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Clinical manifestations,diagnosis and long-term prognosis of adult autoimmune enteropathy:Experience from Peking Union Medical College Hospital

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World Journal of Gastroenterology 2024年第19期30卷 2523-2537页

作者： Mu-Han Li Ge-Chong Ruan Wei-Xun Zhou Xiao-Qing Li Sheng-yu zhang Yang Chen Xiao-Yin Bai Hong Yang yu-jie zhang Peng-yu Zhao Ji Li Jing-Nan Li Department of Gastroenterology Chinese Academy of Medical Sciences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Scinences&Peking Union Medical College HospitalBeijing 100730China Department of Pathology Tianjin First Central HospitalNankai UniversityTianjin 300192China Affairs Office Chinese Academy of Medical Sciences&Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUND Autoimmune enteropathy(AIE)is a rare disease whose diagnosis and long-term prognosis remain challenging,especially for adult AIE *** To improve overall understanding of this disease’s diagnosis and *** We retrospectively analyzed the clinical,endoscopic and histopathological characteristics and prognoses of 16 adult AIE patients in our tertiary medical center between 2011 and 2023,whose diagnosis was based on the 2007 diagnostic *** Diarrhea in AIE patients was characterized by secretory *** common endoscopic manifestations were edema,villous blunting and mucosal hyperemia in the duodenum and *** blunting(100%),deep crypt lymphocytic infiltration(67%),apoptotic bodies(50%),and mild intraepithelial lymphocytosis(69%)were observed in the duodenal ***,there were other remarkable abnormalities,including reduced or absent goblet cells(duodenum 94%,ileum 62%),reduced or absent Paneth cells(duodenum 94%,ileum 69%)and neutrophil infiltration(duodenum 100%,ileum 69%).Our patients also fulfilled the 2018 diagnostic criteria but did not match the 2022 diagnostic criteria due to undetectable anti-enterocyte *** patients received glucocorticoid therapy as the initial medication,of which 14/16 patients achieved a clinical response in 5(IQR:3-20)*** were administered to 9 patients with indications of steroid dependence(6/9),steroid refractory status(2/9),or intensified maintenance medication(1/9).During the median of 20.5 months of followup,2 patients died from multiple organ failure,and 1 was diagnosed with non-Hodgkin’s *** cumulative relapse-free survival rates were 62.5%,55.6%and 37.0%at 6 months,12 months and 48 months,*** Certain histopathological findings,including a decrease or disappearance of goblet and Paneth cells in intestinal biopsies,might be potential diagnostic criteria for adult *** long-term prognosis is still unsatisfac

关键词： Autoimmune enteropathy Clinical manifestations Diagnostic criteria Pathological features Long-term prognosis

Gene cloning,protein expression,and enzymatic characterization of a double-stranded RNA degrading enzyme in Apolygus lucorum

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Insect Science 2024年第1期31卷 119-133页

作者： jie-yu zhang Jing Zhao Keyan Zhu-Salzman Qin-Qin Ji Yi-Ping Jiang Liu-Bin Xiao De-Jin Xu Guang-Chun Xu Lin-Quan Ge Yong-An Tan College of Plant Protection Yangzhou UniversityYangzhouJiangsu ProvinceChina Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjingJiangsu ProvinceChina Department of Entomology Texas A&M UniversityCollege StationTXUSA Taizhou Customs of the People's Republic of China TaizhouJiangsu ProvinceChina

RNA interference(RNAi)is a powerful tool that post-transcriptionally silences target genes in eukaryotic ***,silencing efficacy varies greatly among different insect ***,we met with little success when attempting to knock down genes in the mirid bug Apolygus lucorum via dsRNA *** disappearance of double-stranded RNA(dsRNA)could be a potential factor that restricts RNAi ***,we found that dsRNA can be degraded in midgut fluids,and a dsRNase of ***(AldsRNase)was identified and *** alignment indicated that its 6 key amino acid residues and the Mg2+-binding site were similar to those of other insects’*** signal peptide and endonuclease non-specific domain shared high sequence identity with the brown-winged green stinkbug Plautia stali *** showed high salivary gland and midgut expression and was continuously expressed through the whole life cycle,with peaks at the 4th instar ecdysis in the whole *** purified AldsRNase protein obtained by heterologously expressed can rapidly degrade *** comparing the substrate specificity of AldsRNase,3 specific substrates(dsRNA,small interfering RNA,and dsDNA)were all degraded,and the most efficient degradation is ***,immunofluorescence revealed that AldsRNase was expressed in the cytoplasm of midgut *** cloning and functional study of AldsRNase,the enzyme activity and substrate specificity of the recombinant protein,as well as the subcellular localization of nuclease,the reason for the disappearance of dsRNA was explained,which was useful in improving RNAi efficiency in *** and related species.

关键词： Apolygus lucorum cloning dsRNase enzymatic activity protein expression

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鉴定最重QED原子的新方法

Science Bulletin 2024年第10期69卷 1386-1391页

作者：傅靖航贾森周兴玉张玉洁沈成平苑长征 School of Physics Beihang UniversityBeijing 100083China School of Physics Southeast UniversityNanjing 211189China School of Physics and Electronic Technology Liaoning Normal UniversityDalian 116029China Peng Huanwu Collaborative Center for Research and Education Beihang UniversityBeijing 100191China Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443China School of Physics Henan Normal UniversityXinxiang 453007China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China

QED atoms are composed of unstructured and point-like lepton pairs bound together by the electromag-netic *** smallest and heaviest QED atom is formed by a τ^(+)τ^(-)***,the only known atoms of this type are the e^(+)e^(-)and μ^(+)e^(-)atoms,which were discovered 64 years ago and remain the sole examples found thus *** demonstrate that the J_(τ)(τ^(+)τ^(-) atom with J^(PC)=1^(--))atom signal can be observed with a significance larger than 5o including both statistical and systematic uncertainties,*** process e^(+)e^(-)→X^(+)Y^(-)E(X,Y=e,μ,π,K,or ρ,and E is the missing energy due to unobserved neutri-nos)with 1.5 ab^(-1)data taken around the τ pair production *** τ lepton mass can be measured with a precision of 1 keV with the same data *** is within one year's running time of the pro-posed super tau-charm facility in China or super charm-tau factory in Russia.

关键词： QED atom Tau lepton e^(+)e^(-)annihilation STCF SCTF

Modeling effect of cooling conditions on solidification process during thermal cycle of rollers in twin-roll strip casting

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Journal of Iron and Steel Research(International) 2023年第1期30卷 64-73页

作者： Chun-feng Bai Bo Wang jie Ma jie-yu zhang Wan-ping Pan State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200072China School of Materials Science and Engineering Shanghai UniversityShanghai 200072China Anhui Jianzhu University Hefei 230601AnhuiChina

In the twin-roll strip casting process,molten steel solidifies by losing heat through its interface with the casting *** heat extraction along this interface has an effect on the quality of the strips and should be affected by coating,rolls’material,and cooling water flow *** is necessary to understand the effect of these casting parameters on the solidification structure of twin-roll strip casting.A three-dimensional computational domain is set up to simulate the solidification process of molten steel and heat exchange between steel strip/air,coating,rolls,and cooling water in the channel of roll *** effect of the cooling water intensity and flow intensity of molten steel in the pool on the solidification structures is studied during the thermal cycle of rolls in the twin-roll strip *** predicted results are helpful to optimize casting parameters and improve the strip quality in the twin-roll strip casting process.

关键词： Twin-roll strip casting Solidification structure Numerical simulation Thermal cycle Cellular automata finite element model

Advanced electrospinning nanomaterials:From spinning fabrication techniques to electrochemical applications

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Nano Research 2024年第8期17卷 7077-7116页

作者： jie zhang Miao yu Shuhui Tao College of Materials Science and Engineering Sichuan UniversityChengdu 610065China School of Mechanical Engineering Sichuan UniversityChengdu 610065China National University of Singapore(Chongqing)Research Institute Chongqing 401123China

Fuel cells,rechargeable metal–air batteries,metal-ion batteries,and supercapacitors have been regarded as prospective energy sources technologies to replace the fossil ***,electrochemical sensors also have been successfully developed as promising platforms for detecting pollutants,drug analysis,and healthcare *** is a scalable and suitable technique to design and fabricate diverse nanofibers and their nanocomposites for key components in electrochemical ***,a comprehensive review of electrospinning,from the technological innovations to the novel electrospun composite nanofibers,is *** importantly,the recent advances on the diverse components of electrochemical devices are highlighted,followed with the detailed discussion about the corresponding enhancement mechanism based on the electrospun ***,the currently faced challenges on the fabrication of electrospun nanomaterials are raised and a brief perspective for the future development of electrospun nanomaterials-based electrochemical applications is prospected.

关键词： electrospinning carbon nanofibers metal-organic frameworks electrode materials electrochemical applications

Melatonin Alleviates Liver Fibrosis by Inhibiting Autophagy

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Current Medical Science 2022年第3期42卷 498-504页

作者： Lei jie Ru-tao HONG yu-jie zhang Lu-lin SHA Wei CHEN Xiao-fei REN Department of Gastroenterology First Affiliated Hospital of Anhui Medical UniversityKey Laboratory of Digestive Disease of Anhui ProvinceHefei 230022China Department of Critical Care Medicine of Cardiothoracic Surgery First Affiliated Hospital of Anhui Medical UniversityHefei 230022China

Objective Melatonin has been reported to suppress inflammation and alleviate liver fibrosis,but its effect on autophagy in liver fibrosis has not been *** study investigated the effect of melatonin on autophagy in an animal model of liver fibrosis and the hepatic stellate cell(HSC)-T6 cell *** The model was established in rats through carbon tetrachloride treatment,and melatonin was administered at three doses(2.5,5.0,and 10.0 mg/kg).Haematoxylin and eosin staining and Van Gieson’s staining were performed to examine the pathological changes of *** expression of alpha-smooth muscle actin(α-SMA)and Beclin1 in liver tissues was detected by immunohistochemical *** protein levels ofα-SMA,Beclin1 and LC3 in the animal model were detected by Western blot analysis,and gene levels of Beclin1 and LC3 were detected by quantitative real-time PCR(qRT-PCR)in the animal ***-T6 cells were activated by platelet-derived growth factor-BB(PDGF-BB).The expression ofα-SMA,Beclin1 and collagen I was detected by Western blot analysis,and the gene expression of Beclin1 and LC3 was detected by *** Melatonin reduced the expression ofα-SMA,Beclin1 and LC3 in liver *** addition,melatonin inhibited the activation of HSC-T6 cells and the expression ofα-SMA,Beclin1 and LC3 in these *** results revealed that melatonin could inhibit autophagy and HSC *** Melatonin might ameliorate liver fibrosis by regulating autophagy,suggesting that melatonin is a potential therapeutic agent for liver fibrosis.

关键词： autophagy liver fibrosis hepatic stellate cells melatonin

Artificial Intelligence Based Multi-Scenario mmWave Channel Modeling for Intelligent High-Speed Train Communications

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China Communications 2024年第3期21卷 260-272页

作者： zhang Mengjiao Liu yu Huang jie He Ruisi zhang Jingfan yu Chongyang Wang Chengxiang School of Microelectronics Shandong UniversityJinan 250101China The State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong UniversityBeijing 100044China The National Mobile Communications Research Laboratory School of Information Science and EngineeringSoutheast UniversityNanjing 210096China The Purple Mountain Laboratories Nanjing 211111China

A large amount of mobile data from growing high-speed train(HST)users makes intelligent HST communications enter the era of big *** corresponding artificial intelligence(AI)based HST channel modeling becomes a *** paper provides AI based channel characteristic prediction and scenario classification model for millimeter wave(mmWave)HST ***,the ray tracing method verified by measurement data is applied to reconstruct four representative HST *** setting the positions of transmitter(Tx),receiver(Rx),and other parameters,the multi-scenarios wireless channel big data is ***,based on the obtained channel database,radial basis function neural network(RBF-NN)and back propagation neural network(BP-NN)are trained for channel characteristic prediction and scenario ***,the channel characteristic prediction and scenario classification capabilities of the network are evaluated by calculating the root mean square error(RMSE).The results show that RBF-NN can generally achieve better performance than BP-NN,and is more applicable to prediction of HST scenarios.

关键词： artificial intelligence channel characteristic prediction HST channel millimeter wave scenario classification

A model reduction approach for discrete-time linear time-variant systems with delayed inputs

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Science China(Information Sciences) 2024年第4期67卷 197-217页

作者： Ai-Guo WU Guang-Ren DUAN yu WANG jie zhang School of Mechanical Engineering and Automation Harbin Institute of Technology(Shenzhen) HIT Wuhu Robot Technology Research Institute Center for Control Science and Technology Southern University of Science and Technology

A model reduction approach is presented for discrete-time linear time-variant input-delayed systems. According to this proposed approach, a dynamical variable is constructed by taking advantage of the current state and historical information of input. It is revealed that the behavior of this dynamical variable is governed by a discrete-time linear delay-free system. It is worth noting that the presented variable transformation does not require the system matrix to be invertible. Based on the reduced delay-free models,stabilizing control laws can be easily obtained for the original delayed system. For the case with a single input delay, the constructed variable is an exact prediction for the future state, and thus the stabilizing control law could be designed by replacing the future state with its prediction. Finally, three discrete-time periodic systems with delayed input are employed to illustrate how to utilize the presented model reduction approaches.

关键词： reduction approach predictor-based feedback time-varying systems delayed input periodic system

Taiji-TianQin-LISA network:Precisely measuring the Hubble constant using both bright and dark sirens

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Science China(Physics,Mechanics & Astronomy) 2024年第2期67卷 59-77页

作者： Shang-jie Jin Ye-Zhu zhang Ji-yu Song Jing-Fei zhang Xin zhang Key Laboratory of Cosmology and Astrophysics(Liaoning)&College of Sciences Northeastern UniversityShenyang 110819China Key Laboratory of Data Analytics and Optimization for Smart Industry(Ministry of Education) Northeastern UniversityShenyang 110819China National Frontiers Science Center for Industrial Intelligence and Systems Optimization Northeastern UniversityShenyang 110819China

In the coming decades,the space-based gravitational-wave(GW)detectors such as Taiji,TianQin,and LISA are expected to form a network capable of detecting millihertz GWs emitted by the mergers of massive black hole binaries(MBHBs).In this work,we investigate the potential of GW standard sirens from the Taiji-TianQin-LISA network in constraining cosmological *** the optimistic scenario in which electromagnetic(EM)counterparts can be detected,we predict the number of detectable bright sirens based on three different MBHB population models,i.e.,popⅢ,Q3d,and *** results show that the TaijiTianQin-LISA network alone could achieve a constraint precision of 0.9%for the Hubble constant,meeting the standard of precision ***,the Taiji-TianQin-LISA network could effectively break the cosmological parameter degeneracies generated by the CMB data,particularly in the dynamical dark energy *** combined with the CMB data,the joint CMB+Taiji-TianQin-LISA data offerσ(w)=0.036 in the wCDM model,which is close to the latest constraint result obtained from the CMB+SN *** also consider a conservative scenario in which EM counterparts are not *** to the precise sky localizations of MBHBs by the Taiji-TianQin-LISA network,the constraint precision of the Hubble constant is expected to reach 1.2%.In conclusion,the GW standard sirens from the Taiji-TianQin-LISA network will play a critical role in helping solve the Hubble tension and shedding light on the nature of dark energy.

关键词： space-based gravitational wave detection standard sirens the Taiji-TianQin-LISA network the Hubble constant dark energy