Value of shear wave elastography with maximal elasticity in differentiating benign and malignant solid focal liver lesions

作     者：Hui-Ping Zhang Ji-Ying Gu Min Bai Fan Li Yu-Qing Zhou Lian-Fang Du 

作者机构：Department of UltrasoundShanghai Changning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200050China Department of UltrasoundShanghai Fourth People’s HospitalShanghai Tongji University School of MedicineShanghai 200434China Department of UltrasoundShanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 200080China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2020年第26卷第46期

页      面：7416-7424页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Natural Science Foundation of Shanghai of China No.19ZR1441500 

主　　题：Focal hepatic lesions Shear wave elastography Conventional ultrasound Maximal elasticity 

摘      要：BACKGROUND It is important to differentiate benign and malignant focal liver lesions(FLLs)*** the wide use and acceptance of shear wave elastography(SWE),its value for assessing the elasticity of FLLs and differentiating benign and malignant FLLs is still *** studies of SWE for FLLs used mean elasticity as the parameter to reflect the stiffness of *** the inhomogeneity of tumor stiffness,maximal elasticity(Emax)might be the suitable parameter to reflect the stiffness of FLLs and to differentiate malignant FLLs from benign *** To explore the value of SWE with Emax in differential diagnosis of solid *** We included 104 solid FLLs in 95 patients and 50 healthy *** the subjects were examined using conventional ultrasound(US)and virtual touch tissue quantification(VTQ)imaging.A diagnosis of benign or malignant FLL was made using conventional *** VTQ values were acquired after 10 consecutive measurements for each FLL and each normal liver,and the largest value was recorded as *** There were 56 cases of malignant FLLs and 48 cases of benign FLLs in this *** of malignant FLLs(3.29±0.88 m/s)was significantly higher than that of benign FLLs(1.30±0.46 m/s,P0.01)and that of livers in healthy volunteers(1.15±0.17 m/s,P0.01).The cut-off point of Emax was 1.945,and the area under the curve was *** sensitivity and specificity of Emax were 92.9%and 91.7%,respectively,higher(but not significantly)than those of conventional US(80.4%for sensitivity and 81.3%for specificity).Combined diagnosis of conventional US and Emax using parallel testing improved the sensitivity to 100%with specificity of 75%.CONCLUSION SWE is a convenient and easy method to obtain accurate stiffness information of solid *** is useful for differential diagnosis of FLLs,especially in combination with conventional US.