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Theoretical Exploration of Alloying Effects on Stabilities and Mechanical Properties ofγʹPhase in Novel Co–Al–Nb-Base Superalloys

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Acta Metallurgica Sinica(English Letters) 2024年第7期37卷 1238-1248页

作者： Guan-Cheng Gu Zhao-Jing Han Ze-yu Chen Zhao-Xuan Li Sheng-Bao Xia Zheng-Ning Li Hua Jin Wei-Wei Xu Xing-Jun Liu Shenzhen Research Institute of Xiamen University School of Aerospace EngineeringXiamen UniversityXiamen361005China Institute of Materials Genome and Big Data Harbin Institute of TechnologyShenzhen518055China

The new developedγ/γʹCo–Al–Nb-base alloys show great potentials as high-temperature ***,finding appropriate compositions to improve performance of alloys still poses a great challenge to the development of Co–Al–Nb-base *** by the lack of alloying effects on fundamental properties of criticalγʹphase,we systematically performed a theoretical investigation on the effect of alloying elements TM(TM:Ti,v,Cr,Zr,Mo,Ta,W,Re,and Ru)on phase stabilities and mechanical properties of L1_(2)-typeγʹ(Co,Ni)_(3)(Al,Nb).By analyzing the stability ofγʹphase with respect to its competitive B2 and D0_(19) phases,the results shown that Ti,v,and Cr enhance the L1_(2) stability and widen the L1_(2)–D0_(19) energy barrier,in which v yields the maximum *** analysis of electronic structure indicated that the alternation of valence electrons at fermi level would be the atomic origin for doping TM inγʹ*** calculated results of mechanical properties shown that v and Cr are expected to be optimal dopant for enhancing the strength and the ductility ofγʹ*** addition of Ta is also beneficial for enhancing the strength at the slight expense of ductility ofγʹ*** drawing the mechanical maps,the preferred composition range for the phases with desired properties is roughly demarcated in theory for the multi-addition of v/Cr and v/Ta inγʹ*** findings would be useful for optimizing the performance of novelγ/γʹCo–Al–Nb-base superalloys.

关键词： Co-Al-Nb-base superalloys γ/γʹdual-phase Phase stability Mechanical properties First-principle methods

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Non-islet cell tumor hypoglycemia as an initial presentation of hepatocellular carcinoma coupled with end-stage liver cirrhosis: A case report and review of literature

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World Journal of Hepatology 2020年第8期12卷 519-524页

作者： Bo yu Rana Douli Jose Amaya Suarez victor Perez Gutierrez Mohammad Aldiabat Maria Khan Department of Medicine Lincoln Medical CenterBronxNY 10451-5504United States

BACKGROUND Non-islet cell tumor hypoglycemia(NICTH)is a rare cause of persistent hypoglycemia seen in patients with hepatocellular carcinoma(HCC).It is likely to be underdiagnosed especially in the patients with poor hepatic function and ***,we report a rare case of NICTH as the initial presentation of HCC in a patient with chronic hypoglycemia due to end-stage liver *** SUMMARY A 62-year-old male with chronic fasting hypoglycemia secondary to end-stage hepatitis C-related cirrhosis,presented with altered mental status and *** was found to have severe hypoglycemia refractory to glucose *** studies and biopsy discovered well differentiated HCC without *** evaluation showed low insulin,C-peptide and betahydroxybutyrate along with a high insulin-like growth factor-2/insulin-like growth factor ratio,consistent with the diagnosis of *** patient was not a candidate for surgical resection or chemotherapy,he was started on prednisolone with some improvements in the glucose homeostasis,but soon decompensated after a superimposed hospital acquired *** NICTH can occur as the sole initial presentation of HCC and is often difficult to correct without tumor *** should maintain high clinical suspicion for early recognition of paraneoplastic NICTH in patients at risk for HCC,even those with chronic fasting hypoglycemia in the setting of severe hepatic failure and malnutrition.

关键词： Non-islet cell tumor hypoglycemia Hepatocellular carcinoma Liver cirrhosis Insulin-like growth factor-2 Paraneoplastic syndrome Case report

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SERINE METABOLISM AND ANTIvIRAL INNATE IMMUNITY

SERINE METABOLISM AND ANTIVIRAL INNATE IMMUNITY

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第四届中国生物物理学会代谢生物学分会学术研讨会

作者： Qiujing yu

Serine metabolism promotes tumor oncogenesis and regulates immune cell functions, but whether it also contributes to antiviral innate immunity is unknown. Here,we demonstrate that virus-infected macrophages display decreased expression of serine synthesis pathway（SSP） enzymes. Suppressing the SSP key enzyme phosphoglycerate dehydrogenase（PHGDH） by genetic approaches or by treatment with the pharmaceutical inhibitor CBR-5884 and by exogenous serine restriction enhanced IFN-β-mediated antiviral innate immunity in vitro and in vivo. Mechanistic experiments showed that virus infection or serine metabolism deficiency increased the expression of the v-A TPase subunit A TP6v0d2 by inhibiting S-adenosyl methionine-dependent H3K27 me3 occupancy at the promoter. A TP6v0d2 promoted Y AP lysosomal degradation to relieve Y AP-mediated blockade of the TBK1-IRF3 axis and, thus, enhance IFN-β production. These findings implicate critical functions of PHGDH and the key immunometabolite serine in blunting antiviral innate immunity and also suggest manipulation of serine metabolism as a therapeutic strategy against virus infection.

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Control of defensive behavior by the nucleus of Darkschewitsch GABAergic neurons

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National Science Review 2024年第4期11卷 70-83页

作者： Huiying Zhao Jinrong Liu yujin Shao Xiang Feng Binhan Zhao Li Sun Yijun Liu Linghui Zeng Xiao-ming Li Hongbin Yang Shumin Duan Yan-qin yu Department of Neurology of Second Affiliated Hospital and School of Brain Science and Brain Medicine Zhejiang University School of Medicine Nanhu Brain-Computer Interface Institute Liangzhu Laboratory MOE Frontier Science Center for Brain Science and Brain-Machine Integration State Key Laboratory of Brain-Machine Intelligence Zhejiang University NHC and CAMS Key Laboratory of Medical Neurobiology Zhejiang University Key Laboratory of Novel Targets and Drug Study for Neural Repair of Zhejiang Province School of Medicine Hangzhou City University

The nucleus of Darkschewitsch(ND), mainly composed of GABAergic neurons, is widely recognized as a component of the eye-movement controlling system. However, the functional contribution of ND GABAergic neurons(NDGABA) in animal behavior is largely unknown. Here, we show that NDGABA neurons were selectively activated by different types of fear stimuli, such as predator odor and foot *** and chemogenetic manipulations revealed that NDGABA neurons mediate freezing ***, using circuit-based optogenetic and neuroanatomical tracing methods, we identified an excitatory pathway from the lateral periaqueductal gray(l PAG) to the ND that induces freezing by exciting ND inhibitory outputs to the motor-related gigantocellular reticular nucleus, ventral part(Gi v). Together,these findings indicate the NDGABA population as a novel hub for controlling defensive response by relaying fearful information from the l PAG to Gi v, a mechanism critical for understanding how the freezing behavior is encoded in the mammalian brain.

关键词： nucleus of Darkschewitsch GABAergic population defensive behavior freezing neural circuitry

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Epigenetic regulation in cardiac fibrosis

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World Journal of Cardiology 2015年第11期7卷 784-791页

作者： Li-Ming yu Yong Xu Laboratory of Cardiovascular Disease and Molecular Intervention Department of PathophysiologyNanjing Medical University

Cardiac fibrosis represents an adoptive response in the heart exposed to various stress cues. While resolution of the fibrogenic response heralds normalization of heart function, persistent fibrogenesis is usually associated with progressive loss of heart function and eventually heart failure. Cardiac fibrosis is regulated by a myriad of factors that converge on the transcription of genes encoding extracellular matrix proteins, a process the epigenetic machinery plays a pivotal role. In this minireview, we summarize recent advances regarding the epigenetic regulation of cardiac fibrosis focusing on the role of histone and DNA modifications and non-coding RNAs.

关键词： Cardiac fibrosis Epigenetics Endothelial cell Fibr

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钢基体中碳与铁对化学气相沉积TiN动力学的影响

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钢铁研究学报 1999年第5期11卷 47-51页

作者：王豫华东冶金学院冶金工程系马鞍山243002

研究了在碳含量不同的钢基体上化学气相沉积ＴｉＮ的沉积速率。研究结果表明，随着钢中碳含量的提高，沉积速率呈线性增长，涂层硬度也随碳含量的增加而提高。基于铁的触媒作用，推导出ＴｉＮ的沉积速率方程为Ｖ＝ｈ１＋Ｋ１×ｘ（Ｃ... 详细信息

研究了在碳含量不同的钢基体上化学气相沉积ＴｉＮ的沉积速率。研究结果表明，随着钢中碳含量的提高，沉积速率呈线性增长，涂层硬度也随碳含量的增加而提高。基于铁的触媒作用，推导出ＴｉＮ的沉积速率方程为Ｖ＝ｈ１＋Ｋ１×ｘ（Ｃ）；对于碳含量较高的Ｃｒ１２ＭｏＶ钢和碳含量较低的２０钢基体，测得ＴｉＮ沉积表面过程表观活化能分别为１６５．１１ｋＪ／ｍｏｌ和１２０．３８ｋＪ／ｍｏｌ。钢中合金元素对ＴｉＮ沉积速率的影响可忽略。

关键词：氮化钛化学气相沉积涂层炭铁钢基体

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Reversible Mn^(2+)/Mn^(4+)double-electron redox in P3-type layer-structured sodium-ion cathode

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Journal of Energy Chemistry 2024年第2期89卷 79-88,I0004页

作者： Jie Zeng Jian Bao Ya Zhang Xun-Lu Li Cui Ma Rui-Jie Luo Chong-yu Du Xuan Xu Zhe Mei Zhe Qian Yong-Ning Zhou Department of Materials Science Fudan UniversityShanghai 200433China Shanghai Xuanyi New Energy Development Co. LtdShanghai 201800China Global Institute of Future Technology Shanghai Jiao Tong UniversityShanghai 200240China

The balance between cationic redox and oxygen redox in layer-structured cathode materials is an important issue for sodium batteries to obtain high energy density and considerable cycle *** redox can contribute extra capacity to increase energy density,but results in lattice instability and capacity fading caused by lattice oxygen gliding and oxygen *** this work,reversible Mn^(2+)/Mn^(4+)redox is realized in a P3-Na_(0.65)Li_(0.2)Co_(0.05)Mn_(0.75)O_(2)cathode material with high specific capacity and structure stability via Co *** contribution of oxygen redox is suppressed significantly by reversible Mn^(2+)/Mn^(4+)redox without sacrificing capacity,thus reducing lattice oxygen release and improving the structure *** X-ray techniques reveal that P3 phase is well maintained in a wide voltage window of 1.5-4.5 v ***^(+)/Na even at 10 C and after long-term *** is disclosed that charge compensation from Co/Mn-ions contributes to the voltage region below 4.2 v and O-ions contribute to the whole voltage *** synergistic contributions of Mn^(2+)/Mn^(4+),Co^(2+)/Co^(3+),and O^(2-)/(O_n)^(2-)redox in P3-Na_(0.65)Li_(0.2)Co_(0.05)Mn_(0.75)O_(2)lead to a high reversible capacity of 215.0 m A h g^(-1)at 0.1 C with considerable cycle *** strategy opens up new opportunities for the design of high capacity cathode materials for rechargeable batteries.

关键词： Sodium batteries Cathode materials Layered structure Co substitution

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Charmonium Production in Ultrarelativistic Heavy Ion Collisions

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IMP & HIRFL Annual Report 2017年第1期 43-44页

作者： yu Gongming Wang Jiansong 不详

The NRQCD approach[1],which was introduced in 1995,has become the standard framework to study heavy quarkonium *** NRQCD,the Fock state structure of heavy quarkonium state is[2]where v is the relative velocity of the ... 详细信息

关键词： quark Collisions QCD

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Pancreatic necrosis and severity are independent risk factors for pancreatic endocrine insufficiency after acute pancreatitis: A long-term follow-up study

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World Journal of Gastroenterology 2020年第23期26卷 3260-3270页

作者： Bing-Jun yu Nian-Shuang Li Wen-Hua He Cong He Jian-Hua Wan Yin Zhu Nong-Hua Lu Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Pancreatic endocrine insufficiency after acute pancreatitis(AP) has drawn increasing attention in recent *** To assess the impact of risk factors on the development of pancreatic endocrine insufficiency after *** This retrospective observational long-term follow-up study was conducted in a tertiary hospital. Endocrine function was evaluated by the oral glucose tolerance test. The data, including age, sex, body mass index, APACHE II score, history of smoking and drinking, organ failure, pancreatic necrosis, debridement of necrosis(minimally invasive and/or open surgery), and time interval, were collected from the record *** A total of 361 patients were included in the study from January 1, 2012 to December 30, 2018. A total of 150(41.6%) patients were diagnosed with dysglycemia(including diabetes mellitus and impaired glucose tolerance), while211(58.4%) patients had normal endocrine function. The time intervals(mo) of the above two groups were 18.73 ± 19.10 mo and 31.53 ± 27.27 mo, respectively(P= 0.001). The morbidity rates of pancreatic endocrine insufficiency were 46.7%,28.0%, and 25.3%, respectively, in the groups with different follow-up times. The risk factors for pancreatic endocrine insufficiency after AP were severity(odds ratio [OR] = 3.489;95% confidence interval [CI]: 1.501-8.111;P = 0.004) and pancreatic necrosis(OR = 4.152;95%CI: 2.580-6.684;P = 0.001).CONCLUSION Pancreatic necrosis and severity are independent risk factors for pancreatic endocrine insufficiency after AP. The area of pancreatic necrosis can affect pancreatic endocrine function.

关键词： Acute pancreatitis Pancreatic necrosis Diabetes Pancreatic necrosis Pancreatic necrosis debridement Endocrine function

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Ilizarov technique for treatment of a giant aneurysmal bone cyst at the distal femur:A case report

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World Journal of Orthopedics 2024年第11期15卷 1088-1094页

作者： Xing-yu Long Feng Sun Tao Wang Ping Li Zhong Tian Xian-Wei Wu Department of Orthopedics Changsha Hospital for Maternal&Child Health CareChangsha 410000Hunan ProvinceChina Department of Orthopedics Changde First Traditional Chinese Medicine HospitalChangde 415000Hunan ProvinceChina Department of Orthopedics Xinfeng Hospital of Traditional Chinese MedicineGanzhou 341600Jiangxi ProvinceChina

BACKGROUND Aneurysmal bone cyst(ABC)is a benign cystic of unknown etiology,characterized by multiple chambers and a high recurrence *** treatment options include vascular embolization,surgical excision,curettage with cavity filling,sclerosing agent injection into the cavity,radiotherapy,and systemic drug *** these,surgical excision and curettage are the preferred treatment ***,when the cyst reaches a large size,extensive removal of diseased tissue during surgery can hinder bone *** our department,we treated a case of a large ABC at the distal end of the femur in a child using the Ilizarov *** tumor was completely excised,and reconstruction was achieved through autologous femoral bone *** follow-up at two years post-surgery indicated good results without tumor recurrence,and the growth and development of the child were essentially *** SUMMARY An 11-year-old boy was presented with an accidental fracture of his right *** having been examined at other hospitals,he had not received *** the potential for significant bone defects and the difficulty of the surgery,our doctors opted to use the Ilizarov technique to minimize harm to the *** admission,the patient underwent a needle biopsy and complete tumor resection-the Ilizarov technique assisted in the transport and reconstruction of the autologous femoral ***,the patient exhibited regular followups,during which bone transport was gradually performed,and the external fixation frame was removed on ***-up X-rays of the right lower limb displayed no tumor recurrence,with a normal *** formation at the cutting site was satisfactory,and the union of the bone ends indicated good *** two years of follow-up,the patient had essentially returned to *** We successfully applied the Ilizarov technique to treat ABC,reducing the financial burden of patients and the pain of multipl

关键词： Aneurysmal bone cyst Ilizarov technique Bone defect Children Case report

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