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Minocycline in the eradication of Helicobacter pylori infection: A systematic review and meta-analysis

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World Journal of Gastroenterology 2024年第17期30卷 2354-2368页

作者： Kai Zhou Cai-ling Li Hua Zhang Bao-Jun Suo yu-Xin Zhang Xin-Lu Ren yu-Xin wang Chang-Min Mi ling-ling Ma Li-Ya Zhou Xue-Li Tian Zhi-Qiang Song Department of Gastroenterology Peking University Third HospitalBeijing 100191China

BACKGROUND Difficulty in obtaining tetracycline,increased adverse reactions,and relatively complicated medication methods have limited the clinical application of the classic bismuth quadruple ***,the search for new alternative drugs has become one of the research *** recent years,minocycline,as a semisynthetic tetracycline,has demonstrated good potential for eradicating Helicobacter pylori(***)infection,but the systematic evaluation of its role remains *** To explore the efficacy,safety,and compliance of minocycline in eradicating *** *** We comprehensively retrieved the electronic databases of PubMed,Embase,Web of Science,China National Knowledge Infrastructure,SinoMed,and Wanfang database as of October 30,2023,and finally included 22 research reports on *** eradication with minocycline-containing regimens as per the inclusion and exclusion *** eradication rates of *** were calculated using a fixed or a random effect model,and the heterogeneity and publication bias of the studies were *** The single-arm meta-analysis revealed that the minocycline-containing regimens achieved good overall *** eradication rates,reaching 82.3%[95%confidence interval(CI):79.7%-85.1%]in the intention-to-treat analysis and 90.0%(95%CI:87.7%-92.4%)in the per-protocol *** overall safety and compliance of the minocycline-containing regimens were good,demonstrating an overall incidence of adverse reactions of 36.5%(95%CI:31.5%-42.2%).Further by traditional meta-analysis,the results showed that the minocycline-containing regimens were not statistically different from other commonly used eradication regimens in eradication rate and incidence of adverse *** of the adverse reactions were mild to moderate and well-tolerated,and dizziness was relatively prominent in the minocycline-containing regimens(16%).CONCLUSION The minocycline-containing regimens demonstrated good efficacy,safety,and

关键词： Helicobacter pylori Minocycline Eradication Safety Resistance

Design Principles and Mechanistic Understandings of Non-Noble-Metal Bifunctional Electrocatalysts for Zinc-Air Batteries

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Nano-Micro Letters 2024年第9期16卷 13-48页

作者： yunnan Gao ling Liu Yi Jiang Dexin yu Xiaomei Zheng Jiayi wang Jingwei Liu Dan Luo Yongguang Zhang Zhenjia Shi Xin wang Ya‑Ping Deng Zhongwei Chen Power Battery and Systems Research Center State Key Laboratory of CatalysisDalian Institute of Chemical PhysicsDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023People’s Republic of China Department of Chemical Engineering University of WaterlooWaterlooON N2L 3G1Canada Institute of Carbon Neutrality Zhejiang Wanli UniversityNingbo 315100People’s Republic of China College of Materials and Chemistry China Jiliang UniversityHangzhou 310018People’s Republic of China

Zinc-air batteries(ZABs)are promising energy storage systems because of high theoretical energy density,safety,low cost,and abundance of ***,the slow multi-step reaction of oxygen and heavy reliance on noble-metal catalysts hinder the practical applications of ***,feasible and advanced non-noble-metal elec-trocatalysts for air cathodes need to be identified to promote the oxygen catalytic *** this review,we initially introduced the advancement of ZABs in the past two decades and provided an overview of key developments in this ***,we discussed the work-ing mechanism and the design of bifunctional electrocatalysts from the perspective of morphology design,crystal structure tuning,interface strategy,and atomic *** also included theoretical studies,machine learning,and advanced characterization technologies to provide a comprehensive understanding of the structure-performance relationship of electrocatalysts and the reaction pathways of the oxygen redox ***,we discussed the challenges and prospects related to designing advanced non-noble-metal bifunctional electrocatalysts for ZABs.

关键词： Zinc-air batteries Bifunctional electrocatalysts Design principles Mechanistic understandings

Mitochondrial carrier homolog 2 increases malignant phenotype of human gastric epithelial cells and promotes proliferation,invasion,and migration of gastric cancer cells

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 991-1005页

作者： Jing-Wen Zhang ling-Yan Huang Ya-Ning Li Ying Tian Jia yu Xiao-Fei wang School of Basic Medical Science NHC Key Laboratory of Metabolic Cardiovascular Diseases ResearchNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Pathology General Hospital of Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Pathology North China University of Science and Technology Affiliated HospitalTangshan 063000Hebei ProvinceChin

BACKGROUND The precise role of mitochondrial carrier homolog 2(MTCH2)in promoting malignancy in gastric mucosal cells and its involvement in gastric cancer cell metastasis have not been fully *** To determine the role of MTCH2 in gastric *** We collected 65 samples of poorly differentiated gastric cancer tissue and adjacent tissues,constructed MTCH2-overexpressing and MTCH2-knockdown cell models,and evaluated the proliferation,migration,and invasion of human gastric epithelial cells(GES-1)and human gastric cancer cells(AGS)*** mito-chondrial membrane potential(MMP),mitochondrial permeability transformation pore(mPTP)and ATP fluorescence probe were used to detect mitochondrial *** function and ATP synthase protein levels were detected via Western *** The expression of MTCH2 and ATP2A2 in gastric cancer tissues was significantly greater than that in adjacent *** of MTCH2 promoted colony formation,invasion,migration,MMP expression and ATP production in GES-1 and AGS cells while upregulating ATP2A2 expression and inhibiting cell apoptosis;knockdown of MTCH2 had the opposite effect,promoting overactivation of the mPTP and promoting *** MTCH2 can increase the malignant phenotype of GES-1 cells and promote the proliferation,invasion,and migration of gastric cancer cells by regulating mitochondrial function,providing a basis for targeted therapy for gastric cancer cells.

关键词： Gastric cancer Mitochondrial carrier homolog 2 ATP synthase ATP2A2 Mitochondrial permeability transformation pore

Development and validation of a prediction model for early screening of people at high risk for colorectal cancer

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World Journal of Gastroenterology 2024年第5期30卷 450-461页

作者： ling-Li Xu Yi Lin Li-yuan Han yue wang Jian-Jiong Li Xiao-yu Dai Department of General Surgery Ningbo No.2 HospitalNingbo 315000Zhejiang ProvinceChina Center for Health Economics Faculty of Humanities and Social SciencesUniversity of NottinghamNingbo 315100Zhejiang ProvinceChina Department of Global Health Ningbo Institute of Life and Health IndustryUniversity of Chinese Academy of SciencesNingbo 315000Zhejiang ProvinceChina School of Public Health Medical College of Soochow UniversitySuzhou 215123Jiangsu ProvinceChina

BACKGROUND Colorectal cancer(CRC)is a serious threat *** early screening is suggested to be the most effective method to prevent and control CRC,the current situation of early screening for CRC is still not *** China,the incidence of CRC in the Yangtze River Delta region is increasing dramatically,but few studies have been ***,it is necessary to develop a simple and efficient early screening model for *** To develop and validate an early-screening nomogram model to identify individuals at high risk of *** Data of 64448 participants obtained from Ningbo Hospital,China between 2014 and 2017 were retrospectively *** cohort comprised 64448 individuals,of which,530 were excluded due to missing or incorrect *** 63918,7607(11.9%)individuals were considered to be high risk for CRC,and 56311(88.1%)were *** participants were randomly allocated to a training set(44743)or validation set(19175).The discriminatory ability,predictive accuracy,and clinical utility of the model were evaluated by constructing and analyzing receiver operating characteristic(ROC)curves and calibration curves and by decision curve ***,the model was validated internally using a bootstrap resampling *** Seven variables,including demographic,lifestyle,and family history information,were *** logistic regression analysis revealed that age[odds ratio(OR):1.03,95%confidence interval(CI):1.02-1.03,P<0.001],body mass index(BMI)(OR:1.07,95%CI:1.06-1.08,P<0.001),waist circumference(WC)(OR:1.03,95%CI:1.02-1.03 P<0.001),lifestyle(OR:0.45,95%CI:0.42-0.48,P<0.001),and family history(OR:4.28,95%CI:4.04-4.54,P<0.001)were the most significant predictors of high-risk *** lifestyle was a protective factor,whereas family history was the most significant risk *** area under the curve was 0.734(95%CI:0.723-0.745)for the final validation set ROC curve and 0.735(95%CI:0.728-0.742)for the training s

关键词： Colorectal cancer Early screening model High-risk population Nomogram model Questionnaire survey Dietary habit Living habit

Nitric oxide assists nitrogen reduction reaction on 2D MBene: A theoretical study

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Chinese Chemical Letters 2024年第5期35卷 428-433页

作者： Chaozheng He Jia wang ling Fu Wei Wei Henan Engineering Center of New Energy Battery Materials College of Chemistry and Chemical EngineeringShangqiu Normal UniversityShangqiu 476000China School of Chemistry and Chemical Engineering Shandong Provincial Key Laboratory/Collaborative Innovation Center of Chemical Energy Storage&Novel Cell TechnologyLiaocheng UniversityLiaocheng 252059China Institute of Environment and Energy Catalysis Shaanxi Key Laboratory of Optoelectronic Functional Materials and DevicesSchool of Materials Science and Chemical EngineeringXi’an Technological UniversityXi’an 710021China College of Resources and Environmental Engineering Tianshui Normal UniversityTianshui 741001China

Electrocatalytic synthesis of ammonia as an environment-friendly and sustainable development method has received widespread attention in recent ***-dimensional(2D)materials are a promising catalyst for ammonia synthesis due to their large surface *** this work,we have constructed a series of 2D metal borides(MBenes)with transition metal(TM)defects(TMd-MBenes)and comprehensively calculated the reactivity of electrocatalytic synthesis of ammonia-based on density functional *** results have demonstrated that the TMd-MBenes can effectively activate nitrogen oxide(NO)and nitrogen(N2)molecules *** interesting,the co-chemisorption of O atoms,dissociated from NO,can facilitate the spilled of the inert N2 molecules into single N atoms,which can further hydrogenate into ammonia easily with an ultralow limiting potential of 0.59 V on *** research has not only provided clues for catalyst design for experimental study but also paved the way for the industrial application of electrocatalytic ammonia synthesis.

关键词： 2D mbenes Nitrogen electro-reduction DFT N_(2)activation Ammonia synthesis

Paclitaxel Drug-eluting Tracheal Stent Could Reduce Granulation Tissue Formation in a Canine Model

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Chinese Medical Journal 2016年第22期129卷 2708-2713页

作者： Ting wang Jie Zhang Juan wang Ying-Hua Pei Xiao-Jian Qiu yu-ling wang Department of Respiratory Beijing Tian Tan Hospital Capital Medical University Beijing 100069 China

Background：Currently available silicone and metallic stents for tracheal stenosis are associated with many *** proliferation is one of the main *** present study aimed to evaluate the efficacy of paclitaxel drug-eluting tracheal stent in reducing granulation tissue formation in a canine model,as well as the pharmacokinetic features and safety profiles of the coated ***：Eight beagles were randomly divided into a control group （bare-metal stent group,n =4） and an experimental group （paclitaxel-eluting stent group,n =4）.The observation period was 5 *** beagle in both groups was sacrificed at the end of the 1st and 3rd months,*** last two beagles in both groups were sacrificed at the end of 5th *** proliferation of granulation tissue and changes in tracheal mucosa were compared between the two *** routine and liver and kidney function were monitored to evaluate the safety of the paclitaxel-eluting *** elution method and high-performance liquid chromatography were used to characterize the rate of in vivo release of paclitaxel from the ***：Compared with the control group,the proliferation of granulation tissue in the experimental group was significantly *** drug release of paclitaxel-eluting stent was the fastest in the 1st month after implantation （up to 70.9%）.Then,the release slowed down *** the 54 month,the release reached up to 98.5%.During the observation period,a high concentration of the drug in the trachea （in the stented and adjacent unstented areas） and lung tissue was not noted,and the blood test showed no side ***：The paclitaxel-eluting stent could safely reduce the granulation tissue formation after stent implantation in vivo,suggesting that the paclitaxel-eluting tracheal stent might be considered for potential use in humans in the future.

关键词： Canine Drug-eluting Stent Paclitaxel Tracheal Stenosis

Scarring Airway Stenosis in Chinese Adults： Characteristics and Interventional Bronchoscopy Treatment

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Chinese Medical Journal 2018年第3期131卷 276-281页

作者： Ting wang Jie Zhang Xiao-Jian Qiu Juan wang Ying-Hua Pei yu-ling wang Department of Respiratory Beijing Tian Tan Hospital Capital Medical University Beijing 100050 China

Background：Scarring airway stenosis is commonly seen in China as compared to other developed countries,due to the high prevalence of ***,interventional bronchoscopy treatment has been widely used to treat this disease in *** study demonstrated the characteristics of scarring airway stenosis in Chinese adults and retrospectively evaluated the efficacy of interventional bronchoscopy treatment of this ***：Patients with scarring airway stenosis from 18 tertiary hospitals were enrolled between January 2013 and June *** causes,site,and length of scarring airway stenosis were analyzed,and the efficacy of the interventional bronchoscopy treatment was ***：The final study cohort consisted of 392 *** tuberculosis （EBTB） was the most common cause of scarring airway stenosis （305/392,77.8%） in Chinese adults with a high rate of incidence in young *** left main bronchus was most susceptible to EBTB,and most posttuberculosis airway scarring stenosis length was 1.1-2.0 *** average clinical success rate of interventional bronchoscopy treatment for scarring airway stenosis in Chinese patients is 60.5%.The stent was inserted in 8.7% scarring airway stenosis in ***：Scarring airway stenosis exhibits specific characteristics in Chinese *** bronchoscopy is a useful and safe treatment method for the disease.

关键词： Adults Airway Stenosis Bronchoscopy Endotracheobronchial Tuberculosis Stents

Numerical simulations of Atlantic meridional overturning circulation(AMOC)from OMIP experiments and its sensitivity to surface forcing

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Journal of Oceanology and Limnology 2024年第2期42卷 454-467页

作者： Xiaowei wang Yongqiang yu State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China

Atlantic meridional overturning circulation(AMOC)plays an important role in transporting heat meridionally in the Earth’s climate system and is also a key metrical tool to verify oceanic general circulation *** OMIP(Ocean Model Intercomparison Project phase 1 and 2)simulations with LICOM3(version 3 of the LASG/IAP Climate System Ocean Model)developed at the State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG),Institute of Atmospheric Physics(IAP),are compared in this *** simulations well reproduce the fundamental characteristics of the AMOC,but the OMIP1 simulation shows a significantly stronger AMOC than the OMIP2 *** the LICOM3 configurations are identical between these two experiments,any differences between them must be attributed to the surface forcing *** analysis suggests that sea surface salinity(SSS)differences should be mainly responsible for the enhanced AMOC in the OMIP1 simulation,but sea surface temperature(SST)also play an unignorable role in modulating *** the North Atlantic,where deep convection occurs,the SSS in OMIP1 is more saline than that in *** find that in the major region of deep convection,the change of SSS has more significant effect on density than the change of *** a result,the SSS was more saline than that in OMIP2,leading to stronger deep convection and subsequently intensify the *** conduct a series of numerical experiments with LICOM3,and the results confirmed that the changes in SSS have more significant effect on the strength of AMOC than the changes in SST.

关键词： oceanic general circulation model(OGCM) Atlantic meridional overturning(AMOC) surface forcing deep convection

Mott insulator-density ordered superfluid transition and‘shamrock transition’in a frustrated triangle lattice

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Communications in Theoretical Physics 2024年第3期76卷 157-164页

作者： Ce wang yu Chen School of Physics Science and Engineering Tongji UniversityShanghai200092China Institute for Advanced Study Tsinghua UniversityBeijing100084China Graduate School of China Academy of Engineering Physics Beijing100193China

Density order is usually a consequence of the competition between long-range and short-range *** we report a density ordered superfluid emergent from a homogeneous Mott insulator due to the competition between frustrations and local *** transition is found in a Bose–Hubbard model on a frustrated triangle lattice with an extra pairing ***,we find a quantum phase transition between two different density ordered superfluids,which is beyond the Landau–Ginzburg(LG)paradigm.A U(1)symmetry is emergent at the critical point,while the symmetry in each density ordered superfluid is Z_(2)×Z_(3).We call the transition a‘shamrock transition’,due to its degenerate ground state in the parameter space being a shamrock-like curve rather than a circle in an LG-type *** low energy theories are established for the two transitions mentioned above and we find their resemblance and differences with clock models.

关键词： frustrated magnets superfluid mott insulator density wave ordered phase clock model