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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-lin Jiang Hui-Na Liu yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan Bao lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

Numerical Simulation and Sensitivity Analysis of Parameters for Multistand Roll Forming of Channel Section With Outer Edge

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Journal of Iron and Steel Research International 2009年第1期16卷 32-37页

作者： ZENG Guo LAI Xin-min yu Zhong-qi lin Zhong-qin School of Mechanical Engineering Shanghai Jiao Tong University Shanghai 200240 China State Key Laboratory of Mechanical System and Vibration Shanghai 200240 China

Cold roll forming is a high production but complex metal forming process under the conditions of coupled effects with multi-factor. A new booting finite element method （FEM） model using the updated Lagrangian （IAL） method for multistand roll forming process is developed and validated. Compared with most of the literatures related to roll forming simulation, the new model can take the roll rotation into account and is well suited for simulating multistand roll forming. Based on the model, the process of a channel section with outer edge formed with twelve passes is simulated and the sensitivity analysis of parameters is conducted with orthogonal design combined FEM model. It is found that the multistand roll forming process can be efficiently analyzed by the new booting model, and sensitivity analysis shows that the yield strength plays an important role in controlling the quality of the products.

关键词： cold roll forming multistand roll forming sensitivity FEM model

Effects of moxibustion on Treg cells in sarcoma microenvironment

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Journal of Integrative Medicine 2021年第3期19卷 251-257页

作者： Li-jun Li yu-chong Shi min-xiang Luo Chang-lin Zhao Department of Acupuncture Guangdong Clifford HospitalGuangzhou 511495Guangdong ProvinceChina School of Traditional Chinese Medicine Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Health Science College Guangdong Pharmaceutical UniversityGuangzhou 510006Guangdong ProvinceChina

Objective:To investigate the therapeutic effect of moxibustion on sarcomas from mesenchymal tissues,which have a low response rate to chemotherapy and ***:S180 sarcoma cell line was inoculated in C57 BL/6 mice to form transplanted *** therapy was directly applied at the transplanted tumor sites,at a distance of 3.0 cm,10 min per session,till skin temperature reached 45°C,once a day,for 14 consecutive days of *** the mice were killed,serum was collected and used to detect concentrations of interleukin-10(IL-10),transforming growth factor-b1(TGF-b1),IL-4 and interferon-c(IFN-c)by Luminex liquid suspension *** numbers of Treg^(^(+) )T cells and CD4^(+) CD25^(+) Forkhead Box P3(Foxp3)^(+) T cells were detected by flow *** in situ hybridization was used to analyze the changes of CD4,CD8,Foxp3 and TGF-b1 in the tumor microenvironment(TME).Results:Weight of S180 transplanted tumor in the control group was(2.03±0.54)g,and that in the moxibustion group was(1.27±0.29)g,which was statistically different(P=0.023).The mean value of Foxp3^(+) T cells in the normal group was 2.01%,which increased to 3.63%after the formation of transplanted tumor,and decreased to 1.48%after moxibustion *** moxibustion group also had reduced numbers of CD4^(+) CD25^(+) Foxp3^(+) T cells in the spleen of mice with transplanted *** concentrations of IL-10,TGF-b1 and IL-4 decreased in the serum of mice with transplanted tumor,while the concentration of IFN-c *** was associated with downregulation in expression of Foxp3,IL-10 and TGF-b1 genes in the transplanted tumor,and increases in the gene expression of CD4^(+) T cells and CD8^(+) T cells in the ***:Moxibustion may have therapeutic effects on sarcomas by reducing the number of Treg cells in the blood and controlling the infiltration of Treg cells in the TME.

关键词： Sarcoma Moxibustion Treg cells Tumor microenvironment

Correlation Between Yield Stress of Silty Mud Sediments and Continuous Oscillatory Shearing Properties

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China Ocean Engineering 2022年第2期36卷 223-232页

作者： CHEN Xiao-hui ZHANG min-xi yuE Shao-lin ZHOU Huan yu Guo-liang SKLOE CISSEDepartment of Ocean and Civil Engineering Shanghai Jiao Tong UniversityShanghai 200240China CCCC Road&Bridge Special Engineering Co. Ltd.Wuhan 430061China

Analyzing the rheological properties of silty beds subjected to continuous oscillatory shear loading is crucial for understanding the morphological deformation of the seabed and ensuring safety in geological and marine engineering *** this study,the effects of oscillatory shearing properties on the yield stress(S_(u))of silty sediments were quantitatively *** effects of oscillatory shear strength(0-3),water content(26.6%-70.84%),and particle diameter(8.79-50μm)were examined extensively through a series of laboratory *** results indicated that the three aforementioned parameters were the major factors that affected the rheological characteristics of silty ***,their effects could be elucidated using the yield stress of cohesive sediments as the indicator *** ratio of yield stress(S_(u)/S_(u0))varied as the oscillatory shear strength increased up to a critical value,Λ_(cr).S_(u)bsequently,the ratio remained at a constant *** was deduced that the yield stress decreased with increasing oscillatory shear strength forΛΛ_(cr),the sediments entered an equilibrium fluidization stage,and the yield stress remained almost constant,irrespective of the oscillatory shear ***,during the equilibrium fluidization stage,it was observed that the ratio S_(u)/S_(u0)did not vary with water content but decreased as the particle diameter ***,based on regression analysis of the experimental data for non-equilibrium and equilibrium fluidization stages,a correlation between yield stress of silty sediments and continuous oscillatory shearing properties was *** correlation can aid in understanding the changes in solid resistance and assessing safety in piling ***,it can provide a theoretical guidance for reducing soil resistance in marine structures using mechanical vibrations.

关键词： silty sediments yield stress water content particle diameter oscillatory shear strength

Study on viscosity mechanism of caffeine crystallization solutions Author links open overlay panel

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Particuology 2024年第8期91卷 341-350页

作者： linjing yu min Su School of Chemical Engineering Hebei University of TechnologyTianjin300130China

The solid-liquid viscous system formed by high viscosity crystallization solution impacts the flow and separation ***,it is very important to study the viscosity mechanism to improve viscosity and regulate crystallization,ensuring a seamless production ***,the viscosity of crystallization solution was taken as the measurement parameter of caffeine as a model *** investigated the viscosity mechanism of caffeine crystallization solutions by combining experiment and *** results indicated that the weak interactions between caffeine and water result in increased viscosity of the caffeine crystallization ***,caffeine crystals possess elongated needle-like shapes,featuring a substantial specific surface ***,there isπ-πstacking occurring between the(200)crystal face and(110)crystal face,effectively fostering coalescence of the crystals towards the radial side of the crystal along its elongated axis,resulting in a more viscous crystallization *** results contribute to comprehending the viscosity mechanism of crystal systems and provide theoretical foundation to enhance engineering efficiency in crystallization.

关键词： Crystallization Caffeine Viscosity mechanism Molecular simulation

环状RNA CHACR调控压力超负荷诱导心肌肥大和氧化应激损伤

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中国组织工程研究 2025年第25期29卷 5362-5373页

作者：王霜韩瑜袁敏曹济民孙腾山西医科大学细胞生理学教育部重点实验室山西省细胞生理学重点实验室山西医科大学基础医学院生理学系山西省太原市030001

背景:病理性心肌肥大是多种心脏疾病的危险促进因素,但其发病机制仍未阐明。环状RNA与心肌肥大密切相关,然而环状RNA CHACR在心肌肥大中的作用及调控机制尚未见报道。目的:探究环状RNA CHACR在压力超负荷诱导心肌肥大中的作用及机制。方... 详细信息

背景:病理性心肌肥大是多种心脏疾病的危险促进因素,但其发病机制仍未阐明。环状RNA与心肌肥大密切相关,然而环状RNA CHACR在心肌肥大中的作用及调控机制尚未见报道。目的:探究环状RNA CHACR在压力超负荷诱导心肌肥大中的作用及机制。方法:①心脏原位注射环状RNA CHACR过表达慢病毒1周后进行横向主动脉缩窄手术诱导小鼠心肌肥大。术后8周,计算心脏质量/胫骨长比值和肺质量/胫骨长比值,测量心肌细胞表面积,检测肥大标志基因表达水平和心肌纤维化程度,评估心功能。②H9c2心肌细胞给予环状RNA CHACR过表达慢病毒处理72 h,然后加入1μmol/L血管紧张素Ⅱ处理24 h诱导心肌细胞肥大。通过检测心肌细胞表面积、肥大标志基因表达水平、蛋白质/DNA比值评估细胞肥大情况,通过检测活性氧水平和线粒体膜电位评估氧化应激损伤情况。结果与结论:①在体内和体外心肌肥大模型中,环状RNA CHACR的表达水平均显著降低(P<0.01);②过表达环状RNA CHACR显著抑制了横向主动脉缩窄手术诱导的小鼠心肌肥大表型,主要表现为心脏体积减小、心脏质量/胫骨长比值显著降低(P<0.05),肺质量/胫骨长比值显著降低(P<0.05),心肌细胞表面积显著减小(P<0.05),以及心肌肥大相关标志基因心房利钠肽(P<0.05)、脑钠肽(P<0.05)表达水平降低;③过表达环状RNA CHACR显著抑制了横向主动脉缩窄手术诱导的小鼠心脏纤维化,表现为纤维化面积减小(P<0.01)和纤维化标志基因Acta1的表达水平降低(P<0.05);④过表达环状RNA CHACR显著改善了小鼠心功能,主要表现为射血分数(P<0.05)和短轴缩短率(P<0.01)显著升高;(5)过表达环状RNA CHACR显著抑制了血管紧张素Ⅱ诱导的心肌细胞肥大,主要表现为心肌细胞表面积显著减小(P<0.05),心房利钠肽(P<0.05)和脑钠肽(P<0.05)表达水平显著下调,以及蛋白质/DNA比值显著减小(P<0.05);(6)过表达环状RNA CHACR显著抑制了血管紧张素Ⅱ诱导的活性氧水平升高(P<0.001)和线粒体膜电位降低(P<0.05)。结果表明,环状RNA CHACR在体内和体外心肌肥大模型中表达水平显著降低,过表达环状RNA CHACR显著抑制心肌肥大,减轻心肌纤维化,改善心功能,并且显著减轻了血管紧张素Ⅱ诱导的心肌细胞氧化应激损伤。

关键词：心肌肥大环状RNA CHACR 血管紧张素Ⅱ 横向主动脉缩窄手术氧化应激损伤

Molecular analysis of long-term biofilm formation on PVC and cast iron surfaces in drinking water distribution system

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Journal of Environmental Sciences 2014年第4期26卷 865-874页

作者： Ruyin Liu Junge Zhu Zhisheng yu DevRaj Joshi Hongxun Zhang Wenfang lin min Yang College of Environmental and Resource Sciences University of Chinese Academy of Sciences Institute of Microbiology Chinese Academy of Sciences Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

To understand the impacts of different plumbing materials on long-term biofilm formation in water supply system, we analyzed microbial community compositions in the bulk water and biofilms on faucets with two different materials-polyvinyl chloride （PVC） and cast iron, which have been frequently used for more thanlO years. Pyrosequencing was employed to describe both bacterial and eukaryotic microbial compositions. Bacterial communities in the bulk water and biofilm samples were significantly different from each other. Specific bacterial populations colonized on the surface of different materials. Hyphomicrobia and corrosion associated bacteria, such as Acidithiobacillus spp., Aquabacterium spp., Limnobacter thiooxidans, and Thiocapsa spp., were the most dominant bacteria identified in the PVC and cast iron biofilms, respectively, suggesting that bacterial colonization on the material surfaces was selective. Mycobacteria and Legionella spp. were common potential pathogenic bacteria occurred in the biofilm samples, but their abundance was different in the two biofilm bacterial communities. In contrast, the biofilm samples showed more similar eukaryotic communities than the bulk water. Notably, potential pathogenic fungi, i.e., Aspergillus spp. and Candida parapsilosis, occurred in similar abundance in both biofilms. These results indicated that microbial community, especially bacterial composition was remarkably affected by the different pipe materials （PVC and cast iron）.

关键词： drinking waterbiofilm surface material pyrosequencing microbial community

Research on monopulse forward-looking high-resolution imaging algorithm based on adaptive iteration

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Defence Technology（防务技术） 2020年第1期16卷 158-171页

作者： Cheng Cheng Xiao-dong Zhou min Gao Zhu-lin Zong Yong-xiang Ji Bo yu Department of Missile Engineering Army Engineering UniversityNo.97 Westroad HepingShijiazhuangChina Department of Ammunition Engineering Army Engineering UniversityNo.97 Westroad HepingShijiazhuangChina Research Institute of Electronic Science and Technology University of Electronic Science and TechnologyNo.4Section 2Jianbei RoadChengduChina China Huayin Weapon Test Center No.450 Yuemiao StreetHuayinShaanxiChina North Automatic Control Technology Institute No.351 Tiyu RoadTaiyuanChina

In this paper,we proposed a monopulse forward-looking high-resolution imaging algorithm based on adaptive iteration for missile-borne *** iteration,the proposed algorithm automatically selects the echo signal of isolated strong-scattering points from the receiving echo signal data to accurately estimate the actual optimal monopulse response curve(MRC) of the same distance range,and we applied optimal MRC to realize the azimuth self-focusing in the process of *** use real-time echo data to perform error correction for obtaining the optimal MRC,and the azimuth angulation accuracy may reach the optimum at a certain distance *** experimentally demonstrate the validity,reliability and high performance of the proposed *** azimuth angulation accuracy may reach up to ten times of the detection *** simulation experiments have verified the feasibility of this strategy,with the average height measurement error being 7.8%.In the out-field unmanned aerial vehicle(UAV) tests,the height measurement error is less than 25 m,and the whole response time can satisfy the requirements of a missile-borne detector.

关键词： Monopulse imaging High-resolution Adaptive iteration Missile-borne detector

Two Efficient Parameterized Boundaries for Vee's Asian Option Pricing PDE

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Acta Mathematicae Applicatae Sinica 2012年第4期28卷 643-652页

作者： Bai-min yu School of International Trade and Economics University of International Business and Economics

In this paper, we derive two general parameterized boundaries of finite difference scheme for VeSe~＇s PDE which is used to price both fixed and floating strike Asian options. Using these two boundaries, we can deal with all kinds of situations, especially, some extreme cases, like overhigh volatility, very small volatility, etc, under which the Asian option is usually mispriced in many existing numerical methods. Numerical results show that our boundaries are pretty efficient.

关键词： Asian option Vecer's PDE finite difference parameterized boundaries sensitivity