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Review:Acute lung injury/acute respiratory distress syndrome (ALI/ARDS): the mechanism,present strategies and future perspectives of therapies

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2007年第1期8卷 60-69页

作者： LUH Shi-ping chiang Chi-huei Department of Surgery Chung-Shan Medical University Hospital 402 Taichung Taiwan China Division of Pulmonary Immunology and Infectious Diseases Taipei Veterans General Hospital 112 Taipei Taiwan China

Acute lung injury/acute respiratory distress syndrome （ALI/ARDS）, which manifests as non-cardiogcnic pulmonary edema, respiratory distress and hypoxemia, could be resulted from various processes that directly or indirectly injure the lung. Extensive investigations in experimental models and humans with ALI/ARDS have revealed many molecular mechanisms that offer therapeutic opportunities for cell or gene therapy. Herein the present strategies and future perspectives of the treatment for ALI/ARDS, include the ventilatory, pharmacological, as well as cell therapies.

关键词： Acute lung injury Acute respiratory distress syndrome Ventilator Cell therapy

Bile acid metabolism and signaling in liver disease and therapy

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Liver Research 2017年第1期1卷 3-9页

作者： John Y.L.chiang Department of Integrative Medical Sciences College of MedicineNortheast Ohio Medical UniversityRootstownOHUSA

Bile acids play a critical role in the regulation of glucose,lipid,and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor(FXR)and membrane G protein-coupled bile acid receptor-1(Gpbar-1,aka TGR5).Agonist activation of FXR and TGR5 improves insulin and glucose sensitivity and stimulates energy metabolism to prevent diabetes,obesity,and non-alcoholic fatty liver disease(NAFLD).Bile acids have both pro-and anti-inflammatory actions through FXR and TGR5 in the intestine and *** the intestine,bile acids activate FXR and TGR5 to stimulate fibroblast growth factor 15 and glucagon-like peptide-1 *** and TGR5 agonists may have therapeutic potential for treating liver-related metabolic diseases,such as diabetes and NAFLD.

关键词： Bile acid metabolism Cholestatic liver diseases Metabolic diseases

Bile acid-based therapies for non-alcoholic steatohepatitis and alcoholic Iiver disease

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Hepatobiliary Surgery and Nutrition 2020年第2期9卷 152-169页

作者： Tiangang Li John Y.L.chiang Department of Pharmacology Toxicology and TherapeuticsUniversity of Kansas Medical CenterKansas CityKSUSA Department of Integrative Medical Sciences Northeast Ohio Medical UniversityRootstownOHUSA

Bile acids are synthesized from cholesterol only in *** acids circulating in the enterohepatic system act as physiological detergent molecules to help solubilize biliary cholesterol and emulsify dietary lipids and fat-soluble vitamins in small *** acids are signaling molecules that activate nuclear receptor farnesoid X receptor(FXR)and cell surface G protein-coupled receptor *** critically regulates bile acid homeostasis by mediating bile acid feedback inhibition of hepatic bile acid *** addition,bile acid-activated cellular signaling pathways regulate metabolic homeostasis,immunity,and cell proliferation in various metabolically active *** the small and large intestine,gut bacterial enzymes modify primary bile acids to generate secondary bile acids to help shape the bile acid pool composition and subsequent biological *** turn,bile acids exhibit anti-microbial properties and modulate gut microbiota to influence host metabolism and ***,bile acid-based therapies including systemic and intestine-restricted FXR agonists,TGR5 agonists,fibroblast growth factor 19 analogue,intestine FXR antagonists,and intestine apical sodium-bile acid transporter(ASBT)inhibitors have been developed as promising treatments for non-alcoholic steatohepatitis(NASH).These pharmacological agents improved metabolic and inflammatory disorders via distinct mechanisms of action that are subjects of extensive research *** recently,human and experimental alcoholic liver disease(ALD)has been associated with disrupted bile acid *** additional,new findings showed that targeting bile acid metabolism and signaling may be promising therapeutic approaches for treating ALD.

关键词： Bile acid farnesoid X receptor(FXR) microbiota non-alcoholic steatohepatitis(NASH) alcoholic liver disease(ALD)

Structure and Potential Application of Konjac Glucomannan Nano Microfibril Aerogel

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Chinese Journal of Structural Chemistry 2016年第1期35卷 166-168页

作者：陈涵穆若郡庞杰谭小丹王敏 chiang Wei-Yin College of Food Science Fujian Agriculture and Forestry University Physics Department of Harvard University

An ultra-light and high porosity nano microfibril aerogel was prepared from konjac glucomannan（KGM） by the electrospinning and freeze-drying. The structure of aerogel was analyzed by scanning electron microscopy（SEM） and X-ray diffraction（XRD） while the density and compressive strength of the samples were studied separately. Results reveal that porous network structure of the KGM nano microfibril aerogel is constructed by intermolecular hydrogen bonds in random and interpenetrate way. The nano microfibril structure presents in the KGM aerogel,which is an important reason of its high density and compressive strength. There is a potential application for this unique nano microfibril aerogel in the absorption of biodegradation bacteria to solve problems in marine oil spill pollution.

关键词： konjac glucomannan electrospinning nano fibre aerogel absorption of biodegradation bacteria marine oil spill pollution

Hepatocellular carcinoma in patients with renal dysfunction: Pathophysiology, prognosis, and treatment challenges

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World Journal of Gastroenterology 2021年第26期27卷 4104-4142页

作者： Hsuan Yeh Chung-Cheng chiang Tzung-Hai Yen Department of Nephrology Chang Gung Memorial Hospital and Chang Gung UniversityTaipei 105Taiwan Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalTaoyuan 333Taiwan

The population of patients with hepatocellular carcinoma(HCC)overlaps to a high degree with those for chronic kidney disease(CKD)and end-stage renal disease(ESRD).The degrees of renal dysfunction vary,from the various stages of CKD to dialysis-dependent ESRD,which often affects the prognosis and treatment choice of patients with *** addition,renal dysfunction makes treatment more difficult and may negatively affect treatment *** study summarized the possible causes of the high comorbidity of HCC and renal *** possible mechanisms of CKD causing HCC involve uremia itself,long-term dialysis status,immunosuppressive agents for postrenal transplant status,and miscellaneous factors such as hormone alterations and *** possible mechanisms of HCC affecting renal function include direct tumor invasion and hepatorenal ***,we categorized the risk factors that could lead to both HCC and CKD into four categories:Environmental toxins,viral hepatitis,metabolic syndrome,and vasoactive *** CKD and ESRD have been reported to negatively affect HCC prognosis,but more research is warranted to confirm ***,ESRD status itself ought not to prevent patients receiving aggressive *** study then adopted the well-known Barcelona Clinic Liver Cancer guidelines as a framework to discuss the indicators for each stage of HCC treatment,treatment-related adverse renal effects,and concerns that are specific to patients with pre-existing renal dysfunction when undergoing aggressive treatments against CKD and *** aggressive treatments include liver resection,simultaneous liver kidney transplantation,radiofrequency ablation,and transarterial ***,focusing on patients unable to receive active treatment,this study compiled information on the latest systemic pharmacological therapies,including targeted and immunotherapeutic *** on available clinical studies and Food and Drug Administration labe

关键词： Hepatocellular carcinoma Chronic kidney disease End-stage renal disease Hemodialysis Cancer prognosis Cancer therapeutics

Inter-granular liquid phase aiding grain boundary sliding in superplastic deformation of fine-grained ZK60 Mg alloy

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Transactions of Nonferrous Metals Society of China 2010年第B7期20卷 576-579页

作者： LEE Shyong chiang Chih-te CHU Chun-lin HSU Chang-chuan Department of Mechanical Engineering National Central University Jhong-li Taiwan China Chun-Shan Institute of Science Lung-tan Taiwan China

For 7475 Al alloy,there were micrographs showing filaments or whiskers formation during the separation stage of superplastic *** indicates the presence of liquid phase which accommodates grain boundary sliding to reach *** the other hand,there is no such phenomenon reported regarding Mg alloy in *** electron microscopic(SEM)fractography exceptionally exhibits a mark of grain boundary sliding and its accommodating mechanism of inter-granular liquid *** the testing conditions of 350℃ and 1×10- 4s -1,the initially fine-grained structure(3.7μm)yields 642%superplastic elongation and exhibits fluffy appearance on the fractured *** other specimens showing less superplasticity,their fractured surfaces exhibit partial fluffy appearance.

关键词： Mg alloy inter-granular phase grain boundary sliding superplastic deformation

Stellar X-ray Sources in the Rosette Nebula

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Chinese Journal of Astronomy and Astrophysics 2004年第2期4卷 153-165页

作者： W.P.Chen P.S.chiang J.Z.Li Institute of Astronomy National Central UniversityChung-Li 32054Taiwan National Astronomical Observatories Chinese Academy of SciencesBeijing 100012

We present optical photometric and spectroscopic studies of ROSAT X-ray stellar sources in the Rosette Nebula star-forming region. The brightest X-ray sources are either massive stars or active T Tauri stars associated with the open cluster NGC 2244, or are foreground stars. Some of the spectra of the young stars newly identified in the region are presented.

关键词： stars: early-type stars: pre-main sequence stars: formation HII regions

Distinguish models mimicking the SM Higgs

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Frontiers of physics 2013年第3期8卷 285-293页

作者： Jung Chang Kingman Cheung Po-Yan Tseng Tzu-chiang yuan Department of Physics Tsing Hua University Hsinchu 300 Taiwan China Division of Quantum Phases and Devices School of Physics Konkuk University Seoul 143-701 Republic of Korea Institute of Physics Academia Sinica Nangang Taipei 11529 Taiwan China

The new particle around 125 GeV observed at the LHC is almost consistent with the standard model Higgs boson, except that the diphoton decay mode may be excessive. We summarize a number of possibilities. We propose to use the vector-boson fusion to test the underlying model for electroweak symmetry breaking. Using the well known dijet-tagging technique to single out the vector-boson fusion mechanism, we investigate potential of vector-boson fusion to discriminate a number of models suggested to give an enhanced inclusive diphoton production rate.

关键词： Higgs boson vector-boson fusion diphoton electroweak svmmetrv breaking

Progress on the Structures and Functions of Aerogels

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Chinese Journal of Structural Chemistry 2016年第3期35卷 487-497页

作者：穆若郡庞杰袁毅谭小丹王敏陈涵 Wei-Yin chiang College of Food Science Fujian Agriculture and Forestry University Physics Department of Harvard University

Aerogel materials possess a wide variety of excellent functions,hence a striking number of applications have developed for *** this paper,we present a historic review of the aerogel materials,showing the main concepts,research methods,important scientific problems,formation mechanism,structure characteristics and essence of *** applications are evolving as the scientific and engineering community,which becomes familiar with the unusual and exceptional physical properties of *** addition,we also discuss the huge development potential and prospect of polysaccharide aerogels as the research trend in the future.

关键词： aerogel electrospinning ultralight nanofiber material silicon dioxide insulation adsorption environmental protection optical polysaccharide konjac glucomannan