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Weakly Supervised Network with Scribble-Supervised and Edge-Mask for Road Extraction from High-Resolution Remote Sensing Images

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Computers, Materials & Continua 2024年第4期79卷 549-562页

作者： Supeng yu Fen huang Chengcheng Fan College of Artificial Intelligence Nanjing Agricultural UniversityNanjing210095China Innovation Academy for Microsatellites of CAS Shanghai201210China Shanghai Engineering Center for Microsatellites Shanghai201210China Key Laboratory of Satellite Digital Technology Shanghai201210China

Significant advancements have been achieved in road surface extraction based on high-resolution remote sensingimage processing. Most current methods rely on fully supervised learning, which necessitates enormous humaneffort to label the image. Within this field, other research endeavors utilize weakly supervised methods. Theseapproaches aim to reduce the expenses associated with annotation by leveraging sparsely annotated data, such asscribbles. This paper presents a novel technique called a weakly supervised network using scribble-supervised andedge-mask (WSSE-net). This network is a three-branch network architecture, whereby each branch is equippedwith a distinct decoder module dedicated to road extraction tasks. One of the branches is dedicated to generatingedge masks using edge detection algorithms and optimizing road edge details. The other two branches supervise themodel’s training by employing scribble labels and spreading scribble information throughout the image. To addressthe historical flaw that created pseudo-labels that are not updated with network training, we use mixup to blendprediction results dynamically and continually update new pseudo-labels to steer network training. Our solutiondemonstrates efficient operation by simultaneously considering both edge-mask aid and dynamic pseudo-labelsupport. The studies are conducted on three separate road datasets, which consist primarily of high-resolutionremote-sensing satellite photos and drone images. The experimental findings suggest that our methodologyperforms better than advanced scribble-supervised approaches and specific traditional fully supervised methods.

关键词： Semantic segmentation road extraction weakly supervised learning scribble supervision remote sensing image

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Advances in large viewing angle and achromatic 3D holography

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Light(Science & Applications) 2024年第7期13卷 1224-1225页

作者： Jiaming huang yu Chen Guixin Li Department of Materials Science and Engineering Southern University of Science and TechnologyShenzhen 518055China Institute for Applied Optics and Precision Engineering Southern University of Science and TechnologyShenzhen 518055China

Optical holography is a promising technique to achieve a naked-eye 3D ***,the narrow viewing angle and chromatic aberration are the two key issues that usually limit the holographic display performance.A recent work proposes a novel way to circumvent these constraints by introducing a color liquid crystal grating into a timesequenced holography system.

关键词： angle chromatic holographic

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Nanoparticle targeting cGAS-STING signaling in disease therapy

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Nano Research 2024年第8期17卷 7315-7336页

作者： Lan Zhou yu huang yuzhang Wu Shupei Tang Frontier Medical Training Brigade Third Military Medical UniversityHutubi 831200China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqing 400037China Institute of Immunology Third Military Medical UniversityChongqing 400038China Shigatse Branch Xinqiao HospitalThird Military Medical UniversityShigatse 857000China

The cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon(IFN)genes(cGAS-STING)signaling pathway is crucial for sensing abnormal DNA accumulation in the *** binds to abnormal DNA,cGAS catalyzes the production of second messenger cyclic dinucleotides,followed by the activation of downstream *** activation induces the expression of type I interferon and other inflammatory cytokines,ultimately initiating an immune *** to the involvement of the cGAS-STING pathway in various diseases,including infection,tumor,autoimmune disease and kidney disease,ongoing research is focused on developing drugs and treatment methods to target and regulate this *** the development of nanotechnology,nanomedicines targeting cGAS-STING signaling are of great significance in clinical applications due to their targeted delivery,controlled drug release,improved solubility,multifunctionality,and enhanced *** comprehensive review focuses on the most recent progress of nanoplatforms targeting cGAS-STING in disease therapy,aiming to provide references and guidelines for further design and optimization of nanomedicines.

关键词： nanomedicine cGAS-STING pathway and related disease anti-tumor nanotherapy anti-viral nanotherapy

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Unveiling quality of clinical trial in China:from concern to confirmation

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Cancer Communications 2024年第5期44卷 576-579页

作者： Huiyao huang Yiru Hou Hong Fang ling Xu yue yu Huifang Zhang Jing Zhang yu Tang Gongtao Lan Wenbao Zhang Ning Li Clinical Trials Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingJiangsuP.R.China Department of Quality Medicine Boehringer Ingelheim(China)Investment Co LtdShanghaiP.R.China Department of Clinical Development Quality Pfizer Research and Development(China)BeijingP.R.China Department of Drug Registration National Medical Products AdministrationBeijingP.R.China Bureau of Medical Administration National Health CommissionBeijingP.R.China

The cornerstone of scientifically valid and ethically sound clinical trials is in compliance with established global quality *** China has made significant progress over the past 20 years in terms of the clinical trial quantity[1],quality and participation in multiregional trials[2],there still remain concerns regarding the trial quality,which could be associated with the self-inspection initiative in 2015[3].

关键词： clinical corners confirmation

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Stability of water yield in watersheds

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Science China Earth Sciences 2024年第2期67卷 483-496页

作者： yu YAN Zhiyong LIU Xiaohong CHEN Liyan huang Center for Water Resources and Environment School of Civil EngineeringSun Yat-Sen UniversityGuangzhou510275China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai519082China

The hydrological system of a watershed is intricately influenced by both underlying characteristics and climate *** the variability in water yield is essential for effective water resources management and water security in the context of changing *** this study,we adopted the Budyko framework and leveraged simulations from the CMIP6 model to investigate the compensation effects of climate and underlying characteristics on watershed water *** on Taylor expansion and Budyko framework,we estimated the sensitivity of watershed water yield to climate and underlying characteristics(the first-and second-order partial derivatives).By combining external watershed characteristics(e.g.,water yield ratios and underlying characteristics)with internal sensitivity coefficients,this study further used vine copula and principal component analysis to quantify the stability of watershed water *** findings show:(1)Water-yield changes related to underlying characteristics could be offset by climate-related water-yield changes across all climate zones,maintaining the water yield ratio steady(i.e.,the compensation effects).(2)However,global watersheds will turn more sensitive to underlying characteristics and less sensitive to climate variation in the *** climate-and underlying-related sensitivities increase in watersheds with arid climates.(3)The stability of watershed water yield will gradually diminish in the *** 1901–1950to 2051–2100,the global stability of 280 watersheds drops from 0.054 to 0.021(i.e.,stability index identified by the joint probability).Particularly,the largest change in stability of water yield reaches-0.347±0.18 in arid *** semi-arid,semihumid,and humid regions,the changes are-0.039±0.010,-0.028±0.005,and-0.005±0.002,*** findings provide a reference for the future sustainable water resources development under climate change,highlighting the vulnerability of the water resources in ari

关键词： Hydrological system stability Compensation effects on water yield Sensitivities Budyko-Fu decomposition framework Global watersheds

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Electrocatalytic coupling of anodic nitrogen oxidation and cathodic nitrate reduction for ammonia synthesis from air and water

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Nano Research 2024年第9期17卷 7824-7829页

作者： Aijing Ma Jianzhou Gui Yanmei huang Yifu yu State Key Laboratory of Separation Membranes and Membrane Processes Tianjin Key Laboratory of Green Chemical Technology and Process EngineeringSchool of Chemical Engineering and TechnologyTiangong UniversityTianjin 300387China Institute of Molecular Plus School of Chemical EngineeringTianjin UniversityTianjin 300072China

Ammonia plays a vital role in present agriculture and industry,and is also regarded as a next-generation clean energy *** development of electrocatalysis raises an opportunity to make ammonia synthesis compatible with intermittent and variable renewable energy sources such as solar and wind ***,the direct ammonia electrosynthesis from N_(2)reduction is still challenging due to the much easier hydrogen evolution competition *** this perspective,we propose a novel strategy for ammonia electrosynthesis from air and water based on the coupling of anodic nitrogen oxidation and cathodic nitrate *** methods for breaking the bottlenecks of anodic nitrogen oxidation and cathodic nitrate reduction are discussed *** that,key issues that need to be considered in the coupled system are proposed for the application of this strategy.

关键词： electrocatalysis nitrogen oxidation nitrate reduction nitrogen fixation ammonia synthesis

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Immunomodulatory Function of Pien Tze huang in T Cell-Mediated Anti-tumor Activity against B16-F10,MC38 and Hep1-6 Tumor Models

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Chinese Journal of Integrative Medicine 2024年第4期30卷 348-358页

作者： FU yu-bing LIU Chen-feng WANG Jin-jia JI Xiao-lin TANG Rong-han LIAO Kun-yu CHEN ling-yue HONG Ya-zhen FAN Bin-bin WANG Shi-cong LIU Wen-Hsien State Key Laboratory of Cellular Stress Biology School of Life SciencesFaculty of Medicine and Life ScienceXiamen UniversityXiamenFujian Province(361102)China Fujian Pien Tze huang Enterprise Key Laboratory of Natural Medicine Research and Development ZhangzhouFujian Province(363000)China

Objective To investigate the anti-tumor effects of Pien Tze huang(PZH)in mouse models of B16–F10 melanoma,MC38 colorectal cancer,Hep1-6 hepatocellular carcinoma and chemically induced hepatocellular carcinoma *** Various tumor models,including B16–F10,MC38 and Hep1-6 tumor hypodermic inoculation models,B16–F10 and Hep1-6 pulmonary metastasis models,Hep1-6 orthotopic implantation model,and chemically induced hepatocellular carcinoma model,were utilized to evaluate the anti-tumor function of *** growth was assessed by measuring tumor size and weight of solid tumors isolated from C57BL/6 *** cell proliferation and death of tumor cells in vitro,as well as T cell activation markers,cytokine production and immune checkpoints analysis,single-cell suspensions were prepared from mouse spleen,lymph nodes,and tumors after PZH *** PZH demonstrated significant therapeutic efficacy in inhibiting tumor growth(P0.05).Nevertheless,PZH exhibited a remarkable ability to enhance T cell activation and the production of interferon gamma,tumor necrosis factor alpha,and interleukin 2 in CD4^(+)T cells in vitro(P<0.01 or P<0.05).Importantly,PZH substantially inhibited T cell exhaustion and boosted cytokine production by tumor-infiltrating CD8^(+)T cells(P<0.01 or P<0.05).Conclusion This study has confirmed a novel immunomodulatory function of PZH in T cell-mediated anti-tumor immunity,indicating that PZH holds promise as a potential therapeutic agent for cancer treatment.

关键词： Pien Tze huang metastasis anti-tumor immunity T cell activation T cell exhaustion immune checkpoints Chinese medicine

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Optimal Cooperative Secondary Control for Islanded DC Microgrids via a Fully Actuated Approach

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 405-417页

作者： Yi yu Guo-Ping Liu Yi huang Peng Shi IEEE Shenzhen Key Laboratory of Control Theory and Intelligent Systems Southern University of Science and TechnologyShenzhen 518055China School of Electrical Engineering and Automation Wuhan UniversityWuhan 430072China School of Electrical and Mechanical Engineering the University of AdelaideSA 5005Australia Research and Innovation Centre Obuda University1034 BudapestHungary

DC-DC converter-based multi-bus DC microgrids(MGs) in series have received much attention, where the conflict between voltage recovery and current balancing has been a hot topic. The lack of models that accurately portray the electrical characteristics of actual MGs while is controller design-friendly has kept the issue active. To this end, this paper establishes a large-signal model containing the comprehensive dynamical behavior of the DC MGs based on the theory of high-order fully actuated systems, and proposes distributed optimal control based on this. The proposed secondary control method can achieve the two goals of voltage recovery and current sharing for multi-bus DC MGs. Additionally, the simple structure of the proposed approach is similar to one based on droop control, which allows this control technique to be easily implemented in a variety of modern microgrids with different configurations. In contrast to existing studies, the process of controller design in this paper is closely tied to the actual dynamics of the MGs. It is a prominent feature that enables engineers to customize the performance metrics of the system. In addition, the analysis of the stability of the closed-loop DC microgrid system, as well as the optimality and consensus of current sharing are given. Finally, a scaled-down solar and battery-based microgrid prototype with maximum power point tracking controller is developed in the laboratory to experimentally test the efficacy of the proposed control method.

关键词： DC microgrids distributed control high-order fully actuated system approach linear quadratic regulator microgrid modeling secondary control

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Nutritional Assessment Tools for Patients with Cancer:A Narrative Review

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Current Medical Science 2024年第1期44卷 71-80页

作者： Peng-peng WANG Kim Lam Soh Huzwah binti Khazaai Chuan-yi NING Xue-ling huang Jia-xiang yu Jin-lian LIAO Faculty of Medicine and Health Sciences Universiti Putra MalaysiaSerdang 43400Malaysia NursingCollege of Guangxi Medical University Nanning 530021China Department of Biomedical Sciences Universiti Putra MalaysiaSerdang 43400Malaysia Department of Nursing The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021China

Cancer patients are at high risk of malnutrition,which can lead to adverse health outcomes such as prolonged hospitalization,increased complications,and increased *** and timely nutritional assessment plays a critical role in effectively managing malnutrition in these ***,while many tools exist to assess malnutrition,there is no universally accepted *** different tools have their own strengths and limitations,there is a lack of narrative reviews on nutritional assessment tools for cancer *** address this knowledge gap,we conducted a non-systematic literature search using PubMed,Embase,Web of Science,and the Cochrane Library from their inception until May 2023.A total of 90 studies met our selection criteria and were included in our narrative *** evaluated the applications,strengths,and limitations of 4 commonly used nutritional assessment tools for cancer patients:the Subjective Global Assessment(SGA),Patient-Generated Subjective Global Assessment(PG-SGA),Mini Nutritional Assessment(MNA),and Global Leadership Initiative on Malnutrition(GLIM).Our findings revealed that malnutrition was associated with adverse health *** of these 4 tools has its applications,strengths,and *** findings provide medical staff with a foundation for choosing the optimal tool to rapidly and accurately assess malnutrition in cancer *** is essential for medical staff to be familiar with these common tools to ensure effective nutritional management of cancer patients.

关键词： cancer malnutrition nutrition nutritional assessment tool

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Network Intrusion Traffic Detection Based on Feature Extraction

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Computers, Materials & Continua 2024年第1期78卷 473-492页

作者： Xuecheng yu Yan huang yu Zhang Mingyang Song Zhenhong Jia College of Information Science and Engineering Xinjiang UniversityUrumqi830046China Network Department China Mobile Communications Group Xinjiang CoLtd.UrumqiUrumqi830011China Xinjiang Signal Detection and Processing Key Laboratory Xinjiang UniversityUrumqi830000China

With the increasing dimensionality of network traffic,extracting effective traffic features and improving the identification accuracy of different intrusion traffic have become critical in intrusion detection systems(IDS).However,both unsupervised and semisupervised anomalous traffic detection methods suffer from the drawback of ignoring potential correlations between features,resulting in an analysis that is not an optimal ***,in order to extract more representative traffic features as well as to improve the accuracy of traffic identification,this paper proposes a feature dimensionality reduction method combining principal component analysis and Hotelling’s T^(2) and a multilayer convolutional bidirectional long short-term memory(MSC_BiLSTM)classifier model for network traffic intrusion *** method reduces the parameters and redundancy of the model by feature extraction and extracts the dependent features between the data by a bidirectional long short-term memory(BiLSTM)network,which fully considers the influence between the before and after *** network traffic is first characteristically downscaled by principal component analysis(PCA),and then the downscaled principal components are used as input to Hotelling’s T^(2) to compare the differences between *** datasets with outliers,Hotelling’s T^(2) can help identify the groups where the outliers are located and quantitatively measure the extent of the ***,a multilayer convolutional neural network and a BiLSTM network are used to extract the spatial and temporal features of network traffic *** empirical consequences exhibit that the suggested approach in this manuscript attains superior outcomes in precision,recall and F1-score juxtaposed with the prevailing *** results show that the intrusion detection accuracy,precision,and F1-score of the proposed MSC_BiLSTM model for the CIC-IDS 2017 dataset are 98.71%,95.97%,and 90.22%.

关键词： Network intrusion traffic detection PCA Hotelling’s T^(2) BiLSTM

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