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SOME NEW PROPERTIES ON L^p(Ω,H^n)

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Applied Mathematics(A Journal of Chinese Universities) 2007年第2期22卷 174-180页

作者： jia gao College of Science University of Shanghai for Science and Technology Shanghai 200093 China

Let L^p（Ω, H^n） indicate the L^P-space of the maps for Heisenberg group target. In this paper some new properties are obtained for the space L^p（Ω, H^n）

关键词： Heisenberg group L^P-space quasi-center of mass

Commentary:Indirect action pattern:A remote and cross-organ pharmacological mechanism for drug innovation

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3448-3450页

作者： yuan gao jia-bo Wang School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China

The development of molecular medicine has greatly promoted the research and development (R&D) of innovative drugs. However,drug design and development for those novel targets remains a big challenge with low success rates and high attrition of drug candidates1. The current methodology of new drug R&D is deeply influenced by the idea of allopathic medicine, which directly inhibits biological targets.

关键词： Cross-organ Indirect action pattern Phosphatidic acid Liver toxicity IL-6 Epididymal white adipose tissue

High-temperature deformation behavior and processing map of the as-cast Inconel 625 alloy

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Rare Metals 2021年第8期40卷 2083-2091页

作者： Zhi jia Ze-Xi gao Jin-Jin Ji De-Xue Liu Ting-Biao Guo yu-Tian Ding School of Material Science and Engineering Lanzhou University of TechnologyLanzhou730050China Key State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of TechnologyLanzhou730050China School of Materials Engineering Lanzhou Institute of TechnologyLanzhou730050China

A short process of Inconel 625 alloy tube was developed to solve the problems of the traditional extrusion process,and particular attention was paid on the hot deformation behavior of the as-cast Inconel 625 *** hot compression experiments were performed to study the hot deformation behavior of Inconel 625 in the temperature range of 900-1200℃ and strain rate range of0.01-10.00 s^(-1) by *** hot compressed microstructure was examined to study the effects of temperature and strain rate on the microstructural characteristic by electron backscatter diffraction(EBSD).The results show that the processing maps were greatly influenced by the temperature rather than the strain *** is found that with the strain increasing,the instability zone gradually turned to the low-temperature and low strain rate area,while the range of high-temperature instability area *** optimum condition of the as-cast Inconel 625 alloy was determined as high strain rate region(temperature of1100-1200℃,strain rate of 1.00-10.00 s^(-1))with the dissipation efficiency of above *** illustrated by microstructural characteristic of EBSD analysis,the perfect dynamic recrystallization occurred and fine grain structure was obtained under this deformation conditions.

关键词： Inconel 625 Hot deformation behavior Constitutive equation Microstructure Processing map

Some embedding theorems for W～(1,p)(Ω, H～n)

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Applied Mathematics(A Journal of Chinese Universities) 2010年第1期25卷 85-92页

作者： jia gao ZHANG Guo-qing College of Science University of Shanghai for Science and Technology Shanghai 200090 China

For the maps on the Heisenberg group target, we prove a Poincare type inequality. Applying this Poincare type inequality, we obtain the corresponding versions of Sobolev and Rellich embedding theorems.

关键词： Heisenberg group HSlder continuity embedding theorem.

Glymphatic System and Subsidiary Pathways Drive Nanoparticles Away from the Brain

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Research 2022年第3期2022卷 13-30页

作者： Rui Liu Wenfeng jia yushan Wang Chuan Hu Wenqi yu yuan Huang Ling Wang Huile gao Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Although drug delivery systems(DDS)are efficient in brain delivery,they face failure in clinical settings due to their potential toxicity to the central nervous *** is known about where the DDS will go after brain delivery,and no specific elimination route that shares a passage with DDS has been ***,identifying harmless DDS for brain delivery and determining their fate there would strongly contribute to their clinical *** this study,we investigated nonreactive gold nanoclusters,which can deliver into the brain,to determine the elimination route of ***,nanoclusters in the brain were systemically tracked and were found to be critically drained by the glymphatic system from the blood vessel basement membrane to periphery circulations(77.8±23.2%and 43.7±23.4%contribution).Furthermore,the nanoclusters could be actively transported across the blood-brain barrier(BBB)by exosomes(30.5±27.3%and 29.2±7.1%contribution).In addition,microglia promoted glymphatic drainage and passage across the *** simultaneous work of the glymphatic system,BBB,and microglia revealed the fate of gold nanoclusters for brain delivery and provided a basis for further braindelivery DDS.

关键词： drain passage elimination

Grain refinement impact on the mechanical properties and wear behavior of Mg-9Gd-3Y-2Zn-0.5Zr alloy after decreasing temperature reciprocating upsetting-extrusion

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Journal of Magnesium and Alloys 2022年第12期10卷 3506-3519页

作者： Wenlong Xu jianmin yu Leichen jia Chang gao Zhan Miao Guoqin Wu Guojun Li Zhimin Zhang School of Material Science and Engineering North University of ChinaTaiyuan 030051China

Based on the deforming technique of severe plastic deformation(SPD), the grain refinement of a Mg-9Gd-3Y-2Zn-0.5Zr alloy treated with decreasing temperature reciprocating upsetting-extrusion(RUE) and its influence on the mechanical properties and wear behavior of the alloy were studied. The RUE process was carried out for 4 passes in total, starting at 0 ℃ and decreasing by 10 ℃ for each pass. The results showed that as the number of RUE passes increased, the grain refinement effect was obvious, and the second phase in the alloy was evenly distributed. Room temperature tensile properties of the alloy and the deepening of the RUE degree showed a positive correlation trend, which was due to the grain refinement, uniform distribution of the second phase and texture weakening. And the microhardness of the alloy showed that the microhardness of RUE is the largest in 2 passes. The change in microhardness was the result of dynamic competition between the softening effect of DRX and the work hardening effect. In addition, the wear resistance of the alloy showed a positive correlation with the degree of RUE under low load conditions. When the applied load was higher, the wear resistance of the alloy treated with RUE decreased compared to the initial state alloy. This phenomenon was mainly due to the presence of oxidative wear on the surface of the alloy, which could balance the positive contribution of severe plastic deformation to wear resistance to a certain extent.

关键词： Mg-9Gd-3Y-2Zn-0.5Zr alloy Reciprocating upsetting-extrusion Grain refinement Texture Mechanical properties Wear behavior

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan yu-Ming Wang Han-Zhou Li Wei-Quan Xu jia-Bao Liao Wei-Bo Wen Jing Miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

A 3-DOF Pseudo-Rigid-Body Model for Tension-Based Compliant Bistable Mechanisms

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Chinese Journal of Mechanical Engineering 2010年第2期23卷 149-153页

作者： CHEN Guimin gao Hongwei jia jianyuan School of Mechatronics Xidian University Xi ＇an 710071 China

Compliant bistable mechanisms, devices with two distinct stable equilibrium positions, are used in a variety of applications, such as switches, clasps, and valves. Many kinds of compliant bistable mechanisms were proposed and studied during the past decade. Among them, tension-based compliant bistable mechanisms, that incorporate tension pivots as their flexible members, feature in short travel distance and low power consuming. So far, the design of this kind of bistable mechanisms is done using finite element method through trial and error, thus is time-consuming. By treating the tension pivots as fixed-guided segments and their elongation as a spring, we developed a novel three degree-of-freedom （3-DOF） pseudo-rigid-body model （PRBM） for this kind of bistable mechanisms. The principle of virtual work is used to derive the force-deflection relationship of the PRBM model. The comparison between the PRBM results and the experimental results of the force-deflection characteristics shows that the PRBM can predict not only the bistable behavior of the tension-based bistable mechanisms, but also their soft spring-like post-bistable behavior and the spring-like force-deflection characteristics when pulling in the reverse direction from the as-fabricated position, which is called reverse behavior. The 3-DOF PRBM can be used to design and identify tension-based bistable mechanisms. Using the PRBM instead of the trial-and-error method can greatly reduce the development time of this kind of bistable mechanisms.

关键词： compliant bistable mechanism pseudo-rigid-body model tension pivot

Vacuum joints of dispersion-strengthened copper and its applications in synchrotron radiation front end

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Nuclear Science and Techniques 2016年第6期27卷 74-78页

作者： Yong-Jun Li Song Xue Min Zhang Dan-Dan jia Dong-Bai Dou yu gao Shanghai Institute of Applied Physics Chinese Academy ofSciencesZhangJiangShanghai 201204China University of Chinese Academy of Sciences Beijing 100049China SKY Technology Development Co. LtdChinese Academyof SciencesShenyang 110179China

Masks are critical elements of synchrotron radiation front end that are exposed to high temperature and *** absorber material is typically comprised of dispersion-strengthened copper,which can retain high performance at elevated *** processes under vacuum,including brazing and electron beam welding,are novel approaches for prolonging the absorber and for reducing power *** mechanical properties of brazed joints and electron beam welded joints of dispersion-strengthened copper workpieces are evaluated by tensile testing at 20,100,and 200 *** testing results indicate that the tensile strength and elongation of both vacuum joints decrease with increasing *** to brazed joints,electron beam welded joints have higher tensile strength,better ductility,and more stable performance.A novel welded mask with a total length of 600 mm is presented and shown to be practical for use in the highest heat load front end in the Shanghai synchrotron radiation facility phase-Ⅱ beamline project.

关键词：上海同步辐射装置弥散强化铜焊接接头前端真空电子束焊接应用钎焊接头