检索结果-南通市图书馆

The marriage of immunomodulatory,angiogenic,and osteogenic capabilities in a piezoelectric hydrogel tissue engineering scafold for military medicine

引用

Military Medical Research 2024年第3期11卷 323-344页

作者： Ping Wu lin Shen Hui-Fan liu Xiang-Hui Zou Juan zhao yu Huang yu-Fan Zhu zhao-yu li Chao Xu li-Hua Luo Zhi-Qiang Luo Min-Hao Wu lin Cai Xiao-Kun li Zhou-Guang Wang Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research the Fifth Affiliated Hospital of Wenzhou Medical UniversityLishui 323000ZhejiangChina Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325000ZhejiangChina Department of Spine Surgery and Musculoskeletal Tumor Zhongnan Hospital of Wuhan UniversityWuhan 430071China National Engineering Research Center for Nanomedicine College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina School and Hospital of Stomatology Wenzhou Medical UniversityWenzhou 325035ZhejiangChina

Background:Most bone-related injuries to grassroots troops are caused by training or accidental *** establish preventive measures to reduce all kinds of trauma and improve the combat effectiveness of grassroots troops,it is imperative to develop new strategies and scafolds to promote bone ***:In this study,a porous piezoelectric hydrogel bone scafold was fabricated by incorporating polydopamine(PDA)-modified ceramic hydroxyapatite(PDA-hydroxyapatite,PHA)and PDA-modified barium titanate(PDABaTiO_(3),PBT)nanoparticles into a chitosan/gelatin(Cs/Gel)*** physical and chemical properties of the Cs/Gel/PHA scafold with 0–10 wt%PBT were *** and animal experiments were performed to characterize the immunomodulatory,angiogenic,and osteogenic capabilities of the piezoelectric hydrogel scafold in vitro and in ***:The incorporation of BaTiO_(3) into the scafold improved its mechanical properties and increased self-generated *** to their endogenous piezoelectric stimulation and bioactive constituents,the prepared Cs/Gel/PHA/PBT hydrogels exhibited cytocompatibility as well as immunomodulatory,angiogenic,and osteogenic capabilities;they not only effectively induced macrophage polarization to M2 phenotype but also promoted the migration,tube formation,and angiogenic differentiation of human umbilical vein endothelial cells(HUVECs)and facilitated the migration,osteodifferentiation,and extracellular matrix(ECM)mineralization of MC3T3-E1 *** in vivo evaluations showed that these piezoelectric hydrogels with versatile capabilities significantly facilitated new bone formation in a rat large-sized cranial injury *** underlying molecular mechanism can be partly attributed to the immunomodulation of the Cs/Gel/PHA/PBT hydrogels as shown via transcriptome sequencing analysis,and the PI3K/Akt signaling axis plays an important role in regulating macrophage M2 ***:The piezoelectric Cs/Gel/PHA/PBT hy

关键词： Piezoelectric hydrogel Tissue engineering scafold Immunomodulation Angiogenesis Osteogenic differentiation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mesenchymal stem cell-derived extracellular vesicles in skin wound healing:roles,opportunities and challenges

引用

Military Medical Research 2024年第3期11卷 400-429页

作者： Jia-Yi Ding Min-Jiang Chen ling-Feng Wu Gao-Feng Shu Shi-Ji Fang zhao-yu li Xu-Ran Chu Xiao-Kun li Zhou-Guang Wang Jian-Song Ji Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiangLishui 323000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Clinical College of the Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000ZhejiangChina Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina Department of Medicine Ⅱ Internal MedicineCardio-Pulmonary Institute(CPI)Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany Pulmonary and Critical Care Department of Medicine VInternal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany

Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or *** such injuries are common to all human groups,they may at times represent a serious socioeconomic ***,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound *** a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell *** based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair *** addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix ***,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma *** the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound *** conclusion,MSCderived EV-based therapies have important application prospects in wound *** we provide a comprehensive overview of their current status,application potential,and associated drawbacks.

关键词： Mesenchymal stem cell(MSC) Extracellular vesicles(EVs) Wound repair Engineered nanoparticles

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

等值反磁通瞬变电磁法在浅部岩溶探测中的应用研究——以惠州市龙门县某地区为例

引用

地下水 2024年第3期46卷 141-142,269页

作者：赵玉立天津华北地质勘查局核工业二四七大队天津301800

传统瞬变电磁法受关断时间和互感的过渡过程影响,存在较大浅部盲区;新近发展迅速的等值反磁通瞬变电磁法从理论和仪器上实现了纯二次场的观测,大大提高了浅部区域的探测精度。为研究等值反磁通瞬变电磁法在100 m以浅岩溶探测的应用效果... 详细信息

传统瞬变电磁法受关断时间和互感的过渡过程影响,存在较大浅部盲区;新近发展迅速的等值反磁通瞬变电磁法从理论和仪器上实现了纯二次场的观测,大大提高了浅部区域的探测精度。为研究等值反磁通瞬变电磁法在100 m以浅岩溶探测的应用效果,以惠州市龙门县某岩溶发育区为靶区,开展了方法有效性研究,取得主要成果与结论:(1)界定的土石界面和圈定的岩溶发育区与已知钻孔揭露情况吻合较好,验证了基于等磁反磁通瞬变电磁法在100 m以浅岩溶探测的有效性;(2)反映区内岩溶具有一定连通性,岩溶大小约1~20 m,岩溶主要发育于20~40 m及60 m以下埋深。研究结果一方面有效圈定了研究区100 m以浅岩溶发育区,对后续桥梁工程的安全建设具有重要意义;另一方面等值反磁通瞬变电磁法具有施工便捷、采集高效、抗干扰强等优势,未来有望在城市浅部空间探测领域实现更大作为。

关键词：瞬变电磁法等磁反磁通岩溶勘察浅部盲区惠州市龙门县

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NUMERICAL SIMULATION OF THE HYDRODYNAMIC PERFORMANCE OF AN UNSYMMETRICAL FLAPPING CAUDAL FIN

引用

Journal of Hydrodynamics 2012年第3期24卷 354-362页

作者： ZHANG Xi SU yu-min WANG zhao-li State Key Laboratory of Autonomous Underwater Vehicle Harbin Engineering University Harbin 150001 China

A comprehensive numerical simulation of the hydrodynamic performance of a caudal fin with unsymmetric flapping motion is carried out. The unsymmetrical motion is induced by adding a pitch bias or a heave bias. A numerical simulation program based on the unsteady panel method is developed to simulate the hydrodynamics of an unsymmetrical flapping caudal fin. A CFD code based on Navier-Stokes equations is used to analyze the flow field. Computational results of both the panel method and the CFD method indicate that the hydrodynamics are greatly affected by the pitch bias and the heave bias. The mean lateral force coefficient is not zero as in contrast with the symmetrical flapping motion. By increasing the pitch bias angle, the mean thrust force coefficient is reduced rapidly. By adding a heave bias, the hydrodynamic coefficients are separated as two parts： in one part, the amplitude is the heave amplitude plus the bias and in the other part, it is the heave amplitude minus the bias. Analysis of the flow field shows that the vortex distribution is not symmetrical, which generates the non-zero mean lateral force coefficient.

关键词： flapping caudal fin caudal fin shape numerical simulations hydrodynamic experiments hydrodynamic performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Management of variceal hemorrhage： current status

引用

Chinese Medical Journal 2009年第7期122卷 763-765页

作者： BAI yu li zhao-shen Department of Gastro-enterology Digestive Endoscopy Center Changhai HospitalSecond Military Medical University Shanghai 200433 China

Despite much progress has been made in treatment and research in recent decades, variceal hemorrhage is still one of the most severe complications of liver cirrhosis. Studies of the natural history of gastroesophageal varices indicate that gastroesophageal varices are present in about half of cirrhotic patients when endoscopy is performed at the time of the diagnosis of cirrhosis. The presence of gastroesophageal varices correlates with the severity of liver disease. It is present in 40% of Child A patients, in 85% of Child C patients,

关键词： natural history diagnosis of treatment endoscopy research progress Studies time made

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evolution of gastrointestinal endoscopy in the mainland of China

引用

Chinese Medical Journal 2009年第19期122卷 2220-2223页

作者： BAI yu li zhao-shen Evidence-Based Medicine Group Department of Gastroenterology Digestive Endoscopy Center Center of Clinical Epidemiology Changhai Hospital Second Militaby Medical University Shanghai 200433 China

INVENTION OF GASTROINTESTINAL ENDOSCOPYGastrointestinal endoscopy is an important diagnostic and therapeutic tool in our daily medical practice. The evolution of endoscopic technologies from simple tubes to the flexi... 详细信息

关键词： evolution endoscopy, gastrointestinal China

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CaY-zeolite Catalyzed Etherification and Alkylation of Substituted Benzyl Alcohols

引用

Chinese Chemical Letters 2006年第1期17卷 15-18页

作者： Wei yu Miao WEN Guang yu zhao li YANG Zhong li liU National Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000

The reaction of p- and/ α-subtituted benzyl alcohols in CaY-zeolite produced the corresponding dibenzyl ethers and/or benzyl toluenes as the principal products.

关键词： Benzyl alcohols CaY-zeolite etherification alkylation.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparative experiment on layered li(Ni_(1/3)Co_(1/3)Mn_(1/3))O_2 as the alternative material for liCoO_2

引用

Journal of University of Science and Technology Beijing 2007年第2期14卷 173-177页

作者： Jingjing liu Weihua Qiu lingyan yu Hailei zhao Tao li Materials Science and Engineering School University of Science and Technology Beijing Beijing 100083 China

This work was financially supported by the National Natural Science Foundation of China （No.50472093）.

关键词： li(Ni1/3Co1/3Mn1/3)O2 cathode material lithium-ion batteries liCoO2

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

NUMERICAL AND EXPERIMENTAL STUDIES OF INFLUENCE OF THE CAUDAL FIN SHAPE ON THE PROPULSION PERFORMANCE OF A FLAPPING CAUDAL FIN

引用

Journal of Hydrodynamics 2011年第3期23卷 325-332页

作者： ZHANG Xi SU yu-min WANG zhao-li State Key Laboratory of Autonomous Underwater Vehicle Harbin Engineering University Harbin 150001 China

This article presents a comprehensive study of the effects of the caudal fin shape on the propulsion performance of a candal fin in harmonic heaving and pitching. A numerical simulation based on an unsteady panel method was carried out to analyze the hydrodynamic performance of flapping caudal fins of three shapes （the whale caudal fin with the largest projected area, the dolphin caudal fin with the median projected area, and the tuna caudal fin with the smallest projected area）. Then, a series of hydrodynamic experiments for three caudal fin shapes were performed. Both computational and experimental results indicate that the tuna caudal fin produces the highest efficiency. However the mean thrust coefficient of the tuna caudal fin is the smallest. It is found that although the mean thrust coefficient for the tuna caudal fin is not large, the input power of the tuna caudal fin is also quite small. So the tuna caudal fin achieves a high efficiency.

关键词： flapping caudal fin caudal fin shape numerical simulations hydrodynamic experiments hydrodynamic performance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Geochemistry of the limahe Intrusion in the Panxi District, SW China:Discussion on the Relationship to the Emeishan Basalts

引用

Acta Geologica Sinica(English Edition) 2008年第1期82卷 105-116页

作者： li Ying ZHANG zhaochong AI yu zhao li YANG Tiezheng State Key Laboratory of Processed and Mineral Resources China University of Geoscinces Beijing 100083 China

The limahe intrusion is a typical rock hosting Cu-Ni sulfide deposit in the Panxi district. The major element, trace element and Sr-Nd isotopic geochemical data are reported in this study both firstly and systemically. Age-corrected （87Sr/86Sr） and εNd（t） isotope values, ranging from 0.687062 to 0.709298, from -0.6 to -4.13 respectively, are partly overlap the field of the Emeishan basalt and OIB, and they lie between upper crust and OIB generally. The similar patterns between the limahe intrusion and the picrites of the Emeishan large igneous province imply the genetic relationship to the Emeishan basalts. Their lower Nb/U （〈30）, higher （La/Nb）pM and （Th/Ta）pM ratio values （〉1） indicate contamination of the upper crust material. The correlation between MgO and major oxides reflects the fractional crystallization of olivine, clinopyroxene and minor plagioclase in the deep-seated chamber. Therefore increased SiO2 and lowered FeO by the upper crustal contamination may trigger immiscible sulfide melt, which then flowed along the structural fracture and intruded into gabbrodiorite, resulting in the formation of Cu-Ni sulfide orebody.

关键词： assimilation geochemistry mafic-utramafic intrusions limahe Panxi district

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：