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Does type 1 diabetes serve as a protective factor against inflammatory bowel disease:A Mendelian randomization study

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World Journal of Diabetes 2024年第7期15卷 1551-1561页

作者： ke-ke Tong yun-Feng yu Xin-yu Yang Jing-Yi Wu Rong yu Chuan-Chuan Tan The First Hospital of Hunan University of Chinese Medicine Changsha 410007Hunan ProvinceChina School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The Third Hospital Zhejiang Chinese Medical UniversityHangzhou 310005Zhejiang ProvinceChina

BACKGROUND The impact of type 1 diabetes(T1D)on inflammatory bowel disease(IBD)remains *** To analyze the causal relationship between T1D and IBD using Mendelian randomization(MR).METHODS Single nucleotide polymorphisms were sourced from FinnGen for T1D,IBD,ulcerative colitis(UC)and Crohn’s disease(CD).Inverse variance-weighted,MREgger,and weighted median tests were used to assess exposure-outcome *** MR-Egger intercept was used to assess horizontal ***’s Q and leave-one-out method were used to analyze heterogeneity and sensitivity,*** Our MR analysis indicated that T1D was associated with a reduced risk of IBD[odds ratio(OR):0.959;95%confidence interval(CI):0.938-0.980;P0.05).Cochran’s Q and leave-one-out sensitivity analyses showed that the results were not heterogeneous(P>0.05)and were *** This MR analysis suggests that T1D serves as a potential protective factor against IBD and UC but is independent of CD.

关键词： Type 1 diabetes Inflammatory bowel disease Ulcerative colitis Crohn’s disease Mendelian randomization

A Novel Approach for Trajectory Tracking Control of an Under-Actuated Quad-Rotor UAV

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IEEE/CAA Journal of Automatica Sinica 2024年第9期11卷 2030-2032页

作者： ke Shao Kang Huang Shengchao Zhen Hao Sun Rongrong yu School of Civil Aviation Northwestern Polytechnical UniversityXi’an 710072 School of Mechanical Engineering Hefei University of TechnologyHefei 230009China

Dear Editor,This letter presents a novel Udwadia-Kalaba(U-K)approach for the trajectory tracking control of a quad-rotor unmanned aerial vehicle(UAV).Compared to conventional control approaches,the desired trajectorie... 详细信息

关键词： letter desired constraints

Extraction and evolution of grader’s bionic morphological feature line using shape structure behavior function model

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 74-84页

作者： bin Qi yubin Lan Xiaoming Sun He Zhu Yanhao Li ke Lou College of Agricultural Engineering and Food Science Shandong University of TechnologyZibo 255049ShandongChina Shandong Provincial Engineering Technology Research Center for Agricultural Aviation Intelligent Equipment Zibo 255049China

To improve the innovation of agricultural machinery product styling,this paper proposes a shape structure behavior function(SSBF)model suitable for the industrial design *** feature line evolution method combining shape grammar and genetic algorithm was used for modelling the of the grader,which not only maintains the product style characteristics but also reflects the typical identification characteristics of the bionic prototype and produces a new product modelling *** conducting cognitive and recognition experiments on product styling features,the ranking of product styling features and the contribution of each component to product styling were *** method of combining shape grammar and quadratic Bézier curve was used to express and encode feature lines,and genetic algorithm was used to evolve biomimetic forms to form product feature lines with typical biological morphological features;The extracted form bionic elements were integrated into the grader modelling design,and the interaction evaluation was carried out through the genetic algorithm evolution *** basic form elements were extracted and analyzed,and the deduction rules were formulated and *** derived feature line geometric data considered the product’s image features and the bio-inspired prototype,which can be used for the follow-up guidance of industrial design schemes.

关键词： bionic design shape-structure-behavior-function SSBF biologically inspired design BID shape grammars Quadratic Bézier curves

Illuminating spin-crossover octanuclear metal-organic cages

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Science China Chemistry 2024年第4期67卷 1208-1215页

作者： Zhi-Kun Liu Alyona A.Starikova yu-Xia Li ke Sun Meng yu Zi-Shuo Yao Jun Tao key Laboratory of Cluster Science of Ministry of Education School of Chemistry and Chemical EngineeringLiangxiang CampusBeijing Institute of TechnologyBeijing 102488China Institute of Physical and Organic Chemistry Southern Federal UniversityRostov-on-Don 344090Russia

Spin-crossover(SCO)materials that reversibly switch between high-and low-spin states have potential for the storage of spin state-relative information,and have gained much attention incorporating secondary physical properties,such as fluorescence and magneto-optical *** this study,we synthesized three octanuclear metal-organic cages(MOCs)using tetraphenylethylene-based luminophores,aldehydes,and Fe^(Ⅱ)salts,by subcomponent self-assembly approach,namely[Fe1]-[Fe3].By controlling the ligand-field strength and guest encapsulation,we finely tuned their SCO *** them,MOC[Fe2]displayed nearly complete SCO behavior in the solid state,which is rare for high-nuclearity *** also demonstrated the coupling of SCO with fluorescence emission in these MOCs by using isostructural Zn^(Ⅱ)complexes([Zn1]-[Zn3])as control experiments,for the first *** calculations revealed the energy-transfer mechanism between fluorophores and SCOactive centers,which emphasizes the significant contribution of d-d transitions in the interplay between the occurrence of SCO and fluorescence emission.

关键词： metal-organic cages spin crossover fluorescence switching materials DFT calculation

Dynamic interactive bitwise meta-holography with ultra-high computational and display frame rates

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Opto-Electronic Advances 2024年第1期7卷 36-46页

作者： yuncheng Liu ke Xu Xuhao Fan Xinger Wang Xuan yu Wei Xiong Hui Gao Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan 430074China Optics Valley Laboratory Wuhan 430074China

Interactive holography offers unmatched levels of immersion and user engagement in the field of future *** of the substantial progress has been made in dynamic meta-holography,the realization of real-time,highly smooth interactive holography remains a significant challenge due to the computational and display frame rate *** this study,we introduced a dynamic interactive bitwise meta-holography with ultra-high computational and display frame *** our knowledge,this is the first reported practical dynamic interactive metasurface holographic *** spa-tially divided the metasurface device into multiple distinct channels,each projecting a reconstructed *** switching states of these channels were mapped to bitwise operations on a set of bit values,which avoids complex holo-gram computations,enabling an ultra-high computational frame *** approach achieves a computational frame rate of 800 kHz and a display frame rate of 23 kHz on a low-power Raspberry Pi computational *** to this methodology,we demonstrated an interactive dynamic holographic Tetris game system that allows interactive gameplay,color display,and on-the-fly hologram *** technology presents an inspiration for advanced dynamic meta-holography,which is promising for a broad range of applications including advanced human-computer interaction,real-time 3D visualization,and next-generation virtual and augmented reality systems.

关键词： interactive display meta-holography bitwise operation ultra-high frame rate

Sub-Seasonal Predictability of the Northeast China Cold Vortex in BCC and ECMWF S2S Model Forecasts for 2006-2021

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Journal of Meteorological Research 2024年第3期38卷 453-468页

作者： Yiqiu yu Jie WU Yihe FANG Chunyu ZHAO Zongjian ke Yitong LIN Liaoning Provincial Climate Centre Liaoning Provincial Meteorological AdministrationShenyang110166China key Opening Laboratory for Northeast China Cold Vortex Research China Meteorological AdministrationShenyang110166China Panjin National Climate Observatory Panjin124000China China Meteorological Administration key Laboratory for Climate Prediction Studies National Climate CentreChina Meteorological AdministrationBeijing100081China Jilin Provincial Climate Centre Jilin Provincial Meteorological AdministrationChangchun130062China

As an important atmospheric circulation system in the mid-high latitudes of East Asia,the Northeast China cold vortex(NCCV)substantially influences weather and climate in this *** far,systematic assessment on the performance of numerical prediction of the NCCVs has not been carried *** on the Beijing Climate Centre(BCC)and the ECMWF model hindcast and forecast data that participated in the Sub-seasonal to Seasonal(S2S)Prediction Project,this study systematically examines the performance of both models in simulating and forecasting the NCCVs at the sub-seasonal *** results demonstrate that the two models can effectively capture the seasonal variations in the intensity,active days,and spatial distribution of NCCVs;however,the duration of NCCVs is shorter and the intensity is weaker in the models than in the *** analysis shows that the differences in the intensity and location of the East Asian subtropical westerly jet and the wave train pattern from North Atlantic to East Asia may be responsible for the deficient simulation of NCCV events in the S2S ***,in the deterministic forecasts,BCC and ECMWF provide skillful prediction on the anomalous numbers of NCCV days and intensity at a lead time of 4-5(5-6)pentads,and the skill limit of the ensemble mean is 1-2 pentads longer than that of individual *** the probabilistic forecasts of daily NCCV activities,BCC and ECMWF exhibit a forecasting skill of approximately 7 and 11 days,respectively;both models show seasonal dependency in the simulation performance and forecast skills of NCCV events,with better performance in winter than in *** results from this study provide helpful references for further improvement of the S2S prediction of NCCVs.

关键词： Northeast China cold vortex(NCCV) predictability sub-seasonal to seasonal(S2S)prediction deterministic forecast probabilistic forecast

Low cost and low density chloride solid electrolyte for all solid state cathode with high active material ratio

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Nano Research 2024年第10期17卷 8826-8833页

作者： Hao-yuan Tan Mei-yu Zhou Zhongyuan Huang Jin-Da Luo Jing-Tian Yang Jian-Ping Wang Ye-Chao Wu Xiao-bin Cheng Zi-Wei Wang Xu-Dong Hao Linjun Wang ke Gong Yi-Chen Yin Yinguo Xiao Hong-bin Yao Hefei National Research Center for Physical Sciences at the Microscale University of Science and Technology of ChinaHefei 230026China Department of Applied Chemistry University of Science and Technology of ChinaHefei 230026China School of Advanced Materials Peking University Shenzhen Graduate SchoolShenzhen 518055China

Chloride solid electrolytes(SEs)have attracted widespread attention due to their high room-temperature ionic conductivity and excellent cathode ***,the conventionally selected central metal elements(e.g.,In,Y and Ta)are usually rare and heavy,inevitably causing the high cost and high density of the obtained chloride ***,by choosing abundant and light Mg and Al as central metal elements,we develop a cheap and low density Li_(1.2)Mg_(0.95)Al_(0.3)Cl_(4)SE for high active material ratio in all solid state *** replacement of Mg^(2+)by Al^(3+)in the framework yields vacancies and lowers the non-lithium metal ions occupancy at Mg/Li co-occupied 16d site,effectively relieving the blocking effects by Mg^(2+)in the pristine spinel Li_(2-2x)Mg_(1+x)Cl_(4).Thus,a significantly improved room-temperature conductivity of 3.08×10^(-4)S·cm^(-1)is achieved,two orders of magnitude higher than that of Li_(1.2)Mg_(1.4)Cl_(4).More attractively,its low density of only 1.98 g·cm-3 enables low SE mass ratio in cathodes(only 16 wt.%)with still effective electrolyte/cathode contact and lithium-ion conduction *** charged to potential of 4.30 V,the asfabricated Li_(1.2)Mg_(0.95)Al_(0.3)Cl_(4)-based solid lithium battery with uncoated NCM523 cathode can be cycled for over 100 cycles with a capacity retention of 86.68%at room temperature.

关键词： chloride solid electrolytes low cost low density Li+conductivities

High-resolution recognition of FOAM modes via an improved EfficientNet V2 based convolutional neural network

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Frontiers of physics 2024年第3期19卷 175-183页

作者： Youzhi Shi Zuhai Ma Hongyu Chen Yougang ke yu Chen Xinxing Zhou International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology Institute of Microscale OptoelectronicsShenzhen UniversityShenzhen 518060China key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Synergetic Innovation Center for Quantum Effects and ApplicationsSchool of Physics and ElectronicsHunan Normal UniversityChangsha 410081China key Laboratory of Hunan Province on Information Photonics and Freespace Optical Communications School of Information Science and EngineeringHunan Institute of Science and TechnologyYueyang 414006China

Vortex beam with fractional orbital angular momentum (FOAM) is the excellent candidate for improving the capacity of free-space optical (FSO) communication system due to its infinite modes. Therefore, the recognition of FOAM modes with higher resolution is always of great concern. In this work, through an improved EfficientNetV2 based convolutional neural network (CNN), we experimentally achieve the implementation of the recognition of FOAM modes with a resolution as high as 0.001. To the best of our knowledge, it is the first time this high resolution has been achieved. Under the strong atmospheric turbulence (AT) (C_(n)^(2)=10^(-15)m^(-2/3)), the recognition accuracy of FOAM modes at 0.1 and 0.01 resolution with our model is up to 99.12% and 92.24% for a long transmission distance of 2000 m. Even for the resolution at 0.001, the recognition accuracy can still remain at 78.77%. This work provides an effective method for the recognition of FOAM modes, which may largely improve the channel capacity of the free-space optical communication.

关键词： OAM free-space optical communication deep learning convolutional neural network

Recent advances in zwitterionic nanoscale drug delivery systems to overcome biological barriers

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Asian Journal of Pharmaceutical Sciences 2024年第1期19卷 49-68页

作者： Xumei Ouyang yu Liu ke Zheng Zhiqing Pang Shaojun Peng Zhuhai Institute of Translational Medicine Zhuhai Precision Medical CenterZhuhai People’s Hospital(Zhuhai Hospital Affiliated with Jinan University)Zhuhai 519000China key Laboratory of Smart Drug Delivery Ministry of EducationDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China School of Materials Science and Engineering Dongguan University of TechnologyDongguan 523808China

Nanoscale drug delivery systems(nDDS)have been employed widely in enhancing the therapeutic efficacy of drugs against diseases with reduced side *** several nDDS have been successfully approved for clinical use up to now,biological barriers between the administration site and the target site hinder the wider clinical adoption of nDDS in disease *** glycol(PEG)-modification(or PEGylation)has been regarded as the gold standard for stabilising nDDS in complex biological ***,the accelerated blood clearance(ABC)of PEGylated nDDS after repeated injections becomes great challenges for their clinical *** polymer,a novel family of antifouling materials,have evolved as an alternative to PEG due to their super-hydrophilicity and *** nDDS could avoid the generation of ABC phenomenon and exhibit longer blood circulation time than the PEGylated *** impressively,zwitterionic nDDS have recently been shown to overcome multiple biological barriers such as nonspecific organ distribution,pressure gradients,impermeable cell membranes and lysosomal degradation without the need of any complex chemical *** realization of overcoming multiple biological barriers by zwitterionic nDDS may simplify the current overly complex design of nDDS,which could facilitate their better clinical ***,we summarise the recent progress of zwitterionic nDDS at overcoming various biological barriers and analyse their ***,prospects and challenges are introduced to guide the rational design of zwitterionic nDDS for disease treatment.

关键词： Zwitterionic polymer Nano drug delivery system Biological barrier Targeting delivery Disease treatment