Comprehensive treatment and a rare presentation of Cronkhite–Canada syndrome: Two case reports and review of literature

作     者：Yan-Qing Lv Mei-Lan Wang Tong-Yu Tang Yu-Qin Li 

作者机构：Department of Hepatobiliary and Pancreatic MedicineThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of GastroenterologyJilin Provincial People's HospitalChangchun 130021Jilin ProvinceChina Department of GastroenterologyThe First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2023年第15卷第11期

页      面：2646-2656页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：Jilin Provincial Science and Technology Department Project,No.20200201343JC Science and Technology Development Program of Jilin Province,No.20210402013GH 

主　　题：Cronkhite–Canada syndrome Clinical features Gastrointestinal polyps Hypothyroidism Case report 

摘      要：BACKGROUND Cronkhite–Canada syndrome(CCS)is a rare sporadic polyposis syndrome that presents with gastrointestinal and ectodermal symptoms in addition to nutritional *** combined with hypothyroidism is an even rarer condition,with no standard treatment *** SUMMARY The present study described 2 patients with CCS:A 67-year-old woman with concomitant hypothyroidism and 68-year-old man treated with endoscopic mucosal resection(EMR).Both patients had multiple gastrointestinal symptoms and ectodermal changes,along with multiple gastrointestinal *** examination showed that the mucosa in both patients was hyperemic and edematous,with pathologic examination showing distorted,atrophic,and dilated *** 1 had concomitant hypothyroidism and was treated with *** to her self-reduction of hormone dose,her disease *** 2 underwent EMR,but refused further hormonal or biological ***,he was treated with an oral Chinese medical *** Pharmacotherapy can induce and maintain remission in CCS patients,with adjuvant EMR,long-term follow-up,and endoscopic surveillance being *** 1:Based on the aforementioned findings,Patient 1 was diagnosed with CCS and *** 2:Based on the aforementioned findings,Patient 2 was diagnosed with CCS.