检索结果-南通市图书馆

Application of Fusobacterium nucleatum as a biomarker in gastrointestinal malignancies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2271-2283页

作者： Long-Chen yu Ya-Ping Li yue-Ming Xin Mai Mao Ya-Xin Pan Yi-xuan Qu Zheng-Dong Luo Yi Zhang Xin Zhang Department of Clinical Laboratory Qilu Hospital of Shandong UniversityShandong Engineering Research Center of Biomarker and Artificial Intelligence ApplicationJinan 250012Shandong ProvinceChina

The morbidity and mortality of gastrointestinal(GI)malignancies are among the highest in the world,posing a serious threat to human *** of the insidious onset of the cancer,it is difficult for patients to be diagnosed at an early stage,and it rapidly progresses to an advanced stage,resulting in poor treatment and *** nucleatum(***)is a gram-negative,sporefree anaerobic bacterium that primarily colonizes the oral cavity and is implicated in the development of colorectal,esophageal,gastric,and pancreatic cancers via various intricate *** development in novel research suggests that *** may function as a biomarker in GI *** the abundance of *** in stool,saliva,and serum samples of patients may aid in the diagnosis,risk assessment,and prognosis monitoring of GI *** editorial systematically describes the biological roles and mechanisms of *** in GI malignancies focusing on the application of *** as a biomarker in the diagnosis and prognosis of GI malignancies to promote the clinical translation of *** and GI tumors-related research.

关键词： Gastrointestinal malignancies Fusobacterium nucleatum Biomarker Diagnosis Prognosis

论历史的方法与逻辑的方法——与张庆熊讨论有关本体论问题

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

南京大学学报（哲学．人文科学．社会科学） 2024年第3期61卷 142-156页

作者：俞宣孟上海社会科学院哲学研究所上海市200025

本体论一向被当作第一哲学,所谓第一哲学就是原理的原理,它可以解释其他各种问题而其自身则不能被进一步地解释。这一看法不仅把中国哲学排除在哲学之外,而且封闭了哲学本身的发展。其实本体论也是可以被解释的,解释它的方法就是追溯它... 详细信息

本体论一向被当作第一哲学,所谓第一哲学就是原理的原理,它可以解释其他各种问题而其自身则不能被进一步地解释。这一看法不仅把中国哲学排除在哲学之外,而且封闭了哲学本身的发展。其实本体论也是可以被解释的,解释它的方法就是追溯它产生的历史。从历史的方法去看,对本体论的产生具有决定意义的是普遍性的概念。普遍性的概念是从柏拉图的理念发展而来的。普遍性概念依其特征不仅生成了本体论,而且其自身的内涵也随着本体论的发展而发展。因此,循着普遍概念规定性形成和发展的轨迹,能够找到我们理解本体论哲学各种问题和特征的方便入口。从普遍概念入手解说本体论的方法,可以称作历史的方法。若这个方法能够成功——对“第一哲学”作了解释,也许能让我们对哲学本身的发展兴起新的期望。

关键词：本体论普遍概念历史的方法中国哲学西方哲学

维普期刊数据库

Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis (BASIS): protocol of a prospective, multicentre, randomised, controlled trial

在线全文

学校读者我要写书评

暂无评论

Stroke & Vascular Neurology 2024年第1期9卷 66-74页

作者： xuan Sun Ming Yang Dapeng Sun Guangge Peng Yiming Deng Xingquan Zhao Liping Liu Ning Ma Feng Gao Dapeng Mo Wengui yu Yongjun Wang Yilong Wang Zhongrong Miao Department of Interventional Neuroradiology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Department of Neurology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Neurology Comprehensive Stroke&Cerebrovascular CenterUniversity of California IrvineIrvineCaliforniaUSA Chinese Institute for Brain Research BeijingChina National Center for Neurological Diseases BeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Beijing Laboratory of Oral Health Capital Medical UniversityBeijingChina

Background The superiority of balloon angioplasty plus aggressive medical management(AMM)to AMM alone for symptomatic intracranial artery stenosis(sICAS)on efficacy and safety profiles still lacks evidence from randomised controlled trials(RCTs).Aim To demonstrate the design of an RCT on balloon angioplasty plus AMM for *** Balloon Angioplasty for Symptomatic Intracranial Artery Stenosis(BASIS)trial is a multicentre,prospective,randomised,open-label,blinded end-point trial to investigate whether balloon angioplasty plus AMM could improve clinical outcome compared with AMM alone in patients with *** eligible in BASIS were 35–80 years old,with a recent transient ischaemic attack within the past 90 days or ischaemic stroke between 14 days and 90 days prior to enrolment due to severe atherosclerotic stenosis(70%–99%)of a major intracranial *** eligible patients were randomly assigned to receive balloon angioplasty plus AMM or AMM alone at a 1:1 *** groups will receive identical AMM,including standard dual antiplatelet therapy for 90 days followed by long-term single antiplatelet therapy,intensive risk factor management and life-style *** participants will be followed up for *** outcomes Stroke or death in the next 30 days after enrolment or after balloon angioplasty procedure of the qualifying lesion during follow-up,or any ischaemic stroke or revascularisation from the qualifying artery after 30 days but before 12 months of enrolment,is the primary *** BASIS trail is the first RCT to compare the efficacy and safety of balloon angioplasty plus AMM to AMM alone in sICAS patients,which may provide an alternative perspective for treating *** registration number NCT03703635;https://***.

关键词： balloon prospective centre

Comprehensive transcriptional atlas of human adenomyosis deciphered by the integration of single-cell RNA-sequencing and spatial transcriptomics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2024年第7期15卷 530-546页

作者： Tao Chen Yiliang Xu Xiaocui Xu Jianzhang Wang Zhiruo Qiu Yayuan yu Xiaohong Jiang Wanqi Shao Dandan Bai Mingzhu Wang Shuyan Mei Tao Cheng Li Wu Shaorong Gao xuan Che Department of Obstetrics and Gynecology Affiliated Women and Children Hospital of Jiaxing UniversityJiaxing 314000China Shanghai Key Laboratory of Maternal Fetal Medicine Clinical and Translational Research Center of Shanghai First Maternity and Infant HospitalFrontier Science Center for Stem Cell ResearchSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China Key Laboratory of Animal Bioengineering and Disease Prevention of Shandong Province College of Animal Science and TechnologyShandong Agricultural UniversityTaian 271018China Women’s Hospital School of MedicineZhejiang UniversityHangzhou 310013China Postgraduate training base Alliance of Wenzhou Medical University Wenzhou Medical UniversityWenzhou 325035China Jiaxing University Master Degree Cultivation Base Zhejiang Chinese Medical UniversityHangzhou 310053China Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai Institute of Maternal-Fetal Medicine and Gynecologic OncologyClinical and Translational Research CenterShanghai First Maternity and Infant HospitalSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Adenomyosis is a poorly understood gynecological disorder lacking effective *** persists regarding“invagination”and“metaplasia”*** endometrial-myometrial junction(EMJ)connects the endometrium and myometrium and is important for diagnosing and classifying adenomyosis,but its in-depth study is just *** single-cell RNA sequencing and spatial profiling,we mapped transcriptional alterations across eutopic endometrium,lesions,and *** lesions,we identified unique epithelial(LGR5+)and invasive stromal(PKIB+)subpopulations,along with WFDC1+progenitor cells,supporting a complex interplay between“invagination”and“metaplasia”theories of ***,we observed endothelial cell heterogeneity and abnormal angiogenic signaling involving vascular endothelial growth factor and angiopoietin ***-cell communication differed markedly between ectopic and eutopic endometrium,with aberrant signaling in lesions involving pleiotrophin,TWEAK,and WNT *** study reveals unique stem cell-like and invasive cell subpopulations within adenomyosis lesions identified,dysfunctional signaling,and EMJ abnormalities critical to developing precise diagnostic and therapeutic strategies.

关键词： adenomyosis single-cell RNA sequencing spatial transcriptomics endometrial-myometrial junction progenitor cells

维普期刊数据库

Finite-temperature ductility-brittleness and electronic structures of Al_nSc（n=1,2 and 3）

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第8期43卷 3974-3989页

作者： Xue-Qian Wang Ying Zhao Hao-xuan Liu Shu-Chen Sun Hong-Bo Yang Jia-Min Zhong Gan-Feng Tu Song Li yu-Dong Zhang Claude Esling Hai-Le Yan Liang Zuo Key Laboratory for Anisotropy and Texture of Materials (Ministry of Education) School of Material Science and EngineeringNortheastern University School of Metallurgy Northeastern University Rare Earth Functional Materials (Xiong'an) Innovation Center Co. Ltd. Laboratoire d'étude des Microstructures et de Mécanique des Matériaux (LEM3) Unikersité de Lorraine

Finite-temperature ductility-brittleness and electronic structures of Al3Sc,Al2Sc and AlSc are studied comparatively by first-principles calculations and ab initio molecular *** show that Al3Sc and Al2Sc are brittle at both ground state and finite temperatures,while AlSc possesses a significantly superior *** ground state,AlSc is ductile from Pugh's and Poisson's criteria,while it is brittle in Pettifor's *** ductility of all Al3Sc,Al2Sc and AISc improves greatly with the elevated ***,the Cauchy pressure of AlSc undergoes a transition from negative to *** T> 600 K,AlSc is unequivocally classified as ductile from all criteria *** all compounds,the Al-Al bond originated from s-p and p-p orbital hybridizations,and the Al-Sc bond dominated by p-d covalent hybridization,are the first and second strongest chemical bonds,*** explain the difference in mechanical properties,the mean bond strength（MBS） is introduced in this *** weaker Al-Al bond in AlSc,leading to a smaller MBS,could be the origin of the softer elastic stiffness and superior intrinsic *** longer length of the Al-Al bond in AlSc is responsible for its weaker bond ***,the enhanced metallicity of the Al-Al bond in AlSc would also contribute to its exceptional *** longer length of the Al-Al bond in AISc is responsible for its weaker bond ***,the enhanced metallicity of the Al-Al bond in AlSc would also contribute to its exceptional ductility.

关键词： Al–Sc Target materials Intrinsic ductility Finite-temperature elastic constant First-principles calculation

Risk factors associated with intraoperative persistent hypotension in pancreaticoduodenectomy

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2024年第6期16卷 1582-1591页

作者： Xing-Jun Wang Xi-Chen xuan Zhao-Chu Sun Shi Shen Fan yu Na-Na Li Xue-Chun Chu Hui Yin You-Li Hu Department of Anesthesia and Perioperative Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Intraoperative persistent hypotension(IPH)during pancreaticoduodenectomy(PD)is linked to adverse postoperative outcomes,yet its risk factors remain *** To clarify the risk factors associated with IPH during PD,ensuring patient safety in the perioperative *** A retrospective analysis of patient records from January 2018 to December 2022 at the First Affiliated Hospital of Nanjing Medical University identified factors associated with IPH in *** factors included age,gender,body mass index,American Society of Anesthesiologists classification,comorbidities,medication history,operation duration,fluid balance,blood loss,urine output,and blood gas *** was defined as sustained mean arterial pressure30 min despite additional deoxyepinephrine and fluid *** Among 1596 PD patients,661(41.42%)experienced *** logistic regression identified key risk factors:increased age[odds ratio(OR):1.20 per decade,95%confidence interval(CI):1.08-1.33](P<0.001),longer surgery duration(OR:1.15 per additional hour,95%CI:1.05-1.26)(P<0.01),and greater blood loss(OR:1.18 per 250-mL increment,95%CI:1.06-1.32)(P<0.01).A novel finding was the association of arterial blood Ca^(2+)<1.05 mmol/L with IPH(OR:2.03,95%CI:1.65-2.50)(P<0.001).CONCLUSION IPH during PD is independently associated with older age,prolonged surgery,increased blood loss,and lower plasma Ca^(2+).

关键词： Risk factors Pancreaticoduodenectomy Perioperative period Intraoperative persistent hypotension Retrospective cohort study

Development of a novel critical nitrogen concentration-cumulative transpiration curve for optimizing nitrogen management under varying irrigation conditions in winter wheat

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Crop Journal 2024年第4期12卷 1242-1251页

作者： Tianyang Ye yu Zhang Jingyan xuan Xintian Wang Yang Li Junhao Xu Liujun Xiao Leilei Liu Liang Tang Weixing Cao Bing Liu Yan Zhu National Engineering and Technology Center for Information Agriculture Engineering Research Center of Smart AgricultureMinistry of EducationKey Laboratory for Crop System Analysis and Decision MakingMinistry of AgricultureJiangsu Key Laboratory for Information AgricultureJiangsu Collaborative Innovation Center for Modern Crop ProductionNanjing Agricultural UniversityNanjing 210095JiangsuChina Institute of Remote Sensing and Digital Agriculture Sichuan Academy of Agricultural SciencesChengdu 610066SichuanChina

Accurate nitrogen(N)nutrition diagnosis is essential for improving N use efficiency in crop *** widely used critical N(Nc)dilution curve traditionally depends solely on agronomic variables,neglecting crop water *** three-year field experiments with winter wheat,encompassing two irrigation levels(rainfed and irrigation at jointing and anthesis)and three N levels(0,180,and 270 kg ha1),this study aims to establish a novel approach for determining the Nc dilution curve based on crop cumulative transpiration(T),providing a comprehensive analysis of the interaction between N and water *** Nc curves derived from both crop dry matter(DM)and T demonstrated N concentration dilution under different conditions with different *** equation Nc=6.43T0.24 established a consistent relationship across varying irrigation *** test results indicated that the nitrogen nutrition index(NNI),calculated from this curve,effectively identifies and quantifies the two sources of N deficiency:insufficient N supply in the soil and insufficient soil water concentration leading to decreased N availability for root ***,the NNI calculated from the Nc-DM and Nc-T curves exhibited a strong negative correlation with accumulated N deficit(Nand)and a positive correlation with relative grain yield(RGY).The NNI derived from the Nc-T curve outperformed the NNI derived from the Nc-DM curve concerning its relationship with Nand and RGY,as indicated by larger R2 values and smaller *** novel Nc curve based on T serves as an effective diagnostic tool for assessing winter wheat N status,predicting grain yield,and optimizing N fertilizer management across varying irrigation *** findings would provide new insights and methods to improve the simulations of water-N interaction relationship in crop growth models.

关键词： Crop dry matter Crop cumulative transpiration Bayesian statistical model Critical nitrogen dilution curve Nitrogen nutrition index

维普期刊数据库

Microbiome and metabolome dysbiosis analysis in impaired glucose tolerance for the prediction of progression to diabetes mellitus

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第1期51卷 75-86页

作者： Boxun Zhang xuan Zhang Zhen Luo Jixiang Ren Xiaotong yu Haiyan Zhao Yitian Wang Wenhui Zhang Weiwei Tian Xiuxiu Wei Qiyou Ding Haoyu Yang Zishan Jin Xiaolin Tong Jun Wang Linhua Zhao Institute of Metabolic Diseases Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Faculty of Biological Science and Technology Baotou Teacher's CollegeBaotouInner Mongolia 014030China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Infinitus(China)Company Ltd GuangzhouGuangdong 510405China Affiliated Hospital of Changchun University of Chinese Medicine ChangchunJilin 130021China Department of Endocrinology Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Xinjiekou Community Health Service Center in Xicheng District Beijing 100035China Department of Spleen and Stomach Shenzhen Traditional Chinese Medicine HospitalShenzhenGuangdong 518033China University of Chinese Academy of Sciences Beijing 100049China Beijing University of Chinese Medicine Beijing 100105China Northeast Asia Institute of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchunJilin 130117China

Gut microbiota and circulating metabolite dysbiosis predate important pathological changes in glucose metabolic disorders;however,comprehensive studies on impaired glucose tolerance(IGT),a diabetes mellitus(DM)precursor,are ***,we perform metagenomic sequencing and metabolomics on 47 pairs of individuals with IGT and newly diagnosed DM and 46 controls with normal glucose tolerance(NGT);patients with IGT are followed up after 4 years for progression to *** of baseline data reveals significant differences in gut microbiota and serum metabolites among the IGT,DM,and NGT *** addition,13 types of gut microbiota and 17 types of circulating metabolites showed significant differences at baseline before IGT progressed to DM,including higher levels of Eggerthella unclassified,Coprobacillus unclassified,Clostridium ramosum,L-valine,L-norleucine,and L-isoleucine,and lower levels of Eubacterium eligens,Bacteroides faecis,Lachnospiraceae bacterium 3_1_46FAA,Alistipes senegalensis,Megaspaera elsdenii,Clostridium perfringens,α-linolenic acid,10E,12Z-octadecadienoic acid,and dodecanoic acid.A random forest model based on differential intestinal microbiota and circulating metabolites can predict the progression from IGT to DM(AUC=0.87).These results suggest that microbiome and metabolome dysbiosis occur in individuals with IGT and have important predictive values and potential for intervention in preventing IGT from progressing to DM.

关键词： Impaired glucose tolerance Diabetes mellitus Gut microbiota Metabolomics

shinyTempSignal:an R shiny application for exploring temporal and other phylogenetic signals

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第7期51卷 762-768页

作者： Li Zhan Xiao Luo Wenqin Xie xuan-An Zhu Zijing Xie Jianfeng Lin Lin Li Wenli Tang Rui Wang Lin Deng yufan Liao Bingdong Liu Yantong Cai Qianwen Wang Shuangbin Xu Guangchuang yu Department of Bioinformatics School of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China Faculty of Computers Guangdong University of TechnologyGuangzhouGuangdong 510006China Ubigene Biosciences Co. Ltd.GuangzhouGuangdong 510530China State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyGuangdong Institute of MicrobiologyGuangdong Academy of SciencesGuangzhouGuangdong 510070China

The molecular clock model is fundamental for inferring species divergence times from molecular ***,its direct application may introduce significant biases due to sequencing errors,recombination events,and inaccurately labeled sampling *** accuracy necessitates rigorous quality control measures to identify and remove potentially erroneous ***,while not all branches of a phylogenetic tree may exhibit a clear temporal signal,specific branches may still adhere to the assumptions,with varying evolutionary *** a relaxed molecular clock model better aligns with the complexities of *** root-to-tip regression method has been widely used to analyze the temporal signal in phylogenetic studies and can be generalized for detecting other phylogenetic *** its utility,there remains a lack of corresponding software implementations for broader *** address this gap,we present shinyTempSignal,an interactive web application implemented with the shiny framework,available as an R package and publicly accessible at https://***/yuLab-SMU/*** tool facilitates the analysis of temporal and other phylogenetic signals under both strict and relaxed *** extending the root-to-tip regression method to diverse signals,shinyTempSignal helps in the detection of evolving features or traits,thereby laying the foundation for deeper insights and subsequent analyses.

关键词： Molecular clock Root-to-tip regression Temporal signal Phylogenetic signal