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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： yu-qin li Wen-Tao Kuai lin Chen Ming-Hui Zeng Xue-Mei Tao Jia-Xin Han yue-Kui Wang lian-Xin Xu li-Ying Ge Yong-Gang liu Shuang li liang Xu yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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Synthesis and Crystal Structure of (2S,2'S,4'R)-2-(1-Hydroxy-1-ethylpropyl)-1-[(1'-p-tosyl-4'-hydroxypyrrolidin-2'-yl)methyl]pyrrolidine

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Chinese Journal of Structural Chemistry 2006年第10期25卷 1203-1208页

作者： FU yu-qin DING li-Na ZHANG Sheng-Hong TAO Jing-Chao ZHU yu Department of Chemistry New Drug Research ＆ Development Center Zhengzhou University Zhengzhou 450052 China

The title compound （2S,2＇S,4＇R）-2-（1-hydroxy-1-ethylpropyl）-1-[（1＇-p-tosyl-4＇- hydroxypyrolidin-2＇-yl）methyl]pyrrolidine synthesized by using （2S,4R）-4-hydroxy-L-proline and L-proline as the main materials was characterized through IR, ^1H NMR, ^13C NMR and HRMS spectra as well as single-crystal X-ray diffraction analysis. There is one equivalent ethanol involved in the crystal （C23H40N2O5S, Mr = 456.63）. The crystal belongs to the triclinic system, space group P1, a = 6.5628（13）, b = 8.4228（17）, c = 11.957（2）°A, α= 80.54（3）,β= 83.19（3）, γ= 89.89（3）°, V= 647.3（2） °A^3, Z = 1, D, = 1.171 g/cm^3, λ（MoKα） = 0.71073°A,β = 0.158 mm^-1, F（000） = 248, the final R = 0.0465 and wR = 0.1336 for 1769 observed reflections with I〉 2σ（I）. The adjacent molecules of compound 5 are linked through intermolecular hydrogen bonds formed by the secondary hydroxy group of one molecule with the tertiary hydroxy group of another one, and the molecular chains are further linked by ethanol through two kinds of hydrogen bonds with two molecules from different chains respectively to form a supramolecular structure.

关键词： proline derivative chiral amino alcohol synthesis crystal structure

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Comprehensive treatment and a rare presentation of Cronkhite–Canada syndrome: Two case reports and review of literature

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World Journal of Gastrointestinal Surgery 2023年第11期15卷 2646-2656页

作者： Yan-qing Lv Mei-Lan Wang Tong-yu Tang yu-qin li Department of Hepatobiliary and Pancreatic Medicine The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Gastroenterology Jilin Provincial People's HospitalChangchun 130021Jilin ProvinceChina Department of Gastroenterology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina

BACKGROUND Cronkhite–Canada syndrome(CCS)is a rare sporadic polyposis syndrome that presents with gastrointestinal and ectodermal symptoms in addition to nutritional *** combined with hypothyroidism is an even rarer condition,with no standard treatment *** SUMMARY The present study described 2 patients with CCS:A 67-year-old woman with concomitant hypothyroidism and 68-year-old man treated with endoscopic mucosal resection(EMR).Both patients had multiple gastrointestinal symptoms and ectodermal changes,along with multiple gastrointestinal *** examination showed that the mucosa in both patients was hyperemic and edematous,with pathologic examination showing distorted,atrophic,and dilated *** 1 had concomitant hypothyroidism and was treated with *** to her self-reduction of hormone dose,her disease *** 2 underwent EMR,but refused further hormonal or biological ***,he was treated with an oral Chinese medical *** Pharmacotherapy can induce and maintain remission in CCS patients,with adjuvant EMR,long-term follow-up,and endoscopic surveillance being *** 1:Based on the aforementioned findings,Patient 1 was diagnosed with CCS and *** 2:Based on the aforementioned findings,Patient 2 was diagnosed with CCS.

关键词： Cronkhite–Canada syndrome Clinical features Gastrointestinal polyps Hypothyroidism Case report

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Cascade Enzymatic Hydrolysis Coupling with Ultrafine Grinding Pretreatment for Sugarcane Bagasse Saccharification

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Chinese Journal of Chemical Physics 2015年第3期28卷 355-360,I0002页

作者： Zheng-qiu yuan Jin-xing Long Tie-jun Wang yu-qin li Qi Zhang Long-long Ma Key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Science Guangzhou 510640 China University of Chinese Academy of Science Beijing 100049 China School of Chemical EngineerinE Xiangtan University Xiangtan 411105 China

The biorefinery process for sugarcane bagasse saccharification generally requires signifcant accessibility of cellulose. We reported a novel method of cascade cellulase enzymatic hydrol- ysis coupling with ultrafine grinding pretreatment for sugarcane bagasse saccharification. Three enzymatic hydrolysis modes including single cellulase enzymatic hydrolysis, mixed cellulase enzymatic hydrolysis, and cascade cellulase enzymatic hydrolysis were compared. The changes on the functional group and surface morphology of bagasse during cascade cellulase enzymatic hydrolysis were also examined by FT-IR and SEM respectively. The results showed that cascade enzymatic hydrolysis was the most efficient way to enhance the sugarcane bagasse saccharification. More than 65% of reducing sugar yield with 90.1% of glucose selectivity was achieved at 50 ℃, pH=4.8 for 72 h （1200 r/min） with cellulase I of 7.5 FPU/g substrate and cellulase II of 5 FPU/g substrate.

关键词： Sugarcane bagasse Ultrafine grinding pretreatment Cascade enzymatic hydrolysis Reducing sugars Glucose

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The association between mutations in ubiquitin-specific protease 26(USP26)and male infertility:a systematic review and meta-analysis

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Asian Journal of Andrology 2022年第4期24卷 422-429页

作者： qin-yu li yu-Cong Zhang Chao Wei Zhuo liu Guo-Da Song Bing-liang Chen Man liu Ji-Hong liu li-Cheng Wu Xia-Ming liu Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Geriatric Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

During recent decades,the association between mutations in ubiquitin-specific protease 26(USP26)and male infertility remains *** conducted this meta-analysis to evaluate the association between mutations in USP26 and male infertility according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)2020 *** was registered in the International Prospective Register of Systematic Reviews(PROSPERO;CRD42021225251).PubMed,Web of Science,and Scopus were systematically searched for comparative clinical studies,which were written in English and provided eligible *** were included when they compared USP26 mutations in azoospermic,oligozoospermic,and asthenozoospermic patients with controls with normal sperm parameter values or whose partners had experienced spontaneous *** odds ratio(OR)with 95%confidence interval(CI)was calculated with random effect ***,twelve studies with 3927 infertility patients and 4648 healthy controls were *** association between overall USP26 mutations and infertility was not significant(OR=1.60,95%CI:0.51-5.01).For specific mutations,the pooled ORs were 1.65(95%CI:1.02-2.69)for cluster mutation(including 370-371insACA,494T>C,and 1423C>T),1.80(95%CI:0.35-9.15)for c.576G>A,1.43(95%CI:0.79-2.56)for c.1090C>T,and 3.59(95%CI:2.30-5.59)for c.1737G>*** results suggest that several mutations(cluster mutation,c.1737G>A)may play roles in male infertility,while others(c.576G>A and c.1090C>T)do not show notable associations with male *** high-quality clinical researches are needed for validation.

关键词： azoospermia haplotype male infertility mutation ubiquitin-specific protease 26

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Identification of Quantitative Trait Loci for Grain Traits in Japonica Rice

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Agricultural Sciences in China 2010年第7期9卷 929-936页

作者： li Mao-mao XU Lei REN Jun-fang CAO Gui-lan yu li-qin HE Hao-hua HAN Long-zhi KohHee-jong Institute of Crop Sciences Chinese Academy of Agricultural Sciences/National Key Facility for Crop Gene Resources and Genetic Improvement （NFCRI） Beijing 100081 P.R. China College of Agronomy Jiangxi Agricultural University Nanchang 330045 P.R.China Rice Research institute Jiangxi Academy of Agricultural Sciences Nanchang 330200 P.R.China School of Plant Science College of Agriculture and Life Science Seoul National University Seoul 151-921 Korea

Quantitative trait loci（QTLs） of grain traits were detected to provide theoretical basis for fine mapping and molecular marker-assisted breeding of grain traits in japonica *** an F2 population including 200 individuals derived from a cross combination between two japonica rice DL115 with large grain and XL005 with small grain,the grain length,grain width,grain thickness,ratio of grain length to width and 1 000-grain weight were evaluated in Beijing;and the quantitative trait loci for above five grain traits were identified by composite interval mapping using SSR *** results showed that the five grain traits exhibited a normal continuous distribution in F2 population,indicating they were quantitative traits controlled by multiple genes.A total of 16 QTLs conferring the five grain traits were detected on chromosomes 2,3,5 and 12,*** QTLs,namely qGL3a,qGW2,qGW5,qGT2,qRLW2,qRLW3,qGWT2 and qGWT3,were major QTLs and explained 15.42,40.89,13.54,33.43,13.82,13.61,12.51 and 10.1% of the observed phenotypic variance,*** them,qGW2,qGT2,qRLW2 and qGWT2 were mapped in same interval RM12776-RM324 on chromosome *** marker interval RM12776-RM324 on chromosome 2 was common marker intervals of four major QTLs,and the two SSR markers RM12776 and RM324 would be used in molecular markerassisted breeding in japonica *** modes of gene action were mainly additive and partial *** QTLs＇ alleles were derived from small grain parent XL005,and other 12 QTLs＇ alleles were derived from large grain parent *** alleles from larger parent were showed significant effects to grain length,grain width,grain thickness and 1 000-grain weight.

关键词： japonica rice drain trait SSR marker quantitative trait locus gene action

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Synthesis and in vitro biological evaluation of farnesylthiosalicylic acid derivatives as anti-tumor carcinoma agents

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Chinese Chemical Letters 2012年第10期23卷 1141-1144页

作者： Yong ling You An Xiao Guang Tong Chen Dong Geng Wang yu qin li Xin Yang Wang Heng Zheng Department of Pharmacy School of MedicalNantong UniversityNantong 226001China Medicinal College Anhui College of Traditional Chinese MedicineHefei 230031China Department of Bioinformatics College of Life Science and TechnologyChina Pharmaceutical UniversityNanjing 210009China

Novel farnesylthiosalicylic acid （PTA） derivatives 5a-m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b, 5e, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cells tested. Furthermore, 5e induced tumor cell apoptosis, which was accompanied by lower Bcl-2 expression, but with higher Bax and caspase 3 expression activities in cancer cells.

关键词： Synthesis Farnesylthiosalicylic acid 1,3,4-Thiodiazole Anti-tumor agents Cytotoxic activities Cell apoptosis

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Dual-radical-based molecular anisotropy and synergy effect of semi-conductivity and valence tautomerization in a photoswitchable coordination polymer

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National Science Review 2023年第6期10卷 200-214页

作者： Jing-Wei Dai yu-qin li Zhao-Yang li Hai-Tao Zhang Carmen Herrmann Shohei Kumagai Marko Damjanovi? Markus Enders Hiroyuki Nojiri Masakazu Morimoto Norihisa Hoshino Tomoyuki Akutagawa Masahiro Yamashita State Key Laboratory of Medicinal Chemical Biology Nankai University School of Materials Science and Engineering Nankai University Institute of Inorganic and Applied Chemistry University of Hamburg Department of Chemistry Graduate School of Science Tohoku University Institute of Inorganic Chemistry University of Heidelberg Institute for Materials Research Tohoku University Department of Chemistry Rikkyo University Institute of Multidisciplinary Research for Advanced Materials (IMRAM) Tohoku University

Organic radicals are widely used as linkers or ligands to synthesize molecular magnetic ***,studies regarding the molecular anisotropies of radical-based magnetic materials and their multifunctionalities are ***,a photoisomerizable diarylethene ligand was used to form{[CoⅢ(3,5-DTSQ·-)(3,5-DTCat2-)]2(6F-DAE-py2)}·3CH3CN·H2O(o-1·3CH3CN·H2O,6F-DAE-py2=1,2-bis(2-methyl-5-(4-pyridyl)-3-thienyl)perfluorocyclopentene),a valence-tautomeric(VT) coordination *** directly observed dual radicals for a single crystal using high-field/-frequency(～13.3 T and～360 GHz) electron paramagnetic resonance(EPR) spectroscopy along the c-axis,which was further confirmed by angle-dependent Q-band EPR ***,a conductive anomaly close to the VT transition temperature was observed only when probes were attached at the ab plane of the single crystal,indicative of synergy between valence tautomerism and *** anisotropy studies and density functional theory(DFT) calculations revealed that this synergy is due to electron transfer associated with valence *** study presents the first example of dual-radical-based molecular anisotropy and charge-transfer-induced conductive anisotropy in a photoswitchable coordination polymer.

关键词： valence tautomerization charge transfer photo switching diradical coordination polymer

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Metallicity calibration for solar type stars based on red spectra

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Research in Astronomy and Astrophysics 2011年第5期11卷 563-576页

作者： Jing-KunZhao GangZhao yu-qinChen A-liLuo KeyLaboratoryofOpticalAstronomy NationalAstronomicalObservatoriesChineseAcademyofSciencesBeijing100012China

Based on a high resolution and high signal-to-noise ratio （S/N） spectral analysis of 90 solar-type stars, we have established several new metaUicity calibrations in the Tefr range [5600, 6500] K based on red spectra with the wavelength range of 560-880 nm. The new metallicity calibrations are applied to determine the metallicity of solar analogs selected from Sloan Digital Sky Survey （SDSS） spectra. There is a good consistent result with the adopted value presented in SDSS-DR7 and a small scatter of 0.26 dex for stars with S/N 〉 50 being obtained. This study provides a new reliable way to derive the metallicity for solar-like stars with low resolution spectra. In particular, our calibrations are useful for finding metal-rich stars, which are missing in the SEGUE Stellar Parameter Pipeline.

关键词： techniques: radial velocities - stars: temperatures - stars: abundances

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Flavonoids in myocardial ischemia-reperfusion injury: Therapeutic effects and mechanisms

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Chinese Herbal Medicines 2021年第1期13卷 49-63页

作者： Jun-ying Jia Er-huan Zang li-juan Lv qin-yu li Chun-hua Zhang Ying Xia Lei Zhang lian-sheng Dang Min-hui li College of Agriculture Inner Mongolia University for NationalitiesTongliao 028000China Baotou Medical College Baotou 014040China Department of Basic Science.Tianjin Agricultural University Tianjin 300384China Inner Mongolia Institute o f Traditional Chinese Medicine Hohhot 010020China Inner Mongolia Medical University Hohhot 010110China Department of Geriatrics The First Affiliated Hospital of Baotou Medical CollegeBaotou 014000China Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources and Utilization Baotou Medical CollegeBaotou 014040China

Ischemic heart diseases are one of the major causes of death worldwide. Effective restoration of blood flow can significantly improve patients’ quality of life and reduce mortality. However, reperfusion injury cannot be ignored. Flavonoids possess well-established antioxidant properties;They also have other benefits that may be relevant for ameliorating myocardial ischemia-reperfusion injury(MIRI). In this review,we focus on flavonoids with cardiovascular-protection function and emphasize their pharmacological effects. The main mechanisms of flavonoid pharmacological activities against MIRI involve the following aspects: a) antioxidant, b) anti-inflammatory, c) anti-platelet aggregation, d) anti-apoptosis, and e)myocardial-function regulation activities. We also summarized the effectiveness of flavonoids for MIRI.

关键词： anti-apoptosis anti-inflammation antioxidant activity flavonoids myocardial ischemia-reperfusion injury

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