Diagnostic accuracy of K-ras mutation for pancreatic carcinoma:a meta-analysis

作     者：Shang-Long Liu Ge Chen Yu-Pei Zhao Wen-Ming Wu Tai-Ping Zhang 

作者机构：Department of General SurgeryPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2013年第12卷第5期

页      面：458-464页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：cancer diagnosis K-ras pancreatic carcinoma meta-analysis 

摘      要：BACKGROUND:The conventional tests for the diagnosis of early stage pancreatic carcinoma are not *** metaanalysis is to evaluate the accuracy of K-ras mutation for the diagnosis of pancreatic *** SOURCES:A systemic search of all relevant literature was performed in Web of Science,EMBASE,Cochrane Database,and MEDLINE(PubMed as the search engine) prior to June 1,***-four studies fulfilled the inclusion criteria and data were pooled for ***:The pooled estimates for K-ras mutation in diagnosis of pancreatic carcinoma were as follows:sensitivity 0.68(95% CI:0.66-0.71),specificity 0.87(95% CI:0.85-0.88),positive likelihood ratio 4.54(95% CI:3.47-5.94),negative likelihood ratio 0.37(95% CI:0.30-0.44) and diagnostic odds ratio 14.90(95% CI:10.02-22.15).Summary receiver operating characteristic analysis demonstrated that the maximum joint sensitivity and specificity was 0.79,and the overall area under the curve was ***:Diagnostic accuracy of K-ras mutation was not superior to that of conventional ***,K-ras mutation analysis alone is not recommended for the diagnosis of pancreatic carcinoma.