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Diagnosis and treatment experience of atypical hepatic cystic echinococcosis type 1 at a tertiary center in China

World Journal of Gastroenterology 2024年第5期30卷 462-470页

作者： yu-peng li Jie Zhang Zhi-De li Chao Ma Guang-Lei Tian yuan Meng Xiong Chen Zhi-Gang Ma Department of Hepatobiliary Surgery People's Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830000Xinjiang Uygur Autonomous RegionChina

BACKGROUND Some hydatid cysts of cystic echinococcosis type 1(CE1)lack well-defined cyst walls or distinctive endocysts,making them difficult to differentiate from simple hepatic *** To investigate the diagnostic methods for atypical hepatic CE1 and the clinical efficacy of laparoscopic *** The clinical data of 93 patients who had a history of visiting endemic areas of CE and were diagnosed with cystic liver lesions for the first time at the People's Hospital of Xinjiang Uygur Autonomous Region(China)from January 2018 to September 2023 were retrospectively *** diagnoses were made based on findings from serum immunoglobulin tests for echinococcosis,routine abdominal ultrasound,high-frequency ultrasound,abdominal computed tomography(CT)scan,and *** to the treatments,these patients underwent reexaminations at the outpatient clinic until October *** evaluations included the diagnostic precision of diverse examinations,the efficacy of surgical approaches,and the incidence of CE *** All 93 patients were diagnosed with simple hepatic cysts by conventional abdominal ultrasound and abdominal CT *** them,16 patients were preoperatively diagnosed with atypical CE1,and 77 were diagnosed with simple hepatic cysts by high-frequency *** the 16 patients preoperatively diagnosed with atypical CE1 underwent laparoscopy,of whom 14 patients were intraoperatively confirmed to have CE1,which was consistent with the postoperative pathological diagnosis,one patient was diagnosed with a mesothelial cyst of the liver,and the other was diagnosed with a hepatic cyst combined with local *** the 77 patients who were preoperatively diagnosed with simple hepatic cysts,4 received aspiration sclerotherapy of hepatic cysts,and 19 received laparoscopic *** patients were intraoperatively diagnosed with simple hepatic *** the followup period,none of the 14 patients with CE1 expe

关键词： Hepatic echinococcosis Hepatic cystic echinococcosis type 1 Hepatic cyst Color Doppler ultrasound Laparoscopy

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Deep learning characterization of rock conditions based on tunnel boring machine data

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Underground Space 2023年第5期12卷 89-101页

作者： Xu li Min Yao Ji-dong yuan yu-jie Wang peng-yu li Key Laboratory of Urban Underground Engineering of Ministry of Education Beijing Jiaotong UniversityBeijing 100044China School of Computer and Information Technology Beijing Jiaotong UniversityBeijing 100044China China Institute of Water Resources and Hydropower Research Beijing 100048China China Railway Engineering Equipment Group Co. Ltd.Zhengzhou 450000China

Rock condition perception based on tunnel boring machine(TBM)data is of great importance for not only ensuring tunnel boring safety but also improving construction *** prediction of TBM boring responses(i.e.,torque and total thrust of the cutterhead)largely determines the reliability of rock condition *** this paper,a new architecture of a two-dimensional convolutional neural network(2D-CNN)with a dual-input strategy is proposed to predict the TBM *** TBM Lot 3 of the Yinsong project in Jilin province,China,is taken as the case study in this *** types of models that follow different learning strategies are compared:one is defined as the point model,which only learns data of the stable phase,and the other is defined as the line model,which learns data from both the loading and stable boring *** line model is further improved by the weighted loss function *** results indicate that the strategy of learning data from both the loading phase and stable boring phase and increasing the weight of samples from the stable phase is shown to be optimal in predicting TBM boring *** terms of learning strategies,the line model can learn the influence of active control parameters on passive response parameters,but the point model *** terms of machine learning algorithms,2D-CNN has the best performance,with R2 values of 0.865 and 0.923 for torque and total thrust,*** proposed line model can overcome the problem that the traditional model failed to learn the influence of control *** a model can provide a solid base for the timely optimization of the control parameters in TBM boring process.

关键词： TBM Rock condition perception 2D-CNN Weighted loss function line model

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Climatologic comparison of HadISST1 and TMI sea surface temperature datasets

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Science China Earth Sciences 2011年第8期54卷 1238-1247页

作者： WANG yu liU peng li TianYi FU yunFei Laboratory of Atmospheric Observation and Climatological Environment School of Earth and Space Sciences University of Science and Technology of China Hefei 230026 China

Two monthly datasets of sea surface temperature (SST),TMI SST retrieved from satellite observations by Remote Sensing System and HadISST1 (Hadley Centre Sea-ice and Sea-surface Temperature Data Set Version 1) derived from in situ measurements by Hadley Centre,were compared on climatologic multiple time scales over tropical and subtropical areas from 1998 to *** indicate that there is a good consistency in the horizontal global distribution,with 1.0° resolution on multi-year and multi-season mean scales between the two datasets,and also in the time series of global mean SST ***,there are still some significant differences between the ***,TMI SST is relatively higher than *** addition,the differences between the two datasets show not only remarkable regionality,but also distinct seasonal ***,the maximum departure occurs in summer,while theminimum takes place in *** all seasons,over 30% of the regions in the Tropical and Subtropical areas have a difference of more than 0.3°*** analysis of the SST anomaly field also shows that there are differences between the two datasets,where HadISST1 has more significant statistical characteristics than TMI *** the other hand,results show that the difference between the two datasets is related to the vertical structure of ocean temperatures,as well as other simultaneously retrieved parameters in TMI products,such as wind speed,water vapor,liquid cloud water and rain *** addition,large biases between HadISST1 and TMI SST are found in coastal regions,where TMI SST cannot be accurately retrieved because of polluted microwave signals.

关键词： sea surface temperature HadISST1 TMI EOF analysis

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Effects of postweld aging on the microstructure and properties of bobbin tool friction stir-welded 6082-T6 aluminum alloy

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International Journal of Minerals,Metallurgy and Materials 2019年第7期26卷 849-857页

作者： yu-peng li Da-qian Sun Wen-biao Gong liang liu Key Laboratory of Automobile Materials Ministry of Education Jilin University Changchun 130025 China School of Materials Science and Engineering Jilin University Changchun 130025 China Key Laboratory of Advanced Structural Materials Ministry of Education Changchun University of Technology Changchun 130012 China School of Materials Science and Engineering Changchun University of Technology Changchun 130012 China

Samples of 6082-T6 aluminum alloy were subjected to bobbin tool friction stir welding (BT-FSW), and the joints were treated by postweld natural aging (PWNA) and postweld artificial aging (PWAA). The microstructure, microhardness, and tensile properties of the aged and as-welded specimens were investigated. Transmission electron microscopy (TEM) observations revealed that a large number of Guinier–Preston (GP) zones precipitated in the form of a network on the stir zone (SZ) after PWNA for 60 d, and a large number of β'' phases precipitated in the matrix for after PWAA for 6 h. As the aging time increased, the microhardness of the SZ and the thermomechanically affected zone (TMAZ) increased significantly, and the hardness of the SZ after PWAA for 6 h was close to that of the base metal (BM). With increasing PWNA time, the strength and strain increased slightly. When the PWAA time increased, the strength clearly increased, with a maximum value of 279.9 MPa after 6 h, while the strain decreased.

关键词： postweld aging aluminum alloys bobbin tool friction stir welding microstructure properties

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Fourth-order phase-field modeling for brittle fracture in piezoelectric materials

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Applied Mathematics and Mechanics(English Edition) 2024年第5期45卷 837-856页

作者： yu TAN Fan peng Chang liU Daiming peng Xiangyu li State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China College of Science Chang'an UniversityXi'an 710064China Applied Mechanics and Structure Safety Key Laboratory of Sichuan Province School of Mechanics and Aerospace EngineeringSouthwest Jiaotong UniversityChengdu 610031China

Failure analyses of piezoelectric structures and devices are of engineering and scientific *** this paper,a fourth-order phase-field fracture model for piezoelectric solids is developed based on the Hamilton *** typical electric boundary conditions are involved in the present model to characterize the fracture behaviors in various physical situations.A staggered algorithm is used to simulate the crack *** polynomial splines over hierarchical T-meshes(PHT-splines)are adopted as the basis function,which owns the *** numerical simulations are performed to study the influence of the electric boundary conditions and the applied electric field on the fracture behaviors of piezoelectric *** electric boundary conditions may influence crack paths and fracture loads *** present research may be helpful for the reliability evaluation of the piezoelectric structure in the future applications.

关键词： isogeometric analysis(IGA) brittle fracture fourth-order phase-field model piezoelectric solid

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Ionizable drug delivery systems for efficient and selective gene therapy

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Military Medical Research 2023年第6期10卷 818-847页

作者： yu-Qi Zhang Ran-Ran Guo Yong-Hu Chen Tian-Cheng li Wen-Zhen Du Rong-Wu Xiang Ji-Bin Guan yu-peng li yuan-yu Huang Zhi-Qiang yu Yin Cai peng Zhang Gui-Xia ling Faculty of Medical Device Shenyang Pharmaceutical UniversityShenyang 110016LiaoningChina Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016LiaoningChina School of Pharmacy Yanbian UniversityYanji 133002JilinChina School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016LiaoningChina Masonic Cancer Center University of MinnesotaMinneapolisMN 55455USA Masonic Cancer Center and Department of Medicinal Chemistry University of MinnesotaMinneapolisMN 55455USA Advanced Research Institute of Multidisciplinary Science School of Life ScienceSchool of Medical TechnologyKey Laboratory of Molecular Medicine and BiotherapyKey Laboratory of Medical Molecule Science and Pharmaceutics EngineeringBeijing Institute of TechnologyBeijing 100081China Department of Laboratory Medicine Dongguan Institute of Clinical Cancer ResearchAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523018GuangdongChina Department of Health Technology and Informatics The Hong Kong Polytechnic UniversityHong KongHong Kong SARChina

Gene therapy has shown great potential to treat various diseases by repairing the abnormal gene ***,a great challenge in bringing the nucleic acid formulations to the market is the safe and effective delivery to the specific tissues and *** be excited,the development of ionizable drug delivery systems(IDDSs)has promoted a great breakthrough as evidenced by the approval of the BNT162b2 vaccine for prevention of coronavirus disease 2019(COVID-19)in *** with conventional cationic gene vectors,IDDSs can decrease the toxicity of carriers to cell membranes,and increase cellular uptake and endosomal escape of nucleic acids by their unique pH-responsive *** the progress,there remain necessary requirements for designing more efficient IDDSs for precise gene ***,we systematically classify the IDDSs and summarize the characteristics and advantages of IDDSs in order to explore the underlying design *** delivery mechanisms and therapeutic applications of IDDSs are comprehensively reviewed for the delivery of plasmid DNA(pDNA)and four kinds of *** particular,organ selecting considerations and high-throughput screening are highlighted to explore efficiently multifunctional ionizable nanomaterials with superior gene delivery *** anticipate providing references for researchers to rationally design more efficient and accurate targeted gene delivery systems in the future,and indicate ideas for developing next generation gene vectors.

关键词： Ionizable nanomaterials Ionizable drug delivery systems(IDDSs) Nucleic acids Gene therapy

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Effects of vibration therapy on bone mineral density in postmenopausal women with osteoporosis

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Chinese Medical Journal 2008年第13期121卷 1155-1158页

作者： RUAN Xiang-yan JIN Feng-yu liU yu-lan peng Zhou-li SUN yun-gao Beijing Obstetrics and Gynecology Hospital Capital Medical University Beijing 100026 China

Background Jaw osteonecrosis possibly associated with the administration of bisphosphonates is expected to be treated with a non-pharmacologic approach. This study aimed to determine whether noninvasive, mechanically mediated vibration would inhibit the decline in bone mineral density （BMD） that follows menopause, enhance the BMD of the lumbar and femoral neck, and reduce chronic back pain in postmenopausal women with osteoporosis. Methods A total of 116 postmenopausal women with osteoporosis participated in this study, and they were divided into groups A （66 patients） and B （50）. Group A received vibration treatment （Subjects vertically stand on the vibration platform, with a vibration frequency of 30 Hz, amplitude of 5 mm; they received the treatment five times per week, ten minutes each time and totally for six months）, whereas women of group B served as controls without any treatment. L2-4 BMD, bilateral femoral neck BMD, and body mass index （BMI） were recorded before the treatment or at the third and sixth months of the treatment respectively. After the ending of the treatment, the change of BMD in each group was compared and analyzed. Chronic back pain was evaluated by visual analogue scale （VAS） at baseline and the third and sixth months of the treatment. Results Of the 116 women, 94 including 51 women from group A （（61.23±8.20） years） and 43 women from group B （（63.73±5.45） years）, completed the study. There were no significant differences in baseline characteristics including age, BMI, menopausal years, lumbar BMD, femoral neck BMD, and VAS between the two groups. The lumbar BMD of the 51 women in group A increased by 1.3% （P=0.034） after vibration treatment for 3 months and by 4.3% at the sixth month （P=0.000）. The lumbar BMD in group B was decreased at the third month, but there was not statistical significance （P〉0.05） At the sixth month, it was decreased by 1.9% （P 〈0.05）. The femoral neck BMD of the 51 women in group A was slightly increased after

关键词： postmenopausal women vibration treatment osteoporosis bone mineral density

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Machine Learning-based Identification of Contaminated Images in light Curve Data Preprocessing

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Research in Astronomy and Astrophysics 2024年第4期24卷 287-295页

作者： Hui li Rong-Wang li peng Shu yu-Qiang li yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Space Object and Debris Observation Chinese Academy of SciencesNanjing 210023China

Attitude is one of the crucial parameters for space objects and plays a vital role in collision prediction and debris *** light curves to determine attitude is the most commonly used *** photometric observations,outliers may exist in the obtained light curves due to various ***,preprocessing is required to remove these outliers to obtain high quality light *** statistical analysis,the reasons leading to outliers can be categorized into two main types:first,the brightness of the object significantly increases due to the passage of a star nearby,referred to as“stellar contamination,”and second,the brightness markedly decreases due to cloudy cover,referred to as“cloudy contamination.”The traditional approach of manually inspecting images for contamination is time-consuming and ***,we propose the utilization of machine learning methods as a *** Neural Networks and SVMs are employed to identify cases of stellar contamination and cloudy contamination,achieving F1 scores of 1.00 and 0.98 on a test set,*** also explore other machine learning methods such as ResNet-18 and light Gradient Boosting Machine,then conduct comparative analyses of the results.

关键词： techniques:image processing methods:data analysis light pollution

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Room-temperature ferroelectricity in van der Waals SnP_(2)S_(6)

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Frontiers of physics 2024年第4期19卷 113-123页

作者： Chaowei He Jiantian Zhang li Gong peng yu State Key Laboratory of Optoelectronic Materials and Technologies Guangzhou Key Laboratory of Flexible Electronic Materials and Wearable Devices Nanotechnology Research Center School of Materials Science and EngineeringSun Yat-sen UniversityGuangzhou 510275China Instrumental Analysis and Research Center Sun Yat-sen UniversityGuangzhou 510275China

Two-dimensional(2D)ferroelectric materials,which possess electrically switchable spontaneous polarization and can be easily integrated with semiconductor technologies,is of utmost importance in the advancement of high-integration low-power *** the experimental discovery of certain 2D ferroelectric materials such as CuInP2S6 and In2Se3,achieving stable ferroelectricity at room temperature in these materials continues to present a significant ***,stable ferroelectric order at room temperature in the 2D limit is demonstrated in van der Waals SnP_(2)S_(6) atom layers,which can be fabricated via mechanical exfoliation of bulk SnP_(2)S_(6) *** polarization is observed in thin SnP_(2)S_(6) of~7 ***,a van der Waals ferroelectric field-effect transistor(Fe-FET)with ferroelectric SnP_(2)S_(6) as top-gate insulator and ptype WTe0.6Se1.4 as the channel was designed and fabricated successfully,which exhibits a clear clockwise hysteresis loop in transfer characteristics,demonstrating ferroelectric properties of SnP_(2)S_(6) atomic *** addition,a multilayer graphene/SnP_(2)S_(6)/multilayer graphene van der Waals vertical heterostructure phototransistor was also fabricated successfully,exhibiting improved optoelectronic performances with a responsivity(R)of 2.9 A/W and a detectivity(D)of 1.4×10^(12) *** results show that SnP_(2)S_(6) is a promising 2D ferroelectric material for ferroelectric-integrated low-power 2D devices.

关键词： two-dimensional ferroelectric materials ferroelectric fieldeffect transistors photodetectors

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Research on the mechanism of the two-dimensional ultrasonic surface burnishing process to enhance the wear resistance for aluminum alloy

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Friction 2024年第3期12卷 490-509页

作者： Zhen-yu ZHOU Qiu-Yang ZHENG yu li Cong DING Guang-Jian peng Zhong-yu PIAO College of Mechanical Engineering Zhejiang University of TechnologyHangzhou 310023China Key Laboratory of Special Purpose Equipment and Advanced Processing Technology Ministry of Education and Zhejiang ProvinceZhejiang University of TechnologyHangzhou 310014China

The gradient nanostructure is machined on the aluminum(Al)alloy by the two-dimensional ultrasonic surface burnishing process(2D-USBP).The mechanism of why the gradient nanostructure enhances wear resistance is *** mechanical properties and microstructure characterization for the gradient nanostructure are performed by operating a nanoindenter,transmission electron microscopy(TEM),and electron backscattered diffraction(EBSD).Dry wear tests are performed on the samples before and after machining to evaluate the wear resistance and *** effect of the gradient nanostructure on the wear resistance is explored by developing the crystal plasticity(CP)finite element and molecular dynamics(MD)*** characterization results show that the 2D-USBP sample prepared a gradient structure of~600μm thick on the aluminum surface,increasing the surface hardness from 1.13 to 1.71 GPa and reducing the elastic modulus from 78.84 to 70.14 *** optimization of the surface microstructure and the increase of the mechanical properties effectively enhance the wear resistance of the sample,with 41.20%,39.07%,and 54.58% of the wear scar areas for the 2D-USBP treated samples to the original samples under 5,10,and 15 N loads,*** gradient nanostructure hinders the slip of dislocations inside the sample during the wear process and reduces the size and scope of plastic deformation;meanwhile,the resistance to deformation,adhesion,and crack initiation and propagation of the sample surface is improved,resulting in enhanced wear resistance.

关键词： structural superlubricity lattice registry elastic deformation strained solitons crystal plasticity molecular dynamics simulations

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