检索结果-南通市图书馆

Novel hydroxymethylbilane synthase gene mutation identified and confirmed in a woman with acute intermittent porphyria:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2022年第33期10卷 12319-12327页

作者： yu-qing zhou Xiao-qing Wang Jun Jiang Shu-Ling Huang Zhuo-Jin Dai Qiao-Qiong Kong Department of Endocrinology Dongguan Hospital of Traditional Chinese MedicineDongguan 523003Guangdong ProvinceChina Department of Science and Technology ServicesChina Beijing Macro and Micro Test Biotech Co.Ltd Beijing 100318China The First Clinical Medical College Guangdong Medical UniversityZhanjiang 523003Guangdong ProvinceChina Department of Medicine Wanjiang People's Hospital of DongguanDongguan 523003Guangdong ProvinceChina

BACKGROUND Acute intermittent porphyria(AIP)is a rare autosomal dominant porphyrin metabolic disease caused by a mutation in the hydroxymethylbilane synthase(HMBS)*** study aimed to explore the clinical manifestations of a patient with AIP,to identify a novel HMBS gene mutation in the proband and some of her family members,and to confirm the pathogenicity of the *** SUMMARY A 22-year-old Chinese woman developed severe abdominal pain,lumbago,sinus tachycardia,epileptic seizure,hypertension,and weakness in lower limbs in March,*** examinations indicated hypohepatia and *** last menstrual period was 45 d prior to admission,and she was unaware of the pregnancy,which was confirmed by a pregnancy test after *** exposure of her urine sample for 1 h turned it from yellow to wine *** porphyrin test result was *** on these clinical manifestations,AIP was *** increasing her daily glucose intake(250–300 g/d),abdominal pain was partially *** days after hospitalization,spontaneous vaginal bleeding occurred,which was confirmed as spontaneous abortion;thereafter,her clinical symptoms completely *** testing revealed a novel heterozygous splicing variant of the HMBS gene in exon 10(c.648_651+1delCCAGG)in the proband and four other family *** pathogenicity of the variant was verified through bioinformatic methods and a minigene *** We identified a novel HMBS gene mutation in a Chinese patient with AIP and confirmed its pathogenicity.

关键词： Acute intermittent porphyria Hydroxymethylbilane synthase gene Novel mutation Minigene assay Bioinformatics analysis Case report

Differential diagnosis of different types of solid focal liver lesions using two-dimensional shear wave elastography

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2022年第32期28卷 4715-4724页

作者： Jia Guo Dong Jiang Yi Qian Jiao yu Yi-Jun Gu yu-qing zhou Hui-Ping Zhang Department of Ultrasound Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Ultrasound Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical UniversityShanghai 200433China Department of Infectious Diseases Eastern Hepatobiliary Surgery Hospital Affiliated to Naval Medical UniversityShanghai 200433China Department of Ultrasound Shanghai Changning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200050China

BACKGROUND The clinical management and prognosis differ between benign and malignant solid focal liver lesions(FLLs),as well as among different pathological types of malignant *** diagnosis of the possible types of solid FLLs is *** previous study confirmed the value of shear wave elastography(SWE)using maximal elasticity(Emax)as the parameter in the differential diagnosis between benign and malignant ***,the value of SWE in the differential diagnosis among different pathological types of malignant FLLs has not been *** To explore the value of two-dimensional SWE(2D-SWE)using Emax in the differential diagnosis of FLLs,especially among different pathological types of malignant *** All the patients enrolled in this study were diagnosed as benign,malignant or undetermined FLLs by conventional *** of FLLs and the periphery of FLLs was measured using 2D-SWE and compared between benign and malignant FLLs or among different pathological types of malignant *** The study included 32 benign FLLs in 31 patients and 100 malignant FLLs in 96 patients,including 16 cholangiocellular carcinomas(CCCs),72 hepatocellular carcinomas(HCCs)and 12 liver ***-five FLLs were diagnosed as undetermined by conventional *** were significant differences between Emax of malignant(2.21±0.57 m/s)and benign(1.59±0.37 m/s)FLLs(P=0.000),and between Emax of the periphery of malignant(1.52±0.39 m/s)and benign(1.36±0.44 m/s)FLLs(P=0.040).Emax of liver metastases(2.73±0.99 m/s)was significantly higher than that of CCCs(2.14±0.34 m/s)and HCCs(2.14±0.46 m/s)(P=0.002).The sensitivity,specificity and accuracy were 71.00%,84.38%and 74.24%respectively,using Emax>1.905 m/s(AUC 0.843)to diagnose as malignant and 23 of 35(65.74%)FLLs with undetermined diagnosis by conventional ultrasound were diagnosed *** Malignant FLLs were stiffer than benign ones and liver metastases were stiffer than primary liver carc

关键词： Focal liver lesions Conventional ultrasound Two-dimensional shear wave elastography Differential diagnosis

Content-Based Hierarchical Analysis of News Video Using Audio and Visual Information

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2001年第4期6卷 779-783页

作者： yu Jun-qing zhou Dong-ru Jin Ye Liu Hua-yong School of Computer Wuhan University Wuhan 430072 China

A schema for content-based analysis of broadcast news video is presented. First, we separate commercials from news using audiovisual features. Then, we automatically organize news programs into a content hierarchy at various levels of abstraction via effective integration of video, audio, and text data available from the news programs. Based on these news video structure and content analysis technologies, a TV news video Library is generated, from which users can retrieve definite news story according to their demands.

关键词： content-based audio news video segmentation

Value of shear wave elastography with maximal elasticity in differentiating benign and malignant solid focal liver lesions

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第46期26卷 7416-7424页

作者： Hui-Ping Zhang Ji-Ying Gu Min Bai Fan Li yu-qing zhou Lian-Fang Du Department of Ultrasound Shanghai Changning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200050China Department of Ultrasound Shanghai Fourth People’s HospitalShanghai Tongji University School of MedicineShanghai 200434China Department of Ultrasound Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 200080China

BACKGROUND It is important to differentiate benign and malignant focal liver lesions(FLLs)*** the wide use and acceptance of shear wave elastography(SWE),its value for assessing the elasticity of FLLs and differentiating benign and malignant FLLs is still *** studies of SWE for FLLs used mean elasticity as the parameter to reflect the stiffness of *** the inhomogeneity of tumor stiffness,maximal elasticity(Emax)might be the suitable parameter to reflect the stiffness of FLLs and to differentiate malignant FLLs from benign *** To explore the value of SWE with Emax in differential diagnosis of solid *** We included 104 solid FLLs in 95 patients and 50 healthy *** the subjects were examined using conventional ultrasound(US)and virtual touch tissue quantification(VTQ)imaging.A diagnosis of benign or malignant FLL was made using conventional *** VTQ values were acquired after 10 consecutive measurements for each FLL and each normal liver,and the largest value was recorded as *** There were 56 cases of malignant FLLs and 48 cases of benign FLLs in this *** of malignant FLLs(3.29±0.88 m/s)was significantly higher than that of benign FLLs(1.30±0.46 m/s,P<0.01)and that of livers in healthy volunteers(1.15±0.17 m/s,P<0.01).The cut-off point of Emax was 1.945,and the area under the curve was *** sensitivity and specificity of Emax were 92.9%and 91.7%,respectively,higher(but not significantly)than those of conventional US(80.4%for sensitivity and 81.3%for specificity).Combined diagnosis of conventional US and Emax using parallel testing improved the sensitivity to 100%with specificity of 75%.CONCLUSION SWE is a convenient and easy method to obtain accurate stiffness information of solid *** is useful for differential diagnosis of FLLs,especially in combination with conventional US.

关键词： Focal hepatic lesions Shear wave elastography Conventional ultrasound Maximal elasticity

Modeling Digital Video Database System with UML

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2001年第Z1期6卷 234-238页

作者： yu Jun qing, zhou Dong ru, Jin Ye, Xu Jun College of Computer Science and Technology, Wuhan University, Wuhan 430072, China College of Computer Science and Technology Wuhan University Wuhan China

The main purpose of the model is to present how the Unified Modeling Language (UML) can be used for modeling digital video database system (VDBS). It demonstrates the modeling process that can be followed during the analysis phase of complex applications. In order to guarantee the continuity mapping of the models, the authors propose some suggestions to transform the use case diagrams into an object diagram, which is one of the main diagrams for the next development phases.

关键词： UML video database class object sequence

Vapor Online Monitor Model of Vapor Power Station Based on UML

在线全文

学校读者我要写书评

暂无评论

Wuhan University Journal of Natural Sciences 2001年第4期6卷 775-778页

作者： Jin Ye, Tang Xu\|zhang, yu Jun\|qing, zhou Dong\|ru School of Computer, Wuhan University, Wuhan 430072, China School of Computer Wuhan University Wuhan China

We presents a vapor online monitor system model of vapor power station developed by visual tool rational rose 2000. Use cases such as on line instrument (onlineinstr), control, query, report, real database (realdb) and alarm are generated according to the system requirements. Use case view and class view of the system are formed at the same time. As for all the UML models of the system, this paper focuses the discussion on the class view, the component diagram of the control class and the sequence diagram of the query class. Corresponding C++ codes are produced and finally transferred into the spot running software.

关键词： online monitor model UML

C634Y mutation in RET-induced multiple endocrine neoplasia type 2A:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第15期12卷 2627-2635页

作者： Hui-Fen Zhang Shu-Ling Huang Wen-Li Wang yu-qing zhou Jun Jiang Zhuo-Jin Dai Department of Endocrinology Dongguan Hospital of Guangzhou University of Chinese MedicineDongguan 523003Guangdong ProvinceChina Department of Science and Technology Services Beijing Macro and Micro Test Co.Ltd.Beijing 100318China The First Clinical Medical College Guangdong Medical UniversityZhanjiang 524023Guangdong ProvinceChina

BACKGROUND Multiple endocrine neoplasia type 2(MEN2)is a rare,autosomal dominant endocrine ***,the RET proto-oncogene is the only gene implicated in MEN2A *** an RET carrier is detected,family members should be screened to enable early detection of medullary thyroid carcinoma,pheochromocytoma,and *** these,medullary thyroid carcinoma is the main factor responsible for patient ***,delineating strategies to inform clinical follow-up and treatment plans based on genes is paramount for clinical *** SUMMARY Herein,we present RET proto-oncogene mutations,clinical characteristics,and treatment strategies in a family with MEN2A.A family study was conducted on patients diagnosed with *** was extracted from the peripheral blood of family members,and first-generation exon sequencing of the RET protooncogene was *** C634Y mutation was identified in three family members spanning three *** patients were sequentially diagnosed with pheochromocytomas and bilateral medullary thyroid carcinomas.A 9-yearold child harboring the gene mutation was diagnosed with medullary thyroid *** resection of the tumors was *** family members were advised to undergo complete genetic testing related to the C634Y mutation,and the corresponding treatments administered based on test results and associated clinical *** Advancements in MEN2A research are important for familial management,assessment of medullary thyroid cancer invasive risk,and deciding surgical timing.

关键词： Multiple endocrine neoplasia type 2A Mutation RET proto-oncogene Medullary thyroid carcinoma Pheochromocytoma Case report

Antenatal Diagnosis and Outcome of 12 Congenital Cystic Adenomatoid Malformation of Lung

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Reproduction and Contraception 2007年第4期18卷 289-295页

作者： Xue-lian LI yu-qing zhou Jue-hua ZHANG Ying-liu YAN Xiao-tian LI Obstetrics Department the Obstetrics ＆ Gynecology Hospital of FudanUniversity Shanghai 200011 China Ultrasonography Department the Obstetrics ＆ Gynecology Hospital of FudanUniversity Shanghai 200011 China

Objective To investigate the ultrasonic detection probability, type, prenatal diagnosis, and outcome of congenital cystic adenomatoid malformation of lung （CCAM）. Methods In this retrospective study, all 12 cases which were diagnosed with suspected prenatal CC,4M over the period in the hospital were analyzed. Information on diagnosis time, types and progression of the lesions during pregnancy, the additional abnormalities, and the outcome of pregnancies were recorded.Results The positive rate of ultrasonic detection of CCAM was about 1.01‰ （1/11 124） before 28 gestation weeks. There were 1 case of type Ⅰ （8%）, 2 cases of type Ⅱ （17%） and 9 cases of type Ⅲ （75%）. Nine pregnancies were terminated and 2 cases were confirmed by pathology. Three neonates were alive and without any symptom now. Conclusions Type Ⅲ is the major type. Ultrasound examination during 20-28 weeks and following up, prenatal consultation, chromosome examination offetus, delivery with a pediatrician standing by, and all suspected neonates being investigated are recommended.

关键词： congenital cystic adenomatoid malformation of lung ultrasonic detection type prenatal diagnosis outcome

Conversion-type cathode materials for high energy density solid-state lithium batteries

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2025年第1期100卷 409-425页

作者： yuhao Ma Shihong qing Hongyu Liu Chuntao Ma yuan yu Chuang yu Liping Wang School of Materials and Energy University of Electronic Science and Technology of China Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology Zhejiang Sci-Tech University State Key Laboratory of Advanced Electromagnetic Engineering and Technology School of Electrical and Electronic Engineering Huazhong University of Science and Technology

Solid-state lithium batteries （SSLBs） are regarded as an essential growth path in energy storage systems due to their excellent safety and high energy *** particular,SSLBs using conversion-type cathode materials have received widespread attention because of their high theoretical energy densities,low cost,and *** the great progress in research and development of SSLBs based on conversiontype cathodes,their practical applications still face challenges such as blocked ionic-electronic migration pathways,huge volume change,interfacial incompatibility,and expensive processing *** review focuses on the advantages and critical issues of coupling conversion-type cathodes with solid-state electrolytes （SSEs）,as well as state-of-the-art progress in various promising cathodes （e.g.,FeS2,CuS,FeF3,FeF2,and S） in ***,representative research on conversion-type solid-state full cells is discussed to offer enlightenment for their practical ***,the energy density exhibited by the S cathode stands out impressively,while sulfide SSEs and halide SSEs have demonstrated immense potential for coupling with conversion-type ***,perspectives on conversion-type cathodes are provided at the material,interface,composite electrode,and battery levels,with a view to accelerating the development of conversion-type cathodes for high-energy–density SSLBs.

关键词： Sulfur compounds