Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rats hippocampus
作者单位：The Molecular Biology LaboratoryHangzhou Seventh People's HospitalHangzhou 310013China Mental Hea Department of Geriatric PsychiatryHangzhou Seventh People's HospitalHangzhou 310013China Mental H Mental Health CenterZhejiang University School of MedicineHangzhou 310013China
会议名称：《2019第四届之江精神医学交流会、浙江省医学会精神病学学术大会、浙江省医师协会精神科医师分会第十二届年会》
会议日期：1000年
学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学]
关 键 词：melatonin chronic unpredictable mild stress depressive behavior endoplasmic reticulum stress
摘 要：Background:Depression is a debilitating psychiatric disorder with a huge socioeconomic burden,and its treatment relies on ***,the melatonergic system has been implicated in the pathophysiology and treatment of *** this study,We observed the effects of melatonin(MT) on depression-like behavior induced by chronic unpredictable mild stress(CUMS) in rats,and its molecular mechanism was ***:Adult male Sprague-Dawley(SD) rats were exposed to CUMS for 4 *** or saline were injected *** changes of SD rats was detected by open field test,sugar preference test,elevated O maze test and forced swimming *** addition,the plasma corticosterone level and the expression of endoplasmic reticulum stress-related protein in hippocampus of rats were ***:Compared with the control group,the CUMS-exposed SD rats showed depression-like behavior,which was significantly improved by MT ***,CUMS induced endoplasmic reticulum stress and JNK phosphorylation in *** treatment could significantly reverse the endoplasmic reticulum stress and JNK phosphorylation induced by *** results suggest that MT improves depression-like behavior by inhibiting endoplasmic reticulum stress induced by ***:This study demonstrates that MT can improve depression-like behavior induced by CUMS,which may be related to the inhibition of endoplasmic reticulum stress cascade in hippocampus.