检索结果-南通市图书馆

Clinical evaluation of sintilimab in conjunction with bevacizumab for advanced colorectal cancer with microsatellite stable-type after failure of first-line therapy

引用

World Journal of Gastrointestinal Surgery 2024年第10期16卷 3277-3287页

作者： Liang Wang Yong-Zhi Diao Xin-Fu Ma yu-shuang luo Qi-Jing Guo Xiao-Qian Chen Department of Gastrointestinal Oncology Surgery Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina Department of Gastroenterology The First People’s Hospital of XiningXining 810000Qinghai ProvinceChina Department of Medical Oncology Affiliated Hospital of Qinghai UniversityXining 810000Qinghai ProvinceChina

BACKGROUND At present,immune checkpoint inhibitors(ICIs)remain the 1st-line therapy me-thod for patients suffering from high microsatellite instability/deficient misma-tch repair metastatic colorectal cancer(mCRC).However,ICI treatments demon-strate minimal therapeutic efficacy against microsatellite stable(MSS)/proficient mismatch repair(pMMR)*** is mainly because this type of tumor is a“cold tumor”with almost no lymphocyte ***-angiogenic drugs have been found to improve the immune microenvironment by promoting many immune cells to enter the immune microenvironment,thereby exerting anti-tumor *** To investigate the effects of ICIs combined with bevacizumab monoclonal anti-body on tumor immune cells in MSS/pMMR advanced CRC patients with first-line treatment *** A total of 110 MSS/pMMR patients with advanced CRC after first-line treatment failure in the Affiliated Hospital of Qinghai University were enrolled for a ran-domized controlled *** short,patients in the experimental group(n=60)were given sintilimab plus bevacizumab for 4 cycles,and those in the control group(n=50)patients were treated with FOLFIRI combined with bevacizumab for 4 *** expression levels of cluster of differentiation(CD)8(+)T cells,tumor-associated macrophages(TAMs),and cancer-associated fibroblasts(CAFs)were comprehensively evaluated to assess the effects of sintilimab combined with bevacizumab on MSS/pMMR advanced CRC sufferers following failure of 1st-line *** The positive expression rates of CD8(+)T lymphocytes(30%vs 50%),TAMs(23.30%vs 60%),and CAFs(23.30%vs 50%)before and after treatment in both groups exhibited statistical significance(P<0.05).Additionally,the therapeutic effects of both groups(partial remission:26.67%vs 10%;objective response rate:26.70%vs 10%)were significantly different(P<0.05).Although the experimental group showed a higher progression-free survival,median progression-free survival,and disease control rate

关键词： Immune checkpoint inhibitors Bevacizumab Colorectal cancer Cytotoxic T lymphocytes Tumor-associated macrophages Cancer-associated fibroblasts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synergistically enhanced ORR and HER performance on Co-N-C coupled in-situ generated PtCo intermetallic

引用

Journal of Energy Chemistry 2025年第1期100卷 721-729页

作者： Guanyu luo Min Song Lulu An Xiao Huang Qian Zhang Chenhao Zhang Tao Shen shuang Wang Deli Wang Key Laboratory of Material Chemistry for Energy Conversion and Storage (Huazhong University of Science and Technology) Ministry of Education School of Chemistry and Chemical Engineering Huazhong University of Science and Technology

Integrating multi-scale sites in a composite catalyst is vital to realize efficient ***,a synergistic composite catalyst consisting of Co atomic sites and in-situ generated PtCo intermetallic compounds （IMCs）(o-PtCo@CoNC) is proposed through Co pre-anchoring and subsequent impregnation-reduction *** loading of Co atoms provides a chance for in-situ generating PtCo ordered intermetallic *** remaining Co single atoms and PtCo IMCs construct synergistic electrocatalytic *** from the ordered structure,synergistic effect of Pt Co IMCs and Co single atoms,o-PtCo@CoNC exhibits excellent electrocatalytic performance for oxygen reduction reaction （ORR） and hydrogen evolution reaction （HER） with mass activity of 1.21 A mgPt-1（at 0.9 V） and5.70 A mgPt-1（at an overpotential of 100 mV）,***,o-PtCo@CoNC delivers negligible loss of half-wave potential and overpotential during long-term stability test in acid solutions,with 13 mV decay after 50,000 potential cycles for ORR and a 2.7 mV decay after 20,000 potential cycles for *** integration strategy of single-atomic sites coupled IMCs paves the way for enhancing the activity and durability of Pt-based electrocatalysts.

关键词： Electrolytic reduction

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist

引用

Neural Regeneration Research 2025年第10期20卷 2895-2897页

作者： Nicolas Hugues yu luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA Division of Immunobiology Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOHUSA

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the *** the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

关键词： Figure signature critical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

预浸泡对桃金娘果汁中抗氧化物质和抗氧化活性的影响

引用

食品工业科技 2017年第1期38卷 75-80,86页

作者：邹雨辰罗爽妍段翰英刘柳罗尧欣王超暨南大学食品科学与工程系广东广州510632

本研究将桃金娘整果分别浸泡在不同温度的水、盐酸、柠檬酸、抗坏血酸和亚硫酸氢钠溶液中10、20、30 min,分析不同处理对桃金娘果汁中总多酚、总花青素、总黄酮和抗氧化活性的影响。结果表明,在40~60℃水中浸泡,桃金娘果汁中总多酚、总... 详细信息

本研究将桃金娘整果分别浸泡在不同温度的水、盐酸、柠檬酸、抗坏血酸和亚硫酸氢钠溶液中10、20、30 min,分析不同处理对桃金娘果汁中总多酚、总花青素、总黄酮和抗氧化活性的影响。结果表明,在40~60℃水中浸泡,桃金娘果汁中总多酚、总花青素、总黄酮含量和抗氧化活性显著降低,然而在80℃热水和1%盐酸中预浸泡可保持或增加抗氧化物含量。柠檬酸、抗坏血酸或NaHSO_3溶液能降低抗氧化物质的损失程度。同时研究了桃金娘中多酚氧化酶(PPO)和过氧化酶(POD)在不同pH和温度下的稳定性。温度达到100℃、pH小于2时PPO和POD活性才被完全抑制。因此不同的预浸泡方式影响桃金娘果汁PPO和POD的酶活,而抗氧化物质和抗氧化活性的稳定性与PPO和POD的活性负相关。

关键词：桃金娘果汁预浸泡抗氧化物质多酚氧化酶过氧化酶

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Consistent and Accurate TDOA Localization in Dynamic NLOS Environments via Prior Information Independent Estimation

引用

China Communications 2024年第9期21卷 198-210页

作者： luo Mei Long yu Xiong Youzhi Qin shuang Key Laboratory of Wireless Sensor Network in University of Sichuan Province College of Physics and Electronic EngineeringSichuan Normal UniversityChengdu 610101China

In the time-difference-of-arrival(TDOA)localization,robust least squares(LS)problems solved by mathematical programming were proven to be superior in mitigating the effects of non-line-of-sight(NLOS)***,the existing algorithms still suffer from two disadvantages:1)The algorithms strongly depend on prior information;2)The approaches do not satisfy the mean square error(MSE)optimal criterion of the measurement *** tackle the troubles,we first formulate an MSE minimization model for measurement noise by taking the source and the NLOS biases as *** obtain stable solutions,we introduce a penalty function to avoid abnormal *** further tackle the nonconvex locating problem with semidefinite relaxation ***,we incorporate mixed constraints and variable information to improve the estimation *** and experiments show that the proposed method achieves consistent performance and good accuracy in dynamic NLOS environments.

关键词： mathematical programming NLOS mitigation robust least squares TDOA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

药物性肝损伤的免疫学机制

引用

临床肝胆病杂志 2025年第12期40卷 2538-2542页

作者：王宇李爽刘成海上海市宝山区中西医结合医院消化科上海 201999 上海中医药大学附属曙光医院肝病研究所上海 201203 教育部肝肾疾病重点实验室上海市中医临床重点实验室上海 201203

药物性肝损伤（DILI）机制复杂，涉及多种途径协同促进并互为因果，其中免疫反应在致病机制中扮演重要角色。在遗传背景因素下，药物活性代谢产物、药物-分子复合物、危险信号分子或可作为DILI发生的免疫反应触发因子，激活药物抗原性... 详细信息

药物性肝损伤（DILI）机制复杂，涉及多种途径协同促进并互为因果，其中免疫反应在致病机制中扮演重要角色。在遗传背景因素下，药物活性代谢产物、药物-分子复合物、危险信号分子或可作为DILI发生的免疫反应触发因子，激活药物抗原性超敏反应机制、P-i假说和固有免疫危险信号机制。使肝脏出现固有免疫、适应性免疫级联反应，导致肝脏固有免疫耐受状态失衡，进而造成肝脏组织的免疫炎症性损伤。本文主要阐述DILI的免疫学发生机制，以期为DILI治疗靶点的研发及规避用药不良反应等提供新的思路。

关键词：化学性与药物性肝损伤免疫治疗学

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exploring the latest Pantheon SN Ia dataset by using three kinds of statistics techniques

引用

Communications in Theoretical Physics 2021年第4期73卷 92-98页

作者： shuang Wang Xiaolin luo School of Physics and Astronomy Sun Yat-Sen UniversityGuangzhou 510297China

In this work,we explore the cosmological consequences of the latest Type Ia supernova(SN Ia)dataset,Pantheon,by adopting the wCDM *** Pantheon dataset currently contains the largest number of SN Ia samples,which conta... 详细信息

关键词： Dark Energy Type Ia supernova Cosmological Observations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Gastrointestinal contrast-enhanced ultrasonography for diagnosis and treatment of peptic ulcer in children

引用

World Journal of Gastroenterology 2024年第7期30卷 705-713页

作者： yu-Hua Zhang Zhi-Hua Xu shuang-shuang Ni Hong-Xia luo Department of Ultrasound The Second Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The detection rate of peptic ulcer in children is improving,with development of diagnostic *** is the gold standard for the diagnosis of peptic ulcer,but it is an invasive *** contrast-enhanced ultrasonography(CEUS)has the advantages of being painless,noninvasive,nonradioactive,easy to use,and *** To investigate the clinical value of CEUS for diagnosis and treatment of peptic ulcer in *** We investigated 43 children with digestive tract symptoms in our hospital from January 2021 to June *** children were examined by routine ultrasound,gastrointestinal CEUS,and *** pathological results of gastroscopy were taken as the gold *** ultrasonography was performed before gastrointestinal *** ultrasound showed the thickness of the gastroduodenal wall,gastric peristalsis,and the adjacent organs and tissues around the abdominal *** CEUS recorded the thickness of the gastroduodenal wall;the size,location and shape of the ulcer;gastric peristalsis;and adjacent organs and tissues around the abdominal *** results of routine ultrasound and gastrointestinal ultrasound were compared with those of gastroscopy to evaluate the diagnostic results and coincidence rate of routine ultrasound and gastrointestinal *** children received informed consent from their guardians for *** study was reviewed and approved by the hospital medical ethics *** Among the 43 children,17(15 male,2 female)were diagnosed with peptic ulcer by *** were 26 children with nonpeptic *** were eight cases of peptic ulcer and 35 of nonpeptic ulcer diagnosed by conventional *** diagnostic coincidence rate of peptic ulcer in children diagnosed by conventional ultrasound was 79.1%(34/43),which was significantly different from that of gastroscopy(P=0.033).It indicates that the coincidence rate of gastrointestinal contrast-enhanc

关键词： Contrast-enhanced ultrasound Peptic ulcer Children Gastrointestinal tract Abdominal pain Acoustic contrast agent

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quantifying Process Nonclassicality in Bosonic Fields

引用

Chinese Physics Letters 2019年第10期36卷 36-40页

作者： shuang-shuang Fu Shun-Long luo School of Mathematics and Physics University of Science and Technology BeijingBeijing 100083 Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing 100190 School of Mathematical Sciences University of the Chinese Academy of SciencesBeijing 100049

Nonclassicality of optical states,as a key characteristic of bosonic fields,is a valuable resource for quantum information *** investigate the generation of nonclassicality in quantum processes from a quantitative perspective,introduce three information-theoretic measures of nonclassicality for quantum-optical processes based on the Wigner–Yanase skew information and coherent states,and illustrate their physical significance through several well-known single-mode quantum processes.

关键词： processes. quantum states

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Analysis of Micromechanical Properties at the Interface of Pre-wet SBS Modified Asphalt Mixture Based on Molecular Simulation Technology

引用

Journal of Wuhan University of Technology(Materials Science) 2025年第1期 103-113页

作者：陈伍兴 CHEN shuang yu Yan ZHANG Jiangyi XU Haiyang 郭威 School of Mines China University of Mining and Technology College of Construction Engineering Jilin University

The pre-wetting of aggregate surface is a means to improve the interface performance of SBS modified asphalt and *** effect of pre-wetting technology on the interaction between SBS modified asphalt and aggregate was analyzed by molecular dynamics *** diffusion coefficient and concentration distribution of SBS modified asphalt on aggregate surface are *** simulation results show that the diffusion coefficient of the aggregate surface of SBS modified asphalt is increased by 47.6% and 70.5% respectively after 110# asphalt and 130# asphalt are *** concentration distribution of SBS modified asphalt on the aggregate surface after pre-wetting is more *** to the results of interface energy calculation,the interface energy of SBS modified bitumen and aggregate can be increased by about 5% after *** to the results of molecular dynamics simulation,the pre-wetting technology can effectively improve the interface workability of SBS modified bitumen and aggregate,so as to improve the interface performance.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：