Commentary:Indirect action pattern:A remote and cross-organ pharmacological mechanism for drug innovation

作     者：Yuan Gao Jia-bo Wang Yuan Gao;Jia-bo Wang

作者机构：School of Traditional Chinese MedicineCapital Medical UniversityBeijing 100069China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2022年第12卷第8期

页      面：3448-3450页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Cross-organ Indirect action pattern Phosphatidic acid Liver toxicity IL-6 Epididymal white adipose tissue 

摘      要：The development of molecular medicine has greatly promoted the research and development (R&D) of innovative drugs. However,drug design and development for those novel targets remains a big challenge with low success rates and high attrition of drug candidates1. The current methodology of new drug R&D is deeply influenced by the idea of allopathic medicine, which directly inhibits biological targets.