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Hydrophobic modification of polysaccharides and the construction and properties of their micelles:a review of applications in the field of biomedicine

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Science China Chemistry 2024年第6期67卷 1881-1903页

作者： Dayang Wang Xiaohua Li Huanchen Yao Xin Liu Yan Gao Hailin Cong bing yu Youqing shen College of Chemistry and Chemical Engineering College of Life SciencesCollege of Materials Science and EngineeringInstitute of Biomedical Materials and EngineeringQingdao UniversityQingdao266071China State Key Laboratory of Bio-Fibers and Eco-Textiles Qingdao UniversityQingdao266071China School of Materials Science and Engineering Shandong University of TechnologyZibo255000China Key Laboratory of Biomass Chemical Engineering of Ministry of Education Center for Bionanoengineeringand Department of Chemical and Biological EngineeringZhejiang UniversityHangzhou310027China

Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific *** have the characteristics of wide sources,excellent biocompatibility,and *** addition,there are multifunctional groups on the main chain of polysaccharides,which can be surface-modified or functionalized to have targeting ability through specific sugar *** polysaccharide micelles with good biocompatibility,degradability,high safety,easy structural modification,and special core-shell structure are regarded as ideal carriers for ***,this review is focused on the hydrophobic modification designs of polysaccharides,the preparation methods and characteristics of micelles,and the applications of amphiphilic polysaccharide micelles in the field of *** is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.

关键词： polysaccharide hydrophobic modification micelle drug delivery biomedicine

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Strain-promoted S-arylation and alkenylation of sulfinamides using arynes and cyclic alkynes

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Science China Chemistry 2024年第3期67卷 928-935页

作者： Xi Zou Boming shen Gao-lin Li Qian Liang Yanhua Ouyang binghe Yang Peiyuan yu bing Gao State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringInstitute of Chemical Biology and NanomedicineHunan UniversityChangsha 410082China Department of Chemistry and shenzhen Grubbs Institute Guangdong Provincial Key Laboratory of CatalysisSouthern University of Science and TechnologyShenzhen 518055China

The conversion of commercially available chiral sulfinamides into pharmaceutically useful chiral sulfoximines via direct SIVfunctionalization is synthetically attractive but challenging due to the competitive reaction of N-functionalization. Herein, we disclose a novel strain-release strategy to access stereospecific and chemoselective SIV-arylation and alkenylation of sulfinamides using arynes and strained cyclic alkynes. This method tolerates an unprecedented chemical diversity of functional groups attached to the nitrogen center(N-R). The origin of the high SIV-selectivity is elucidated by density functional theory calculations, suggesting a stepwise mechanism for the aryne substrates and a concerted mechanism for the cyclic alkynes.

关键词： arylation alkenylation sulfoximines sulfinamides arynes

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Analysis of metabolic characteristics of metabolic syndrome in elderly patients with gastric cancer by non-targeted metabolomics

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2419-2428页

作者： Huan Zhang Wen-bing shen Lin Chen Medical School of Chinese PLA Chinese PLA General HospitalBeijing 100853China Department of Gastrointestinal Surgery Shanghai Sixth People’s HospitalShanghai 250063China Department of General Surgery The First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND The relationship between metabolic syndrome(MetS)and gastric cancer(GC),which is a common metabolic disease,has attracted much ***,the specific metabolic characteristics of MetS in elderly patients with GC remain *** To investigate the differentially abundant metabolites and metabolic pathways between preoperative frailty and MetS in elderly patients with GC based on nontargeted metabolomics *** In this study,125 patients with nonfrail nonmeal GC were selected as the control group,and 50 patients with GC in the frail group were selected as the frail ***-five patients with GC combined with MetS alone were included in the MetS group,and 50 patients with GC combined with MetS were included in the MetS *** metabolomics techniques were used to measure plasma metabolite levels by ultrahigh-performance liquid chromatography-mass *** statistical analysis was performed by principal component analysis,orthogonal partial least squares,pattern recognition analysis,cluster analysis,and metabolic pathway *** A total of 125 different metabolites,including amino acids,glycerophospholipids,sphingolipids,fatty acids,sugars,nucleosides and nucleotides,and acidic compounds,were identified via nontargeted metabolomics *** with those in the control group,there were 41,32,and 52 different metabolites in the MetS group,the debilitated group,and the combined group,*** metabolites were significantly increased in the MetS *** the weak group,amino acids and most glycerol phospholipid metabolites decreased significantly,and fatty acids and sphingosine increased *** combined group was characterized by significantly increased levels of nucleotide metabolites and acidic *** alanine,aspartic acid,and glutamate metabolic pathways were obviously enriched in the asthenic group,and the glycerol and phospholipid metabolic pathways were obv

关键词： Nervous breakdown Metabolic syndrome Elderly individuals Gastric cancer Nontargeted metabolomics

Doppler-resilient waveform design in integrated MIMO radar-communication systems

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Science China(Information Sciences) 2024年第1期67卷 187-202页

作者： Zhengchun ZHOU bing LIU bingsheng shen Avik Ranjan ADHIKARY Pingzhi FAN Institute of Mobile Communications Southwest Jiaotong University Department of Mathematics Southwest Jiaotong University

In recent years,the increased high-rate wireless services(5G and 6G) and reliable sensing capabilities(automotive radar,air traffic control,geophysical monitoring),have led to more serious spectrum ***,radars and communication systems are often seen to be “competing” for the same *** this scenario,an integrated platform for radar and communication systems seems to be an optimal solution to address the *** this paper,we propose a preamble waveform design based on zero-correlation zone(ZCZ) and zero odd-correlation zone(ZOCZ) sequence sets,which are Doppler resilient in multiple-input,multiple-output(MIMO) *** preamble waveforms can be simultaneously used for channel estimation and radar sensing in RadCom *** ambiguity function of the proposed waveforms displays low/zero sidelobes within a time-delay correlation ***,we give some numerical results to show the efficiency of the proposed waveforms in radar sensing and channel estimation.

关键词： ambiguity function correlation channel estimation integrated radar and communication (RadCom) systems MIMO radar zero correlation zone (ZCZ) sequence set zero odd-correlation zone (ZOCZ) sequence set

Two-Way Neural Network Performance PredictionModel Based onKnowledge Evolution and Individual Similarity

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1183-1206页

作者： Xinzheng Wang bing Guo Yan shen College of Computer Science Sichuan UniversityChengdu610065China School of Information Science and Engineering Guilin University of TechnologyGuilin541004China School of Control Engineering Chengdu University of Information TechnologyChengdu610225China

Predicting students’academic achievements is an essential issue in education,which can benefit many stakeholders,for instance,students,teachers,managers,*** with online courses such asMOOCs,students’academicrelateddata in the face-to-face physical teaching environment is usually sparsity,and the sample size is *** makes building models to predict students’performance accurately in such an environment even *** paper proposes a Two-WayNeuralNetwork(TWNN)model based on the bidirectional recurrentneural network and graph neural network to predict students’next semester’s course performance using only theirprevious course *** experiments on a real dataset show that our model performs better thanthe baselines in many indicators.

关键词： Computer education performance prediction deep learning

Investigation of Ce/BEA as a passive NO_(x)adsorber:*** occurrences of cerium and adsorption behavior

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Journal of Rare Earths 2024年第7期42卷 1265-1271,I0003页

作者： Minghui yu Yiying Ding Xiaojie yu Siwei Yan Meiqing shen Jianqiang Wang Jun Wang Gurong shen School of Materials Science and Engineering Tianjin UniversityTianjin300350China School of Chemical Engineering and Technology Tianjin UniversityTianjin300350China National Rare Earth Catalysis Research Institute Dongying257000China

Ce/BEA has great potential as a passive NO_(x)absorber(PNA)to reduce the NO_(x)emissions during the cold start phase especially in diesel engine for its high resistance to CO and suitable NO_(x)desorption temperature ***,as a novel material,its physical and chemical properties still remain *** this work,Ce/BEA was synthesized by ion-exchange method to identify the active species in NO_(x)adsorption,compared with aggregated Ce species in Ce/SiAlO_(x) prepared by impregnation method.X-ray diffraction(XRD),high resolution-transmission electron microscopy(HR-TEM)and aberration-corrected-scanning transmission electron microscopy(AC-STEM)were performed to confirm the isolated single atom formation of Ce species in Ce/***-vis diffraction reflection spectra(DRS)and X-ray photoelectron spectroscopy(XPS)were conducted to find the difference of chemical environment between the isolated Ce species and aggregated *** performance evaluation and temperature programmed reduction of hydrogen(H_(2)-TPR)results show the high NO_(x)storage capacity and active oxygen species quantity in Ce/*** is also found that the main NO_(x)adsorption species are Ce^(4+)-O^(∗)rather than Ce^(3+).NO_(x)-diffuse reflectance infrared Fourier transform spectroscopy(NO_(x)-DRIFTS)confirms that the bidentate nitrite species are the critical NO_(x)adsorption intermediates and the conception of NO_(x)adsorption and desorption processes is proposed.

关键词： Passive NO_(x)absorber Ce/BEA Isolated Ce species Rare earths

Parallel Light Fields: A Perspective and A Framework

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IEEE/CAA Journal of Automatica Sinica 2024年第2期11卷 542-544页

作者： Fei-yue Wang yu shen IEEE State Key Laboratory for Management and Control of Complex Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China School of Artificial Intelligence University of Chinese Academy of ScienceBeijing 100049

Dear Editor,Light fields give relatively complete description of scenes from perspective of angles and positions of rays. At present time, most of the computer vision algorithms take 2D images as input which are simplified expression of light fields with depth information discarded. In theory, computer vision tasks may achieve better performance as long as complete light fields are acquired.

关键词： computer Framework simplified

Observation of ballistic-diffusive thermal transport in GaN transistors using thermoreflectance thermal imaging

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Rare Metals 2024年第1期43卷 389-394页

作者： Zhi-Ke Liu Yang shen Han-Ling Li bing-Yang Cao Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering MechanicsTsinghua UniversityBeijing 100084China

To develop effective thermal management strategies for gallium-nitride (GaN) transistors, it is essential to accurately predict the device junction temperature. Since the width of the heat generation in the devices is comparable to phonon mean free paths (MFPs) of GaN, phonon ballistic transport exists and can significantly affect the heat transport process.

关键词： temperature. transistors GaN

Coupled simulation of fluid-particle interaction for large complex granules:A resolved CFD-DEM method for modelling the airflow in a vertical fixed bed of irregular sinter particles

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Particuology 2024年第7期90卷 292-306页

作者： Chengzhi Li yu Zhang Jiahe shen Wei Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China School of Transportation and Logistics Engineering Wuhan University of TechnologyWuhan 430063China Centre for Bulk Solids and Particulate Technologies The University of NewcastleCallaghan NSW 2308Australia

A resolved CFD-DEM method is proposed to simulate the fluid-particle interaction for large complex *** airflow in a vertical sinter fixed bed is numerically studied using this *** multi-sphere clumped method is used to create irregular sinter particles in *** immersed boundary method and dynamic cell refinement are applied to describe the fluid flow around particles with higher resolution,by which the fluid-particle interaction can be simulated more *** simulation results presented the packing voidage distributions and the airflow fields in the sinter beds of different single and mixed particle size *** bed pressure drops were simulated and the results were compared with the corresponding experimental *** good agreement indicated that the proposed resolved CFD-DEM method is an effective tool to model the fluid-particle interaction for irregular large granules in the gas-solid multi-phase systems.

关键词： Resolved CFD-DEM method Irregular sinter particles Multi-sphere clumped method Immersed boundary method Dynamic cell refinement