cancers and 32 healthy *** The expression of Heparanase-1 gene in esophageal cancers was higher than that in normal esophageal tissue （P 〈 0.001）, and the expression of Syndecan-1 gene in the normal esophageal tissue was higher compared with esophageal cancers （P 〈 0.001）. The positive rates of Syndecan-1 and Heparanase-1 gene in esophageal cancer were 13.4% （9/67） and 85.1% （57/67）.The expression of Syndecan-1 and Heparanase-1 genes was signifi cantly related to di. erentiation, depth of infi ltration, lymph node metastasis, vessel metastasis, and TNM stages of disease （P 〈 0.05）. In an attempt to measure the association between the 2 agents, this study found that the expression of Syndecan-1 mRNA had a significantly negative correlation with the expression of Heparanase-1 mRNA by using Spearman rank correlation test （OR = -0.572, P 〈 0.001）.CONCLUSION Syndecan-1 and Heparanase-1 play important roles in the invasion and metastasis of esophageal cancer. The reduction of Syndecan-1 and/or the increase of Heparanase-1 may influence the invasion and metastasis of malignant *** the combination assay of Syndecan-1 and Heparanase-1 may contribute to the diagnosis and treatment of malignant tumors.

关键词： Syndecan-1 esophageal neoplasms neoplasm invasiveness neoplasm metastasis PCR

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Structural mapping on nucleoproteins of nonsegmented negative-sense RNA viruses

Structural mapping on nucleoproteins of nonsegmented negativ...

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第六届全国冷冻电子显微学与结构生物学专题研讨会

作者： Shan HONG Na ZHANG yu-qi qin qing-Tao SHEN iHuman Institute ShanghaiTech University

The nucleoprotein (N) of non-segmented negative-sense RNA viruses, such as Measles,Ebola and Newcastle disease viruses (NDV), enwrap viral genomic RNAs and assemble them into helical filaments which serve as the template for replication and transcription. Using cryo-Electron Microscopy, we identified and resolved NDV N forming a 4.8?resolution clam-shaped structure with two single-turn spirals packing in a back-to-back mode, which have not been reported before.

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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo qi Han Tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

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Electrocatalytic cleavage of a lignin β-O-4 model compound and coupling with nitrogen-containing aromatics using Prussian blue analogue-derived nickel–cobalt spinel

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Journal of Energy Chemistry 2025年第1期100卷 628-636页

作者： Yi qi Xueying Chen Bowen Liu Xuliang Lin Xueqing qiu Yanlin qin Guangdong Provincial Key Laboratory of Plant Resources Biorefinery School of Chemical Engineering and Light Industry Guangdong University of Technology Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Guangdong Basic Research Center of Excellence for Ecological Security and Green Development Guangdong University of Technology

Electrochemical conversion of lignin for the production of high-value heterocyclic aromatic compounds has great *** demonstrate the targeted synthesis and cation modulation of NiCo2O4spinel nanoboxes,synthesized via cation exchange and calcination *** catalysts exhibit excellent efficacy in the electrocatalytic conversion of lignin model compounds,specifically 2-phenoxy-1-phenylethanol,into nitrogen-containing aromatics,achieving high conversion rates and *** catalysts were synthesized via a cation exchange and calcination oxidation process,using Prussian blue nanocubes as *** porous architecture and polymetallic composition of the NiCo2O4spinel demonstrated superior performance in electrocatalytic oxidative coupling,achieving a 99.2 wt%conversion rate of the 2-phenoxy-1-phenylethanol with selectivities of 37.5 wt%for quinoline derivatives and 31.5 wt%for *** innovations include the development of a sustainable one-pot synthesis method for quinoline derivatives,the elucidation of a multistage reaction pathway involving CAO bond cleavage,hydroxyaldol condensation,and CAN bond formation,and a deeper mechanistic understanding derived from DFT *** work establishes a new strategy for lignin valorization,offering a sustainable route to produce high-value nitrogen-containing aromatics from renewable biomass under mild conditions,without the need for additional reagents.

关键词： Spinel Biomass valorization Electrocatalysis Lignin oxidation Coupling

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老年人多原了癌14例分析

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中华老年医学杂志 1991年第1期10卷 33-35页

作者：齐玉琴王年吉 210002

报道14例经病理证实符合Warren标准的老年人多原发癌，占同期住院老年人恶性肿瘤总例数的2.4%。其中肺的双原发癌2例，肺与其它器官合并的多原发癌5例，肺癌占本组首位。第一癌与第二癌的时间间隔最长者为13年，平均5年5个月。对第一癌... 详细信息

报道14例经病理证实符合Warren标准的老年人多原发癌，占同期住院老年人恶性肿瘤总例数的2.4%。其中肺的双原发癌2例，肺与其它器官合并的多原发癌5例，肺癌占本组首位。第一癌与第二癌的时间间隔最长者为13年，平均5年5个月。对第一癌治疗，手术5例，手术加化疗4例，手术加放疗1例，放射治疗3例，1例放弃治疗。14例中，至今存活7例，其中11～14年者2例，4～5年2例，1年～1年半3例。我们对本组多原发癌患病率高的原因、发病因素、间隔时间和癌肿组合的特点等进行了分析。

关键词：老年人多原发性肿瘤

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用于MEMS陀螺阵列信号处理的OBE平滑算法（英文）

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中国惯性技术学报 2017年第1期25卷 109-114页

作者：沈强刘洁瑜王琪秦伟伟火箭军工程大学控制工程系西安710025

为提高MEMS陀螺的精度,提出了一种基于最优定界椭球(OBE)的平滑算法,并将其用于陀螺阵列信号的处理。首先,利用多个相同型号的MEMS陀螺构成阵列,测量同一角速率信号,并建立数据融合模型。对于融合问题而言,噪声统计特性的不确定会导致... 详细信息

为提高MEMS陀螺的精度,提出了一种基于最优定界椭球(OBE)的平滑算法,并将其用于陀螺阵列信号的处理。首先,利用多个相同型号的MEMS陀螺构成阵列,测量同一角速率信号,并建立数据融合模型。对于融合问题而言,噪声统计特性的不确定会导致传统融合方法精度下降。为解决该问题,引入仅要求噪声未知但有界的集员估计理论,结合RTS平滑思想,提出一种新的平滑算法作为融合方法,它由前向滤波和反向平滑两个过程构成:前者采用集员估计理论中的OBE滤波估计角速率,后者则逆序执行OBE算法进一步提高估计精度。实验表明:该方法能够将陀螺的静态漂移由0.5130(°)/s降低到0.1368(°)/s;动态条件下,在有效跟踪载体角度变化的同时,将漂移由0.5343(°)/s降低到0.1704(°)/s,显著提高了陀螺的使用精度。

关键词： MEMS陀螺阵列数据融合集员估计 RTS平滑 OBE算法

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174例糖耐量正常人群HbA_1c结果分析

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中国糖尿病杂志 2011年第11期19卷 812-815页

作者：王娈马瑞欣綦玉琴青岛大学医学院附属医院内分泌科 266003

目的分析HbA_1c在糖耐量正常(NGT)人群中的分布特点及相关因素。方法对健康体检和糖尿病筛查者进行75g OGTT试验,同时检测HbA_1c、血尿常规、FPG、2hPG及血生化,所有参加者进行人体学测量。将174名NGT人群的结果纳入分析,比较HbA_1c在... 详细信息

目的分析HbA_1c在糖耐量正常(NGT)人群中的分布特点及相关因素。方法对健康体检和糖尿病筛查者进行75g OGTT试验,同时检测HbA_1c、血尿常规、FPG、2hPG及血生化,所有参加者进行人体学测量。将174名NGT人群的结果纳入分析,比较HbA_1c在不同性别及年龄组间的差异,用线性回归方法分析HbA_1c与年龄、FPG和2hPG的相关性;根据HbA_1c结果分为≤5.6%和5.7%～6.4%两组,比较两组的临床特点。结果 NGT人群的HbA_1c呈正态分布,结果是(5.62±0.38)%,95%CI为4.88%～6.36%;不同性别间HbA_1c无统计学差异;青年组(16～44岁)的HbA_1c及FPG分别与中年组(45～59岁)和老年组(60～79岁)间均有统计学差异(P<0.01),而2hPG无统计学差异;HbA_1c≤5.6%和5.7%～6.4%组的年龄、血TG水平、FPG和2hPG均有统计学差异(P<0.01或P<0.05)。结论应建立本实验室HbA_1c的正常参考值范围;NGT人群的HbA_1c随年龄的增长而升高,并与FPG呈正相关;处于高危HbA_1c范围的非糖尿病人群应加强对FPG、2hPG和TG的监测。

关键词：糖化血红蛋白参考范围年龄空腹血浆葡萄糖甘油三酯

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Cross-subcarrier precoder design for massive MIMO-OFDM downlink with symplectic optimization

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Science China(Information Sciences) 2025年

作者： yu-Xuan ZHANG An-An LU Xiang-Gen XIA Xi-qi GAO National Mobile Communications Research Laboratory Southeast University Purple Mountain Laboratories Department of Electrical and Computer Engineering University of Delaware

We propose a cross-subcarrier precoder design(CSPD) for massive multiple-input multiple-output(MIMO) orthogonal frequency division multiplexing(OFDM) downlink. This work aims to significantly improve the channel estimation and signal detection performance by enhancing the smoothness of the frequency domain effective channel. This is accomplished by designing a few vectors known as the transform domain precoding vectors(TDPVs), which are then transformed into the frequency domain to generate the precoders for a set of subcarriers. To combat the effect of channel aging, the TDPVs are optimized under imperfect channel state information(CSI). The optimal precoder structure is derived by maximizing an upper bound of the ergodic weighted sum-rate(WSR) and utilizing the a posteriori beam-based statistical channel model(BSCM). To avoid the large-dimensional matrix inversion, we propose an algorithm with symplectic optimization. Simulation results indicate that the proposed cross-subcarrier precoder design significantly outperforms conventional methods.

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Multilevel analysis of the central-peripheral-target organ pathway:contributing to recovery after peripheral nerve injury

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Neural Regeneration Research 2025年第10期20卷 2807-2822页

作者： Xizi Song Ruixin Li Xiaolei Chu qi Li Ruihua Li qingwen Li Kai-yu Tong Xiaosong Gu Dong Ming Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Haihe Laboratory of Brain-Machine Interface and Human-Machine Fusion TianjinChina Department of Rehabilitation Tianjin University Tianjin HospitalTianjinChina Department of Hand Microsurgery Tianjin University Tianjin HospitalTianjinChina School of Exercise and Health Tianjin University of SportTianjinChina Department of Biomedical Engineering the Chinese University of Hong KongHong Kong Special Administrative RegionChina

Peripheral nerve injury is a common neurological condition that often leads to severe functional limitations and *** on the pathogenesis of peripheral nerve injury has focused on pathological changes at individual injury sites,neglecting multilevel pathological analysis of the overall nervous system and target *** has led to restrictions on current therapeutic *** this paper,we first summarize the potential mechanisms of peripheral nerve injury from a holistic perspective,covering the central nervous system,peripheral nervous system,and target *** peripheral nerve injury,the cortical plasticity of the brain is altered due to damage to and regeneration of peripheral nerves;changes such as neuronal apoptosis and axonal demyelination occur in the spinal *** nerve will undergo axonal regeneration,activation of Schwann cells,inflammatory response,and vascular system regeneration at the injury *** damage to target organs can occur,including skeletal muscle atrophy and sensory receptor *** then provide a brief review of the research advances in therapeutic approaches to peripheral nerve *** main current treatments are conducted passively and include physical factor rehabilitation,pharmacological treatments,cell-based therapies,and physical ***,most treatments only partially address the problem and cannot complete the systematic recovery of the entire central nervous system-peripheral nervous system-target organ ***,we should further explore multilevel treatment options that produce effective,long-lasting results,perhaps requiring a combination of passive(traditional)and active(novel)treatment methods to stimulate rehabilitation at the central-peripheral-target organ levels to achieve better functional recovery.

关键词： central nervous system central peripheral target organ multilevel pathological analysis nerve regeneration peripheral nerve injury peripheral nervous system target organs therapeutic approach

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牛乳中五种无机元素含量测定

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青海畜牧兽医杂志 2007年第1期37卷 17-18页

作者：祁玉琴青海省天峻县新源镇畜牧兽医工作站天峻817200

对西宁奶牛场34头荷斯坦奶牛乳中钾、钠、氯、总钙、总磷、无机磷、结合磷的含量进行了测定,结果为:钾,34.49±8.42(mmol/L);钠,37.61±26.88(mmol/L);氯,35.18±11.72(mmol/L);总钙,26.25±4.72(mmol/L);总磷,25.58±6.00(mmol/L);无机... 详细信息

关键词：牛乳无机元素荷斯坦奶牛

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