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Conversion therapy in advanced perihilar cholangiocarcinoma based on patient-derived organoids:A case report

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4274-4280页

作者： Yong-Gang He ling-yu zhang Jing Li Zheng Wang Chong-yu Zhao Lu Zheng Xiao-Bing Huang Department of Hepatobiliary The Second Affiliated Hospital of Army Medical UniversityChongqing 400037China School of Clinical Oncology Fujian Medical UniversityFujian Cancer HospitalFuzhou 350014Fujian ProvinceChina Fujian Key Laboratory of Translational Cancer Medicine Fuzhou 350014Fujian ProvinceChina

BACKGROUND Patient-derived organoids(PDOs)have been demonstrated to predict the response to drugs in multiple cancer ***,it remains unclear about its application in *** SUMMARY A 59-year-old woman was admitted to the hospital due to upper abdominal pain for over 8 *** to relevant examinations,she was diagnosed as perihilar cholangiocarcinoma(pCCA)with intrahepatic metastasis and perihilar lymphatic *** multidisciplinary team discussion,percutaneous transhepatic cholangiodrainage was performed to relieve biliary obstruction,and puncture biopsy was conducted to confirm the pathological *** chemoembolization with nab-paclitaxel was used in combination with toripalimab and lenvatinib,but the levels of tumor markers including alpha fetal protein,carcinoembryonic antigen,carbohydrate antigen 15-3 and cancer antigen 125 were still *** PDO for drug screening showed sensitive to gemcitabine and ***,the chemotherapy regimen was adjusted to gemcitabine and cisplatin in combination with toripalimab and *** 4 cycles of treatment,the tumor was assessed resectable,and radical surgical resection was performed *** year after surgery,the patient was still alive,and no recurrence or *** PDOs for drug sensitivity contribute to screening effective chemotherapy drugs for advanced pCCA,promoting conversion therapy and improving the prognosis.

关键词： Patient-derived organoids Perihilar cholangiocarcinoma Conversion therapy Drug screening Intrahepatic metastasis Case report

Evaluation of retinal and choroidal thickness changes in overweight and obese adults without ocular symptoms by swept-source optical coherence tomography

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 707-712页

作者： Qing-Jian Li Sheng-Mei Zhou ling-yu zhang An-Ni Lin Yang zhang Jing Jiang Xin Che Yi-Wen Qian Yan Liu Zhi-Liang Wang Department of Ophthalmology Huashan HospitalFudan UniversityShanghai 200040China Eye Institute of Xiamen University Xiamen University School of MedicineXiamen 361005Fujian ProvinceChina Department of Gastroenterology Huashan HospitalFudan UniversityShanghai 200040China

AIM:To evaluate the relationship of overweight and obesity with retinal and choroidal thickness in adults without ocular symptoms by swept-source optical coherence tomography(SS-OCT).METHODS:According to the body mass index(BMI)results,the adults enrolled in the cross-sectional study were divided into the normal group(18.50≤BMI<25.00 kg/m^(2)),the overweight group(25.00≤BMI<30.00 kg/m^(2)),and the obesity group(BMI≥30.00 kg/m^(2)).The one-way ANOVA and the Chi-square test were used for ***’s correlation analysis was used to evaluate the relationships between the measured ***:This research covered the left eyes of 3 groups of 434 age-and sex-matched subjects each:normal,overweight,and *** mean BMI was 22.20±1.67,26.82±1.38,and 32.21±2.35 kg/m^(2) in normal,overweight and obesity groups,*** choroid was significantly thinner in both the overweight and obesity groups compared to the normal group(P<0.05 for all),while the retinal thickness of the three groups did not differ ***’s correlation analysis showed that BMI was significantly negatively correlated with choroidal thickness,but no significant correlation was observed between BMI and retinal ***:Choroidal thickness is decreased in people with overweight or *** on changes in choroidal thickness contributes to the understanding of the mechanisms of certain ocular disorders in overweight and obese adults.

关键词： overweight obesity body mass index choroidal thickness retinal thickness swept-source optical coherence tomography

Pilot plant study on ozonation and biological activated carbon process for drinking water treatment

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Journal of Environmental Sciences 2006年第2期18卷 232-235页

作者： KONG ling-yu zhang Xiao-jian WANG Zhan-sheng Department of Environmental Science and Engineering Tsinghua University Beijing 100084 China

A study on advanced drinking water treatment was conducted in a pilot scale plant taking water from conventional treatment process. Ozonation-biological activated carbon process （O3-BAC） and granular activated carbon process （GAC） were evaluated based on the following parameters： CODMn, UV254, total organic carbon （TOC）, assimilable organic carbon （AOC） and biodegradable dissolved organic carbon （BDOC）. In this test, the average removal rates of CODMn, UV254 and TOC in O3-BAC were 18.2%, 9.0% and 10.2% higher on （AOC） than in GAC, respectively. Ozonation increased 19.3-57.6 μg Acetate-C/L in AOC-P17, 45.6-130.6 μg Acetate-C/L in AOC-NOX and 0.1-0.5 mg/L in BDOC with ozone doses of 2 8 mg/L. The optimum ozone dose for maximum AOC formation was 3 mgO3/L. BAC filtration was effective process to improve biostability.

关键词： ozonation biological activated carbon CODMn UV254 TOC AOC BDOC biostability

A novel bioinspired mechanism to elucidate the movement flexibility of the honeybee abdomen driven by muscles

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Insect Science 2022年第4期29卷 1181-1194页

作者： yu-ling zhang Shao-Ze Yan You-Jian Liang Division of Intelligent and Biomechanical Systems State Key Laboratory of TribologyDepartment of Mechanical EngineeringTsinghua UniversityBeijingChina DFH Satellite Co. Ltd.BeijingChina

The abdomen of a honeybee is a blueprint for bioinspired mechanical design because of its movement flexibility and ***,the abdominal muscles closely related to the movement flexibility mechanism have not been fully identified,limiting the potential biological advantage of their use in bionic mechanism *** this study,we reveal the muscle distribution of the complete muscular driving unit in a honeybee abdomen using stereoscopy and scanning electron microscopy,and the muscle distribution was effectively verified using X-ray tomography.A novel equivalent unit mechanism(EUM)was then proposed and the kinematic analysis indicated that the extension ratio,bending angle,and swing angle of the EUM reached 9.36%,1.22°,and 4.43°,*** deformation ability of the EUM was consistent with the movement of the abdomen,confirming the movement *** work may provide a new perspective for distributed bionic mechanism design.

关键词： bionics equivalent unit mechanism honeybee abdomen movement flexibility muscle

Behavior of aqueous stable colloidal nano-C60 aggregates exposed to TX100 micelles under different environmental conditions

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Frontiers of Environmental Science & Engineering 2015年第2期9卷 197-205页

作者： Jing HUO Ye yu ling GE Bo zhang Yiliang HE School of Environmental Science & Engineering Shanghai Jiaotong University Shanghai 200240 China

C60, as one of carbon nanomaterials widely used in various fields, could be released into the water environment thus exerting some potential health risks to human beings. This work examined the behavior of aqueous stable colloidal nano-C60 （nC60） aggregates under different environmental conditions including Polyethylene glycol octylphenol ether （TX100） micelles concentration, pH, and reaction time when exposed to TX100micelles. Results show that the nC60 aggregates became more dispersive and restored the capability of generating the singlet oxygen when exposed to TX100 micelles. With the increase of TX100 concentration, smaller average size of nC60 aggregates was observed in dynamic light scattering （DLS） analysis, the fluorescence intensity of TX100 was more quenched by nC60 aggregates, and the kinetic rate constant of generating the singlet oxygen for nC60 aggregates was improved. The mean size of nC60 aggregates in the presence of TX 100 had no obvious variations when the pH ranged from 4 to 8. The longer reaction time between nCro aggregates and TX100 led to a higher kinetic rate constant of generating the singlet oxygen. Collective data suggest that variations in physicochemical properties of nC60 aggregates are strongly dependent on the surrounding media under different environmental conditions and directly govern nC60＇S transport behavior and potential toxicity.

关键词： Keywords nano-C60 (nC60) aggregates photochemicalreactivity artificial biological membrane

Glucagon-like peptide-1/glucose-dependent insulinotropic polypeptide dual receptor agonist DA-CH5 is superior to exendin-4 in protecting neurons in the 6-hydroxydopamine rat Parkinson model

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Neural Regeneration Research 2021年第8期16卷 1660-1670页

作者： ling-yu zhang Qian-Qian Jin Christian Hölscher Lin Li Gerontology Institute Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Forensic Pathology Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Second HospitalShanxi Medical UniversityTaiyuanShanxi ProvinceChina Research and Experimental Center Henan University of Chinese MedicineZhengzhouHenan ProvinceChina

Patients with Parkinson's disease(PD) have impaired insulin signaling in the brain. Incretin hormones, including glucagon-like peptide-1(GLP-1) and glucose-dependent insulinotropic polypeptide(GIP), can re-sensitize insulin signaling. In a recent phase II clinical trial, the first GLP-1 mimic, exendin-4, has shown reliable curative effect in patients with PD. DA-CH5 is a novel GLP-1/GIP receptor unimolecular coagonist with a novel peptide sequence added to cross the blood-brain barrier. Here we showed that both exendin-4 and DA-CH5 protected against 6-hydroxydopamine(6-OHDA) cytotoxicity, inhibited apoptosis, improved mitogenesis and induced autophagy flux in SH-SY5Y cells via activation of the insulin receptor substrate-1(IRS-1)/alpha serine/threonine-protein kinase(Akt)/c AMP response element-binding protein(CREB) pathway. We also found that DA-CH5(10 nmol/kg) daily intraperitoneal administration for 30 days post-lesion alleviated motor dysfunction in rats and prevented stereotactic unilateral administration of 6-OHDA induced dopaminergic neurons loss in the substantia nigra pars compacta. However, DA-CH5 showed curative effects in reducing the levels of α-synuclein and the levels of pro-inflammatory cytokines(tumor necrosis factor-α, interleukin-1β). It was also more effective than exendin-4 in inhibiting apoptotic process and protecting mitochondrial functions. In addition, insulin resistance was largely alleviated and the expression of autophagy-related proteins was upregulated in PD model rats after DA-CH5 treatment. These results in this study indicate DA-CH5 plays a therapeutic role in the 6-OHDAunilaterally lesioned PD rat model and is superior to GLP-1 analogue exendin-4. The study was approved by the Animal Ethics Committee of Shanxi Medical University of China.

关键词： neurodegenerative disease Parkinson's disease insulin resistance inflammation GLP-1/GIP receptor unimolecular co-agonist

A positive feedback circuit for ROP-mediated polar growth

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Molecular Plant 2021年第3期14卷 395-410页

作者： En Li yu-ling zhang Xuelian Shi Han Li Xuefeng yuan Sha Li Yan zhang State Key Laboratory of Crop Biology College of Life SciencesShandong Agricultural UniversityTai'an 271018China Shandong Province Key Laboratory of Agricultural Microbiology College of Plant ProtectionShandong Agricultural UniversityTai'an 271018China

Tip growth is a special type of polarized growth in which a single and unique polarization site is established and *** of Plants(ROP)proteins,which represent the only class of Rho GTPases in plants,regulate tip *** dynamic and asymmetric distribution of ROPs is critical for the establishment and maintenance of tip growth,and requires at least one positive feedback loop,which is still ***,we report a positive feedback circuit essential for tip growth of root hairs,in which ROPs,ROP activators and effectors,and AGC1.5 subfamily kinases are interconnected by sequential oligomerization and ***1.5 subfamily kinases interact with and phosphorylate two guanine nucleotide exchange factors(GEFs)of ROPs,RopGEF4 and *** also interact with two ROP effectors,ICR2/RIP3 and MIDD1/RIP4,which bridge active ROPs with *** loss of the AGC1.5 subfamily kinases or ICR2 and MIDD1 compromised root hair growth due to reduced ROP *** found that asymmetric targeting of RopGEF4 and RopGEF10 is controlled by AGC1.5-dependent ***,we discovered that the ROP effectors recruit AGC1.5 to active ROP domains at the plasma membrane during root hair growth and are critical for AGC1.5-dependent phosphorylation of *** the large number of AGC kinases in plants,this positive feedback circuit may be a universal theme for plant cell polar growth.

关键词： Rho GTPases AGC kinase membrane recruitment phosphorylation asymmetric growth

High-order harmonic generation of ZnO crystals in chirped and static electric fields

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Chinese Physics B 2024年第1期33卷 335-343页

作者：张玲玉何永林谢卓璇高芳艳徐清芸葛鑫磊罗香怡郭静 Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China School of Physics and Electromechanical Engineering Hexi UniversityZhangye 734000China Institute of Theoretical Physics Hexi UniversityZhangye 734000China College of Physical Science and Technology Bohai UniversityJinzhou 121013China College of Physics and Electronic Information Baicheng Normal UniversityBaicheng 137000China

High harmonic generation in ZnO crystals under chirped single-color field and static electric field are investigated by solving the semiconductor Bloch equation(SBE). It is found that when the chirp pulse is introduced, the interference structure becomes obvious while the harmonic cutoff is not extended. Furthermore, the harmonic efficiency is improved when the static electric field is included. These phenomena are demonstrated by the classical recollision model in real space affected by the waveform of laser field and inversion symmetry. Specifically, the electron motion in k-space shows that the change of waveform and the destruction of the symmetry of the laser field lead to the incomplete X-structure of the crystal-momentum-resolved(k-resolved) inter-band harmonic spectrum. Furthermore, a pre-acceleration process in the solid four-step model is confirmed.

关键词： high-order harmonic generation the semiconductor Bloch equation k-resolved inter-band harmonic spectrum four-step semiclassical model

A nonlocal dispersal and time delayed HIV infection model with general incidences

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Applied Mathematics(A Journal of Chinese Universities) 2024年第3期39卷 448-457页

作者： WU Peng zhang yu-huai WANG ling School of Sciences Hangzhou Dianzi UniversityHangzhou 310018China School of Humanities and Management Zhejiang Chinese Medical UniversityHangzhou 311402China Public Foundational Courses Department Nanjing Vocational University of Industry TechnologyNanjing 210023China

Biologically,because of the impact of reproduction period and nonlocal dispersal of HIV-infected cells,time delay and spatial heterogeneity should be *** this paper,we establish an HIV infection model with nonlocal dispersal and infection ***,applying the theory of Fourier transformation and von Foerster rule,we transform the model to an integrodifferential equation with nonlocal time delay and *** well-posedness,positivity,and boundedness of the solution for the model are studied.

关键词： HIV model nonlocal dispersal time delay general incidences