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A DFT study on Pt single atom loaded COF for efficient photocatalytic CO_(2)reduction

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Journal of Materials Science & Technology 2024年第3期170卷 87-94页

作者： Fei Xie Chuanbiao bie Jian Sun Zhenyi Zhang Bicheng Zhu Laboratory of Solar Fuel Faculty of Materials Science and ChemistryChina University of GeosciencesWuhan430078China Key Laboratory of New Energy and Rare Earth Resource Utilization of State Ethnic Affairs Commission Key Laboratory of Photosensitive Materials and Devices of Liaoning ProvinceSchool of Physics and Materials EngineeringDalian Minzu UniversityDalian116600China

Photocatalytic CO_(2)reduction provides a promising strategy for the alleviation of greenhouse effect and energy shortage *** single atom modification is an effective method to improve the CO_(2)reduction performance of covalent organic framework(COF)photocatalysts,while the intrinsic mechanism is not revealed in ***,a Pt-COF photocatalytic system was constructed by embedding Pt single atom in TFPT-TMT-COF(TFPT:1,3,5-tris(4-formylphenyl)-triazine,TMT:2,4,6-trimethyl-1,3,5-triazine).Based on density functional theory(DFT)calculation,the geometric structure and electronic property of Pt-COF were investigated,and the CO_(2)adsorption and reduction reaction process on Pt-COF were *** results show that the Pt atom can be steadily anchored in COF via the formation of Pt-N and Pt-C ***,there is strong electronic interaction between Pt and *** incorporation of Pt atom benefits the CO_(2)reduction activity of COF from multiple aspects:(ⅰ)reducing the band gap and improving light absorption;(ⅱ)enhancing CO_(2)adsorption and activating the CO_(2)molecule;(ⅲ)decreasing the energy barrier in the hydrogenation step of CO_(2)→COOH,thus facilitating CO_(2)conversion to CO;(ⅳ)inhibiting the hydrogenation of CO,thereby increasing the selectivity of *** work brings a novel insight into the excellent CO_(2)reduction performance of Pt modified COF,and provides useful references for the design of single atom photocatalysts.

关键词： Photocatalysis Carbon dioxide reduction Covalent organic framework Pt single atom Theoretical calculation

Identifying influential spreaders in complex networks based on density entropy and community structure

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Chinese Physics B 2024年第5期33卷 765-774页

作者：苏湛陈磊艾均郑雨语别娜 School of Optical-Electrical and Computer Engineering University of Shanghai for Science and Technology

In recent years,exploring the relationship between community structure and node centrality in complex networks has gained significant attention from researchers,given its fundamental theoretical significance and practical *** address the impact of network communities on target nodes and effectively identify highly influential nodes with strong propagation capabilities,this paper proposes a novel influential spreaders identification algorithm based on density entropy and community structure(DECS).The proposed method initially integrates a community detection algorithm to obtain the community partition results of the *** then comprehensively considers the internal and external density entropies and degree centrality of the target node to evaluate its *** validation is conducted on eight networks of varying sizes through susceptible–infected–recovered(SIR)propagation experiments and network static attack *** experimental results demonstrate that the proposed method outperforms five other node centrality methods under the same comparative conditions,particularly in terms of information spreading capability,thereby enhancing the accurate identification of critical nodes in networks.

关键词： corrigendum electron impact ionization cross sections carbon monoxide

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Design of antiviral AGO2-dependent short hairpin RNAs

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Virologica Sinica 2024年第4期39卷 645-654页

作者： yuanyuan bie Jieling Zhang Jiyao Chen yumin Zhang Muhan Huang Leike Zhang Xi Zhou Yang Qiu Key Laboratory of Virology and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China State Key Laboratory of Virology Wuhan Institute of VirologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China School of Life Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China

The increasing emergence and re-emergence of RNA virus outbreaks underlines the urgent need to develop effective *** interference(RNAi)is a sequence-specific gene silencing mechanism that is triggered by small interfering RNAs(siRNAs)or short hairpin RNAs(shRNAs),which exhibits significant promise for antiviral ***2-dependent shRNA(agshRNA)generates a single-stranded guide RNA and presents significant advantages over traditional siRNA and *** this study,we applied a logistic regression algorithm to a previously published chemically siRNA efficacy dataset and built a machine learning-based model with high predictive *** this model,we designed siRNA sequences targeting diverse RNA viruses,including human enterovirus A71(EV71),Zika virus(ZIKV),dengue virus 2(DENV2),mouse hepatitis virus(MHV)and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),and transformed them into *** validated the performance of our agshRNA design by evaluating antiviral efficacies of agshRNAs in cells infected with different *** the agshRNA targeting EV71 as an example,we showed that the anti-EV71 effect of agshRNA was more potent compared with the corresponding siRNA and ***,the antiviral effect of agshRNA is dependent on AGO2-processed guide RNA,which can load into the RNA-induced silencing complex(RISC).We also confirmed the antiviral effect of agshRNA in ***,this work develops a novel antiviral strategy that combines machine learning-based algorithm with agshRNA design to custom design antiviral agshRNAs with high efficiency.

关键词： AgshRNA Antiviral strategy Machine learning model

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揭示S型电荷转移机理

物理化学学报 2024年第4期40卷 1-3页

作者：余维来别传彪 Department of Chemical Engineering Stanford UniversityStanfordCA 94305USA 中国地质大学(武汉)材料与化学学院太阳燃料实验室武汉430078

The photoconversion efficiency of semiconductor photocatalysts is severely hindered by uncontrolled recombination of photogenerated charge carriers *** charge transfer dynamics and achieving manipulative carrier separ... 详细信息

关键词：电荷转移 charge separation

Distinct roles of H3K27me3 and H3K36me3 in vernalization response,maintenance,and resetting in winter wheat

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Science China(Life Sciences) 2024年第10期67卷 2251-2266页

作者： Xuemei Liu Min Deng Bingxin Shi Kehui Zhu Jinchao Chen Shujuan Xu Xiaomin bie Xiansheng Zhang Xuelei Lin Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute of Science and Technology Austria(ISTA) Klosterneuburg 3400Austria National Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai’an 271018China Centre of Excellence for Plant and Microbial Science(CEPAMS) JIC-CASBeijing 100101China

Winter plants rely on vernalization,a crucial process for adapting to cold conditions and ensuring successful ***,understanding the role of histone modifications in guiding the vernalization process in winter wheat remains *** this study,we investigated the transcriptome and chromatin dynamics in the shoot apex throughout the life cycle of winter wheat in the *** core histone modifications,H3K27me3 and H3K36me3,exhibited opposite patterns on the key vernalization gene VERNALIZATION1(VRN1),correlating with its induction during cold ***,the H3K36me3 level remained high at VRN1 after cold exposure,which may maintain its active *** in FERTILIZATION-INDEPENDENT ENDOSPERM(TaFIE)and SET DOMAIN GROUP 8/EARLY FLOWERING IN SHORT DAYS(TaSDG8/TaEFS),components of the writer complex for H3K27me3 and H3K36me3,respectively,affected flowering ***,VRN1 lost its high expression after the cold exposure memory in the absence of *** embryo development,VRN1 was silenced with the removal of active histone modifications in both winter and spring wheat,with selective restoration of H3K27me3 in winter *** mutant of Tafie-cr-87,a component of H3K27me3“writer”complex,did not influence the silence of VRN1during embryo development,but rather attenuated the cold exposure requirement of winter *** gene expression with H3K27me3 and H3K36me3 patterns identified potential regulators of *** study unveils distinct roles of H3K27me3 and H3K36me3 in controlling vernalization response,maintenance,and resetting in winter wheat.

关键词： vernalization H3K27me3 H3K36me3 winter wheat resetting maintenance

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IL-13/IL-13RA2 signaling promotes colorectal cancer stem cell tumorigenesis by inducing ubiquitinated degradation of p53

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Genes & Diseases 2024年第1期11卷 495-508页

作者： Baoyu He Jing Liang Qianqian Qin yuqin Zhang Shuo Shi Jinghe Cao Zhixin Zhang Qingli bie Rou Zhao Li Wei Baogui Zhang Bin Zhang Department of Laboratory Medicine Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Postdoctoral Mobile Station of Shandong University of Traditional Chinese Medicine JinanShandong 250355China Department of Reproductive Medicine Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Department of Gastrointestinal Surgery Affiliated Hospital of Jining Medical UniversityJining Medical UniversityJiningShandong 272000China Institute of Forensic Medicine and Laboratory Medicine Jining Medical UniversityJiningShandong 272067China

Cancer stem cells(CSCs)are considered tumor-initiating cells and the main drivers of disease *** these rare cancer cells,however,remains challenging with respect to therapeutic ***,we report the up-regulation of IL-13RA2 expression in colorectal cancer(CRC)tissues and spheroid *** expression of IL-13RA2 was positively correlated with canonical stemness markers in *** further demonstrated that the level of IL-13 was up-regulated in the serum of CRC ***,recombinant IL-13(rIL13)stimulation promoted the sphere formation,proliferation,and migration of CRC cells in vitro and enhanced tumorigenesis in *** phenotype could be reversed by knocking down ***,IL-13 activated autophagy by inducing LC3I/LC3II transformation in CRC-CSCs,which was crucial for the biological functions of *** further demonstrated that IL-13RA2 acted as a modular link of the E3 ligase UBE3C and the substrate p53 protein,enhancing the interaction of UBE3C and p53,thereby inducing the K48-linked ubiquitination of *** conclusion,the IL-13/IL-13RA2 signaling cascade promotes CRC-CSC self-renewal and tumorigenesis by inducing p53 ubiquitination,adding an important layer to the connection between IL-13 and p53,which can be translated into novel targeted therapies.

关键词： Autophagy Colorectal cancer stem cells IL-13/IL-13RA2 signaling p53

Exploring biofilm-forming molecular determinants in Listeria monocytogenes by comparative genome-wide and transcriptomic analyses

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Food Science and Human Wellness 2024年

作者： Xinyi Zhang Changzheng Shi Zhaoxin Lu Fanqiang Meng Moutong Chen Xiaomei bie College of Food Science and Technology， Nanjing Agricultural University Guangdong Provincial Key Laboratory of Microbial Safety and Health， State Key Laboratory of Applied Microbiology Southern China， Institute of Microbiology， Guangdong Academy of Sciences

In the food industry， bacterial cells usually adhere to equipment surfaces， forming biofilms that may cause persistent contamination. This study aimed to identify the key genes responsible for the stronger biofilm-forming capability of the LMB 33426 strain compared to that of the CICC 21662 strain through comparative genomics. Additionally， the expression of genes and related metabolic pathways of LMB 33426 and CICC 21662 strains were analyzed at the transcriptional level by high-throughput sequencing technology to uncover key differentially expressed genes between planktonic and biofilm cells of those two strains. Subsequently， the key genes found to present differences that were uncovered by those genome-wide and transcriptomic analyses were used to construct gene deletion strains. The crystalline violet assay and motility assay showed that GL002291， GL002712 and lmo1438 genes were involved in the regulation of biofilm formation as well as motility. The hydrophobicity and auto-aggregation ability assay results demonstrated an association between the clpB， lmo1438， and lmo0294 genes and bacterial adhesion. However， no significant differences were found regarding this association in the GL002291 and GL002712 genes. This study elucidates some potential regulatory genes associated with biofilm formation in L. monocytogenes， and laying a theoretical foundation for future research.

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虚拟教研室的功能与建设路径

中国高教研究 2024年第4期 7-14页

作者：别敦荣厦门大学高等教育发展研究中心厦门大学教育研究院福建厦门361005 中国高等教育学会学术发展咨询委员会北京100191

虚拟教研室是实体教研室的数字化变体,是利用信息技术和互联网建立起来的一种新型高等教育教学支持机制。它以学科专业教学研究、课程或课程群教学研究和重大教学改革主题研究为核心,组成全国性或区域性高校和相关机构专家学者教学研究... 详细信息

虚拟教研室是实体教研室的数字化变体,是利用信息技术和互联网建立起来的一种新型高等教育教学支持机制。它以学科专业教学研究、课程或课程群教学研究和重大教学改革主题研究为核心,组成全国性或区域性高校和相关机构专家学者教学研究网络,是新时代高等教育普及化发展所必需,可能引领高等教育高质量发展方向。虚拟教研室具有校际共生、关系松散、协同创新、学术导航等特性,应当充分利用组织优势,发挥协调、推介、平台、凝聚、导航等作用。其作用的发挥,须拥有学术高地、热心教学研究的学术带头人、学术骨干以及高质量研讨交流活动等条件。加强虚拟教研室建设,可采取举办教学学术论坛、组织跨校性教育教学项目研究、发挥网络连接辐射作用、建立跨校性虚拟运行机制,以及争取热心参与高校支持等举措。

关键词：虚拟教研室实体教研室高校高等教育高质量发展

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人工智能文艺生产方式新变与人机关系省思

中国文学批评 2024年第2期 178-185,192页

作者：别君华杭州师范大学文化创意与传媒学院杭州311121

生成式AI向人工智能写作领域拓展,为反思媒介技术革新与文艺生产的关系带来契机。生成式AI借助模型迭代持续进化,带来文艺生产方式的新变化,传统文艺生产方式向“人机生产”发展。在人与AI生产者、自动化生产工具等因素的交互作用下,新... 详细信息

生成式AI向人工智能写作领域拓展,为反思媒介技术革新与文艺生产的关系带来契机。生成式AI借助模型迭代持续进化,带来文艺生产方式的新变化,传统文艺生产方式向“人机生产”发展。在人与AI生产者、自动化生产工具等因素的交互作用下,新的文艺生产方式得到快速发展,并向人机间性生产模式转型。文艺生产方式的更新产生了新型的人机关系,人机之间具有复杂的矛盾。为此,应探索一种人与AI和谐共存,在“共鸣”中充分发挥各自创造力的合作方式,充分释放人机生产活力,实现文艺健康发展。

关键词：生成式AI人工智能写作人机生产人机关系