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Serum gastrin-17 concentration for prediction of upper gastrointestinal tract bleeding risk among peptic ulcer patients

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World Journal of Clinical Cases 2021年第35期9卷 10948-10955页

作者： Jun-Xian Wang yu-ping cao Peng Su Wei He Xiao-ping Li Ya-Meng Zhu Department of Gastroenterology The Second People’s Hospital of Anhui ProvinceHefei 230011Anhui ProvinceChina

BACKGROUND Serum gastrin-17(G-17),pepsinogen I(PGI),and pepsinogen II(PGII)concentrations regulate gastric acid secretion,and hypersecretion of gastric acid increases the risks of peptic ulcer and upper gastrointestinal *** associations suggest that serum G-17,PGI,and(or)PGII may predict gastrointestinal bleeding risk among peptic ulcer *** To evaluate the efficacies of serum G-17,PGI,PGII,and PGI/PGII ratio(PGR)for predicting upper gastrointestinal bleeding among peptic ulcer *** A total of 199 patients diagnosed with peptic ulcer confirmed by gastroscopy and positivity for Helicobacter pylori by the 14C-urea breath test were recruited,including 107 patients with simple peptic ulcer and 92 cases complicated by upper gastrointestinal *** PGI,PGII,G-17,and PGR were measured by immune methods and compared between bleeding and non-bleeding groups by univariate *** specificity and sensitivity of PGs and G-17 for evaluating upper gastrointestinal bleeding risk were then assessed by constructing receiver operating characteristic(ROC)*** Serum G-17 was significantly higher among peptic ulcer patients with upper gastrointestinal bleeding compared to simple peptic ulcer patients(25.34±14.29 vs 8.84±8.03 pmol/L,t=9.822,P0.05).The risk of bleeding was significantly higher among peptic ulcer patients with elevated serum G-17(>15 pmol/L)compared to patients with normal or low serum G-17(73.2%vs 27.4%,χ2=40.72,P<0.01).The area under the ROC curve for serum G-17 was 0.866±0.024,and a cut-off of 9.86 pmol/L yielded 90.2%sensitivity and 68.2%specificity for distinguishing peptic ulcer with and without upper gastrointestinal *** Serum G-17 is significantly upregulated in peptic ulcer patients and higher levels are predictive of upper gastrointestinal ***,serum PGI,PGII,and PGR

关键词： Peptic ulcer Upper gastrointestinal bleeding Gastrin Pepsinogen Receiver operating characteristic curve

Co-selection may explain the unexpectedly high prevalence of plasmid-mediated colistin resistance gene mcr-1 in a Chinese broiler farm

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Zoological Research 2020年第5期41卷 569-575页

作者： yu-ping cao Qing-Qing Lin Wan-yun He Jing Wang Meng-Ying Yi Lu-Chao Lv Jun Yang Jian-Hua Liu Jian-Ying Guo College of Veterinary Medicine South China Agricultural UniversityGuangzhouGuangdong 510642China Guangdong Laboratory for Lingnan Modern Agriculture GuangzhouGuangdong 510642China

DEAR EDITOR,The rise of the plasmid-encoded colistin resistance gene mcr-1 is a major concern ***,during a routine surveillance,an unexpectedly high prevalence of Escherichia coli with reduced susceptibility to colistin (69.9%) was observed in a Chinese broiler ***-three (63.9%) *** isolates were positive for *** identified mcr-1-positive E.

关键词： globally routine explain

Some Massively Parallel Algorithms from Nature

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Wuhan University Journal of Natural Sciences 2002年第1期7卷 37-46页

作者： Li Yan, Kang Li-shan, Chen yu-ping, Liu Pu, cao Hong-qing, Pan Zheng-jun The State Key Laboratory of Software Engineering, Wuhan University, Wuhan 430072, Hubei, China Wuhan University The State Key Laboratory of Software Engineering Wuhan Hubei China (GRID:grid.49470.3e) (ISNI:***)

We introduced the work on parallel problem solvers from physics and biology being developed by the research team at the State Key Laboratory of Software Engineering, Wuhan University. Results on parallel solvers include the following areas: Evolutionary algorithms based on imitating the evolution processes of nature for parallel problem solving, especially for parallel optimization and model-building; Asynchronous parallel algorithms based on domain decomposition which are inspired by physical analogies such as elastic relaxation process and annealing process, for scientific computations, especially for solving nonlinear mathematical physics problems. All these algorithms have the following common characteristics: inherent parallelism, self-adaptation and self-organization, because the basic ideas of these solvers are from imitating the natural evolutionary processes.

关键词： evolutionary computation parallel algorithm imitating nature domain decomposition knowledge discovery in databases

Empirical study on the financial repression of rural households＇ debit and credit and the effects on their welfare in less developed regions --Take Suqian city of Jiangsu province as an example

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Journal of Modern Accounting and Auditing 2008年第12期4卷 27-34页

作者： ZHANG Bing XU Guo-yu ZUO ping-gui cao Yang yuAN Shuai College of Economics and Management Nanjing Agricultural University Nanjing 210095 China

This paper carries out empirical analysis of the ration behavior of rural credit cooperatives in less developed regions in providing loan services to rural households. It also inspects the interaction between rural households＇ demand for credit and the loan supply from rural credit cooperatives with simultaneous discrete model. The performance of supporting agriculture through a new round reform of rural credit cooperatives is doubtable in this sample region.

关键词： the credit of rural households financial repression credit rationing mode

Tbx20 suppresses oxidized low-density lipoprotein-induced oxidative stress,apoptosis and adhesion molecule expression by upregulating PPARγ in human umbilical vein endothelial cells

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中国病理生理杂志 2012年第11期 2042-2043页

作者： LI Jian,SHEN Tao,ZHU yu-ping,yuAN cao,GUO Hang-bang,MAN Yong,WANG Shu(Key Laboratory of Geriatrics,Beijing Hospital and Beijing Institute of Geriatrics,Ministry of Health,Beijing 100730,China)

AIM:Atherosclerosis is a chronic inflammation disease which is initiated by the endothelial cell *** low-density lipoprotein(ox-LDL)is directly associated with chronic vascular *** transcription factors take part in t... 详细信息

关键词： PPAR LDL in human umbilical vein endothelial cells Tbx20 suppresses oxidized low-density lipoprotein-induced oxidative stress,apoptosis and adhesion molecule expression by upregulating PPAR

Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer's disease

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Neural Regeneration Research 2025年第7期20卷 1981-1988页

作者： Shan ping yu Emily Choi Michael QJiang Ling Wei Department of Anesthesiology Emory University School of MedicineAtlantaGAUSA Center for Visual and Neurocognitive Rehabilitation Atlanta Veterans Affairs Medical CenterDecaturGAUSA

Stroke and Alzheimer's disease are common neurological disorders and often occur in the same *** comorbidity of the two neurological disorders represents a grave health threat to older *** review presents a brief background of the development of novel concepts and their clinical *** activity of glutamatergic N-methyl-D-aspartate receptors and N-methyl-D-aspartate receptor-mediated Ca^(2+)influx is critical for neuronal *** ischemic insult induces prompt and excessive glutamate release and drastic increases of intracellular Ca^(2+)mainly via N-methyl-D-aspartate receptors,particularly of those at the extrasynaptic *** Ca^(2+)-evoked neuronal cell death in the ischemic core is dominated by necrosis within a few hours and days known as acute ***,mild but sustained Ca^(2+)increases under neurodegenerative conditions such as in the distant penumbra of the ischemic brain and early stages of Alzheimer's disease are not immediately toxic,but gradually set off deteriorating Ca^(2+)-dependent signals and neuronal cell loss mostly because of activation of programmed cell death *** on the Ca^(2+)hypothesis of Alzheimer's disease and recent advances,this Ca^(2+)-activated“silent”degenerative excitotoxicity evolves from years to decades and is recognized as a unique slow and chronic *** N-methyl-D-aspartate receptor subunit GluN3A,primarily at the extrasynaptic site,serves as a gatekeeper for the N-methyl-D-aspartate receptor activity and is neuroprotective against both acute and chronic *** stroke and Alzheimer's disease,therefore,share an N-methyl-D-aspartate receptor-and Ca^(2+)-mediated mechanism,although with much different time *** is thus proposed that early interventions to control Ca^(2+)homeostasis at the preclinical stage are pivotal for individuals who are susceptible to sporadic late-onset Alzheimer's disease and Alzheimer's disease-related

关键词： Ca^(2+)hypothesis cognitive deficits hyperactivity late-onset Alzheimer's disease neurodegeneration N-methyl-D-aspartate receptors N-methyl-D-aspartate receptor subunits pathogenesis preventive treatment

Gut microbiota-astrocyte axis: new insights into age-related cognitive decline

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Neural Regeneration Research 2025年第4期20卷 990-1008页

作者： Lan Zhang Jingge Wei Xilei Liu Dai Li Xiaoqi Pang Fanglian Chen Hailong cao ping Lei Haihe Laboratory of Cell Ecosystem Department of GeriatricsTianjin Medical University General HospitalTianjinChina Tianjin Geriatrics Institute Tianjin Medical University General HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalNational Key Clinical SpecialtyTianjin Institute of Digestive DiseasesTianjin Key Laboratory of Digestive DiseasesTianjinChina Department of Urology Tianjin Medical University General HospitalTianjinChina Tianjin Neurological Institution Tianjin Medical University General HospitalTianjinChina

With the rapidly aging human population,age-related cognitive decline and dementia are becoming increasingly prevalent *** is considered the main risk factor for cognitive decline and acts through alterations in the composition of the gut microbiota,microbial metabolites,and the functions of *** microbiota–gut–brain axis has been the focus of multiple studies and is closely associated with cognitive *** article provides a comprehensive review of the specific changes that occur in the composition of the gut microbiota and microbial metabolites in older individuals and discusses how the aging of astrocytes and reactive astrocytosis are closely related to age-related cognitive decline and neurodegenerative *** article also summarizes the gut microbiota components that affect astrocyte function,mainly through the vagus nerve,immune responses,circadian rhythms,and microbial ***,this article summarizes the mechanism by which the gut microbiota–astrocyte axis plays a role in Alzheimer’s and Parkinson’s *** findings have revealed the critical role of the microbiota–astrocyte axis in age-related cognitive decline,aiding in a deeper understanding of potential gut microbiome-based adjuvant therapy strategies for this condition.

关键词： age aging Alzheimer’s disease astrocytes cognitive decline dementia gut microbiota gut–brain axis microbial metabolites neuroinflammation Parkinson’s disease

MXene Hybridized Polymer with Enhanced Electromagnetic Energy Harvest for Sensitized Microwave Actuation and Self-Powered Motion Sensing

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NANO-MICRO LETTERS 2025年第1期17卷 1-15页

作者： Wang, yu-Ze Wang, yu-Chang Liu, Ting-Ting Zhao, Quan-Liang Li, Chen-Sha cao, Mao-Sheng Beijing Inst Technol Sch Mat Sci & Engn Beijing 100081 Peoples R China Peking Univ Sch Mat Sci & Engn Beijing 100871 Peoples R China North China Univ Technol Sch Mech & Mat Engn Beijing 100144 Peoples R China Heilongjiang Univ Minist Educ Peoples Republ China Key Lab Funct Inorgan Mat Chem Harbin 150080 Peoples R China

Polymeric microwave actuators combining tissue-like softness with programmable microwave-responsive deformation hold great promise for mobile intelligent devices and bionic soft robots. However, their application is challenged by restricted electromagnetic sensitivity and intricate sensing coupling. In this study, a sensitized polymeric microwave actuator is fabricated by hybridizing a liquid crystal polymer with Ti3C2Tx (MXene). Compared to the initial counterpart, the hybrid polymer exhibits unique space-charge polarization and interfacial polarization, resulting in significant improvements of 230% in the dielectric loss factor and 830% in the apparent efficiency of electromagnetic energy harvest. The sensitized microwave actuation demonstrates as the shortened response time of nearly 10 s, which is merely 13% of that for the initial shape memory polymer. Moreover, the ultra-low content of MXene (up to 0.15 wt%) benefits for maintaining the actuation potential of the hybrid polymer. An innovative self-powered sensing prototype that combines driving and piezoelectric polymers is developed, which generates real-time electric potential feedback (open-circuit potential of similar to 3 mV) during actuation. The polarization-dominant energy conversion mechanism observed in the MXene-polymer hybrid structure furnishes a new approach for developing efficient electromagnetic dissipative structures and shows potential for advancing polymeric electromagnetic intelligent devices.

关键词： Microwave absorption Electromagnetic response Energy harvest Self-sensing Soft actuator

人工智能文生视频大模型Sora对科技伦理的冲击及应对

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 142-148页

作者：曹贤平南昌工程学院马克思主义学院江西南昌330099

Sora的推出是人类社会发展和人工智能进步的标志性事件,凸显出生成式人工智能的强大功能。Sora的爆火离不开规模化数据、先进算法和规模化算力,其内在运行机制紧扣文本输入、文本编码、视频生成和视频输出的基本逻辑,在人类社会具有广... 详细信息

Sora的推出是人类社会发展和人工智能进步的标志性事件,凸显出生成式人工智能的强大功能。Sora的爆火离不开规模化数据、先进算法和规模化算力,其内在运行机制紧扣文本输入、文本编码、视频生成和视频输出的基本逻辑,在人类社会具有广阔应用前景。但Sora在技术更迭和运用过程中可能给科技伦理带来诸如冲击人的主体性地位、导致人们认知的混乱性、冲击伦理规则的适用性、冲击数字隐私伦理并造成数字歧视等风险。因此,要坚持以人为本,运用技术手段增强Sora的数据筛选力度和敏捷治理效度,防止数据泄露和侵犯隐私,进行伦理设计实现科技伦理与时俱进,辅之必要的教育培训,以此提升全民运用人工智能技术的能力。

关键词： Sora 生成式人工智能科技伦理