检索结果-南通市图书馆

Differential distribution of PINK1 and Parkin in the primate brain implies distinct roles

Neural Regeneration Research 2025年第4期20卷 1124-1134页

作者： Yanting Liu Wei huang Jiayi Wen Xin Xiong ting Xu Qi Wang Xiusheng Chen Xianxian Zhao Shihua Li Xiaojiang Li Weili Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority of in vitro studies have demonstrated that PINK1 phosphorylates Parkin to work together in mitophagy to protect against neuronal ***,it remains largely unclear how PINK1 and Parkin are expressed in mammalian *** has been difficult to address because of the intrinsically low levels of PINK1 and undetectable levels of phosphorylated Parkin in small *** this issue is critical for elucidating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selectively expressed as a truncated form(PINK1–55)in the primate *** the present study,we used multiple antibodies,including our recently developed monoclonal anti-PINK1,to validate the selective expression of PINK1 in the primate *** found that PINK1 was stably expressed in the monkey brain at postnatal and adulthood stages,which is consistent with the findings that depleting PINK1 can cause neuronal loss in developing and adult monkey ***1 was enriched in the membrane-bound fractionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not colocalize under physiological conditions in cultured monkey astrocytes,though they did colocalize on mitochondria when the cells were exposed to mitochondrial *** findings suggest that PINK1 and Parkin may have distinct roles beyond their well-known function in mitophagy during mitochondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subcellular distribution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

引用

World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： Kun huang Zhu Chen Heng Xiao Hai-Yang Hu Xing-yu Chen Cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

一个鉮从盐简便合成α,β不饱和酸酯、腈的方法

引用

化学学报 1986年第4期44卷 421-423页

作者：施莉兰肖文娟葛玉庭黄耀曾中国科学院上海有机化学研究所中国科学院上海有机化学研究所上海上海上海科技大学应届毕业生

前文曾报道带有吸电子基团取代的甲基三苯钟盐与酮在K2CO3（固）/冠醚/苯体系中直接烯化的方法,不仅操作简便,并可避免强碱对原料和产物所引起的副反应,目前,研究相转移催化Wittig反应的报道渐多,但还不够完善.例如:在改良的Wittig反应... 详细信息

前文曾报道带有吸电子基团取代的甲基三苯钟盐与酮在K2CO3（固）/冠醚/苯体系中直接烯化的方法,不仅操作简便,并可避免强碱对原料和产物所引起的副反应,目前,研究相转移催化Wittig反应的报道渐多,但还不够完善.例如:在改良的Wittig反应中,用碳酸钾水溶液作为碱,副反应仍然容易发生,固体碳酸钾在季胺盐存在下,反应须在甲苯回流下进行,在氯化锂影响下,1,5-二氮杂双环[5,4,0]-5-十一烯（DBU）只能将β-位带有羰基的膦酸酯转化成碳阴离子.固体碳酸钾及含水的二氧六环曾用于带有推电子基团的鏻盐与醛的反应,但

关键词：不饱和酸三苯甲基链烷基相转移催化剂叶立德二恶烷二氧六环溶剂

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

不同贮藏条件下干红辣椒的品质变化

引用

食品科技 2016年第11期41卷 38-42页

作者：付杨黄雨婷黄紫霖贾冬英迟原龙姚开四川大学轻纺与食品学院成都610065 成都大学医护学院成都610106

辛辣味和颜色是干红辣椒重要的评价指标,二者取决于辣椒素类物质含量和色价。不同贮藏条件对干红辣椒的辣椒素类物质含量及色价具有很大的影响。研究结果表明,贮藏期间干红辣椒的辣椒素类物质含量和色价遵循二次动力学方程逐渐降低;贮... 详细信息

辛辣味和颜色是干红辣椒重要的评价指标,二者取决于辣椒素类物质含量和色价。不同贮藏条件对干红辣椒的辣椒素类物质含量及色价具有很大的影响。研究结果表明,贮藏期间干红辣椒的辣椒素类物质含量和色价遵循二次动力学方程逐渐降低;贮藏温度低、与空气接触量少和水分含量低的干红辣椒在贮藏期间辣椒素类物质和色价损失率小。

关键词：干红辣椒贮藏条件辣椒素类物质色价

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Enhancing postoperative pain control by surgically-initiated rectus sheath block in abdominal aortic aneurysm open repair: A case report

引用

World Journal of Clinical Cases 2025年第6期13卷 41-47页

作者： Kuan-Hua Chen Ming-yuan Kang Yi-ting Chang Sheng-Yang huang yung-Szu Wu Center for Cardiovascular Disease Taichung Veterans General HospitalTaichung 407219TaiwanChina Department of Anesthesiology Taichung Veterans General HospitalTaichung 407219TaiwanChina Division of Pediatric Surgery Department of SurgeryTaichung Veterans General HospitalTaichung 407219TaiwanChina School of Medicine National Yang Ming Chiao Tung UniversityTaipei 112304TaiwanChina Department of Post-Baccalaureate Medicine National Chung Hsing UniversityTaichung 402202TaiwanChina

BACKGROUND Abdominal aortic aneurysm(AAA)repair often involves significant postoperative pain,traditionally managed with systemic opioids,which can cause undesirable side *** case report explores the novel use of a surgically-initiated rectus sheath block with a catheter-over-needle assembly for pain management in AAA *** SUMMARY A 67-year-old female with hypertension and previous aortic dissection underwent elective open repair of an infrarenal AAA,which had grown from 3.4 cm to 4.3 cm over 14 months.A rectus sheath block was initiated surgically for postoperative pain *** patient reported low pain scores and did not require systemic intravenous opioids,enabling early ambulation and discharge on postoperative day seven without *** preventing complications of systemic opi-oids,the method indicating a promising direction for postoperative pain management in major vascular *** Surgically-initiated rectus sheath block as a valuable tool for managing postoperative pain in AAA repair.

关键词： Abdominal aortic aneurysm Postoperative pain management Rectus sheath block Surgical anesthesia Opioid-sparing techniques Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于旋转变换和鲁棒主成分分析的车牌校正方法

引用

数学杂志 2017年第2期37卷 439-444页

作者：臧玉婷黄樟灿刘海明熊江孙昊武汉理工大学理学院湖北武汉430070

本文研究了受到非高斯噪声污染及边框信息不完整的车牌图像校正的问题.利用鲁棒主成分分析与旋转变换结合的方法,获得了更具普适性的车牌矫正方法.并通过与主成分分析法、旋转投影法的矫正结果相比较,推广了本文方法具有更好的鲁棒性和... 详细信息

本文研究了受到非高斯噪声污染及边框信息不完整的车牌图像校正的问题.利用鲁棒主成分分析与旋转变换结合的方法,获得了更具普适性的车牌矫正方法.并通过与主成分分析法、旋转投影法的矫正结果相比较,推广了本文方法具有更好的鲁棒性和普适性的结果.

关键词：鲁棒主成分分析低秩恢复旋转

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

卟啉化合物的研究 Ⅵ.双环双金属钴卟啉的合成

引用

化学学报 1986年第9期44卷 955-959页

作者：汪玉廷黄素秋武汉大学化学系武汉大学化学系武汉

金属卟啉配合物对氧还原反应有良好的电催化活性,是一种高效的氧还原反应催化剂.查全性等的研究表明,四对甲氧苯基钴卟啉配合物对氧还原反应有很好的电催化活性和稳定性,是适用于广泛pH范围的氧化还原反应催化剂.Collman等发现双环双金... 详细信息

金属卟啉配合物对氧还原反应有良好的电催化活性,是一种高效的氧还原反应催化剂.查全性等的研究表明,四对甲氧苯基钴卟啉配合物对氧还原反应有很好的电催化活性和稳定性,是适用于广泛pH范围的氧化还原反应催化剂.Collman等发现双环双金属卟啉配合物比单环单金属卟啉的催化活性好,这可能是由于两个卟啉环和两个中心金属离子协同作用的结果.Collman和Anson等合成了一系列“面-面”双环双金属卟啉配合物,并用于催化氧还原反应,发现它们可催化氧还原的四电子反应,将氧分子直接还原成水,可极大限度地

关键词：叶琳红外光谱 IR 光谱氧还原反应双环配合物电催化活性精密合金双金属真空干燥

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

引用

Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong Tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu yu Wang Hanlin huang Jun Ke Feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quickly obtaining densely dispersed coherent particles in steel matrix and its related mechanical property

引用

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 111-118页

作者： Xiaoxiao Wang Qingsong huang School of Chemical Engineering Sichuan UniversityChengdu 610065China

Densely distributed coherent nanoparticles(DCN)in steel matrix can enhance the work-hardening ability and ductility of steel *** the routes to this end can be generally classified into the liquid-solid route and the solid-solid ***,the formation of DCN structures in steel requires long processes and complex *** far,obtaining steel with coherent particle enhancement in a short time remains a bottleneck,and some necessary steps remain ***,we show a high-efficiency liquid-phase refining process reinforced by a dynamic magnetic ***-Y-Mn-O particles had an average size of around(3.53±1.21)nm and can be obtained in just around 180 *** small nanoparticles were coherent with the matrix,implying no accumulated dislocations between the particles and the steel *** findings have a potential application for improving material machining capacity,creep resistance,and radiation resistance.

关键词： ferritic steels coherent particles microstructure compression test work hardening

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

农地转入规模扩大有助于农民农业增收吗?——基于中国中部5省农户调查的实证研究

引用

自然资源学报 2016年第10期31卷 1624-1636页

作者：徐玉婷黄贤金陈志刚钟太洋孙晋坤徐国良南京大学地理与海洋科学学院南京210023 安徽师范大学国土资源与旅游学院安徽芜湖241003 江西财经大学旅游与城市管理学院南昌330013

在全国农地流转、规模经营的呼声越来越高的背景下,农地流转政策的推行是否起到应有的效果有待检验和反思。论文基于来自我国中部5省925个转入户的调查数据,从3组模型全面考察了农地转入规模与农户农业收入之间的关系。实证研究表明:1)... 详细信息

在全国农地流转、规模经营的呼声越来越高的背景下,农地流转政策的推行是否起到应有的效果有待检验和反思。论文基于来自我国中部5省925个转入户的调查数据,从3组模型全面考察了农地转入规模与农户农业收入之间的关系。实证研究表明:1)农地转入规模与农业收入呈正向关系,但农地转入规模的经济收益率仅为2.9%。2)农地转入规模对农业收入的作用在不同区域、流转方式、农户类型之间有明显差异:安徽、湖北和湖南较之河南、江西的规模经济收益率更高,农户自发流转下的规模经济收益率高于集体主导方式,农地转入规模对纯农户农业收入的影响要大于对兼业农户。3)农户平均收入水平随着转入规模增加呈现出先增加后降低的"倒U型"趋势,农地转入规模等级越大,其经济收益率却越低。因此,目前我们亟待解决的是加强农地流转对农户收入影响的系统机制研究,寻找制约流转规模效益的因子,降低农户大规模流转时的风险和损失,而不是盲目扩大流转面积。

关键词：农地流转转入户农业收入规模经济中部5省

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：