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Predictive value of preoperative routine examination for the prognosis of patients with pT2N0M0 or pT3N0M0 colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2429-2438页

作者： Peng-Fei Jing Jin c.en en-Da yu chao-yu Miao Department of colorectal Surgery Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Department of endocrinology and Metabolism Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Department of Pharmacology Second Military Medical University/Naval Medical UniversityShanghai 200433China

BAcKGROUND In recent years,the incidence of colorectal cancer(cRc)has been *** the popularization of endoscopic technology,a number of early cRc has been ***,despite current treatment methods,some patients with early cRc still experience postoperative recurrence and *** To search for indicators associated with early cRc recurrence and metastasis to identify high-risk *** A total of 513 patients with pT2N0M0 or pT3N0M0 cRc were retrospectively enrolled in this *** of blood routine test,liver and kidney function tests and tumor markers were collected before *** were followed up through disease-specific database and telephone *** recurrence,metastasis or death were used as the end point of study to find the risk factors and predictive value related to early cRc recurrence and *** We comprehensively compared the predictive value of preoperative blood routine,blood biochemistry and tumor markers for disease-free survival(DFS)and overall survival(OS)of *** multivariate analysis demonstrated that low platelet count was significantly associated with poor DFS[hazard ratio(HR)=0.995,95% confidence interval(cI):0.991-0.999,P=0.015],while serum carcinoembryonic antigen(cEA)level(HR=1.008,95%cI:1.001-1.016,P=0.027)and serum total cholesterol level(HR=1.538,95%cI:1.026-2.305,P=0.037)were independent risk factors for *** cutoff value of serum cEA level for predicting OS was 2.74 ng/*** the OS of cRc patients with serum cEA higher than the cutoff value was worse than those with lower cEA level,the difference between the two groups was not statistically significant(P=0.075).cONcLUSION For patients with T2N0M0 or T3N0M0 cRc,preoperative platelet count was a protective factor for DFS,while serum cEA level was an independent risk factor for *** that these measures are easier to detect and more acceptable to patients,they may have broader applications.

关键词： colorectal cancer Platelet count Serum carcinoembryonic antigen Total cholesterol level Overall survival Disease-free survival

Troy: Effic.ent Service Deployment for Windows Systems

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chinese Journal of Electronics 2024年第1期33卷 313-322页

作者： Deyu ZHANG yu XIE Mucong XU en c.enG Xiaoyan KUI Bangwen HE yunhao LI School of computer Sc.ence and engineering Central South University

The modern university computer lab and kindergarden through 12th grade classrooms require a centralized solution to effic.ently manage a large number of desktops. The existing solutions either bring virtualization overhead in runtime or requires loading a large image over 30 GB leading to an unacceptable network latency. In this work, we propose Troy which takes advantage of the differencing virtual hard disk techniques in Windows *** such, Troy only loads the modifications made on one machine to all other machines. Troy consists of two modules that are responsible to generate an initial image and merge a differencing image with its parent image, respectively. Specifically, we identify the key fields in the virtual hard disk image that links the differencing image and the parent image and find the modified blocks in the differencing images that should be used to replace the blocks in the parent image. We further design a lazy copy solution to reduce the I/O burden in image merging. We have implemented Troy on bare metal machines. The evaluation results show that the performance of Troy is comparable to the native implementation in Windows, without requiring the Windows environment.

关键词： Runtime Image synthesis Merging Loading Metals Hard disks Virtualization

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Molecular mechanism of Xuebijing in treating pyogenic liver abscess complicated with sepsis

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World Journal of Emergency Medicine 2024年第1期15卷 35-40页

作者： Wei Zhou Maiying Fan Xiang Li Fang yu en Zhou Xiaotong Han Department of Emergency Medicine the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China Department of Otolaryngology-head and Neck Surgery the First Affi liated Hospital of Hunan Normal University/Hunan Provincial People’s HospitalChangsha 410005China

BAcKGROUND:Xuebijing(XBJ)can alleviate the inflammatory response,improve organ function,and shorten the intensive care unit(IcU)stay in patients with pyogenic liver abscess(PLA)complicated with sepsis,but the molecular mechanisms have not been *** study aimed to explore the molecular mechanism of XBJ in treating PLA complicated with sepsis using a network pharmacology ***:The active ingredients and targets of XBJ were retrieved from the ETcM *** targets related to PLA and sepsis were retrieved from the Genecards,PharmGKB,DisGenet,Online Mendelian Inheritance in Man(OMIM),Therapeutic Targets Database(TTD),and DrugBank *** targets of PLA complicated with sepsis were mapped to the targets of XBJ to identify potential treatment ***-protein interaction networks were analyzed using the STRING *** treatment targets were imported into the Metascape platform for Gene Ontology(GO)functional enrichment and Kyoto encyclopedia of Genes and Genomes(KEGG)pathway enrichment *** docking was performed to validate the interactions between active ingredients and core ***:XBJ was found to have 54 potential treatment targets for PLA complicated with ***-1β(IL-1β),interleukin-6(IL-6),and tumor necrosis factor(TNF)were identifi ed as core *** enrichment analysis revealed important pathways,including the interleukin-17(IL-17)signaling pathway,the TNF signaling pathway,the nuclear factor-kappa B(NF-κB)signaling pathway,and the Toll-like receptor(TLR)signaling *** docking experiments indicated stable binding between XBJ active ingredients and core ***:XBJ may exert therapeutic eff ects on PLA complicated with sepsis by modulating signaling pathways,such as the IL-17,TNF,NF-κB,and TLR pathways,and targeting IL-1β,IL-6,and TNF.

关键词： Xuebijing injection Pyogenic liver abscess Sepsis

Spherical Polyelectrolyte Brush Nanoreactor:Preparation of Hollow TiO_(2) Nanospheres and characterization by Small Angle X-Ray Scattering

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chinese Journal of Polymer Sc.ence 2024年第9期42卷 1393-1400,I0009页

作者： yu-Hua Zhang Zi-yu Zhang Xin Liu en-Guang Ma Jiang-Tao Guo Li Li Xu-Hong Guo State Key Laboratory of chemical engineering East China University of Science and TechnologyShanghai200237China Shandong Provincial Key Laboratory of Monocrystalline Silicon Semiconductor Materials and Technology College of Chemistry and Chemical EngineeringDezhou UniversityDezhou253023China Institute of Bast Fiber crops&center of Southern Economic crops Chinese Academy of Agricultural SciencesChangsha410205China

Titanium dioxide(TiO_(2))hollow nanoparticles present significant potential for photocatalytic applications while their straightforward preparation with precise structure control is still *** work reports the approach to preparing tunable hollow TiO_(2) nanospheres by utilization of spherical polyelectrolyte brushes(SPB)as nanoreactors and *** the preparation,the evolution of the structure was characterized by small angle X-ray scattering(SAXS),and in combination with dynamic light scattering and transmission electron *** formation of TiO_(2) shell within the brush(SPB@TiO_(2))is confirmed by the significant increase of the electron density,and its internal structure has been analyzed by fitting SAXS data,which can be influenced by Titanium precursors and ammonia *** calcining SPB@TiO_(2) in a muffle furnace,hollow TiO_(2) nanospheres are produced,and their transition to the anatase crystal form is triggered,as confirmed by X-ray diffraction *** the advantages of their hollow structure,these TiO_(2) nanospheres exhibit exceptional catalytic degradation effic.ency of methylene blue(MB),tetracycline(Tc),and 2,4-dichlorophenoxyacetic acid(2,4-D),and also demonstrate excellent recyclability.

关键词： Spherical polyelectrolyte brush Nanoreactor Hollow titanium dioxide X-ray scattering

Factors influencing willingness to participate in ophthalmic clinical trials and strategies for effective recruitment

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International Journal of Ophthalmology(english edition) 2024年第1期17卷 157-163页

作者： Jia-en Liang Meng-Yin Liang en-en Zhang yu-Ying Peng Ling-Ling c.en Jia-yu Deng Ting Lin Jun Fu Jia-Ni Zhang Shao-Li Li Fei Li Hui-Ming Xaio Wen-Min Huang yu-Hong Liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

AIM:To explore the factors influencing individuals’willingness to participate in ophthalmic clinical ***:A questionnaire survey was conducted from January to April 2021 among patients and their family members at Zhongshan Ophthalmic center,Sun Yat-sen University,in Guangzhou,*** survey gathered data on respondents’willingness,demographic and socioeconomic profiles,as well as their reasons and concerns regarding engagement in clinical ***:Of the 1078 residents surveyed(mean age 31.2±13.1y;65.8%females)in Guangzhou,749(69.5%)expressed a willingness to participate in future ophthalmic clinical *** characteristics associated with greater willingness included a younger age,lower annual income,higher education,prior participation experience,previous ophthalmic treatment,and a better understanding of clinical *** the exception of age,these characteristics were significantly linked to a higher *** primary barrier to participation,expressed by 64.8%of those willing and 54.4%of those unwilling,was“Uncertain efficacy”.In terms of motivations,the willing group ranked“Better therapeutic benefits”(35.0%),“Professional monitoring”(34.3%),and“Trust in healthcare professionals”(33.1%)as their top three reasons,whereas the unwilling participants indicated“Full comprehension of the protocol”(46.2%)as the key ***:This study reveals a substantial willingness to participate in ophthalmic clinical trials and demonstrates the predictive role of demographic and socioeconomic *** in motivators and concerns between willing and unwilling participants highlight the significance of tailored recruitment ***,the need for and trust in healthcare professionals stand out as powerful motivations,underscoring the importance of enhancing physician-patient relationships,adopting patient-centered communication approaches,and addressing individualized needs to improve accrual rates.

关键词： participation willingness recruitment strategy ophthalmic clinical trial

Ethanol-assisted synthesis of a Ni single-atom catalyst with poriferous 3D framework for effic.ent cascade cO_(2)electroreduction

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Rare Metals 2024年第9期43卷 4612-4619页

作者： Feng Wu Shi-Qi Wang Sebastian Kunze Xiao-Ping Gao Pei-Qun Yin yu-en Wu Division of Life Sc.ences and Medicine Department of EndocrinologySchool of Chemistry and Materials ScienceThe First Affiliated Hospital of USTCUniversity of Science and Technology of ChinaHefei 230026China Department of chemistry Seoul National UniversitySeoul 08826South Korea School of Biomedical engineering Anhui Medical UniversityHefei 230032China

The electroreduction of carbon dioxide to generate multicarbon products is significant for achieving a carbon-neutral ***,the selectivity for multi-carbon products faces several challenges,such as the intricate nature of the multistep hydrogenation processes,slow reaction kinetics and the bicarbonate precipitate issue caused by alkaline *** factors hinder the extensive utilization of this ***,we successfully developed and implemented a tandem electrolyzer cascade to separate and optimize the complex elementary reactions involved in the process of multi-carbon production.

关键词： reaction. synthesis catalyst

Autophagy and its role in gastrointestinal diseases

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World Journal of Gastroenterology 2024年第36期30卷 4014-4020页

作者： Bo-Zong Shao Wen-Gang Zhang Zhen-yu Liu en-Qiang Linghu Department of Gastroenterology First Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100853China

Gastrointestinal disorders encompass a spectrum of conditions affecting various organs within the digestive system,such as the esophagus,stomach,colon,rectum,pancreas,liver,small intestine,and bile *** role of autophagy in the etiology and progression of gastrointestinal diseases has garnered significant *** paper seeks to evaluate the impact and mechanisms of autophagy in gastrointestinal disorders by synthesizing recent research ***,we delve into inflammation-related gastrointestinal conditions,including ulcerative colitis,crohn’s disease,and pancreatitis,as well as gastrointestinal cancers such as esophageal,gastric,and colorectal ***,we provide commentary on a recent publication by chang et al in the World Journal of *** objective is to offer fresh perspectives on the mechanisms and therapeutic approaches for these gastrointestinal *** review aims to offer new perspectives on the mechanisms and therapeutic strategies for gastrointestinal disorders by critically analyzing relevant *** discussed,the role of autophagy in gastrointestinal diseases is complex and,at times,*** harness the full therapeutic potential of autophagy in treating these conditions,more in-depth research is imperative.

关键词： Autophagy Inflammation cancer Inflammatory bowel disease Pancreatitis

ABLkit: a Python toolkit for abductive learning

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Frontiers of computer Sc.ence 2024年第6期18卷 186354-186354页

作者： HUANG yu-Xuan HU Wen-chao GAO en-Hao JIANG yuan National Key Laboratory for Novel Software Technology Nanjing University School of Artificial Intelligence Nanjing University

Interconnections between diabetic corneal neuropathy and diabetic retinopathy:diagnostic and therapeutic implications

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Neural Regeneration Research 2025年第8期20卷 2169-2180页

作者： Mingyi yu Faith Teo en Ning chang Liu yu-chi Liu Tissue engineering and Stem cell Group Singapore Eye Research InstituteSingapore Yong Loo Lin School of Medicine National University of SingaporeSingapore Department of cornea and External Eye Disease Singapore National Eye CenterSingapore Ophthalmology and Visual Sc.ences Academic clinical Program Duke-NUS Medical SchoolSingapore

Diabetic corneal neuropathy and diabetic retinopathy are ocular complications occurring in the context of diabetes *** corneal neuropathy refers to the progressive damage of corneal *** retinopathy has traditionally been considered as damage to the retinal ***,growing evidence suggests that diabetic retinopathy is a complex neurovascular disorder resulting from dysfunction of the neurovascular unit,which includes both the retinal vascular structures and neural *** retinopathy is one of the leading causes of blindness and is frequently screened for as part of diabetic ocular ***,diabetic corneal neuropathy is commonly overlooked and underdiagnosed,leading to severe ocular surface *** studies have found that these two conditions tend to occur together,and they share similarities in their pathogenesis pathways,being triggered by a status of chronic *** review aims to discuss the interconnection between diabetic corneal neuropathy and diabetic retinopathy,whether diabetic corneal neuropathy precedes diabetic retinopathy,as well as the relation between the stage of diabetic retinopathy and the severity of corneal *** also endeavor to explore the relevance of a corneal screening in diabetic eyes and the possibility of using corneal nerve measurements to monitor the progression of diabetic retinopathy.

关键词： cornea corneal nerves diabetes diabetic corneal neuropathy diabetic retinopathy retina