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Prognostic significance of SUVmax and serum carbohydrate antigen 19-9 in pancreatic cancer

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World Journal of Gastroenterology 2014年第19期20卷 5875-5880页

作者： Jian-Guo zhao Ya Hu Quan Liao Zhe-yu Niu yu-pei zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College

AIM: To investigate the prognostic significance of pretreatment standardized maximum uptake value (SUVmax) and serum carbohydrate antigen (CA)19-9 in pancreatic cancer.

关键词： Pancreatic cancer Maximum standardized uptake value Carbohydrate antigen 19-9 Prognostic factors

Advances in understanding the molecular mechanism of pancreatic cancer metastasis

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Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 361-370页

作者： Yong-Xing Du Zi-Wen Liu Lei You Wen-Ming Wu yu-pei zhao Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND： Pancreatic cancer（PC） is usually diagnosed at the late-stage and therefore, has widespread metastasis and a very high mortality rate. The mechanisms underlying PC metastasis are not well understood. Recent advances in genomic sequencing have identified groups of gene mutations that affect PC metastasis, but studies elucidating their roles are lacking. The present review was to investigate the molecular mechanisms of PC *** SOURCES： Relevant articles on PC metastasis were searched in MEDLINE via Pub Med prior to April 2015. The search was limited in English ***： PC metastatic cascades are multi-factorial events including both intrinsic and extrinsic elements. This review highlights the most important genetic alterations and other mechanisms that account for PC invasion and metastasis, with particular regard to epithelial-mesenchymal transition, inflammation, stress response, and circulating tumor ***： Analyses of relevant gene functions and signaling pathways are needed to establish the gene regulatory network and to define the pivotal modulators. Another promising area of study is the genotyping and phenotyping of circulating tumor cells, which could lead to a new era of personalized therapy by identifying specific markers and targets.

关键词： pancreatic cancer metastasis molecular mechanism targeted therapy

Recent studies of 5-fluorouracil resistance in pancreatic cancer

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World Journal of Gastroenterology 2014年第42期20卷 15682-15690页

作者： Wei-Bin Wang yu Yang yu-pei zhao Tai-Ping Zhang Quan Liao Hong Shu Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

Resistance to 5-fluorouracil(5-FU), an important anticancer drug, is a serious challenge in the treatment of pancreatic cancer. Equilibrative nucleoside transporter 1 and multidrug-resistance protein(MRP) 5 and MRP8, rather than P-glycoprotein, play important roles in 5-FU transport. Thymidylate synthase, dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidine phosphorylase are four key enzymes involved in 5-FU metabolism. Other metabolic enzymes, including uridine monophosphate synthetase, also contribute to chemoresistance. Intracellular signaling pathways are an integrated network, and nuclear factor kappa-light-chain-enhancer of activated B cells, AKT and extracellular signal-regulated kinases are signaling pathways that are particularly relevant to 5-FU resistance. In addition, recent reports indicate that STAT-3 is a crucial survival protein. Proteomic assays provide a powerful tool for identifying target proteins and understanding the role of micro RNAs and stromal factors to facilitate the development of strategies to combat 5-FU resistance.

关键词： 5-fluorouracil Resistance Transporters Metabolic enzyme Signaling pathway Stromal factors MicroRNA Proteomic investigation

DIAGNOSIS AND MANAGEMENT OF ISOLATED PANCREATIC TUBERCULOSIS: EXPERIENCE OF 13 CASES

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Chinese Medical Sciences Journal 2007年第3期22卷 152-155页

作者： Chang-qing Yan Jun-chao Guo yu-pei zhao Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 Department of General Surgery Second Hospital of Hebei Medical University Shijiazhuang 050000

Objective To analyze the diagnosis and treatment of pancreatic tuberculosis. Methods Retrospectively reviewed and summarized 13 pancreatic tuberculosis patients＇ clinical information, presentation, diagnostic methods, therapeutic approaches, and prognosis from 1958 to 2004 at Peking Union Medical College Hospital. Resuits All cases presented a wide series of symptoms, including fever in 6 cases, upper abdominal tenderness in 13, epigastric mass in 4, obstructive jaundice in 3, night sweat in 4, weight loss in 7, hypersplenoa＇ophy and hypersplenism in 1, and being complicated with tuberculosis of other organs in 3. One case was diagnosed by clinical symptoms and biopsy of lymph node, and only received anti-tubercular treatment. Others were diagnosed by intra-operative biopsy and anti-tubercular treatment, and got well without recurrent tuberculosis in pancreas and other organs during 6 months to 2 years of follow-up. The non-operative case presented extrahepatic portal hypertension. Conclusions Pancreatic tuberculosis may be considered in the patients with fever, abdominal tenderness, weight loss, and imaging evidence of regional pancreatic lesion. Efficacy of anti-tubercular agents and laparotomy for pancreatic tuberculosis is evident.

关键词： pancreatic tuberculosis diagnosis management

Pancreatic cancer with ovarian metastases: A case report and review of the literature

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World Journal of Clinical Cases 2020年第21期8卷 5380-5388页

作者： Shun-Da Wang Liang Zhu Huan-Wen Wu Meng-Hua Dai yu-pei zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Department of Pathology Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China

BACKGROUND Pancreatic cancer with ovarian metastases is rare and easily *** patients are first diagnosed with ovarian *** report a rare case of ovarian metastases secondary to pancreatic *** also review the literature to analyze the clinical characteristics of,diagnostic methods for,and perioperative management strategies for this rare *** SUMMARY A 48-year-old woman with an abdominal mass presented to our *** tomography revealed lesions in the pancreas and lower *** examination and histological investigation of biopsy specimens revealed either an ovarian metastasis from a pancreatic neoplasm or two primary tumors,with metastasis strongly *** patient simultaneously underwent distal pancreatectomy plus splenectomy by a general surgeon and salpingo-oophorectomy with hysterectomy by a *** examination of the surgical specimen revealed a pancreatic adenocarcinoma(intermediate differentiation,mucinous)and a metastatic mucinous adenocarcinoma in the *** For this rare tumor,surgical resection is the most effective treatment,and the final diagnosis depends on tumor pathology.

关键词： Pancreas Ovary Pancreatic cancer Ovarian cancer Metastasis Case report

Diagnostic accuracy of K-ras mutation for pancreatic carcinoma:a meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2013年第5期12卷 458-464页

作者： Shang-Long Liu Ge Chen yu-pei zhao Wen-Ming Wu Tai-Ping Zhang Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND:The conventional tests for the diagnosis of early stage pancreatic carcinoma are not *** metaanalysis is to evaluate the accuracy of K-ras mutation for the diagnosis of pancreatic *** SOURCES:A systemic search of all relevant literature was performed in Web of Science,EMBASE,Cochrane Database,and MEDLINE(PubMed as the search engine) prior to June 1,***-four studies fulfilled the inclusion criteria and data were pooled for ***:The pooled estimates for K-ras mutation in diagnosis of pancreatic carcinoma were as follows:sensitivity 0.68(95% CI:0.66-0.71),specificity 0.87(95% CI:0.85-0.88),positive likelihood ratio 4.54(95% CI:3.47-5.94),negative likelihood ratio 0.37(95% CI:0.30-0.44) and diagnostic odds ratio 14.90(95% CI:10.02-22.15).Summary receiver operating characteristic analysis demonstrated that the maximum joint sensitivity and specificity was 0.79,and the overall area under the curve was ***:Diagnostic accuracy of K-ras mutation was not superior to that of conventional ***,K-ras mutation analysis alone is not recommended for the diagnosis of pancreatic carcinoma.

关键词： cancer diagnosis K-ras pancreatic carcinoma meta-analysis

Risk factors for the occurrence of insulinoma: a case-control study

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Hepatobiliary & Pancreatic Diseases International 2013年第3期12卷 324-328页

作者： Han-Xiang Zhan Lin Cong yu-pei zhao Tai-Ping Zhang Ge Chen Department of General Surgery Peking Union Medical College Hospital Peking Union Medical College Chinese Academy of Medical Sciences

BACKGROUND: The etiology of insulinoma is poorly understood. Few studies investigated the possible roles of environmental factors and lifestyle in the pathogenesis of insulinoma. The aim of this study is to identify risk factors associated with occurrence of insulinoma in the Chinese population. METHODS: This study consisted of 196 patients with insulinoma and 233 controls. Demographic information of the patients and controls and risk factors of the disease were analyzed. Univariate and unconditional multivariable logistic regression analyses were made to estimate odds ratios (ORs) and possible risk factors. RESULTS: Approximately 68.88% (135/196) of the patients were from rural areas in contrast to 10.30% (24/233) of the controls (P<0.0001). This difference was confirmed by the multivariate analysis (OR=4.950; 95% CI: 2.928-8.370). Family history of pancreatic endocrine tumor (OR=16.754; 95% CI: 2.125-132.057) and other cancers (OR=2.360; 95% CI: 1.052-5.291) was also related to a high-risk population of insulinoma. CONCLUSION: Rural residents or people who have a family history of pancreatic endocrine tumor and other cancers are a high-risk population of insulinoma.

关键词： insulinoma risk factors case-control study family history

Prognostic Impact of Cell Division Cycle Associated 2 Expression on Pancreatic Ductal Adenocarcinoma

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Chinese Medical Sciences Journal 2016年第3期31卷 149-154页

作者： Meng-yi Wang Zhe-yu Niu Xiang-Gao Li Zhou Quan Liao yu-pei zhao Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences & Peking Union Medical College

Objective To examine the expression of cell division cycle associated 2(CDCA 2) in pancreatic ductal adenocarcinoma(PDAC) and investigate its role in prognosis of PDAC *** This retrospective study included 155 PDAC patients who underwent surgical treatment and complete post-operative *** data were collected through clinical *** microarray was constructed and immunohistochemistry was performed to detect CDCA2 expression in the PDAC tumor tissues and adjacent non-tumor *** characteristics between high and low CDCA2 expression were *** of CDCA2 expressions with patients' survival was analyzed using Kaplan-Meier method and Cox regression *** Expression of CDCA2 in PDAC cells was significantly higher than that in adjacent non-tumor tissues(U=4056.5,P<0.001).Univariate analysis showed that CDCA2 expression [hazard ratio(HR)=1.574,95% confidence interval(CI)=1.014-2.443,P=0.043] and node metastasis(HR=1.704,95%CI=1.183-2.454,P=0.004) were significantly associated with *** regression analysis showed CDCA2 expression was not an independent prognostic risk factor(HR=1.418,95%CI=0.897-2.242,P=0.135) for PDCA *** survival analysis demonstrated CDCA2 expression as an independent prognostic risk factor in male patients(HR=2.554,95%CI=1.446-4.511,P=0.003) or in non-perineural invasion patients(HR=2.290,95%CI=1.146-4.577,P=0.012).Conclusions CDCA2 is highly expressed in PDAC tumor *** CDCA2 is not an independent prognostic risk factor for PDAC patients,it might be used to help predict prognosis of male or non-perineural invasion patients of PDAC.

关键词： cell division cycle associated 2 immunohistochemistry prognosis pancreatic ductal adenocarcinoma

Ileal duplication mimicking intestinal intussusception:A congenital condition rarely reported in adult

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World Journal of Gastroenterology 2013年第38期19卷 6500-6504页

作者： Bing-Lu Li Xin Huang Chao-Ji Zheng Jiao-Lin Zhou yu-pei zhao The First Department of General Surgery Peking Union Medical College Hospital

Intestinal duplication is an uncommon congenital condition in young adults.A 25-year-old man complained of chronic,intermittent abdominal pain for 3 years following previous appendectomy for the treatment of suspected *** discomfort and pain,suggestive of intestinal obstruction,recurred after operation.A tubular mass was palpable in the right lower *** tomography enterography scan identified suspicious intestinal intussusception,while Tc-99m pertechnetate scintigraphy revealed a cluster of strip-like abnormal radioactivity in the right lower *** exploratory laparotomy,a tubular-shaped ileal duplication cyst was found arising from the mesenteric margin of the native ileal segment located 15 cm proximal to the ileocecal *** was performed along with the removal of the duplication disease,and the end-to-end anastomosis was done to restore the gastrointestinal tract *** examination showed ileal duplication with ectopic gastric *** patient experienced an eventless postoperative recovery and remained asymptomatic within 2 years of postoperative follow-up.

关键词： Ileal duplication cyst Adulthood Computed tomography enterography Tc-99m pertechnetate scintigraphy