Does type 1 diabetes serve as a protective factor against inflammatory bowel disease:A Mendelian randomization study
作者机构：The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina School of Traditional Chinese MedicineHunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina The Third HospitalZhejiang Chinese Medical UniversityHangzhou 310005Zhejiang ProvinceChina
出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)
年 卷 期：2024年第15卷第7期
页 面：1551-1561页
核心收录：
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by the Discipline Construction Project of Hunan University of Chinese Medicine No.22JBZ002
主 题：Type 1 diabetes Inflammatory bowel disease Ulcerative colitis Crohn’s disease Mendelian randomization
摘 要：BACKGROUND The impact of type 1 diabetes(T1D)on inflammatory bowel disease(IBD)remains *** To analyze the causal relationship between T1D and IBD using Mendelian randomization(MR).METHODS Single nucleotide polymorphisms were sourced from FinnGen for T1D,IBD,ulcerative colitis(UC)and Crohn’s disease(CD).Inverse variance-weighted,MREgger,and weighted median tests were used to assess exposure-outcome *** MR-Egger intercept was used to assess horizontal ***’s Q and leave-one-out method were used to analyze heterogeneity and sensitivity,*** Our MR analysis indicated that T1D was associated with a reduced risk of IBD[odds ratio(OR):0.959;95%confidence interval(CI):0.938-0.980;P0.05).Cochran’s Q and leave-one-out sensitivity analyses showed that the results were not heterogeneous(P0.05)and were *** This MR analysis suggests that T1D serves as a potential protective factor against IBD and UC but is independent of CD.
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