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慢性甲基苯丙胺依赖患者与酒精依赖、抑郁障碍及精神分裂症患者的认知功能比较（英文）

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慢性甲基苯丙胺依赖患者与酒精依赖、抑郁障碍及精神分裂症患者的...

Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rats hippocampus

2020年浙江省医学会精神病学学术大会浙江省医师协会精...

作者： Wang SD Xu XH Ju X Li J Yan P yu zh Song MF Wang SQ The Molecular Biology Laboratory Hangzhou Seventh People's Hospital Mental Health Center Zhejiang University School of Medicine Department of Geriatric Psychiatry Hangzhou Seventh People's Hospital

Background:Depression is a debilitating psychiatric disorder with a huge socioeconomic burden,and its treatment relies on ***,the melatonergic system has been implicated in the pathophysiology and treatment of *** this study,We observed the effects of melatonin(MT) on depression-like behavior induced by chronic unpredictable mild stress(CUMS) in rats,and its molecular mechanism was ***:Adult male Sprague-Dawley(SD) rats were exposed to CUMS for 4 *** or saline were injected *** changes of SD rats was detected by open field test,sugar preference test,elevated O maze test and forced swimming *** addition,the plasma corticosterone level and the expression of endoplasmic reticulum stress-related protein in hippocampus of rats were ***:Compared with the control group,the CUMS-exposed SD rats showed depression-like behavior,which was significantly improved by MT ***,CUMS induced endoplasmic reticulum stress and JNK phosphorylation in *** treatment could significantly reverse the endoplasmic reticulum stress and JNK phosphorylation induced by *** results suggest that MT improves depression-like behavior by inhibiting endoplasmic reticulum stress induced by ***:This study demonstrates that MT can improve depression-like behavior induced by CUMS,which may be related to the inhibition of endoplasmic reticulum stress cascade in hippocampus.

关键词： melatonin chronic unpredictable mild stress depressive behavior endoplasmic reticulum stress

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Melatonin ameliorated CUMS-induced depression-like behavior ...

Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rats hippocampus

2019第四届之江精神医学交流会、浙江省医学会精神病学学术大会、浙江省医师协会精神科医师分会第十二届年会

作者： Wang SD Xu XH Ju X Li J Yan P yu zh Song MF Wang SQ The Molecular Biology Laboratory Hangzhou Seventh People's HospitalHangzhou 310013China Mental Hea Department of Geriatric Psychiatry Hangzhou Seventh People's HospitalHangzhou 310013China Mental H Mental Health Center Zhejiang University School of MedicineHangzhou 310013China

关键词： melatonin chronic unpredictable mild stress depressive behavior endoplasmic reticulum stress

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Melatonin ameliorated CUMS-induced depression-like behavior ...

Technology of Porous Tantalum Production

2020年浙江省医学会精神病学学术大会浙江省医师协会精...

Background:Depression is a debilitating psychiatric disorder with a huge socioeconomic burden,and its treatment relies on ***,the melatonergic system has been implicated in the pathophysiology and treatment of *** this study,We observed the effects of melatonin(MT) on depression-like behavior induced by chronic unpredictable mild stress(CUMS) in rats,and its molecular mechanism was ***:Adult male Sprague-Dawley(SD) rats were exposed to CUMS for 4 *** or saline were injected *** changes of SD rats was detected by open field test,sugar preference test,elevated 0 maze test and forced swimming *** addition,the plasma corticosterone level and the expression of endoplasmic reticulum stress-related protein in hippocampus of rats were ***:Compared with the control group,the CUMS-exposed SD rats showed depression-like behavior,which was significantly improved by MT ***,CUMS induced endoplasmic reticulum stress and JNK phosphorylation in *** treatment could significantly reverse the endoplasmic reticulum stress and JNK phosphorylation induced by *** results suggest that MT improves depression-like behavior by inhibiting endoplasmic reticulum stress induced by ***:This study demonstrates that MT can improve depression-like behavior induced by CUMS,which may be related to the inhibition of endoplasmic reticulum stress cascade in hippocampus.

关键词： melatonin chronic unpredictable mild stress depressive behavior endoplasmic reticulum stress

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World Journal of Nano Science and Engineering 2016年第2期6卷 51-57页

作者： yu. zh. Tuleushev V. N. Volodin Е. А. zhakanbaev V. N. Lisitsin A. A. Migunova A. S. Suleymenova Institute of Nuclear Physics Almaty Republic of Kazakhstan

Ion-plasma sputtering and codeposition of ultrafine Ta and Cd particles on a moving substrate were used to prepare the solid solutions, in particular, the alloys with up to 66.2 at.% Cd in the form of coatings. In vacuum heat treatment cadmium evaporates at 700°C from cadmium based solid solutions resulting in formation of a porous tantalum with a highly developed surface. The prepared tantalum-based materials assume the technological application of the investigation results.

关键词： Tantalum Cadmium Porous Structures Specific Surface

Heterogeneous body compositions and all-cause mortality in acute coronary syndrome patients:a ten-year retrospective cohort study

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Journal of Geriatric Cardiology 2024年第5期21卷 534-541页

作者： Guang-zhi LIAO Lin BAI yu-Yang YE Xue-Feng CHEN Xin-Ru HU Yong PENG Department of Cardiology West China HospitalSichuan UniversityChengduSichuanChina

BACKGROUND The association of different body components,including lean mass and body fat,with the risk of death in acute coronary syndrome(ACS)patients are *** We enrolled adults diagnosed with ACS at our center between January 2011 and December 2012 and obtained fol-low-up outcomes via telephone *** used restricted cubic splines(RCS)with the Cox proportional hazards model to analyze the associations between body mass index(BMI),predicted lean mass index(LMI),predicted body fat percentage(BF),and the value of LMI/BF with 10-year *** also examined the secondary outcome of death during *** During the maximum 10-year follow-up of 1398 patients,331 deaths(23.6%)occurred,and a U-shaped relationship was found between BMI and death risk(P_(nonlinearity)=0.03).After adjusting for age and history of diabetes,the overweight group(24≤BMI<28 kg/m^(2))had the lowest mortality(HR=0.53,95%CI:0.29-0.99).Predicted LMI and LMI/BF had an inverse linear relationship with a 10-year death risk(P_(nonlinearity)=0.24 and P_(nonlinearity)=0.38,respectively),while an increase in BF was associ-ated with increased mortality(P_(nonlinearity)=0.64).During hospitalization,31 deaths(2.2%)were recorded,and the associations of the indicators with in-hospital mortality were consistent with the long-term outcome *** Our study provides new insight into the“obesity paradox”in ACS patients,highlighting the importance of considering body composition *** LMI and BF may serve as useful tools for assessing nutritional status and predicting the prognosis of ACS,based on their linear associations with all-cause mortality.

关键词： patients mortality coronary

肿瘤基因单核苷酸多态性研究及个体化医疗的思考

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世界华人消化杂志 2005年第5期13卷 592-595页

作者：许玲孙大志余志红中国人民解放军第二军医大学附属长征医院中医科上海市200003

单核苷酸多态性(SNPs)是指存在于某一人群或个体基因组内的单个碱基发生突变,从而导致了群体与群体及个体与个体之间的差异.肿瘤患者个体治疗敏感性和与治疗相关的毒副反应等均与SNPs有关.解析人类基因组的碱基序列差异,将为相关联的医... 详细信息

单核苷酸多态性(SNPs)是指存在于某一人群或个体基因组内的单个碱基发生突变,从而导致了群体与群体及个体与个体之间的差异.肿瘤患者个体治疗敏感性和与治疗相关的毒副反应等均与SNPs有关.解析人类基因组的碱基序列差异,将为相关联的医药领域疾病的治疗带来革命性飞跃,在不久的将来有望实现“量体裁衣”式的个体化给药治疗方案.

关键词：个体化医疗多态性研究肿瘤基因单核苷酸多态性人类基因组治疗敏感性个体化给药序列差异 SNPS 毒副反应治疗相关肿瘤患者医药领域治疗方案碱基群体

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高温pHt对pH25换算关系的探讨

成都科技大学学报 1981年第1期 89-95页

作者：彭少方张正元张达懋

目前湿法冶金正向高温高压过程发展,作为研究水溶液热力学工具的高温电位-pH图也成为各国学者研究的对象。有关高温电位-pH图的计算,国内外文献都有介绍。本文仅讨论高温电位-pH图中高温pHp对25℃下的pH25换算关系。高温电位-pH图是用... 详细信息

目前湿法冶金正向高温高压过程发展,作为研究水溶液热力学工具的高温电位-pH图也成为各国学者研究的对象。有关高温电位-pH图的计算,国内外文献都有介绍。本文仅讨论高温电位-pH图中高温pHp对25℃下的pH25换算关系。高温电位-pH图是用热力学函数计算出来的,其中pHt是计算温度下的标度。计算出来的pHt将不同于pH25。因温度升高,水的离解常数增加,中和点的pH将减小,如25℃中和点的pH=7,而100℃中和点的pH=6.13。对此如不加以换算,

关键词：标度中和点温度升高换算关系水解反应平衡常数 pH_t 实验结果金属离子成都科技大学一期

正常和骨质疏松模型动物不同部位及不同器官摄取^(18)F-NaF的差异对骨代谢评估的意义

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中国组织工程研究与临床康复 2007年第27期11卷 5346-5349页

作者：吴启跃马雯余正红雷洋洋李钦宗深圳市体育运动学校广东省深圳市518131 河南省人民医院小儿骨科河南省郑州市450003 南方医科大学临床解剖研究所广东省广州市510515 天津中医药大学第一附属医院肾内科天津市300193 南方医科大学中医药学院骨伤系广东省广州市510515

目的:利用18F-NaF进行药代动力学研究,观察正常动物和骨质疏松模型动物在不同部位、不同器官摄取18F-NaF的差异评估骨代谢的改变情况。方法:实验于2005-05/2006-02在南方医科大学中医药学院实验室和南方医科大学附属南方医院PET中心完... 详细信息

目的:利用18F-NaF进行药代动力学研究,观察正常动物和骨质疏松模型动物在不同部位、不同器官摄取18F-NaF的差异评估骨代谢的改变情况。方法:实验于2005-05/2006-02在南方医科大学中医药学院实验室和南方医科大学附属南方医院PET中心完成。①分组:选取清洁级3月龄SD大鼠20只,随机数字表法分为两组:对照组和激素组,每组10只。②干预:激素组用注射过量激素法制作大鼠骨质疏松模型,用0.2μL/g地塞米松磷酸钠注射液(广东南国药业有限公司)肌肉注射,2次/周(每周2,5注射);对照组用同等剂量的NaCl注射液(武汉健民药业集团十堰康迪制药有限公司)注射。两组均注射8周。③骨密度测定:干预8周后,应用美国NORLAND生产的XR-36型双能骨密度测量仪对两组大鼠进行扫描,部位包括股骨颈、脊柱和肱骨下段。④18F-NaF扫描及图像重建:干预8周后,两组大鼠尾静脉注射18F-NaF,利用GE公司产的正电子发射计算机体层摄影-CT进行全身扫描,观察各处骨骼及肌肉和血液对18F-NaF的摄取,计算骨骼与肌肉和血液的比值,并进行统计学分析。将扫描得到的数据经迭代重建后进行图像融合,得到冠状、矢状、横断面CT,PET及PET/CT融合图像,然后通过融合软件进行组间对比。结果:20只大鼠全部进入结果分析。①骨密度值:激素组大鼠股骨颈、脊柱(T4)处低于对照组[(0.083±0.007),(0.086±0.013)g/cm2;(0.129±0.014),(0.124±0.018)g/cm2;P均<0.05]。②骨骼与肌肉和血液摄取18F-NaF的比值:激素组股骨颈、胫腓骨、桡骨远端、肱骨下端等部位低于对照组(0.71±0.27,0.61±0.27,0.55±0.23,1.16±0.98;1.12±0.54,0.90±0.51,0.75±0.39,1.44±1.09,P<0.05)。结论:骨质疏松部位对18F-NaF的摄取值的改变反应了骨的代谢变化,提示18F-NaF作为显像剂的正电子发射计算机体层摄影技术可以无创伤的检测骨质疏松骨代谢的改变,为早期检测骨质疏松提供理论依据。

关键词： ^18F-NaF 正电子发射计算机体层摄影-CT 骨质疏松症骨代谢

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai Meng Tian Huali yu Xiaoxiao He Xiaojuan zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan