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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui yu Yan Xie Jian yu Kun-Ning zhang Zhou-Bo Guo Di Wang Zhao-Xian Li wei-Qi zhang yu-Ying Tan Li zhang Wen-tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Roles of liver innate immune cells in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2010年第37期16卷 4652-4660页

作者： yu-tao zhan.wei an Department of Gastroenterology and Hepatology Beijing Tongren Hospital Capital Medical University Beijing 100730 China Department of Cell Biology Capital Medical UniversityBeijing 100069China

Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease in the United States and other developed countries and is expected to increase in the next few years. Emerging data suggest that some patients with NAFLD may progress to nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma. NAFLD can also promote the development and progression of disease in other organ systems, such as the cardiovascular and endocrine (i.e. diabetes) systems. Thus, understanding the pathogenesis of NAFLD is of great clinical importance and is critical for the prevention and treatment of the disease. Although the "two-hit hypothesis" is generally accepted, the exact pathogenesis of NAFLD has not been clearly established. The liver is an important innate immune organ with large numbers of innate immune cells, including Kupffer cells (KCs), natural killer T (NKT) cells and natural killer (NK) cells. Recent data show that an imbalance in liver cytokines may be implicated in the development of fatty liver disease. For example, Th1 cytokine excess may be a common pathogenic mechanism for hepatic insulin resistance and NASH. Innate immune cells in the liver play important roles in the excessive production of hepatic Th1 cytokines in NAFLD. In addition, liver innate immune cells participate in the pathogenesis of NAFLD in other ways. For example, activated KCs can generate reactive oxygen species, which induce liver injury. This review will focus primarily on the possible effect and mechanism of KCs, NKT cells and NK cells in the development of NAFLD.

关键词： Innate immune cells Nonalcoholic fatty liver disease Kupffer cell Natural killer T cell Natural killer cell

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Glycosyltransferases and non-alcoholic fatty liver disease

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World Journal of Gastroenterology 2016年第8期22卷 2483-2493页

作者： yu-tao zhan Hai-Ying Su wei An Department of Gastroenterology Beijing Tongren Hospital Capital Medical University Department of Obstetrics and Gynecology Shandong Jining First People’s Hospital Department of Cell Biology Municipal Laboratory for Liver Protection and Regulation of Regeneration Capital Medical University

Non-alcoholic fatty liver disease(NAFLD) is the most common form of chronic liver disease and its incidence is increasing worldwide. However, the underlying mechanisms leading to the development of NAFLD are still not fully understood. Glycosyltransferases(GTs) are a diverse class of enzymes involved in catalyzing the transfer of one or multiple sugar residues to a wide range of acceptor molecules. GTs mediate a wide range of functions from structure and storage to signaling, and play a key role in many fundamental biological processes. Therefore, it is anticipated that GTs have a role in the pathogenesis of NAFLD. In this article, we present an overview of the basic information on NAFLD, particularly GTs and glycosylation modification of certain molecules and their association with NAFLD pathogenesis. In addition, the effects and mechanisms of some GTs in the development of NAFLD are summarized.

关键词： Non-alcoholic fatty liver disease Pathogenesis Glycosyltransferases Glycosylation

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Plasmonic molecular assays： Recent advances and applications for mobile health

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Nano Research 2018年第10期11卷 5439-5473页

作者： tao yu Qingshan wei Department of Chemical and Biomolecular Engineering North Carolina State University 911 Partners Way Campus Box 7905Raleigh NC 27695 USA

Plasmonics-based biosensing assays have been extensively employed for biomedical applications. Significant advancements in use of plasmonic assays for the construction of point-of-care （POC） diagnostic methods have been made to provide effective and urgent health care of patients, especially in resource- limited settings. This rapidly progressive research area, centered on the unique surface plasmon resonance （SPR） properties of metallic nanostructures with exceptional absorption and scattering abilities, has greatly facilitated the development of cost-effective, sensitive, and rapid strategies for disease diagnostics and improving patient healthcare in both developed and developing worlds. This review highlights the recent advances and applications of plasmonic technologies for highly sensitive protein and nucleic acid biomarker detection. In particular, we focus on the implementation and penetration of various plasmonic technologies in conventional molecular diagnostic assays, and discuss how such modification has resulted in simpler, faster, and more sensitive alternatives that are suited for point-of-use. Finally, integration of plasmonic molecular assays with various portable POC platforms for mobile health applications are highlighted.

关键词： plasmonics molecular assay point-of-care diagnostics mobile health imaging sensing

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A quantitative benefit evaluation of code search platform for enterprises

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Science China(Information Sciences) 2020年第9期63卷 58-60页

作者： zhan SHI Jie TANG Hao yu Yongxu XING Zhiwei LIU wei BAI tao LI Baidu (China) Co. Ltd Baidu Online Network Technology (Beijing) Co. Ltd

Dear editor,With the size and complexity of modern software growing, developers need more efficient tools to accomplish all kinds of routine tasks, such as coding,compiling, and analyzing program structure [1].Among t... 详细信息

关键词： code search efficiency evaluation software engineering efficiency engineer development platform

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Relative Broken Family Sensitivity

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Acta Mathematica Sinica,English Series 2024年第9期40卷 2297-2306页

作者： Zhuo wei LIU tao yu Department of Mathematics Shantou UniversityShantou 515063P.R.China

Letπ:(X,T)→(Y,S)be a factor map between two topological dynamical systems,and F_(a) Furstenberg family of *** introduce the notion of relative broken *** Fs(***,Finf)be the families consisting of all syndetic subsets(*** upper Banach density subsets,infinite subsets).We show that for a factor mapπ:(X,T)→(Y,S)between transitive systems,πis relatively broken F-sensitive for F=Fs or Fpubd if and only if there exists a relative sensitive pair which is an F-recurrent point of(R_(π),T^((2)));is relatively broken Finf-sensitive if and only if there exists a relative sensitive pair which is not *** a factor mapπ:(X,T)→(Y,S)between minimal systems,we get the structure of relative broken F-sensitivity by the factor map to its maximal equicontinuous factor.

关键词： Relative sensitivity recurrent points Furstenberg family relative sensitive pairs maximal equicontinuous factor

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Differentiation of rat bone marrow stem cells in liver after partial hepatectomy

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World Journal of Gastroenterology 2006年第31期12卷 5051-5054页

作者： yu-tao zhan yu Wang Lai wei Bin Liu Hong-Song Chen Xu Cong Ran Fei Department of Gastroenterology Beijing Tongren Hospital Capital Medical University Beijing 100730 China Hepatology Institute Beijing University People's Hospital Beijing 100044 China

AIM： To investigate the differentiation of rat bone marrow stem cells in liver after partial hepatectomy. METHODS： Bone marrow cells were collected from the tibia of rat with partial hepatectomy, the medial and left hepatic lobes were excised. The bone marrow stem cells （Thy^＋CD3^-CD45RA^- cells） were enriched from the bone marrow cells by depleting red cells and fluorescence-activated cell sorting. The sorted bone marrow stem cells were labeled by PKH26-GL in vitro and autotransplanted by portal vein injection. After 2 wk, the transplanted bone marrow stem cells in liver were examined by the immunohistochemistry of albumin （hepatocyte-specific marker）. RESULTS： The bone marrow stem cells （Thy^＋CD3^-CD45RA^- cells） accounted for 2.8% of bone marrow cells without red cells. The labeling rate of 10 μM PKH26- GL on sorted bone marrow stem cells was about 95%. There were sporadic PKH26-GL-labeled cells among hepatocytes in liver tissue section, and some of the cells expressed albumin. CONCLUSION： Rat bone marrow stem cells can differentiate into hepatocytes in regenerative environment and may participate in liver regeneration after partial hepatectomy.

关键词： Bone marrow stem cells Liver regeneration Differentiation

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Velocity and Temperature of In-Flight Particles and Its Significance in Determining the Microstructure and Mechanical Properties of TBCs

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Acta Metallurgica Sinica(English Letters) 2019年第10期32卷 1269-1280页

作者： Lei zhang tao He yu Bai Fang-Li yu wei Fan yu-Shan Ma zhan-Dong Chang Hai-Bo Liu Ben-Qiang Li State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Xi'an 710049 China Wuzhong Instrument Co. Ltd Wu Zhong 751100 China School of Materials Engineering Xi'an Aeronautical University Xi'an 710077 China Department of Mechanical Engineering University of Michigan Dearborn MI 4812& USA

The correlation between particle in-flight parameter, defect content and mechanical property of yttria-stabilized zirconia coating was systematically studied in the present work. The melting state of in-flight particle during spraying was simulated using computational fluid dynamics. The results suggested that, with the increase of velocity and temperature of in-flight particles in the plasma jet, the particles changed from partially melted state to fully melted one. As a result, the total defect content of as-sprayed coating gradually decreased, while elastic modulus and microhardness increased correspondingly. However, the fracture toughness of as-sprayed coating reached a maximum value when the total defect content reached approximately 9.1%.

关键词： Yttria-stabilized zirconia Thermal barrier coating Defect content Computational fluid dynamics Mechanical property

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Farmers using insurance and cooperatives to manage agricultural risks: A case study of the swine industry in China

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Journal of Integrative Agriculture 2019年第12期18卷 2910-2918页

作者： zhanG Yan-yuan JU Guang-wei zhan Jin-tao College of Economics and Management Nanjing Forestry UniversityNanjing 210037P.R.China Chinese Academy of Agricultural Sciences Beijing 100081P.R.China College of Economics and Management Nanjing Agricultural UniversityNanjing 210095P.R.China

Purchasing agricultural insurance and joining agricultural cooperatives are two prevalent instruments used by farmers in China for dealing with agricultural risks. Data from 443 swine farmers in Jiangsu and Henan provinces of China were collected. Factors affecting the farmers’ decision to purchase agricultural insurance and join agricultural cooperatives were assessed. The possibility of simultaneous use of both instruments and the potential correlation between these two decisions was considered as well. Results showed that the farmers’ decision to use agricultural insurance and cooperatives was positively correlated, indicating that farmers who purchased agricultural insurance which mainly used to mitigate production risks were more likely to join agricultural cooperatives which more used to share market risks, and vice versa. Farmers’ knowledge of swine insurance and trust in the local government positively impacted the purchase of agricultural insurance, while education, years involved in swine production and scale of swine production positively impacted farmers joining agricultural cooperatives.

关键词： agricultural insurance agricultural cooperatives simultaneous decisions Bivariate Probit China

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Routing protocol for wireless quantum multi-hop mesh backbone network based on partially entangled GHZ state

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Frontiers of physics 2017年第4期12卷 187-196页

作者： Pei-Ying Xiong Xu-tao yu Zai-Chen zhang Hai-tao zhan Jing-yu Hua State Key Lab of Millimeter Waves Southeast University Nanjing 210096 China National Mobile Communications Research Laboratory Southeast University Nanjing 210096 China College of Information Engineering Zhejiang University of Technology Hangzhou 310023 China

Quantum multi-hop teleportation is important in the field of quantum communication. In this study, we propose a quantum multi-hop communication model and a quantum routing protocol with multi- hop teleportation for wireless mesh backbone networks. Based on an analysis of quantum multi-hop protocols, a partially entangled Greenberger-Horne-Zeilinger （GHZ） state is selected as the quantum channel for the proposed protocol. Both quantum and classical wireless channels exist between two neighboring nodes along the route. With the proposed routing protocol, quantum information can be transmitted hop by hop from the source node to the destination node. Based on multi-hop telepor- tation based on the partially entangled GHZ state, a quantum route established with the minimum number of hops. The difference between our routing protocol and the classical one is that in the for- mer, the processes used to find a quantum route and establish quantum channel entanglement occur simultaneously. The Bell state measurement results of each hop are piggybacked to quantum route finding information. This method reduces the total number of packets and the magnitude of air inter- face delay. The deduction of the establishment of a quantum channel between source and destination is also presented here. The final success probability of quantum multi-hop teleportation in wireless mesh backbone networks was simulated and analyzed. Our research shows that quantum multi-hop teleportation in wireless mesh backbone networks through a partially entangled GHZ state is feasible.

关键词： wireless mesh backbone network multi-hop teleportation partially entangled GHZ state,quantum routing protocol

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